Targeting protein modifications in metabolic diseases: molecular mechanisms and targeted therapies

[1]  M. Ekstedt,et al.  Changing epidemiology, global trends and implications for outcomes of NAFLD. , 2023, Journal of hepatology.

[2]  Ye Ding,et al.  AMPKα2 controls the anti-atherosclerotic effects of fish oils by modulating the SUMOylation of GPR120 , 2022, Nature communications.

[3]  A. Akhmedov,et al.  JCAD promotes arterial thrombosis through PI3K/Akt modulation: a translational study. , 2022, European heart journal.

[4]  G. Saxena,et al.  Lactate-induced lactylation in skeletal muscle is associated with insulin resistance in humans , 2022, Frontiers in Physiology.

[5]  J. Hirschhorn,et al.  Post-translational control of beige fat biogenesis by PRDM16 stabilization , 2022, Nature.

[6]  Ming-wei Sun,et al.  Current methodologies in protein ubiquitination characterization: from ubiquitinated protein to ubiquitin chain architecture , 2022, Cell & bioscience.

[7]  B. Song,et al.  Inhibition of ASGR1 decreases lipid levels by promoting cholesterol excretion , 2022, Nature.

[8]  L. Pirola,et al.  Ketogenic diet administration to mice after a high-fat-diet regimen promotes weight loss, glycemic normalization and induces adaptations of ketogenic pathways in liver and kidney , 2022, Molecular metabolism.

[9]  Kathy O. Lui,et al.  MRG15 aggravates non-alcoholic steaohepatitis progression by regulating the mitochondrial proteolytic degradation of TUFM. , 2022, Journal of hepatology.

[10]  A. Sanyal,et al.  Digital pathology with artificial intelligence analyses provides greater insights into treatment-induced fibrosis regression in NASH. , 2022, Journal of hepatology.

[11]  D. Baptista,et al.  The E3 Ubiquitin Ligase Peli1 Deficiency Promotes Atherosclerosis Progression , 2022, Cells.

[12]  P. Schrauwen,et al.  A randomized placebo-controlled clinical trial for pharmacological activation of BCAA catabolism in patients with type 2 diabetes , 2022, Nature Communications.

[13]  Xin Li,et al.  PAQR3 depletion accelerates diabetic wound healing by promoting angiogenesis through inhibiting STUB1-mediated PPARγ degradation , 2022, Laboratory Investigation.

[14]  Zhongwen Xie,et al.  Large Yellow Tea Extract Ameliorates Metabolic Syndrome by Suppressing Lipogenesis through SIRT6/SREBP1 Pathway and Modulating Microbiota in Leptin Receptor Knockout Rats , 2022, Foods.

[15]  George Liu,et al.  Idol Depletion Protects against Spontaneous Atherosclerosis in a Hamster Model of Familial Hypercholesterolemia , 2022, Oxidative medicine and cellular longevity.

[16]  Q. Cui,et al.  Hepatocellular cystathionine γ lyase/hydrogen sulfide attenuates nonalcoholic fatty liver disease by activating farnesoid X receptor , 2022, Hepatology.

[17]  P. Li,et al.  Dorzagliatin add-on therapy to metformin in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled phase 3 trial , 2022, Nature Medicine.

[18]  H. Ou,et al.  Oxidized high-density lipoprotein promotes CD36 palmitoylation and increases lipid uptake in macrophages , 2022, The Journal of biological chemistry.

[19]  T. Hassanein,et al.  Safety and efficacy of combination therapy with semaglutide, cilofexor and firsocostat in patients with non-alcoholic steatohepatitis: A randomised, open-label phase II trial. , 2022, Journal of hepatology.

[20]  Ronghui Du,et al.  Exercise Ameliorates Atherosclerosis via Up-Regulating Serum β-Hydroxybutyrate Levels , 2022, International journal of molecular sciences.

[21]  J. Heath,et al.  FAIMS Enhances the Detection of PTM Crosstalk Sites , 2022, Journal of proteome research.

[22]  J. Bayascas,et al.  Acox2 is a regulator of lysine crotonylation that mediates hepatic metabolic homeostasis in mice , 2022, Cell Death & Disease.

[23]  J. Bayascas,et al.  Acox2 is a regulator of lysine crotonylation that mediates hepatic metabolic homeostasis in mice , 2022, Cell death & disease.

[24]  A. Gu,et al.  Hsp90 S-nitrosylation at Cys521, as a conformational switch, modulates cycling of Hsp90-AHA1-CDC37 chaperone machine to aggravate atherosclerosis , 2022, Redox biology.

[25]  Zhe Zhang,et al.  Amelioration of hepatic steatosis by dietary essential amino acid-induced ubiquitination. , 2022, Molecular cell.

[26]  Linfeng Hu,et al.  The E3 ubiquitin-protein ligase Trim31 alleviates non-alcoholic fatty liver disease by targeting Rhbdf2 in mouse hepatocytes , 2022, Nature communications.

[27]  Huiling Cao,et al.  Kindlin-2 haploinsufficiency protects against fatty liver by targeting Foxo1 in mice , 2022, Nature communications.

[28]  Qiang Wu,et al.  Sirt5-mediated desuccinylation of OPTN protects retinal ganglion cells from autophagic flux blockade in diabetic retinopathy , 2022, Cell death discovery.

[29]  Xiao He,et al.  Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate , 2022, Cell Research.

[30]  Zhengtao Wang,et al.  2,3,5,4'-tetrahydroxy-stilbene-2-O-β-D-glucoside ameliorates NAFLD via attenuating hepatic steatosis through inhibiting mitochondrial dysfunction dependent on SIRT5. , 2022, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[31]  J. Niu,et al.  PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours , 2022, Acta Pharmacologica Sinica.

[32]  X. Ruan,et al.  Inhibition of fatty acid translocase (FAT/CD36) palmitoylation enhances hepatic fatty acid β-oxidation by increasing its localization to mitochondria and interaction with long-chain acyl-CoA synthetase 1. , 2022, Antioxidants & redox signaling.

[33]  Stephen L. Pinkosky,et al.  Lipogenesis inhibitors: therapeutic opportunities and challenges , 2022, Nature Reviews Drug Discovery.

[34]  Keai Sinn Tan,et al.  Hepatocellular BChE as a therapeutic target to ameliorate hypercholesterolemia through PRMT5 selective degradation to restore LDL receptor transcription. , 2022, Life sciences.

[35]  Jiandie D. Lin,et al.  Histone Deacetylase 6 Inhibition Restores Leptin Sensitivity and Reduces Obesity , 2021, Nature Metabolism.

[36]  Hongna Mu,et al.  Association of Serum β-Hydroxybutyrate and Coronary Artery Disease in an Urban Chinese Population , 2021, Frontiers in Nutrition.

[37]  K. Herold,et al.  Citrullination of glucokinase linked to autoimmune diabetes , 2021, bioRxiv.

[38]  Hiroaki Takayama,et al.  Selenoprotein P-mediated reductive stress impairs cold-induced thermogenesis in brown fat. , 2021, Cell reports.

[39]  B. Song,et al.  Analysis of Protein Cholesterylation by Biorthogonal Labeling. , 2022, Methods in molecular biology.

[40]  J. Liu,et al.  MF-094, a potent and selective USP30 inhibitor, accelerates diabetic wound healing by inhibiting the NLRP3 inflammasome , 2021, Experimental Cell Research.

[41]  Qibo Hu,et al.  Suppressive role of E3 ubiquitin ligase FBW7 in type I diabetes in non-obese diabetic mice through mediation of ubiquitination of EZH2 , 2021, Cell death discovery.

[42]  C. Crews,et al.  Modulation of Phosphoprotein Activity by Phosphorylation Targeting Chimeras (PhosTACs). , 2021, ACS chemical biology.

[43]  R. Cox,et al.  Palmitoylated small GTPase ARL15 is translocated within Golgi network during adipogenesis , 2021, Biology open.

[44]  S. Encarnación-Guevara,et al.  Protein lysine acetylation and its role in different human pathologies: a proteomic approach , 2021, Expert Review of Proteomics.

[45]  Mei J. Zhu,et al.  Dietary succinate supplementation to maternal mice improves fetal brown adipose tissue development and thermogenesis of female offspring. , 2021, The Journal of nutritional biochemistry.

[46]  Ning Jiang,et al.  Protein Lactylation Critically Regulates Energy Metabolism in the Protozoan Parasite Trypanosoma brucei , 2021, Frontiers in Cell and Developmental Biology.

[47]  Mengyao Sun,et al.  The Structure and Functions of PRMT5 in Human Diseases , 2021, Life.

[48]  M. Inglot,et al.  ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials , 2021, Nature Medicine.

[49]  Ning Liu,et al.  Hydrogen sulphide reduced the accumulation of lipid droplets in cardiac tissues of db/db mice via Hrd1 S‐sulfhydration , 2021, Journal of cellular and molecular medicine.

[50]  Q. Tang,et al.  Hepatic Small Ubiquitin‐Related Modifier (SUMO)–Specific Protease 2 Controls Systemic Metabolism Through SUMOylation‐Dependent Regulation of Liver–Adipose Tissue Crosstalk , 2021 .

[51]  Hongliang Li,et al.  The E3 Ubiquitin Ligase Ring Finger Protein 5 Ameliorates NASH Through Ubiquitin‐Mediated Degradation of 3‐Hydroxy‐3‐Methylglutaryl CoA Reductase Degradation Protein 1 , 2021, Hepatology.

[52]  Tae-Il Jeon,et al.  Impairment of ULK1 sulfhydration-mediated lipophagy by SREBF1/SREBP-1c in hepatic steatosis , 2021, Autophagy.

[53]  Qi He,et al.  Efficacy and Safety of Resveratrol Supplements on Blood Lipid and Blood Glucose Control in Patients with Type 2 Diabetes: A Systematic Review and Meta-Analysis of Randomized Controlled Trials , 2021, Evidence-based complementary and alternative medicine : eCAM.

[54]  A. Justino,et al.  Antioxidant compounds from Annona crassiflora fruit peel reduce lipid levels and oxidative damage and maintain the glutathione defense in hepatic tissue of Triton WR-1339-induced hyperlipidemic mice. , 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[55]  Yue Zhao,et al.  USP14 maintains HIF1-α stabilization via its deubiquitination activity in hepatocellular carcinoma , 2021, Cell Death & Disease.

[56]  J. Björkegren,et al.  Histone deacetylase 9 promotes endothelial-mesenchymal transition and an unfavorable atherosclerotic plaque phenotype , 2021, The Journal of clinical investigation.

[57]  Chong Zhang,et al.  Dysfunction of Cullin 3 RING E3 ubiquitin ligase causes vasoconstriction and increased sodium reabsorption in diabetes. , 2021, Archives of biochemistry and biophysics.

[58]  Dan Chen,et al.  E3 ubiquitin ligases: styles, structures and functions , 2021, Molecular Biomedicine.

[59]  N. Dantuma,et al.  MacroGreen, a simple tool for detection of ADP-ribosylated proteins , 2021, Communications biology.

[60]  Hongshan Chen,et al.  S-nitrosylation-mediated coupling of G-protein alpha-2 with CXCR5 induces Hippo/YAP-dependent diabetes-accelerated atherosclerosis , 2021, Nature Communications.

[61]  K. Kavukcuoglu,et al.  Highly accurate protein structure prediction for the human proteome , 2021, Nature.

[62]  Hongliang Li,et al.  The E3 Ubiquitin Ligase Ring Finger Protein 5 Ameliorates NASH Through Ubiquitin‐Mediated Degradation of 3‐Hydroxy‐3‐Methylglutaryl CoA Reductase Degradation Protein 1 , 2021, Hepatology.

[63]  Masaaki Nishihara,et al.  L‐citrulline inhibits body weight gain and hepatic fat accumulation by improving lipid metabolism in a rat nonalcoholic fatty liver disease model , 2021, Food science & nutrition.

[64]  Hongliang Li,et al.  FASN-suppressor screening identifies SNX8 as a novel therapeutic target for NAFLD. , 2021, Hepatology.

[65]  M. Weickert,et al.  Reversal of Insulin Resistance in Overweight and Obese Subjects by trans-Resveratrol and Hesperetin Combination—Link to Dysglycemia, Blood Pressure, Dyslipidemia, and Low-Grade Inflammation , 2021, Nutrients.

[66]  M. Avila,et al.  Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis , 2021, Molecular metabolism.

[67]  D. Pandey,et al.  Inhibition of HDAC6 Activity Protects Against Endothelial Dysfunction and Atherogenesis in vivo: A Role for HDAC6 Neddylation , 2021, Frontiers in Physiology.

[68]  Jun Shi,et al.  Lactylation, a Novel Metabolic Reprogramming Code: Current Status and Prospects , 2021, Frontiers in Immunology.

[69]  Hong Yang,et al.  Protein acetylation: a novel modus of obesity regulation , 2021, Journal of Molecular Medicine.

[70]  P. Jänne,et al.  Kinase drug discovery 20 years after imatinib: progress and future directions , 2021, Nature Reviews Drug Discovery.

[71]  G. Zardo,et al.  Increased PARylation impacts the DNA methylation process in type 2 diabetes mellitus , 2021, Clinical epigenetics.

[72]  Chen Zhao,et al.  Restoration of H3k27me3 Modification Epigenetically Silences Cry1 Expression and Sensitizes Leptin Signaling to Reduce Obesity‐Related Properties , 2021, Advanced science.

