Free fatty acid receptors act as nutrient sensors to regulate energy homeostasis.

[1]  K. Takeuchi,et al.  Overexpression of GPR40 in Pancreatic β-Cells Augments Glucose-Stimulated Insulin Secretion and Improves Glucose Tolerance in Normal and Diabetic Mice , 2009, Diabetes.

[2]  M. Gershengorn,et al.  Two Arginine-Glutamate Ionic Locks Near the Extracellular Surface of FFAR1 Gate Receptor Activation* , 2009, Journal of Biological Chemistry.

[3]  Merlin C. Thomas,et al.  Direct antiatherosclerotic effects of PPAR agonists , 2009, Current opinion in lipidology.

[4]  Kazuo Inoue,et al.  Colocalization of GPR120 with phospholipase-Cβ2 and α-gustducin in the taste bud cells in mice , 2009, Neuroscience Letters.

[5]  T. Wieland,et al.  How reliable are G-protein-coupled receptor antibodies? , 2009, Naunyn-Schmiedeberg's Archives of Pharmacology.

[6]  Takafumi Hara,et al.  Flow Cytometry-Based Binding Assay for GPR40 (FFAR1; Free Fatty Acid Receptor 1) , 2009, Molecular Pharmacology.

[7]  A. M. Habib,et al.  Nutrient-dependent secretion of glucose-dependent insulinotropic polypeptide from primary murine K cells , 2009, Diabetologia.

[8]  Takafumi Hara,et al.  Distribution and regulation of protein expression of the free fatty acid receptor GPR120 , 2009, Naunyn-Schmiedeberg's Archives of Pharmacology.

[9]  S. Bharate,et al.  Discovery of diacylphloroglucinols as a new class of GPR40 (FFAR1) agonists. , 2008, Bioorganic & medicinal chemistry letters.

[10]  Yang Li,et al.  Identification and Functional Characterization of Allosteric Agonists for the G Protein-Coupled Receptor FFA2 , 2008, Molecular Pharmacology.

[11]  M. Makishima,et al.  Identification of G protein-coupled receptor 120-selective agonists derived from PPARgamma agonists. , 2008, Journal of medicinal chemistry.

[12]  E. Kostenis,et al.  Discovery of potent and selective agonists for the free fatty acid receptor 1 (FFA(1)/GPR40), a potential target for the treatment of type II diabetes. , 2008, Journal of medicinal chemistry.

[13]  H. Edlund,et al.  Gpr40 Is Expressed in Enteroendocrine Cells and Mediates Free Fatty Acid Stimulation of Incretin Secretion , 2008, Diabetes.

[14]  Yang Li,et al.  Activation of G protein-coupled receptor 43 in adipocytes leads to inhibition of lipolysis and suppression of plasma free fatty acids. , 2008, Endocrinology.

[15]  Takafumi Hara,et al.  Production and characterization of a monoclonal antibody against GPR40 (FFAR1; free fatty acid receptor 1). , 2008, Biochemical and biophysical research communications.

[16]  Yang Li,et al.  Identification and Functional Characterization of Allosteric Agonists for the G Protein-Coupled Receptor FFA 2 , 2008 .

[17]  G. Tsujimoto,et al.  Free fatty acids induce cholecystokinin secretion through GPR120 , 2008, Naunyn-Schmiedeberg's Archives of Pharmacology.

[18]  C. Bouchard,et al.  G protein‐coupled receptor 84, a microglia‐associated protein expressed in neuroinflammatory conditions , 2007, Glia.

[19]  T. Alquier,et al.  GPR40 Is Necessary but Not Sufficient for Fatty Acid Stimulation of Insulin Secretion In Vivo , 2007, Diabetes.

[20]  G. Tsujimoto,et al.  The regulation of adipogenesis through GPR120. , 2007, Biochemical and biophysical research communications.

[21]  T. Iwanaga,et al.  GPR expression in the rat taste bud relating to fatty acid sensing. , 2007, Biomedical research.

[22]  H. Tian,et al.  Medium-chain Fatty Acids as Ligands for Orphan G Protein-coupled Receptor GPR84* , 2006, Journal of Biological Chemistry.

[23]  J. Fornwald,et al.  Pharmacological regulation of insulin secretion in MIN6 cells through the fatty acid receptor GPR40: identification of agonist and antagonist small molecules , 2006, British journal of pharmacology.

[24]  S. Roh,et al.  Reduction in voltage-gated K+ currents in primary cultured rat pancreatic beta-cells by linoleic acids. , 2006, Endocrinology.

[25]  T. Iwanaga,et al.  Short-chain fatty acid receptor, GPR43, is expressed by enteroendocrine cells and mucosal mast cells in rat intestine , 2006, Cell and Tissue Research.

[26]  Ki-Choon Choi,et al.  Acetate and propionate short chain fatty acids stimulate adipogenesis via GPCR43. , 2005, Endocrinology.

[27]  C. Venkataraman,et al.  The G-protein coupled receptor, GPR84 regulates IL-4 production by T lymphocytes in response to CD3 crosslinking. , 2005, Immunology letters.

[28]  N. Rubins,et al.  The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse. , 2005, Cell metabolism.

[29]  T. Hansen,et al.  Studies of relationships between variation of the human G protein‐coupled receptor 40 Gene and Type 2 diabetes and insulin release , 2005, Diabetic medicine : a journal of the British Diabetic Association.

[30]  O. Civelli,et al.  GPCR deorphanizations: the novel, the known and the unexpected transmitters. , 2005, Trends in pharmacological sciences.

[31]  G. Tsujimoto,et al.  Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120 , 2005, Nature Medicine.

[32]  J. Thevelein,et al.  The eukaryotic plasma membrane as a nutrient-sensing device. , 2004, Trends in biochemical sciences.

[33]  R. Kedzierski,et al.  Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[34]  R. Kedzierski,et al.  Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR 41 , 2004 .

[35]  M. Parmentier,et al.  Functional Characterization of Human Receptors for Short Chain Fatty Acids and Their Role in Polymorphonuclear Cell Activation* , 2003, Journal of Biological Chemistry.

[36]  M. Fujimiya,et al.  Short-chain fatty acids stimulate colonic transit via intraluminal 5-HT release in rats. , 2003, American journal of physiology. Regulatory, integrative and comparative physiology.

[37]  B. Olde,et al.  Identification of a free fatty acid receptor, FFA2R, expressed on leukocytes and activated by short-chain fatty acids. , 2003, Biochemical and biophysical research communications.

[38]  J. Chambers,et al.  The Orphan G Protein-coupled Receptor GPR40 Is Activated by Medium and Long Chain Fatty Acids* , 2003, The Journal of Biological Chemistry.

[39]  S. Dowell,et al.  The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids* , 2003, The Journal of Biological Chemistry.

[40]  Masataka Harada,et al.  Free fatty acids regulate insulin secretion from pancreatic β cells through GPR40 , 2003, Nature.

[41]  B. Olde,et al.  A human cell surface receptor activated by free fatty acids and thiazolidinedione drugs. , 2003, Biochemical and biophysical research communications.

[42]  T. Yokota,et al.  LSSIG is a novel murine leukocyte-specific GPCR that is induced by the activation of STAT3. , 2003, Blood.

[43]  S. Ashcroft,et al.  Acute effects of fatty acids on insulin secretion from rat and human islets of Langerhans. , 2002, The Journal of endocrinology.

[44]  R. Evans,et al.  Nuclear receptors and lipid physiology: opening the X-files. , 2001, Science.

[45]  J. Friedman,et al.  Selective deletion of leptin receptor in neurons leads to obesity. , 2001, The Journal of clinical investigation.

[46]  S. Yousefi,et al.  Cloning and expression analysis of a novel G‐protein‐coupled receptor selectively expressed on granulocytes , 2001, Journal of leukocyte biology.

[47]  H. Schaller,et al.  An expressed sequence tag (EST) data mining strategy succeeding in the discovery of new G-protein coupled receptors. , 2001, Journal of molecular biology.

[48]  T. Pineau,et al.  Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor alpha (PPARalpha)-independent pathway. , 2001, The Biochemical journal.

[49]  G. Warhurst,et al.  Fatty acid‐induced cholecystokinin secretion and changes in intracellular Ca2+ in two enteroendocrine cell lines, STC‐1 and GLUTag , 2000, The Journal of physiology.

[50]  D. Blask,et al.  Mechanism for the antitumor and anticachectic effects of n-3 fatty acids. , 2000, Cancer research.

[51]  J. D. de Winde,et al.  A Saccharomyces cerevisiae G‐protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose , 1999, Molecular microbiology.

[52]  J. Galmiche,et al.  Short-chain fatty acids modify colonic motility through nerves and polypeptide YY release in the rat. , 1998, The American journal of physiology.

[53]  J. McGarry,et al.  Circulating fatty acids are essential for efficient glucose-stimulated insulin secretion after prolonged fasting in humans. , 1998, Diabetes.

[54]  G. Tsujimoto,et al.  Real-Time Optical Monitoring of Ligand-Mediated Internalization of α1b-Adrenoceptor with Green Fluorescent Protein , 1998 .

[55]  J. McGarry,et al.  A fatty acid- dependent step is critically important for both glucose- and non-glucose-stimulated insulin secretion. , 1998, The Journal of clinical investigation.

[56]  G. Tsujimoto,et al.  Real-time optical monitoring of ligand-mediated internalization of alpha1b-adrenoceptor with green fluorescent protein. , 1998, Molecular endocrinology.

[57]  L. F. Kolakowski,et al.  A cluster of four novel human G protein-coupled receptor genes occurring in close proximity to CD22 gene on chromosome 19q13.1. , 1997, Biochemical and biophysical research communications.

[58]  J. McGarry,et al.  The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation. , 1997, The Journal of clinical investigation.

[59]  J. McGarry,et al.  Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat. , 1996, The Journal of clinical investigation.

[60]  M. Coppi,et al.  Propionate induces polymorphonuclear leukocyte activation and inhibits formylmethionyl-leucyl-phenylalanine-stimulated activation , 1992, Infection and immunity.

[61]  I Yuli,et al.  Cytosolic acidification as an early transductory signal of human neutrophil chemotaxis. , 1987, Science.

[62]  J. de Graaff,et al.  Short-chain fatty acids produced by anaerobic bacteria alter the physiological responses of human neutrophils to chemotactic peptide. , 1987, The Journal of infection.