[73]  Jinyun Dong,et al.  PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy , 2021, Frontiers in Pharmacology.

[74]  T. Spector,et al.  Extensive weight loss reduces glycan age by altering IgG N-glycosylation , 2021, International Journal of Obesity.

[75]  Q. Tang,et al.  Hepatic SENP2 Controls Systemic Metabolism via SUMOylation-dependent Regulation of Liver-Adipose Tissue Crosstalk. , 2021, Hepatology.

[76]  Z. Wang,et al.  Redox-sensitive enzyme SENP3 mediates vascular remodeling via de-SUMOylation of β-catenin and regulation of its stability , 2021, EBioMedicine.

[77]  Guoqing Yang,et al.  STAT3 phosphorylation in central leptin resistance , 2021, Nutrition & Metabolism.

[78]  Hongyun Wang,et al.  The effects of S-nitrosylation-induced PPARγ/SFRP5 pathway inhibition on the conversion of non-alcoholic fatty liver to non-alcoholic steatohepatitis , 2021, Annals of translational medicine.

[79]  Haowen Jiang,et al.  DOT1L Regulates Thermogenic Adipocyte Differentiation and Function via Modulating H3K79 Methylation , 2021, Diabetes.

[80]  Yunqian Li,et al.  Adipose-specific knockout of ubiquitin-conjugating enzyme E2L6 (Ube2l6) reduces diet-induced obesity, insulin resistance, and hepatic steatosis. , 2021, Journal of pharmacological sciences.

[81]  Yong Xu,et al.  Function and Mechanism of Novel Histone Posttranslational Modifications in Health and Disease , 2021, BioMed research international.

[82]  G. Yuan,et al.  Sirtuin 2 Prevents Liver Steatosis and Metabolic Disorders by Deacetylation of Hepatocyte Nuclear Factor 4α , 2021, Hepatology.

[83]  T. Madhusudhan,et al.  The MEK inhibitor U0126 ameliorates diabetic cardiomyopathy by restricting XBP1's phosphorylation dependent SUMOylation , 2021, International journal of biological sciences.

[84]  R. Roeder,et al.  The regulatory enzymes and protein substrates for the lysine β-hydroxybutyrylation pathway , 2021, Science Advances.

[85]  Yingming Zhao,et al.  Ketogenesis impact on liver metabolism revealed by proteomics of lysine β-hydroxybutyrylation , 2021, bioRxiv.

[86]  E. Alejandro,et al.  O-linked N-acetylglucosamine transferase (OGT) regulates pancreatic α-cell function in mice , 2021, The Journal of biological chemistry.

[87]  Javad Zahiri,et al.  Post-translational modifications in proteins: resources, tools and prediction methods , 2021, Database J. Biol. Databases Curation.

[88]  Hongshan Chen,et al.  Hydrogen Sulfide Alleviates Liver Injury Through the S‐Sulfhydrated‐Kelch‐Like ECH‐Associated Protein 1/Nuclear Erythroid 2–Related Factor 2/Low‐Density Lipoprotein Receptor–Related Protein 1 Pathway , 2021 .

[89]  Guoshun Luo,et al.  Discovery of an orally active VHL-recruiting PROTAC that achieves robust HMGCR degradation and potent hypolipidemic activity in vivo , 2020, Acta pharmaceutica Sinica. B.

[90]  Matthew J. Potthoff,et al.  ADH5-mediated NO bioactivity maintains metabolic homeostasis in brown adipose tissue , 2020, bioRxiv.

[91]  M. Bennett,et al.  SIRT6 Protects Smooth Muscle Cells From Senescence and Reduces Atherosclerosis , 2020, Circulation research.

[92]  D. Neumann,et al.  Putative Role of Protein Palmitoylation in Cardiac Lipid-Induced Insulin Resistance , 2020, International journal of molecular sciences.

[93]  Sathish Kumar Jayapal,et al.  Global Burden of Cardiovascular Diseases and Risk Factors, 1990–2019 , 2020, Journal of the American College of Cardiology.

[94]  Kai Chen,et al.  Acetylation of lactate dehydrogenase B drives NAFLD progression by impairing lactate clearance. , 2020, Journal of hepatology.

[95]  R. Scharfmann,et al.  Peptidylarginine Deiminase Inhibition Prevents Diabetes Development in NOD Mice , 2020, Diabetes.

[96]  Hong-yu Zhang,et al.  Review of NEDDylation inhibition activity detection methods. , 2020, Bioorganic & medicinal chemistry.

[97]  Jie Luo,et al.  Feeding induces cholesterol biosynthesis via the mTORC1–USP20–HMGCR axis , 2020, Nature.

[98]  Guangzhong Liu,et al.  Succinylation Site Prediction Based on Protein Sequences Using the IFS-LightGBM (BO) Model , 2020, Comput. Math. Methods Medicine.

[99]  V. Wong,et al.  Combination Therapies Including Cilofexor and Firsocostat for Bridging Fibrosis and Cirrhosis Attributable to NASH , 2020, Hepatology.

[100]  Jie Luo,et al.  SUMOylation of the ubiquitin ligase IDOL decreases LDL receptor levels and is reversed by SENP1 , 2020, The Journal of biological chemistry.

[101]  Zhimin Zhang,et al.  Proteolysis targeting chimera (PROTAC) in drug discovery paradigm: Recent progress and future challenges. , 2020, European journal of medicinal chemistry.

[102]  Yoshiki Narimatsu,et al.  Global view of human protein glycosylation pathways and functions , 2020, Nature Reviews Molecular Cell Biology.

[103]  J. Zahiri,et al.  Evaluation of post-translational modifications in histone proteins: A review on histone modification defects in developmental and neurological disorders , 2020, Journal of biosciences.

[104]  YU Peng,et al.  Protein Arginine Methyltransferase PRMT5 Regulates Fatty Acid Metabolism and Lipid Droplet Biogenesis in White Adipose Tissues , 2020, Advanced science.

[105]  Wei-qun Chen,et al.  Histone methyltransferases G9a mediated lipid-induced M1 macrophage polarization through negatively regulating CD36. , 2020, Metabolism: clinical and experimental.

[106]  J. Chan,et al.  Emricasan to prevent new decompensation in patients with NASH-related decompensated cirrhosis. , 2020, Journal of Hepatology.

[107]  Ju-Young Park,et al.  Effects of Statin Use on the Development and Progression of Nonalcoholic Fatty Liver Disease: A Nationwide Nested Case-Control Study. , 2020, The American journal of gastroenterology.

[108]  P. Zhou,et al.  USP7 mediates pathological hepatic de novo lipogenesis through promoting stabilization and transcription of ZNF638 , 2020, Cell Death & Disease.

[109]  R. Petersen,et al.  Muscular G9a Regulates Muscle-Liver-Fat Axis by Musclin Under Overnutrition in Female Mice , 2020, Diabetes.

[110]  C. Margulies,et al.  PARP-1 Flips the Epigenetic Switch on Obesity. , 2020, Molecular cell.

[111]  R. Saldova,et al.  Current methods for the characterization of O-glycans. , 2020, Journal of proteome research.

[112]  Anastasia A Anashkina,et al.  A novel approach for predicting protein S-glutathionylation , 2020, BMC Bioinformatics.

[113]  Kai Huang,et al.  E3 Ligase FBXW2 Is a New Therapeutic Target in Obesity and Atherosclerosis , 2020, Advanced science.

[114]  Q. Tang,et al.  KMT5c modulates adipocyte thermogenesis by regulating Trp53 expression , 2020, Proceedings of the National Academy of Sciences.

[115]  Shuainan Liu,et al.  Histone deacetylase 3-selective inhibitor RGFP966 ameliorates impaired glucose tolerance through β-cell protection. , 2020, Toxicology and applied pharmacology.

[116]  Qingrui Zhuan,et al.  Procyanidin B2 Improves Oocyte Maturation and Subsequent Development in Type 1 Diabetic Mice by Promoting Mitochondrial Function , 2020, Reproductive Sciences.

[117]  G. Hart,et al.  Targeting O-GlcNAcylation to develop novel therapeutics. , 2020, Molecular aspects of medicine.

[118]  C. Proud,et al.  Disabling MNK protein kinases promotes oxidative metabolism and protects against diet-induced obesity , 2020, Molecular metabolism.

[119]  G. Charville,et al.  AGER1 downregulation associates with fibrosis in nonalcoholic steatohepatitis and type 2 diabetes. , 2020, The Journal of clinical investigation.

[120]  M. García-Díaz,et al.  Post-translational succinylation of Mycobacterium tuberculosis enoyl-CoA hydratase EchA19 slows catalytic hydration of cholesterol catabolite 3-oxo-chol-4,22-diene-24-oyl-CoA. , 2020, ACS infectious diseases.

[121]  N. Rahimi,et al.  COVID-19, Renin-Angiotensin System and Endothelial Dysfunction , 2020, Cells.

[122]  Ning Li,et al.  Isobaric Tandem Mass Tag Multiplexed Post-Translational Modification Quantitation of Biopharmaceuticals by Targeted High Resolution Mass Spectrometry. , 2020, Analytical chemistry.

[123]  M. Dichgans,et al.  Histone Deacetylase 9 Activates IKK to Regulate Atherosclerotic Plaque Vulnerability , 2020, Circulation research.

[124]  V. Bergo.  A Multiplexed Microarray Platform for Targeted Proteomics , 2020 .

[125]  M. Sánchez-Niño,et al.  Epigenetic Modifiers as Potential Therapeutic Targets in Diabetic Kidney Disease , 2020, International journal of molecular sciences.

[126]  Kun Liu,et al.  β-hydroxybutyrate antagonizes aortic endothelial injury by promoting generation of VEGF in diabetic rats. , 2020, Tissue & cell.

[127]  Hongwei Fan,et al.  Myocardin-Related Transcription Factor A Mediates LPS-Induced iNOS Transactivation , 2020, Inflammation.

[128]  Ping Li,et al.  Discovery of a potent SCAP degrader that ameliorates HFD-induced obesity, hyperlipidemia and insulin resistance via an autophagy-independent lysosomal pathway , 2020, Autophagy.

[129]  S. Krauss,et al.  Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1α PARylation in db/db mice , 2020, International Journal of Obesity.

[130]  T. Meinnel,et al.  Myristoylation, an Ancient Protein Modification Mirroring Eukaryogenesis and Evolution. , 2020, Trends in biochemical sciences.

[131]  Arda B. Celen,et al.  Sumoylation on its 25th Anniversary: Mechanisms, Pathology and Emerging Concepts. , 2020, The FEBS journal.

[132]  Xiao-Nan Liu,et al.  Downregulated microRNA-130b-5p Prevents Lipid Accumulation and Insulin Resistance in a Murine model of Nonalcoholic Fatty Liver Disease. , 2020, American journal of physiology. Endocrinology and metabolism.

[133]  Hongshan Chen,et al.  Hydrogen Sulfide Alleviates Liver Injury Through the S‐Sulfhydrated‐Kelch‐Like ECH‐Associated Protein 1/Nuclear Erythroid 2–Related Factor 2/Low‐Density Lipoprotein Receptor–Related Protein 1 Pathway , 2020, Hepatology.

[134]  Yun-jie Xie,et al.  Inhibition of the Ubiquitin-Activating Enzyme UBA1 Suppresses Diet-Induced Atherosclerosis in Apolipoprotein E-Knockout Mice , 2020, Journal of immunology research.

[135]  H. Sul,et al.  Epigenetic Regulation of Hepatic Lipogenesis: Role in Hepatosteatosis and Diabetes , 2020, Diabetes.

[136]  R. Virmani,et al.  Myristoylation of LMCD1 leads to its species‐specific derepression of E2F1 and NFATc1 in the modulation of CDC6 and IL‐33 expression during development of vascular lesions , 2020, Arteriosclerosis, thrombosis, and vascular biology.

[137]  K. Irie,et al.  Control of the toxic conformation of amyloid β42 by intramolecular disulfide bond formation. , 2020, Chemical communications.

[138]  Jun Zhu,et al.  Variations in common diseases, hospital admissions, and deaths in middle-aged adults in 21 countries from five continents (PURE): a prospective cohort study , 2020, The Lancet.

[139]  Takamitsu Nakamura,et al.  Protein S‐glutathionylation stimulate adipogenesis by stabilizing C/EBPβ in 3T3L1 cells , 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[140]  Yue Zhao,et al.  The balance of protein farnesylation and geranylgeranylation during the progression of nonalcoholic fatty liver disease , 2020, The Journal of Biological Chemistry.

[141]  D. Wojchowski,et al.  Affinity-Bead Assisted Mass Spectrometry (Affi-BAMS): A Multiplexed Microarray Platform for Targeted Proteomics , 2020, International journal of molecular sciences.

[142]  V. Wong,et al.  Cilofexor, a Nonsteroidal FXR Agonist, in Patients With Noncirrhotic NASH: A Phase 2 Randomized Controlled Trial , 2020, Hepatology.

[143]  P. Tsichlis,et al.  Protein arginine methyltransferase 5 promotes cholesterol biosynthesis-mediated Th17 responses and autoimmunity. , 2020, The Journal of clinical investigation.

[144]  A. Tall,et al.  Inhibition of JAK2 Suppresses Myelopoiesis and Atherosclerosis in Apoe−/− Mice , 2020, Cardiovascular Drugs and Therapy.

[145]  P. Lockhart,et al.  ASK1 inhibition: a therapeutic strategy with multi-system benefits , 2020, Journal of Molecular Medicine.

[146]  Elahe Mahdipour,et al.  Topical application of curcumin regulates the angiogenesis in diabetic‐impaired cutaneous wound , 2020, Cell biochemistry and function.

[147]  Min-Dian Li,et al.  O-GlcNAc transferase inhibits visceral fat lipolysis and promotes diet-induced obesity , 2020, Nature Communications.

[148]  Gaosi Xu,et al.  Altered DNA methylation of TRIM13 in diabetic nephropathy suppresses mesangial collagen synthesis by promoting ubiquitination of CHOP , 2020, EBioMedicine.

[149]  Zheng Duanmu,et al.  Inhibition of JAK2/STAT3/SOCS3 signaling attenuates atherosclerosis in rabbit , 2019, BMC Cardiovascular Disorders.

[150]  Shanshan Luo,et al.  A novel rhynchophylline analog, Y396, inhibits endothelial dysfunction induced by oxidative stress in diabetes through EGF receptor. , 2019, Antioxidants & redox signaling.

[151]  J. Chan,et al.  A randomized, placebo-controlled trial of emricasan in patients with NASH and F1-F3 fibrosis. , 2019, Journal of hepatology.

[152]  J. M. Suh,et al.  PRMT1 Is Required for the Maintenance of Mature β-Cell Identity , 2019, Diabetes.

[153]  Jie Luo,et al.  Mechanisms and regulation of cholesterol homeostasis , 2019, Nature Reviews Molecular Cell Biology.

[154]  B. Laffitte,et al.  Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Novel Non–Bile Acid FXR Agonist Tropifexor (LJN452) in Healthy Volunteers , 2019, Clinical pharmacology in drug development.

[155]  D. Figeys,et al.  A Chemoenzymatic Method for Glycoproteomic N-glycan Type Quantitation. , 2019, Analytical chemistry.

[156]  Hongliang Li,et al.  F‐box/WD Repeat‐Containing Protein 5 Mediates the Ubiquitination of Apoptosis Signal‐Regulating Kinase 1 and Exacerbates Nonalcoholic Steatohepatitis in Mice , 2019, Hepatology.

[157]  Mohammed I. Alghamdi,et al.  An Overview of the Intrinsic Role of Citrullination in Autoimmune Disorders , 2019, Journal of immunology research.

[158]  James R. Roede,et al.  Non-enzymatic Lysine Lactoylation of Glycolytic Enzymes. , 2019, Cell chemical biology.

[159]  Rongting Huang,et al.  Crosstalk of intracellular post-translational modifications in cancer. , 2019, Archives of biochemistry and biophysics.

[160]  B. Geng,et al.  Sulfhydration of perilipin 1 is involved in the inhibitory effects of cystathionine gamma lyase/hydrogen sulfide on adipocyte lipolysis. , 2019, Biochemical and biophysical research communications.

[161]  Su Jin Lee,et al.  Curcumin Ameliorates Nonalcoholic Fatty Liver Disease through Inhibition of O-GlcNAcylation , 2019, Nutrients.

[162]  Sijin Liu,et al.  LncRNA PU.1 AS regulates arsenic-induced lipid metabolism through EZH2/Sirt6/SREBP-1c pathway. , 2019, Journal of environmental sciences.

[163]  T. Kiss,et al.  Treatment with the poly(ADP-ribose) polymerase inhibitor PJ-34 improves cerebromicrovascular endothelial function, neurovascular coupling responses and cognitive performance in aged mice, supporting the NAD+ depletion hypothesis of neurovascular aging , 2019, GeroScience.

[164]  K. Wellen,et al.  Histone lactylation links metabolism and gene regulation , 2019, Nature.

[165]  O. Gozani,et al.  Histone lysine methyltransferases in biology and disease , 2019, Nature Structural & Molecular Biology.

[166]  N. Webster,et al.  Degradation of splicing factor SRSF3 contributes to progressive liver disease. , 2019, The Journal of clinical investigation.

[167]  C. Lebrilla,et al.  Site-Specific Glycoprofiles of HDL-Associated ApoE are Correlated with HDL Functional Capacity and Unaffected by Short-Term Diet. , 2019, Journal of proteome research.

[168]  B. Ren,et al.  Metabolic regulation of gene expression by histone lactylation , 2019, Nature.

[169]  Ž. Reiner,et al.  The effects of resveratrol on metabolic status in patients with type 2 diabetes mellitus and coronary heart disease. , 2019, Food & function.

[170]  Andrew D. Johnson,et al.  HDAC9 is implicated in atherosclerotic aortic calcification and affects vascular smooth muscle cell phenotype , 2019, Nature Genetics.

[171]  G. Omenn,et al.  Progress on Identifying and Characterizing the Human Proteome: 2018-2019 Metrics from the HUPO Human Proteome Project. , 2019, Journal of proteome research.

[172]  G. Chertow,et al.  Effects of Selonsertib in Patients with Diabetic Kidney Disease. , 2019, Journal of the American Society of Nephrology : JASN.

[173]  M. Bergo,et al.  Protein prenylation restrains innate immunity by inhibiting Rac1 effector interactions , 2019, Nature Communications.

[174]  S. Furuta,et al.  S-Nitrosylation: An Emerging Paradigm of Redox Signaling , 2019, Antioxidants.

[175]  J. Ran,et al.  Cyanate Induces Oxidative Stress Injury and Abnormal Lipid Metabolism in Liver through Nrf2/HO-1 , 2019, Molecules.

[176]  Hongquan Zhang,et al.  Functions and mechanisms of lysine crotonylation , 2019, Journal of cellular and molecular medicine.

[177]  G. Liang,et al.  Inhibition of EGFR-STAT3 attenuates cardiomyopathy in streptozotocin-induced type 1 diabetes. , 2019, The Journal of endocrinology.

[178]  Mingyao Liu,et al.  SENP1-Sirt3 Signaling Controls Mitochondrial Protein Acetylation and Metabolism. , 2019, Molecular cell.

[179]  Christian M. Metallo,et al.  Non-canonical mTORC2 Signaling Regulates Brown Adipocyte Lipid Catabolism through SIRT6-FoxO1. , 2019, Molecular cell.

[180]  W. Shen,et al.  Sirtuin 3-mediated pyruvate dehydrogenase activity determines brown adipocytes phenotype under high-salt conditions , 2019, Cell Death & Disease.

[181]  C. Burant,et al.  The Histone Methyltransferase Setdb2 Modulates Macrophage Phenotype and Uric Acid Production in Diabetic Wound Repair. , 2019, Immunity.

[182]  M. T. B. Geller,et al.  Molecular , 2019, Modern Pathology.

[183]  D. Rader,et al.  N-Glycosylation Defects in Humans Lower Low-Density Lipoprotein Cholesterol Through Increased Low-Density Lipoprotein Receptor Expression , 2019, Circulation.

[184]  Q. Cui,et al.  Hydrogen sulfide lowers hyperhomocysteinemia dependent on cystathionine γ lyase S‐sulfhydration in ApoE‐knockout atherosclerotic mice , 2019, British journal of pharmacology.

[185]  Jongkyeong Chung,et al.  A muscle-specific UBE2O/AMPKα2 axis promotes insulin resistance and metabolic syndrome in obesity. , 2019, JCI insight.

[186]  Xin Gao,et al.  Enhanced acetylation of ATP-citrate lyase promotes the progression of nonalcoholic fatty liver disease , 2019, The Journal of Biological Chemistry.

[187]  Allison Doerr.  Probes for protein prenylation , 2019, Nature Methods.

[188]  Ranran Li,et al.  Metformin ameliorates endotoxemia-induced endothelial pro-inflammatory responses via AMPK-dependent mediation of HDAC5 and KLF2. , 2019, Biochimica et biophysica acta. Molecular basis of disease.

[189]  Sean J. Humphrey,et al.  Phosphoproteomics Reveals the GSK3-PDX1 Axis as a Key Pathogenic Signaling Node in Diabetic Islets. , 2019, Cell metabolism.

[190]  Jonathan C. Cohen,et al.  Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis , 2019, Proceedings of the National Academy of Sciences.

[191]  Ha Won Kim,et al.  Enhancer of zeste homolog 2 (EZH2) regulates adipocyte lipid metabolism independent of adipogenic differentiation: Role of apolipoprotein E , 2019, The Journal of Biological Chemistry.

[192]  X. Xie,et al.  Mechanisms, Detection, and Relevance of Protein Acetylation in Prokaryotes , 2019, mBio.

[193]  Q. Luo,et al.  Neddylation: a novel modulator of the tumor microenvironment , 2019, Molecular Cancer.

[194]  I. Ahel,et al.  ADP-ribosylation signalling and human disease , 2019, Open Biology.

[195]  X. Chu,et al.  Lysine methylation of transcription factors in cancer , 2019, Cell Death & Disease.

[196]  G. Gibson,et al.  Succinylation Links Metabolism to Protein Functions , 2019, Neurochemical Research.

[197]  E. Olson,et al.  The intestinal microbiota programs diurnal rhythms in host metabolism through histone deacetylase 3 , 2019, Science.

[198]  D. Carling,et al.  AMP-activated protein kinase: the current landscape for drug development , 2019, Nature Reviews Drug Discovery.

[199]  J. Novak,et al.  Glycosylation in health and disease , 2019, Nature Reviews Nephrology.

[200]  W. Gu,et al.  p53 β-hydroxybutyrylation attenuates p53 activity , 2019, Cell Death & Disease.

[201]  Wenyi Wei,et al.  Degrading proteins in animals: “PROTAC”tion goes in vivo , 2019, Cell Research.

[202]  Xinli Hu,et al.  Glucose-Sensitive Myokine/Cardiokine MG53 Regulates Systemic Insulin Response and Metabolic Homeostasis , 2019, Circulation.

[203]  D. Giannella‐Neto,et al.  Diabetes induces tri-methylation at lysine 9 of histone 3 at Slc2a4 gene in skeletal muscle: A new target to improve glycemic control , 2019, Molecular and Cellular Endocrinology.

[204]  P. Muti,et al.  Inhibition of Acetyl-CoA Carboxylase by Phosphorylation or the Inhibitor ND-654 Suppresses Lipogenesis and Hepatocellular Carcinoma. , 2019, Cell metabolism.

[205]  J. Roozbeh,et al.  Resveratrol reduces albuminuria in diabetic nephropathy: A randomized double-blind placebo-controlled clinical trial. , 2019, Diabetes & metabolism.

[206]  J. Chan,et al.  Emricasan (IDN‐6556) Lowers Portal Pressure in Patients With Compensated Cirrhosis and Severe Portal Hypertension , 2018, Hepatology.

[207]  P. Meikle,et al.  Inhibition of Adenosine Monophosphate–Activated Protein Kinase–3‐Hydroxy‐3‐Methylglutaryl Coenzyme A Reductase Signaling Leads to Hypercholesterolemia and Promotes Hepatic Steatosis and Insulin Resistance , 2018, Hepatology communications.

[208]  Yue Xu,et al.  CPT1A‐mediated succinylation of S100A10 increases human gastric cancer invasion , 2018, Journal of cellular and molecular medicine.

[209]  Ga Young Do,et al.  Histone deacetylase inhibitor MGCD0103 protects the pancreas from streptozotocin-induced oxidative stress and β-cell death. , 2019, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[210]  J. Moss,et al.  Emerging roles of ADP-ribosyl-acceptor hydrolases (ARHs) in tumorigenesis and cell death pathways. , 2019, Biochemical pharmacology.

[211]  Q. Cui,et al.  Sulfhydrated Sirtuin-1 Increasing Its Deacetylation Activity Is an Essential Epigenetics Mechanism of Anti-Atherogenesis by Hydrogen Sulfide. , 2018, Antioxidants & redox signaling.

[212]  G. Rao,et al.  Protein Kinase C&thgr; Via Activating Transcription Factor 2-Mediated CD36 Expression and Foam Cell Formation of Ly6Chi Cells Contributes to Atherosclerosis , 2018, Circulation.

[213]  Jiandie D. Lin,et al.  Proteome-wide analysis of USP14 substrates revealed its role in hepatosteatosis via stabilization of FASN , 2018, Nature Communications.

[214]  Ethan X. Fang,et al.  Adipocyte OGT governs diet-induced hyperphagia and obesity , 2018, Nature Communications.

[215]  M. Lazar,et al.  Integrative regulation of physiology by histone deacetylase 3 , 2018, Nature Reviews Molecular Cell Biology.

[216]  Allison Doerr.  Finding S-sulfinylated proteins , 2018, Nature Methods.

[217]  M. K. Kim.  Novel insight into the function of tankyrase , 2018, Oncology letters.

[218]  Tingting Li,et al.  SIRT5 deacylates metabolism-related proteins and attenuates hepatic steatosis in ob/ob mice , 2018, EBioMedicine.

[219]  J. Torres,et al.  Targeting Hepatic Protein Carbonylation and Oxidative Stress Occurring on Diet-Induced Metabolic Diseases through the Supplementation with Fish Oils , 2018, Marine drugs.

[220]  Chun Fang,et al.  Ubiquitin‐Specific Peptidase 10 (USP10) Inhibits Hepatic Steatosis, Insulin Resistance, and Inflammation Through Sirt6 , 2018, Hepatology.

[221]  Jie He,et al.  Ubiquitin‐Specific Protease 4 Is an Endogenous Negative Regulator of Metabolic Dysfunctions in Nonalcoholic Fatty Liver Disease in Mice , 2018, Hepatology.

[222]  D. Hwang,et al.  Loss of the E3 ubiquitin ligase MKRN1 represses diet-induced metabolic syndrome through AMPK activation , 2018, Nature Communications.

[223]  G. Omenn,et al.  Progress on Identifying and Characterizing the Human Proteome: 2018 Metrics from the HUPO Human Proteome Project. , 2018, Journal of proteome research.

[224]  Y. Bao,et al.  Dorzagliatin monotherapy in Chinese patients with type 2 diabetes: a dose-ranging, randomised, double-blind, placebo-controlled, phase 2 study. , 2018, The lancet. Diabetes & endocrinology.

[225]  Craig C. Ulrich,et al.  Obesity-mediated regulation of cardiac protein acetylation: parallel analysis of total and acetylated proteins via TMT-tagged mass spectrometry , 2018, Bioscience reports.

[226]  L. Rui,et al.  Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis , 2018, Nature Communications.

[227]  A. Mozzarelli,et al.  Protein carbonylation detection methods: A comparison , 2018, Data in brief.

[228]  A. Jetten,et al.  PIAS-family proteins negatively regulate Glis3 transactivation function through SUMO modification in pancreatic β cells , 2018, Heliyon.

[229]  E. Seto,et al.  Programming and Regulation of Metabolic Homeostasis by HDAC11 , 2018, EBioMedicine.

[230]  N. Zelcer,et al.  Inactivation of the E3 Ubiquitin Ligase IDOL Attenuates Diet-Induced Obesity and Metabolic Dysfunction in Mice , 2018, Arteriosclerosis, thrombosis, and vascular biology.

[231]  Hyungwon Choi,et al.  PTMscape: an open source tool to predict generic post-translational modifications and map modification crosstalk in protein domains and biological processes† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8mo00027a , 2018, Molecular omics.

[232]  Yingmei Wang,et al.  GSK126 alleviates the obesity phenotype by promoting the differentiation of thermogenic beige adipocytes in diet-induced obese mice. , 2018, Biochemical and biophysical research communications.

[233]  Jinke Cheng,et al.  Senp2 regulates adipose lipid storage by de-SUMOylation of Setdb1 , 2018, Journal of molecular cell biology.

[234]  H. Guillou,et al.  The histone demethylase Phf2 acts as a molecular checkpoint to prevent NAFLD progression during obesity , 2018, Nature Communications.

[235]  M. G. Fiore,et al.  Deregulation of autophagy under hyperglycemic conditions is dependent on increased lysine 63 ubiquitination: a candidate mechanism in the progression of diabetic nephropathy , 2018, Journal of Molecular Medicine.

[236]  G. Merrill,et al.  Elevated Nrf-2 responses are insufficient to mitigate protein carbonylation in hepatospecific PTEN deletion mice , 2018, PloS one.

[237]  E. Hinoi,et al.  Therapeutic effects of the allosteric protein tyrosine phosphatase 1B inhibitor KY-226 on experimental diabetes and obesity via enhancements in insulin and leptin signaling in mice. , 2018, Journal of pharmacological sciences.

[238]  H. Aburatani,et al.  Histone demethylase JMJD1A coordinates acute and chronic adaptation to cold stress via thermogenic phospho-switch , 2018, Nature Communications.

[239]  Yanwei Xing,et al.  Traditional Chinese Medicine for Bradyarrhythmia: Evidence and Potential Mechanisms , 2018, Front. Pharmacol..

[240]  T. Muir,et al.  A Chemical Probe for Protein Crotonylation. , 2018, Journal of the American Chemical Society.

[241]  S. Müller,et al.  SUMO-specific proteases and isopeptidases of the SENP family at a glance , 2018, Journal of Cell Science.

[242]  Zhi-Yong Wang,et al.  Hydrogen peroxide positively regulates brassinosteroid signaling through oxidation of the BRASSINAZOLE-RESISTANT1 transcription factor , 2018, Nature Communications.

[243]  P. Wright,et al.  Application of the broadband collision-induced dissociation (bbCID) mass spectrometry approach for protein glycosylation and phosphorylation analysis. , 2018, Rapid communications in mass spectrometry : RCM.

[244]  Feng Li,et al.  The deubiquitinating enzyme cylindromatosis mitigates nonalcoholic steatohepatitis , 2018, Nature Medicine.

[245]  B. Lüscher,et al.  ADP-Ribosylation, a Multifaceted Posttranslational Modification Involved in the Control of Cell Physiology in Health and Disease. , 2017, Chemical reviews.

[246]  Debabrata Ghosh,et al.  Hyposialylated IgG activates endothelial IgG receptor Fc&ggr;RIIB to promote obesity-induced insulin resistance , 2017, The Journal of clinical investigation.

[247]  C. Crews,et al.  Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead. , 2017, Cell chemical biology.

[248]  A. Papapetropoulos,et al.  Reduced adipose tissue H2S in obesity , 2017, Pharmacological research.

[249]  H. Park,et al.  Protein S-glutathionylation induced by hypoxia increases hypoxia-inducible factor-1α in human colon cancer cells. , 2018, Biochemical and biophysical research communications.

[250]  Hong Wang,et al.  IL-35 (Interleukin-35) Suppresses Endothelial Cell Activation by Inhibiting Mitochondrial Reactive Oxygen Species-Mediated Site-Specific Acetylation of H3K14 (Histone 3 Lysine 14) , 2018, Arteriosclerosis, thrombosis, and vascular biology.

[251]  V. Kuchroo,et al.  Augmented Th17 differentiation in Trim21 deficiency promotes a stable phenotype of atherosclerotic plaques with high collagen content , 2018, Cardiovascular research.

[252]  S. Atkin,et al.  Curcuminoids Plus Piperine Modulate Adipokines in Type 2 Diabetes Mellitus. , 2018, Current clinical pharmacology.

[253]  D. Eizirik,et al.  Both conditional ablation and overexpression of E2 SUMO-conjugating enzyme (UBC9) in mouse pancreatic beta cells result in impaired beta cell function , 2018, Diabetologia.

[254]  Z. Goodman,et al.  The ASK1 inhibitor selonsertib in patients with nonalcoholic steatohepatitis: A randomized, phase 2 trial , 2017, Hepatology.

[255]  Gilles Gasser,et al.  A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models , 2017, The Journal of Biological Chemistry.

[256]  James R. Roede,et al.  Differential carbonylation of proteins in end‐stage human fatty and nonfatty NASH , 2017, Free radical biology & medicine.

[257]  S. Santos,et al.  Nuclear sirtuins and inflammatory signaling pathways. , 2017, Cytokine & growth factor reviews.

[258]  F. Agakov,et al.  N-Glycan Profile and Kidney Disease in Type 1 Diabetes , 2017, Diabetes Care.

[259]  M. Connelly,et al.  GlycA, a novel biomarker of systemic inflammation and cardiovascular disease risk , 2017, Journal of Translational Medicine.

[260]  A. Peres,et al.  Acute Strenuous Exercise Induces an Imbalance on Histone H4 Acetylation/Histone Deacetylase 2 and Increases the Proinflammatory Profile of PBMC of Obese Individuals , 2017, Oxidative medicine and cellular longevity.

[261]  N. Leitinger,et al.  Macrophage metabolism in atherosclerosis , 2017, FEBS letters.

[262]  P. Zhang,et al.  Protein SUMOylation modification and its associations with disease , 2017, Open Biology.

[263]  Lin He,et al.  Chromodomain Protein CDYL Acts as a Crotonyl-CoA Hydratase to Regulate Histone Crotonylation and Spermatogenesis. , 2017, Molecular cell.

[264]  Chao-shu Tang,et al.  H2S-Induced Sulfhydration: Biological Function and Detection Methodology , 2017, Front. Pharmacol..

[265]  A. Gaikwad,et al.  Telmisartan and esculetin combination ameliorates type 2 diabetic cardiomyopathy by reversal of H3, H2A, and H2B histone modifications , 2017, Indian journal of pharmacology.

[266]  J. Weng,et al.  SIRT1/HSF1/HSP pathway is essential for exenatide‐alleviated, lipid‐induced hepatic endoplasmic reticulum stress , 2017, Hepatology.

[267]  Jingyan Han,et al.  Glutaredoxin-1 Deficiency Causes Fatty Liver and Dyslipidemia by Inhibiting Sirtuin-1. , 2017, Antioxidants & redox signaling.

[268]  M. Budoff,et al.  Association of Anti–Citrullinated Peptide Antibodies With Coronary Artery Calcification in Rheumatoid Arthritis , 2017, Arthritis care & research.

[269]  K. Kent,et al.  Electron-Transfer/Higher-Energy Collision Dissociation (EThcD)-Enabled Intact Glycopeptide/Glycoproteome Characterization , 2017, Journal of The American Society for Mass Spectrometry.

[270]  Arnab Ray Chaudhuri,et al.  The multifaceted roles of PARP1 in DNA repair and chromatin remodelling , 2017, Nature Reviews Molecular Cell Biology.

[271]  W. Guo,et al.  Atherosclerosis and the Hydrogen Sulfide Signaling Pathway – Therapeutic Approaches to Disease Prevention , 2017, Cellular Physiology and Biochemistry.

[272]  K. Shokat,et al.  Drugging the 'undruggable' cancer targets , 2017, Nature Reviews Cancer.

[273]  Joshua A. Salomon,et al.  Health Effects of Overweight and Obesity in 195 Countries over 25 Years. , 2017, The New England journal of medicine.

[274]  W. Min,et al.  The critical role of SENP1-mediated GATA2 deSUMOylation in promoting endothelial activation in graft arteriosclerosis , 2017, Nature Communications.

[275]  E. Ropelle,et al.  Expression of Concern: Aspirin attenuates insulin resistance in muscle of diet-induced obese rats by inhibiting inducible nitric oxide synthase production and S-nitrosylation of IRβ/IRS-1 and Akt , 2017, Diabetologia.

[276]  Jianjun Yu,et al.  Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription , 2017, Cell Research.

[277]  Lifeng Yang,et al.  Effects of oolonghomobisflavan A on oxidation of low-density lipoprotein , 2017, Bioscience, biotechnology, and biochemistry.

[278]  Liqing Yu,et al.  PARP1-mediated PPARα poly(ADP-ribosyl)ation suppresses fatty acid oxidation in non-alcoholic fatty liver disease. , 2017, Journal of hepatology.

[279]  B. Zhivotovsky,et al.  Post-translational Modification of Caspases: The Other Side of Apoptosis Regulation. , 2017, Trends in cell biology.

[280]  Jia Li,et al.  The Landscape of Histone Modifications in a High-Fat Diet-Induced Obese (DIO) Mouse Model* , 2017, Molecular & Cellular Proteomics.

[281]  F. Lima,et al.  Oral β-hydroxybutyrate increases ketonemia, decreases visceral adipocyte volume and improves serum lipid profile in Wistar rats , 2017, Nutrition & Metabolism.

[282]  Weizhi Xu,et al.  Global profiling of crotonylation on non-histone proteins , 2017, Cell Research.

[283]  Y. Xiong,et al.  Cholesterol Modification of Smoothened Is Required for Hedgehog Signaling. , 2017, Molecular cell.

[284]  M. Dichgans,et al.  Inhibition of atherogenesis by the COP9 signalosome subunit 5 in vivo , 2017, Proceedings of the National Academy of Sciences.

[285]  Mingzi M. Zhang,et al.  Protein S-palmitoylation in cellular differentiation , 2017, Biochemical Society transactions.

[286]  Shelly C. Lu,et al.  Deregulated neddylation in liver fibrosis , 2017, Hepatology.

[287]  T. Lüscher,et al.  Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease , 2017, The Journal of clinical investigation.

[288]  Lars J Jensen,et al.  Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation , 2017, Nature Structural &Molecular Biology.

[289]  U. Laufs,et al.  Pleiotropic Effects of Statins on the Cardiovascular System , 2017, Circulation research.

[290]  Di Zhang,et al.  Metabolic regulation of gene expression through histone acylations , 2016, Nature Reviews Molecular Cell Biology.

[291]  Hongliang Li,et al.  The E3 ligase tripartite motif 8 targets TAK1 to promote insulin resistance and steatohepatitis , 2016, Hepatology.

[292]  J. Auwerx,et al.  Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease. , 2017, Journal of hepatology.

[293]  C. Khosla,et al.  Thioredoxin-1 Selectively Activates Transglutaminase 2 in the Extracellular Matrix of the Small Intestine , 2016, The Journal of Biological Chemistry.

[294]  F. Bäckhed,et al.  Overexpression of protein kinase STK25 in mice exacerbates ectopic lipid accumulation, mitochondrial dysfunction and insulin resistance in skeletal muscle , 2016, Diabetologia.

[295]  Albert-László Barabási,et al.  PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation , 2016, Nature Communications.

[296]  John Calvin Reed,et al.  Ubc13 haploinsufficiency protects against age-related insulin resistance and high-fat diet-induced obesity , 2016, Scientific Reports.

[297]  Sean M. Hartig,et al.  Mitochondrial Activity in Human White Adipocytes Is Regulated by the Ubiquitin Carrier Protein 9/microRNA-30a Axis* , 2016, The Journal of Biological Chemistry.

[298]  B. Zagrovic,et al.  Structural mechanism for the recognition and ubiquitination of a single nucleosome residue by Rad6–Bre1 , 2016, Proceedings of the National Academy of Sciences.

[299]  S. Garcia-Manyes,et al.  Protein S-sulfenylation is a fleeting molecular switch that regulates non-enzymatic oxidative folding , 2016, Nature Communications.

[300]  Christopher D. Brown,et al.  Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents. , 2016, Cell metabolism.

[301]  D. Liao,et al.  The effects of resveratrol intervention on risk markers of cardiovascular health in overweight and obese subjects: a pooled analysis of randomized controlled trials , 2016, Obesity reviews : an official journal of the International Association for the Study of Obesity.

[302]  Dong-Hyun Kim,et al.  Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis , 2016, Nature Communications.

[303]  Xin Wang,et al.  Hydrogen Sulfide Induces Keap1 S-sulfhydration and Suppresses Diabetes-Accelerated Atherosclerosis via Nrf2 Activation , 2016, Diabetes.

[304]  R. Taliyan,et al.  Epigenetic modifications by inhibiting histone deacetylases reverse memory impairment in insulin resistance induced cognitive deficit in mice , 2016, Neuropharmacology.

[305]  R. Guedes,et al.  S‐Glutathionylation of Keap1: a new role for glutathione S‐transferase pi in neuronal protection , 2016, FEBS letters.

[306]  C. Dani,et al.  The size of the primary cilium and acetylated tubulin are modulated during adipocyte differentiation: Analysis of HDAC6 functions in these processes. , 2016, Biochimie.

[307]  Hongyu Zhao,et al.  Metabolic Regulation of Gene Expression by Histone Lysine β‐hydroxybutyrylation , 2016, Molecular cell.

[308]  Haipeng Guan,et al.  Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain. , 2016, Molecular cell.

[309]  J. Matthews,et al.  TCDD-inducible poly-ADP-ribose polymerase (TIPARP/PARP7) mono-ADP-ribosylates and co-activates liver X receptors. , 2016, The Biochemical journal.

[310]  B. Spiegelman,et al.  Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1 , 2016, Nature.

[311]  K. Moore,et al.  Poly(ADP-ribose) Polymerase 1 Represses Liver X Receptor-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages* , 2016, The Journal of Biological Chemistry.

[312]  P. Brzovic,et al.  E2 enzymes: more than just middle men , 2016, Cell Research.

[313]  S. W. Kim,et al.  PPARγ neddylation essential for adipogenesis is a potential target for treating obesity , 2016, Cell Death and Differentiation.

[314]  Dajiang J. Liu,et al.  Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease , 2016, Science.

[315]  P. Gao,et al.  Activating transcription factor 3 SUMOylation is involved in angiotensin II-induced endothelial cell inflammation and dysfunction. , 2016, Journal of molecular and cellular cardiology.

[316]  Brian Finan,et al.  Hypothalamic leptin action is mediated by histone deacetylase 5 , 2016, Nature Communications.

[317]  R. Cox,et al.  Haploinsufficiency of the Insulin Receptor in the Presence of a Splice-Site Mutation in Ppp2r2a Results in a Novel Digenic Mouse Model of Type 2 Diabetes , 2016, Diabetes.

[318]  Yang Cheng,et al.  Quantitative succinylome analysis in the liver of non-alcoholic fatty liver disease rat model , 2016, Proteome Science.

[319]  P. Thompson,et al.  Detection and identification of protein citrullination in complex biological systems. , 2016, Current opinion in chemical biology.

[320]  Liang Hu,et al.  The Succinate Receptor GPR91 Is Involved in Pressure Overload-Induced Ventricular Hypertrophy , 2016, PloS one.

[321]  M. Surani,et al.  Trim28 Haploinsufficiency Triggers Bi-stable Epigenetic Obesity , 2016, Cell.

[322]  P. Casey,et al.  Protein prenylation: unique fats make their mark on biology , 2016, Nature Reviews Molecular Cell Biology.

[323]  James D. Johnson,et al.  Reduced Insulin Production Relieves Endoplasmic Reticulum Stress and Induces β Cell Proliferation. , 2016, Cell metabolism.

[324]  Laura G. Dubois,et al.  The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient-Induced Lysine Acetylation of Mitochondrial Proteins. , 2016, Cell reports.

[325]  Ze Zhang,et al.  Valproate attenuates diabetic nephropathy through inhibition of endoplasmic reticulum stress-induced apoptosis , 2015, Molecular medicine reports.

[326]  Manuel S Rodríguez,et al.  Concepts and Methodologies to Study Protein SUMOylation: An Overview. , 2016, Methods in molecular biology.

[327]  S. Kajimura,et al.  Phosphoproteomics Identifies CK2 as a Negative Regulator of Beige Adipocyte Thermogenesis and Energy Expenditure. , 2015, Cell metabolism.

[328]  Wenpeng Li,et al.  Hydrogen sulfide reduces serum triglyceride by activating liver autophagy via the AMPK-mTOR pathway. , 2015, American journal of physiology. Endocrinology and metabolism.

[329]  W. Min,et al.  SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression , 2015, Nature Communications.

[330]  Jun Yu,et al.  Histone Deacetylase HDAC8 Promotes Insulin Resistance and β-Catenin Activation in NAFLD-Associated Hepatocellular Carcinoma. , 2015, Cancer research.

[331]  A. Chakravarti,et al.  Glucose-Mediated N-glycosylation of SCAP Is Essential for SREBP-1 Activation and Tumor Growth. , 2015, Cancer cell.

[332]  A. Attie.  How do reducing equivalents increase insulin secretion? , 2015, The Journal of clinical investigation.

[333]  S. Gygi,et al.  S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction , 2015, Science.

[334]  S. Poulsen,et al.  Histone deacetylase 3 inhibition improves glycaemia and insulin secretion in obese diabetic rats , 2015, Diabetes, obesity & metabolism.

[335]  Ling-Yun Wu,et al.  iSuc-PseAAC: predicting lysine succinylation in proteins by incorporating peptide position-specific propensity , 2015, Scientific Reports.

[336]  M. Fukata,et al.  ELMOD2 is anchored to lipid droplets by palmitoylation and regulates adipocyte triglyceride lipase recruitment , 2015, Molecular biology of the cell.

[337]  S. Yao,et al.  Phosphorylation-Mediated Assembly of a Semisynthetic Fluorescent Protein for Label-Free Detection of Protein Kinase Activity. , 2015, Analytical chemistry.

[338]  John M Asara,et al.  Nicotinamide N-methyltransferase regulates hepatic nutrient metabolism through Sirt1 protein stabilization , 2015, Nature Medicine.

[339]  A. Zernecke,et al.  Alternation of histone and DNA methylation in human atherosclerotic carotid plaques , 2015, Thrombosis and Haemostasis.

[340]  Henrik Molina,et al.  Intracellular crotonyl-CoA stimulates transcription through p300-catalyzed histone crotonylation. , 2015, Molecular cell.

[341]  Lewis H Romer,et al.  NEDDylation promotes endothelial dysfunction: a role for HDAC2. , 2015, Journal of molecular and cellular cardiology.

[342]  Wenjun Xie,et al.  Calcium release channel RyR2 regulates insulin release and glucose homeostasis. , 2015, The Journal of clinical investigation.

[343]  D. Hwang,et al.  SUMO-Specific Protease 2 (SENP2) Is an Important Regulator of Fatty Acid Metabolism in Skeletal Muscle , 2015, Diabetes.

[344]  G. Melino,et al.  ITCH modulates SIRT6 and SREBP2 to influence lipid metabolism and atherosclerosis in ApoE null mice , 2015, Scientific Reports.

[345]  J. Taunton,et al.  Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function. , 2015, The Journal of clinical investigation.

[346]  L. Mosca,et al.  PARP-1 involvement in neurodegeneration: A focus on Alzheimer’s and Parkinson’s diseases , 2015, Mechanisms of Ageing and Development.

[347]  J. Petersen,et al.  Nitrogen Regulates AMPK to Control TORC1 Signaling , 2015, Current Biology.

[348]  T. Lüscher,et al.  Adverse Epigenetic Signatures by Histone Methyltransferase Set7 Contribute to Vascular Dysfunction in Patients With Type 2 Diabetes Mellitus , 2015, Circulation. Cardiovascular genetics.

[349]  S. Tani,et al.  Palmitate induces insulin resistance in human HepG2 hepatocytes by enhancing ubiquitination and proteasomal degradation of key insulin signaling molecules. , 2015, Archives of biochemistry and biophysics.

[350]  B. Staels,et al.  O-GlcNAcylation Links ChREBP and FXR to Glucose-Sensing , 2015, Front. Endocrinol..

[351]  E. Verdin,et al.  50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond , 2014, Nature Reviews Molecular Cell Biology.

[352]  J. Auwerx,et al.  ARTD1-induced poly-ADP-ribose formation enhances PPARγ ligand binding and co-factor exchange , 2014, Nucleic acids research.

[353]  M. Distefano,et al.  Protein Prenylation: Enzymes, Therapeutics, and Biotechnology Applications , 2014, ACS chemical biology.

[354]  J. Auwerx,et al.  The Sirt1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression , 2014, European heart journal.

[355]  Sean D. Taverna,et al.  Purification of specific chromatin loci for proteomic analysis. , 2015, Methods in molecular biology.

[356]  M. Peter,et al.  Protein neddylation: beyond cullin–RING ligases , 2014, Nature Reviews Molecular Cell Biology.

[357]  T. Hickish,et al.  A randomised, open-label phase II trial of afatinib versus cetuximab in patients with metastatic colorectal cancer. , 2014, European journal of cancer.

[358]  Michael J.A. Williams,et al.  Ribose-cysteine increases glutathione-based antioxidant status and reduces LDL in human lipoprotein(a) mice. , 2014, Atherosclerosis.

[359]  M. Mikuła,et al.  Obesity increases histone H3 lysine 9 and 18 acetylation at Tnfa and Ccl2 genes in mouse liver. , 2014, International journal of molecular medicine.

[360]  Scott M. Carlson,et al.  Emerging technologies to map the protein methylome. , 2014, Journal of molecular biology.

[361]  F. Melchior,et al.  SUMOylation-dependent LRH-1/PROX1 interaction promotes atherosclerosis by decreasing hepatic reverse cholesterol transport. , 2014, Cell metabolism.

[362]  J. Callis.  The Ubiquitination Machinery of the Ubiquitin System , 2014, The arabidopsis book.

[363]  Edward W. Tate,et al.  Global profiling of co- and post-translationally N-myristoylated proteomes in human cells , 2014, Nature Communications.

[364]  J. Repa,et al.  Histone Deacetylase 9 Represses Cholesterol Efflux and Alternatively Activated Macrophages in Atherosclerosis Development , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[365]  S. Abhang,et al.  Ratio Of Serum Asymmetric Dimethyl Arginine (ADMA)/ Nitric Oxide in Coronary Artery Disease patients. , 2014, Journal of clinical and diagnostic research : JCDR.

[366]  Cyril Gueydan,et al.  PARP12, an Interferon-stimulated Gene Involved in the Control of Protein Translation and Inflammation* , 2014, The Journal of Biological Chemistry.

[367]  A. Lusis,et al.  Transgenic Expression of Dominant-Active IDOL in Liver Causes Diet-Induced Hypercholesterolemia and Atherosclerosis in Mice , 2014, Circulation research.

[368]  M. Sajan,et al.  Akt-Dependent Phosphorylation of Hepatic FoxO1 Is Compartmentalized on a WD40/ProF Scaffold and Is Selectively Inhibited by aPKC in Early Phases of Diet-Induced Obesity , 2014, Diabetes.

[369]  Harumi Uto-Kondo,et al.  Citrulline increases cholesterol efflux from macrophages in vitro and ex vivo via ATP-binding cassette transporters , 2014, Journal of clinical biochemistry and nutrition.

[370]  Kim A Connelly,et al.  Diabetes Induces Lysine Acetylation of Intermediary Metabolism Enzymes in the Kidney , 2014, Diabetes.

[371]  Melissa M. Thomas,et al.  AMPK phosphorylation of ACC2 is required for skeletal muscle fatty acid oxidation and insulin sensitivity in mice , 2014, Diabetologia.

[372]  Richard T. Lee,et al.  Thioredoxin-interacting protein regulates protein disulfide isomerases and endoplasmic reticulum stress , 2014, EMBO molecular medicine.

[373]  G. Vámosi,et al.  Deletion of PARP-2 induces hepatic cholesterol accumulation and decrease in HDL levels. , 2014, Biochimica et biophysica acta.

[374]  C. Paul,et al.  A nationwide nested case-control study indicates an increased risk of acute interstitial nephritis with proton pump inhibitor use , 2014, Kidney international.

[375]  S. Gygi,et al.  Trim32 reduces PI3K–Akt–FoxO signaling in muscle atrophy by promoting plakoglobin–PI3K dissociation , 2014, The Journal of cell biology.

[376]  J. Vaya,et al.  The synthesis and analysis of S-nitorsylated paraoxonase 1. , 2014, Biochemical and biophysical research communications.

[377]  S. Murphy,et al.  Hepatic gene expression profiles differentiate presymptomatic patients with mild versus severe nonalcoholic fatty liver disease , 2014, Hepatology.

[378]  Jingyan Han,et al.  A Redox-resistant Sirtuin-1 Mutant Protects against Hepatic Metabolic and Oxidant Stress* , 2014, The Journal of Biological Chemistry.

[379]  J. Marth,et al.  Deficiency of the Sialyltransferase St3Gal4 Reduces Ccl5-Mediated Myeloid Cell Recruitment and Arrest: Short Communication , 2014, Circulation research.

[380]  A. Simm,et al.  Role of advanced glycation end products in cellular signaling , 2014, Redox biology.

[381]  Xiaolei Jin,et al.  Redox regulation of mitochondrial function with emphasis on cysteine oxidation reactions , 2013, Redox biology.

[382]  T. Poland.  PROGRESS and FUTURE DIRECTIONS , 2014 .

[383]  Jongkyeong Chung,et al.  PIASy-Mediated Sumoylation of SREBP1c Regulates Hepatic Lipid Metabolism upon Fasting Signaling , 2013, Molecular and Cellular Biology.

[384]  J. Garcia-Vallejo,et al.  Analytical Tools for the Study of Cellular Glycosylation in the Immune System , 2013, Front. Immunol..

[385]  Matthew J. Rardin,et al.  SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks. , 2013, Cell metabolism.

[386]  M. Watkins,et al.  Poly-ADP-Ribose-Polymerase Inhibition Ameliorates Hind Limb Ischemia Reperfusion Injury in a Murine Model of Type 2 Diabetes , 2013, Annals of surgery.

[387]  J Bruce German,et al.  Human milk secretory immunoglobulin a and lactoferrin N-glycans are altered in women with gestational diabetes mellitus. , 2013, The Journal of nutrition.

[388]  S. Kajimura,et al.  EHMT1 controls brown adipose cell fate and thermogenesis through the PRDM16 complex , 2013, Nature.

[389]  Fen Wang,et al.  Dysregulation of cystathionine γ-lyase (CSE)/hydrogen sulfide pathway contributes to ox-LDL-induced inflammation in macrophage. , 2013, Cellular signalling.

[390]  A. Kiyosue,et al.  Dose‐ranging study with the glucokinase activator AZD1656 as monotherapy in Japanese patients with type 2 diabetes mellitus , 2013, Diabetes, obesity & metabolism.

[391]  M. Dikshit,et al.  S-glutathionylation: relevance in diabetes and potential role as a biomarker , 2013, Biological chemistry.

[392]  R. DePinho,et al.  FoxO3 Transcription Factor and Sirt6 Deacetylase Regulate Low Density Lipoprotein (LDL)-cholesterol Homeostasis via Control of the Proprotein Convertase Subtilisin/Kexin Type 9 (Pcsk9) Gene Expression* , 2013, The Journal of Biological Chemistry.

[393]  C. Wessman,et al.  Dose‐ranging study with the glucokinase activator AZD1656 in patients with type 2 diabetes mellitus on metformin , 2013, Diabetes, obesity & metabolism.

[394]  M. Xian,et al.  Direct methods for detection of protein S-nitrosylation. , 2013, Methods.

[395]  Christer S. Ejsing,et al.  Sterol homeostasis requires regulated degradation of squalene monooxygenase by the ubiquitin ligase Doa10/Teb4 , 2013, eLife.

[396]  D. Townsend,et al.  Causes and Consequences of Cysteine S-Glutathionylation* , 2013, The Journal of Biological Chemistry.

[397]  Kate S. Carroll,et al.  The Redox Biochemistry of Protein Sulfenylation and Sulfinylation* , 2013, The Journal of Biological Chemistry.

[398]  G. Strous,et al.  SUMOylation is a regulator of the translocation of Jak2 between nucleus and cytosol. , 2013, The Biochemical journal.

[399]  T. Osborne,et al.  An SREBP-responsive microRNA operon contributes to a regulatory loop for intracellular lipid homeostasis. , 2013, Cell metabolism.

[400]  W. Robinson,et al.  Brief report: citrullination within the atherosclerotic plaque: a potential target for the anti-citrullinated protein antibody response in rheumatoid arthritis. , 2013, Arthritis and rheumatism.

[401]  Yingming Zhao,et al.  SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. , 2013, Molecular cell.

[402]  K. Ichihara,et al.  Inhibition of the TNF-α-induced serine phosphorylation of IRS-1 at 636/639 by AICAR. , 2013, Journal of pharmacological sciences.

[403]  J. Weng,et al.  S-nitrosylation of ARH is required for LDL uptake by the LDL receptor[S] , 2013, Journal of Lipid Research.

[404]  N. Khaper,et al.  Hydrogen sulfide protects against cellular senescence via S-sulfhydration of Keap1 and activation of Nrf2. , 2013, Antioxidants & redox signaling.

[405]  E. Kremmer,et al.  Regulation of NF-κB signalling by the mono-ADP-ribosyltransferase ARTD10 , 2013, Nature Communications.

[406]  Peter G. Smith,et al.  Role of ubiquitin ligases and the proteasome in oncogenesis: novel targets for anticancer therapies. , 2013, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[407]  Y. Pi,et al.  Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders , 2013, Nature.

[408]  M. Bedford,et al.  Protein arginine methyltransferases and cancer , 2012, Nature Reviews Cancer.

[409]  A. Sharrett,et al.  Association of blood lactate with carotid atherosclerosis: the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study. , 2012, Atherosclerosis.

[410]  L. Morrow,et al.  Safety, pharmacokinetics and pharmacodynamics of multiple‐ascending doses of the novel glucokinase activator AZD1656 in patients with type 2 diabetes mellitus , 2012, Diabetes, obesity & metabolism.

[411]  R. Schwabe,et al.  Deactivation of hepatic stellate cells during liver fibrosis resolution in mice. , 2012, Gastroenterology.

[412]  P. Ongusaha,et al.  Rho-Associated Coiled-Coil-Containing Kinase 2 Deficiency in Bone Marrow–Derived Cells Leads to Increased Cholesterol Efflux and Decreased Atherosclerosis , 2012, Circulation.

[413]  Tony Pawson,et al.  Modular evolution of phosphorylation-based signalling systems , 2012, Philosophical Transactions of the Royal Society B: Biological Sciences.

[414]  Xiao Han,et al.  Inactivation of MARK4, an AMP-activated Protein Kinase (AMPK)-related Kinase, Leads to Insulin Hypersensitivity and Resistance to Diet-induced Obesity* , 2012, The Journal of Biological Chemistry.

[415]  Ping Huang,et al.  A Role for Protein Inhibitor of Activated STAT1 (PIAS1) in Lipogenic Regulation through SUMOylation-independent Suppression of Liver X Receptors* , 2012, The Journal of Biological Chemistry.

[416]  Bo-Liang Li,et al.  Ablation of gp78 in liver improves hyperlipidemia and insulin resistance by inhibiting SREBP to decrease lipid biosynthesis. , 2012, Cell metabolism.

[417]  D. Accili,et al.  Brown Remodeling of White Adipose Tissue by SirT1-Dependent Deacetylation of Pparγ , 2012, Cell.

[418]  Zhaoqing Wang,et al.  Protein S-nitrosylation and cancer. , 2012, Cancer letters.

[419]  S. Jirawatnotai,et al.  Curcumin Extract for Prevention of Type 2 Diabetes , 2012, Diabetes Care.

[420]  S. Menini,et al.  D‐carnosine octylester attenuates atherosclerosis and renal disease in ApoE null mice fed a Western diet through reduction of carbonyl stress and inflammation , 2012, British journal of pharmacology.

[421]  F. Suchy,et al.  Direct methylation of FXR by Set7/9, a lysine methyltransferase, regulates the expression of FXR target genes. , 2012, American journal of physiology. Gastrointestinal and liver physiology.

[422]  E. Greer,et al.  Histone methylation: a dynamic mark in health, disease and inheritance , 2012, Nature Reviews Genetics.

[423]  Hong Chen,et al.  Accumulation of endoplasmic reticulum stress and lipogenesis in the liver through generational effects of high fat diets. , 2012, Journal of hepatology.

[424]  Hong Wang,et al.  Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration , 2012, Nature Medicine.

[425]  K. Wellen,et al.  A two-way street: reciprocal regulation of metabolism and signalling , 2012, Nature Reviews Molecular Cell Biology.

[426]  Z. Berente,et al.  BGP-15, a PARP-inhibitor, prevents imatinib-induced cardiotoxicity by activating Akt and suppressing JNK and p38 MAP kinases , 2012, Molecular and Cellular Biochemistry.

[427]  Wilhelm Krek,et al.  Dietary obesity-associated Hif1α activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system. , 2012, Genes & development.

[428]  K. Storey,et al.  Tissue Distribution of S‐(2‐Succino)cysteine (2SC), a Biomarker of Mitochondrial Stress in Obesity and Diabetes , 2012, Obesity.

[429]  M. Willis,et al.  The story so far: post-translational regulation of peroxisome proliferator-activated receptors by ubiquitination and SUMOylation. , 2012, American journal of physiology. Heart and circulatory physiology.

[430]  R. Kulkarni,et al.  Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1 , 2012, Proceedings of the National Academy of Sciences.

[431]  S. Snyder,et al.  Hydrogen sulfide-linked sulfhydration of NF-κB mediates its antiapoptotic actions. , 2012, Molecular cell.

[432]  A. Kowluru,et al.  Protein farnesylation is requisite for mitochondrial fuel-induced insulin release , 2012, Islets.

[433]  J. Hamming,et al.  Activator protein-1 (AP-1) signalling in human atherosclerosis: results of a systematic evaluation and intervention study , 2011, Clinical science.

[434]  Yuan Zhang,et al.  AMP-Activated Protein Kinase Suppresses Endothelial Cell Inflammation Through Phosphorylation of Transcriptional Coactivator p300 , 2011, Arteriosclerosis, thrombosis, and vascular biology.

[435]  N. Møller,et al.  GLUT4 and UBC9 Protein Expression Is Reduced in Muscle from Type 2 Diabetic Patients with Severe Insulin Resistance , 2011, PloS one.

[436]  Yue Shentu,et al.  Effects of MK-0941, a Novel Glucokinase Activator, on Glycemic Control in Insulin-Treated Patients With Type 2 Diabetes , 2011, Diabetes Care.

[437]  Johan Auwerx,et al.  Sirt5 Is a NAD-Dependent Protein Lysine Demalonylase and Desuccinylase , 2011, Science.

[438]  Jae-Kwan Hwang,et al.  meso-Dihydroguaiaretic acid inhibits hepatic lipid accumulation by activating AMP-activated protein kinase in human HepG2 cells. , 2011, Biological & pharmaceutical bulletin.

[439]  Mei Han,et al.  HDAC2 phosphorylation-dependent Klf5 deacetylation and RARα acetylation induced by RAR agonist switch the transcription regulatory programs of p21 in VSMCs , 2011, Cell Research.

[440]  M. Karin,et al.  Saturated Fatty Acids Induce c-Src Clustering within Membrane Subdomains, Leading to JNK Activation , 2011, Cell.

[441]  Zhike Lu,et al.  Identification of 67 Histone Marks and Histone Lysine Crotonylation as a New Type of Histone Modification , 2011, Cell.

[442]  D. Townsend,et al.  S-glutathionylation: from molecular mechanisms to health outcomes. , 2011, Antioxidants & redox signaling.

[443]  G. Parker,et al.  Pleiotropic and Age-dependent Effects of Decreased Protein Modification by O-Linked N-Acetylglucosamine on Pancreatic β-Cell Function and Vascularization* , 2011, The Journal of Biological Chemistry.

[444]  Mengwei Zang,et al.  AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. , 2011, Cell metabolism.

[445]  J. Auwerx,et al.  PARP-2 regulates SIRT1 expression and whole-body energy expenditure. , 2011, Cell metabolism.

[446]  Xiaoyong Yang,et al.  O-GlcNAcylation Increases ChREBP Protein Content and Transcriptional Activity in the Liver , 2011, Diabetes.

[447]  Xiaolu Yang,et al.  SUMO E3 ligase activity of TRIM proteins , 2011, Oncogene.

[448]  D. Calvisi,et al.  Increased lipogenesis, induced by AKT-mTORC1-RPS6 signaling, promotes development of human hepatocellular carcinoma. , 2011, Gastroenterology.

[449]  P. MacDonald,et al.  SUMOylation Regulates Insulin Exocytosis Downstream of Secretory Granule Docking in Rodents and Humans , 2011, Diabetes.

[450]  G. Lewis,et al.  Sodium Phenylbutyrate, a Drug With Known Capacity to Reduce Endoplasmic Reticulum Stress, Partially Alleviates Lipid-Induced Insulin Resistance and β-Cell Dysfunction in Humans , 2011, Diabetes.

[451]  Mu Wang,et al.  Carbonylation Contributes to SERCA2a Activity Loss and Diastolic Dysfunction in a Rat Model of Type 1 Diabetes , 2011, Diabetes.

[452]  E. Boerwinkle,et al.  Relationship between circulating levels of RANTES (regulated on activation, normal T-cell expressed, and secreted) and carotid plaque characteristics: the Atherosclerosis Risk in Communities (ARIC) Carotid MRI Study. , 2011, European heart journal.

[453]  S. Kume,et al.  Resveratrol Improves Oxidative Stress and Protects Against Diabetic Nephropathy Through Normalization of Mn-SOD Dysfunction in AMPK/SIRT1-Independent Pathway , 2011, Diabetes.

[454]  Zhihong Zhang,et al.  Identification of lysine succinylation as a new post-translational modification. , 2011, Nature chemical biology.

[455]  N. Nagahara.  Intermolecular disulfide bond to modulate protein function as a redox-sensing switch , 2011, Amino Acids.

[456]  J. Schneider,et al.  De Novo Lipogenesis Maintains Vascular Homeostasis through Endothelial Nitric-oxide Synthase (eNOS) Palmitoylation*♦ , 2010, The Journal of Biological Chemistry.

[457]  Y. Jo,et al.  Antidiabetic and antiobesity effects of Ampkinone (6f), a novel small molecule activator of AMP-activated protein kinase. , 2010, Journal of medicinal chemistry.

[458]  Xiaoling Xu,et al.  Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis. , 2010, Cell metabolism.

[459]  T. Veenstra,et al.  SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism* , 2010, The Journal of Biological Chemistry.

[460]  J. Corbin,et al.  cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action , 2010, Pharmacological Reviews.

[461]  M. Roitman,et al.  Inhibition of PTP1B by Trodusquemine (MSI‐1436) Causes Fat‐specific Weight Loss in Diet‐induced Obese Mice , 2010, Obesity.

[462]  Tanya M. Teslovich,et al.  Biological, Clinical, and Population Relevance of 95 Loci for Blood Lipids , 2010, Nature.

[463]  G. Maulucci,et al.  Mammalian life-span determinant p66shcA mediates obesity-induced insulin resistance , 2010, Proceedings of the National Academy of Sciences.

[464]  B. Wung,et al.  The glutaredoxin/glutathione system modulates NF-kappaB activity by glutathionylation of p65 in cinnamaldehyde-treated endothelial cells. , 2010, Toxicological sciences : an official journal of the Society of Toxicology.

[465]  A. Shore,et al.  Adiposity is a major determinant of plasma levels of the novel vasodilator hydrogen sulphide , 2010, Diabetologia.

[466]  H. Morinaga,et al.  Pharmacological profiles of a novel protein tyrosine phosphatase 1B inhibitor, JTT‐551 , 2010, Diabetes, obesity & metabolism.

[467]  I. Tasci.  Clinical usefulness of AGEs as a biomarker for the attenuation of NASH , 2010, Journal of Gastroenterology.

[468]  Jonathan D. Smith,et al.  Lack of Mitogen-Activated Protein Kinase Phosphatase-1 Protects ApoE-Null Mice Against Atherosclerosis , 2010, Circulation research.

[469]  J. Obata,et al.  Mice lacking the glutamate-cysteine ligase modifier subunit are susceptible to myocardial ischaemia-reperfusion injury. , 2010, Cardiovascular research.

[470]  H. Choi,et al.  Reduction of AMP-Activated Protein Kinase &agr;2 Increases Endoplasmic Reticulum Stress and Atherosclerosis In Vivo , 2010, Circulation.

[471]  K. Chayama,et al.  Atorvastatin decreases serum levels of advanced glycation endproducts (AGEs) in nonalcoholic steatohepatitis (NASH) patients with dyslipidemia: clinical usefulness of AGEs as a biomarker for the attenuation of NASH , 2010, Journal of Gastroenterology.

[472]  Jonathan R. Brestoff,et al.  Downregulation of Adipose Glutathione S-Transferase A4 Leads to Increased Protein Carbonylation, Oxidative Stress, and Mitochondrial Dysfunction , 2010, Diabetes.

[473]  G. Hart,et al.  The intersections between O-GlcNAcylation and phosphorylation: implications for multiple signaling pathways , 2010, Journal of Cell Science.

[474]  I. Harris,et al.  A Systematic Review and Meta-Analysis of Randomized Controlled Trials , 2010 .

[475]  V. Preedy,et al.  Prospective Cohort Study , 2010 .

[476]  S. Snyder,et al.  H2S Signals Through Protein S-Sulfhydration , 2009, Science Signaling.

[477]  E. Ropelle,et al.  Aspirin attenuates insulin resistance in muscle of diet-induced obese rats by inhibiting inducible nitric oxide synthase production and S-nitrosylation of IRβ/IRS-1 and Akt , 2009, Diabetologia.

[478]  J. Stamler,et al.  Protein S-nitrosylation in health and disease: a current perspective. , 2009, Trends in molecular medicine.

[479]  A. Hevener,et al.  Hypermetabolism, Hyperphagia, and Reduced Adiposity in Tankyrase-Deficient Mice , 2009, Diabetes.

[480]  P. Tontonoz,et al.  LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor , 2009, Science.

[481]  R. Ceddia,et al.  Regulation of Visceral and Subcutaneous Adipocyte Lipolysis by Acute AICAR‐induced AMPK Activation , 2009, Obesity.

[482]  Keith D Wilkinson,et al.  Regulation and cellular roles of ubiquitin-specific deubiquitinating enzymes. , 2009, Annual review of biochemistry.

[483]  J. Wade Harper,et al.  Ubiquitin-like protein activation by E1 enzymes: the apex for downstream signalling pathways , 2009, Nature Reviews Molecular Cell Biology.

[484]  Qing Xu,et al.  Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. , 2009, Cell metabolism.

[485]  A. Tall,et al.  Macrophage deficiency of p38alpha MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice. , 2009, The Journal of clinical investigation.

[486]  A. Boulares,et al.  Thieno[2,3-c]Isoquinolin-5-one, a Potent Poly(ADP-Ribose) Polymerase Inhibitor, Promotes Atherosclerotic Plaque Regression in High-Fat Diet-Fed Apolipoprotein E-Deficient Mice: Effects on Inflammatory Markers and Lipid Content , 2009, Journal of Pharmacology and Experimental Therapeutics.

[487]  F. Hamel,et al.  Nitric oxide inhibits insulin-degrading enzyme activity and function through S-nitrosylation. , 2009, Biochemical pharmacology.

[488]  P. MacDonald,et al.  SUMOylation regulates Kv2.1 and modulates pancreatic β-cell excitability , 2009, Journal of Cell Science.

[489]  Daniel Veyel,et al.  Molecular Plant @bullet Volume 2 @bullet Number 2 @bullet Methods for Analysis of Protein Glutathionylation and Their Application to Photosynthetic Organisms , 2009 .

[490]  K. Tory,et al.  Improvement of Insulin Sensitivity by a Novel Drug, BGP-15, in Insulin-resistant Patients: A Proof of Concept Randomized Double-blind Clinical Trial , 2009, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.

[491]  M. Memo,et al.  Glutathionylation of the Pro-apoptotic Protein p53 in Alzheimer’s Disease Brain: Implications for AD Pathogenesis , 2009, Neurochemical Research.

[492]  Gregory A. Brown,et al.  A Pooled Analysis of Randomized Controlled Trials for Venous Thromboembolism Prophylaxis after Major Orthopaedic Surgery , 2009 .

[493]  J. Marth,et al.  Core2 1-6-N-Glucosaminyltransferase-I Is Crucial for the Formation of Atherosclerotic Lesions in Apolipoprotein E–Deficient Mice , 2009, Arteriosclerosis, thrombosis, and vascular biology.

[494]  M. Cobb,et al.  Sumoylation Regulates the Transcriptional Activity of MafA in Pancreatic β Cells* , 2009, Journal of Biological Chemistry.

[495]  R. Collins,et al.  Common variants at 30 loci contribute to polygenic dyslipidemia , 2009, Nature Genetics.

[496]  U. Jhala,et al.  COP1 Functions as a FoxO1 Ubiquitin E3 Ligase to Regulate FoxO1-mediated Gene Expression* , 2008, Journal of Biological Chemistry.

[497]  Andrew Min,et al.  Lymphocytes From Patients With Type 1 Diabetes Display a Distinct Profile of Chromatin Histone H3 Lysine 9 Dimethylation , 2008, Diabetes.

[498]  Molly M Gallogly,et al.  Molecular mechanisms and clinical implications of reversible protein S-glutathionylation. , 2008, Antioxidants & redox signaling.

[499]  A. Naura,et al.  Abstract 1685: Thieno[2,3-c]isoquinolin-5-one (TIQ-A), a Potent Poly(ADP-ribose) Polymerase Inhibitor, Promotes Atherosclerotic Plaque Regression in High Fat Diet-fed ApoE-deficient Mice: Effects on Inflammatory Markers and Lipid Content , 2008 .

[500]  S. Snyder,et al.  Nitric oxide-induced nuclear GAPDH activates p300/CBP and mediates apoptosis , 2008, Nature Cell Biology.

[501]  Z. Madar.  Faculty Opinions recommendation of SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta. , 2008 .

[502]  Mitsuru Ohsugi,et al.  SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-δ , 2008, Nature Medicine.

[503]  M. Massett,et al.  GIT1 Mediates HDAC5 Activation by Angiotensin II in Vascular Smooth Muscle Cells , 2008, Arteriosclerosis, thrombosis, and vascular biology.

[504]  B. Berk,et al.  PARP-1 Inhibition Prevents Oxidative and Nitrosative Stress–Induced Endothelial Cell Death via Transactivation of the VEGF Receptor 2 , 2008, Arteriosclerosis, thrombosis, and vascular biology.

[505]  Xiaoyong Yang,et al.  Regulation of Transcription Factor NFAT by ADP-Ribosylation , 2008, Molecular and Cellular Biology.

[506]  J. She,et al.  SUMO4 and its role in type 1 diabetes pathogenesis , 2008, Diabetes/metabolism research and reviews.

[507]  Eunok Paek,et al.  Strategy for comprehensive identification of post-translational modifications in cellular proteins, including low abundant modifications: application to glyceraldehyde-3-phosphate dehydrogenase. , 2008, Journal of proteome research.

[508]  L. Szweda,et al.  Reversible inhibition of alpha-ketoglutarate dehydrogenase by hydrogen peroxide: glutathionylation and protection of lipoic acid. , 2008, Biochemistry.

[509]  J. Borén,et al.  PARP1 is required for adhesion molecule expression in atherogenesis. , 2007, Cardiovascular research.

[510]  G. Misener,et al.  Short Communication , 1990, American Potato Journal.

[511]  Michael A. Freitas,et al.  Identification and characterization of disulfide bonds in proteins and peptides from tandem MS data by use of the MassMatrix MS/MS search engine. , 2008, Journal of proteome research.

[512]  D. Townsend,et al.  S-glutathionylation: indicator of cell stress and regulator of the unfolded protein response. , 2007, Molecular interventions.

[513]  M. Gaestel,et al.  Systemic Deficiency of the MAP Kinase-Activated Protein Kinase 2 Reduces Atherosclerosis in Hypercholesterolemic Mice , 2007, Circulation research.

[514]  Rama Ranganathan,et al.  Dynamic Scaffolding in a G Protein-Coupled Signaling System , 2007, Cell.

[515]  Or Gozani,et al.  Modulation of p53 function by SET8-mediated methylation at lysine 382. , 2007, Molecular cell.

[516]  C. Lowenstein,et al.  Nitric oxide regulation of protein trafficking in the cardiovascular system. , 2007, Cardiovascular research.

[517]  Jayoung Kim,et al.  Cholesterol sensitivity of endogenous and myristoylated Akt. , 2007, Cancer research.

[518]  Frank Brombacher,et al.  Macrophage-specific PPARγ controls alternative activation and improves insulin resistance , 2007, Nature.

[519]  A. Boulares,et al.  Poly(ADP-Ribose) Polymerase Inhibition Reduces Atherosclerotic Plaque Size and Promotes Factors of Plaque Stability in Apolipoprotein E–Deficient Mice: Effects on Macrophage Recruitment, Nuclear Factor-&kgr;B Nuclear Translocation, and Foam Cell Death , 2007, Circulation.

[520]  I. Kola,et al.  Lack of the Antioxidant Enzyme Glutathione Peroxidase-1 Accelerates Atherosclerosis in Diabetic Apolipoprotein E–Deficient Mice , 2007, Circulation.

[521]  Soon-Cheang Quah,et al.  A Current Perspective , 2007 .

[522]  T. Kita,et al.  Serum levels of S-glutathionylated proteins as a risk-marker for arteriosclerosis obliterans. , 2007, Circulation journal : official journal of the Japanese Circulation Society.

[523]  P. Mahadevan,et al.  An overview , 2007, Journal of Biosciences.

[524]  V. Sossi,et al.  Pten (phosphatase and tensin homologue gene) haploinsufficiency promotes insulin hypersensitivity , 2006, Diabetologia.

[525]  M. Aviram,et al.  S-Glutathionylation regulates HDL-associated paraoxonase 1 (PON1) activity. , 2006, Biochemical and biophysical research communications.

[526]  P. Puigserver,et al.  Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α , 2006, Cell.

[527]  E. Clementi,et al.  TNF-alpha downregulates eNOS expression and mitochondrial biogenesis in fat and muscle of obese rodents. , 2006, The Journal of clinical investigation.

[528]  Reto Asmis,et al.  Molecular mechanism of glutathione-mediated protection from oxidized low-density lipoprotein-induced cell injury in human macrophages: role of glutathione reductase and glutaredoxin. , 2006, Free radical biology & medicine.

[529]  W. Prinz,et al.  Caenorhabditis elegans ortholog of a diabetes susceptibility locus: oga-1 (O-GlcNAcase) knockout impacts O-GlcNAc cycling, metabolism, and dauer , 2006, Proceedings of the National Academy of Sciences.

[530]  B. Neel,et al.  Neuronal PTP1B regulates body weight, adiposity and leptin action , 2006, Nature Medicine.

[531]  G. Schreiner,et al.  Preventive and Therapeutic Potential of p38α-Selective Mitogen-Activated Protein Kinase Inhibitor in Nonobese Diabetic Mice with Type 1 Diabetes , 2006, Journal of Pharmacology and Experimental Therapeutics.

[532]  E. Block,et al.  Peptides modified by myristoylation activate eNOS in endothelial cells through Akt phosphorylation , 2006, British journal of pharmacology.

[533]  Colin G. Nichols,et al.  KATP channels as molecular sensors of cellular metabolism , 2006, Nature.

[534]  H. Kiyokawa,et al.  Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity. , 2006, Diabetes.

[535]  M. Czaja,et al.  Jnk1 but not jnk2 promotes the development of steatohepatitis in mice , 2006, Hepatology.

[536]  G. Schreiner,et al.  Preventive and therapeutic potential of p38 alpha-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes. , 2006, The Journal of pharmacology and experimental therapeutics.

[537]  J. Marth,et al.  Dietary and Genetic Control of Glucose Transporter 2 Glycosylation Promotes Insulin Secretion in Suppressing Diabetes , 2005, Cell.

[538]  K. Gumireddy,et al.  Free fatty acids produce insulin resistance and activate the proinflammatory nuclear factor-kappaB pathway in rat liver. , 2005, Diabetes.

[539]  B. Song,et al.  Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase. , 2005, Molecular cell.

[540]  C. Chien,et al.  Neddylation and deneddylation regulate Cul1 and Cul3 protein accumulation , 2005, Nature Cell Biology.

[541]  R. Duggirala,et al.  A single nucleotide polymorphism in MGEA5 encoding O-GlcNAc-selective N-acetyl-beta-D glucosaminidase is associated with type 2 diabetes in Mexican Americans. , 2005, Diabetes.

[542]  Brian D Strahl,et al.  Role of protein methylation in regulation of transcription. , 2005, Endocrine reviews.

[543]  R. Scharpf,et al.  Regulation of platelet granule exocytosis by S-nitrosylation. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[544]  H. E. Marshall,et al.  Protein S-nitrosylation: purview and parameters , 2005, Nature Reviews Molecular Cell Biology.

[545]  Yang Shi,et al.  Histone Demethylation Mediated by the Nuclear Amine Oxidase Homolog LSD1 , 2004, Cell.

[546]  Timothy J. Burroughs,et al.  Activator protein‐1 signalling pathway and apoptosis are modulated by poly(ADP‐ribose) polymerase‐1 in experimental colitis , 2004, Immunology.

[547]  Eliora Z Ron,et al.  Probing the active site of homoserine trans‐succinylase , 2004, FEBS letters.

[548]  J. Holder,et al.  Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3beta on a muscle-specific promoter. , 2004, Metabolism: clinical and experimental.

[549]  A. Daugherty,et al.  &agr;(1,3)Fucosyltransferases FucT-IV and FucT-VII Control Susceptibility to Atherosclerosis in Apolipoprotein E−/− Mice , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[550]  Nathan D. Wong,et al.  Impact of the Metabolic Syndrome on Mortality From Coronary Heart Disease, Cardiovascular Disease, and All Causes in United States Adults , 2004, Circulation.

[551]  T. Sanke,et al.  Functional variants in the glutathione peroxidase-1 (GPx-1) gene are associated with increased intima-media thickness of carotid arteries and risk of macrovascular diseases in japanese type 2 diabetic patients. , 2004, Diabetes.

[552]  Toshiyuki Shimizu,et al.  Structural basis for Ca2+-induced activation of human PAD4 , 2004, Nature Structural &Molecular Biology.

[553]  N. Blom,et al.  Prediction of post‐translational glycosylation and phosphorylation of proteins from the amino acid sequence , 2004, Proteomics.

[554]  Rajendra K. Sharma,et al.  Coenzyme A dependent myristoylation and demyristoylation in the regulation of bovine spleen N-myristoyltransferase , 1996, Molecular and Cellular Biochemistry.

[555]  R. Green,et al.  The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance. , 2004, Journal of hepatology.

[556]  T. Asano,et al.  Hepatic Akt activation induces marked hypoglycemia, hepatomegaly, and hypertriglyceridemia with sterol regulatory element binding protein involvement. , 2003, Diabetes.

[557]  E. Vossenaar,et al.  PAD, a growing family of citrullinating enzymes: genes, features and involvement in disease , 2003, BioEssays : news and reviews in molecular, cellular and developmental biology.

[558]  M. Toledano,et al.  ATP-dependent reduction of cysteine–sulphinic acid by S. cerevisiae sulphiredoxin , 2003, Nature.

[559]  S. Kohno,et al.  Oxidative modulation of NF-κB signaling by oxidized low-density lipoprotein , 2003 .

[560]  E. Fisher,et al.  Overexpression of the Tumor Autocrine Motility Factor Receptor Gp78, a Ubiquitin Protein Ligase, Results in Increased Ubiquitinylation and Decreased Secretion of Apolipoprotein B100 in HepG2 Cells* , 2003, Journal of Biological Chemistry.

[561]  Keiji Tanaka,et al.  Sterol Regulatory Element-binding Proteins Are Negatively Regulated through SUMO-1 Modification Independent of the Ubiquitin/26 S Proteasome Pathway* , 2003, The Journal of Biological Chemistry.

[562]  H. Ploegh,et al.  A role for N‐glycanase in the cytosolic turnover of glycoproteins , 2003, The EMBO journal.

[563]  S. Kohno,et al.  Oxidative modulation of NF-kappaB signaling by oxidized low-density lipoprotein. , 2003, Biochemical and biophysical research communications.

[564]  C. Sevier,et al.  Formation and transfer of disulphide bonds in living cells , 2002, Nature Reviews Molecular Cell Biology.

[565]  M. Munday.  Regulation of mammalian acetyl-CoA carboxylase. , 2002, Biochemical Society transactions.

[566]  D. Bredt,et al.  Protein palmitoylation: a regulator of neuronal development and function , 2002, Nature Reviews Neuroscience.

[567]  P. Cohen.  Protein kinases — the major drug targets of the twenty-first century? , 2002, Nature reviews. Drug discovery.

[568]  Tiequan Zhang,et al.  Quantitation of protein sulfinic and sulfonic acid, irreversibly oxidized protein cysteine sites in cellular proteins. , 2002, Methods in enzymology.

[569]  Margaret S. Wu,et al.  Role of AMP-activated protein kinase in mechanism of metformin action. , 2001, The Journal of clinical investigation.

[570]  R. Yu,et al.  Signal transduction events elicited by cancer prevention compounds. , 2001, Mutation research.

[571]  T. Katagiri,et al.  Synergistic Effect of Urotensin II With Mildly Oxidized LDL on DNA Synthesis in Vascular Smooth Muscle Cells , 2001, Circulation.

[572]  U. V. von Andrian,et al.  The alpha(1,3)fucosyltransferases FucT-IV and FucT-VII exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homing. , 2001, Immunity.

[573]  B. Ochoa,et al.  Lipid and fatty acid composition of canine lipoproteins. , 2001, Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology.

[574]  M. Karin,et al.  Mammalian MAP kinase signalling cascades , 2001, Nature.

[575]  M. Permutt,et al.  Islet beta cell expression of constitutively active Akt1/PKB alpha induces striking hypertrophy, hyperplasia, and hyperinsulinemia. , 2001, The Journal of clinical investigation.

[576]  K. Murthy,et al.  Diabetic endothelial dysfunction: the role of poly(ADP-ribose) polymerase activation , 2001, Nature Medicine.

[577]  S. Korsmeyer,et al.  Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis. , 2000, Science.

[578]  G. A. van der Marel,et al.  Inhibitors of prenylation of Ras and other G-proteins and their application as therapeutics. , 2000, Biochemical pharmacology.

[579]  J. Mehta,et al.  Antisense to LOX-1 inhibits oxidized LDL-mediated upregulation of monocyte chemoattractant protein-1 and monocyte adhesion to human coronary artery endothelial cells. , 2000, Circulation.

[580]  C. Kahn,et al.  The Branch Point Enzyme of the Mevalonate Pathway for Protein Prenylation Is Overexpressed in theob/ob Mouse and Induced by Adipogenesis , 2000, Molecular and Cellular Biology.

[581]  Y. Furukawa,et al.  Induction of ubiquitin-conjugating enzyme by aggregated low density lipoprotein in human macrophages and its implications for atherosclerosis. , 2000, Arteriosclerosis, thrombosis, and vascular biology.

[582]  T. Niwa,et al.  Increased glutathionyl hemoglobin in diabetes mellitus and hyperlipidemia demonstrated by liquid chromatography/electrospray ionization-mass spectrometry. , 2000, Clinical chemistry.

[583]  R. Deschenes,et al.  Erf2, a Novel Gene Product That Affects the Localization and Palmitoylation of Ras2 in Saccharomyces cerevisiae , 1999, Molecular and Cellular Biology.

[584]  T. Niwa,et al.  Determination of glutathionyl hemoglobin in hemodialysis patients using electrospray ionization liquid chromatography-mass spectrometry. , 1999, Journal of chromatography. B, Biomedical sciences and applications.

[585]  P. O'Connell,et al.  Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans. , 1999, American journal of human genetics.

[586]  H. Kolb,et al.  Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin , 1999, Nature Medicine.

[587]  J. Stamler,et al.  Cell-free and erythrocytic S-nitrosohemoglobin inhibits human platelet aggregation. , 1998, Circulation.

[588]  H. Ginsberg.  Lipoprotein physiology. , 1998, Endocrinology and metabolism clinics of North America.

[589]  E. Yeh,et al.  Characterization of NEDD8, a Developmentally Down-regulated Ubiquitin-like Protein* , 1997, The Journal of Biological Chemistry.

[590]  G. Melino,et al.  Protein Unfolding by Peptidylarginine Deiminase , 1996, The Journal of Biological Chemistry.

[591]  P. Beachy,et al.  Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development , 1996, Science.

[592]  G. Garcı́a-Cardeña,et al.  Targeting of nitric oxide synthase to endothelial cell caveolae via palmitoylation: implications for nitric oxide signaling. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[593]  P. Casey,et al.  Protein prenylation: molecular mechanisms and functional consequences. , 1996, Annual review of biochemistry.

[594]  D. Koshland,et al.  Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C. , 1995, Molecular biology of the cell.

[595]  J. Stamler,et al.  Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[596]  D. Ziegler.  Role of reversible oxidation-reduction of enzyme thiols-disulfides in metabolic regulation. , 1985, Annual review of biochemistry.

[597]  R. Levine.  Oxidative modification of glutamine synthetase. I. Inactivation is due to loss of one histidine residue. , 1983, The Journal of biological chemistry.

[598]  S. Ōae,et al.  ORGANIC THIONITRITES AND RELATED SUBSTANCES. A REVIEW , 1983 .

[599]  C. Klee,et al.  Identification of the NH2‐terminal blocking group of calcineurin B as myristic acid , 1982, FEBS letters.

[600]  E Bause,et al.  The role of the hydroxy amino acid in the triplet sequence Asn-Xaa-Thr(Ser) for the N-glycosylation step during glycoprotein biosynthesis. , 1981, The Biochemical journal.

[601]  S. Steiner.  The Mexican Americans , 1979 .

[602]  Y. Kamiya,et al.  Structure of rhodotorucine A, a novel lipopeptide, inducing mating tube formation in Rhodosporidium toruloides. , 1978, Biochemical and Biophysical Research Communications - BBRC.

[603]  I. Llewellyn-Smith,et al.  The origin of citrulline-containing proteins in the hair follicle and the chemical nature of trichohyalin, an intracellular precursor. , 1977, Biochimica et biophysica acta.

[604]  W. Allison.  Formation and reactions of sulfenic acids in proteins , 1976 .

[605]  G Goldstein,et al.  Isolation of a polypeptide that has lymphocyte-differentiating properties and is probably represented universally in living cells. , 1975, Proceedings of the National Academy of Sciences of the United States of America.

[606]  L. Reed,et al.  Alpha-keto acid dehydrogenase complexes. X. Regulation of the activity of the pyruvate dehydrogenase complex from beef kidney mitochondria by phosphorylation and dephosphorylation. , 1969, Proceedings of the National Academy of Sciences of the United States of America.

[607]  A. Mirsky,et al.  ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS. , 1964, Proceedings of the National Academy of Sciences of the United States of America.

[608]  P. Chambon,et al.  Nicotinamide mononucleotide activation of new DNA-dependent polyadenylic acid synthesizing nuclear enzyme. , 1963, Biochemical and biophysical research communications.

[609]  G. Rogers,et al.  Content of Citrulline and Other Amino-Acids in a Protein of Hair Follicles , 1958, Nature.

[610]  E. P. Kennedy,et al.  The enzymatic phosphorylation of proteins. , 1954, The Journal of biological chemistry.

[611]  D. Rittenberg,et al.  STUDIES IN PROTEIN METABOLISM VII. THE METABOLISM OF TYROSINE , 1939 .

[612]  A. Mirsky,et al.  SULFHYDRYL AND DISULFIDE GROUPS OF PROTEINS : I. METHODS OF ESTIMATION. , 1935 .

[613]  H. Johnson,et al.  A comparison of 'traditional' and multimedia information systems development practices , 2003, Inf. Softw. Technol..

[614]  P. Levene,et al.  THE CLEAVAGE PRODUCTS OF VITELLIN , 1906 .