The complement system in rheumatoid synovitis. II. Intracytoplasmic inclusions of immunoglobulins and complement.

Synovial fluid leukocytes from patients with seropositive and seronegative rheumatoid arthritis and degenerative joint disease were examined by immunofluorescence for deposition of γG, γA, γM, γG1, γG2, γG3, γG4, C1q, C4, C3, rheumatoid factor, and albumin. The pattern of immunoglobulin and complement deposition, particularly in seropositive rheumatoid arthritis fluids with low complement levels, was consistent with activation of the complement system and phagocytosis of immune complexes.

[1]  S. Ruddy,et al.  The complement system in rheumatoid synovitis. I. An analysis of complement component activities in rheumatoid synovial fluids. , 1970, Arthritis and rheumatism.

[2]  H. Kunkel,et al.  THE JOINT‐FLUID γG‐GLOBULIN COMPLEXES AND THEIR RELATIONSHIP TO INTRAARTICULAR COMPLEMENT DIMINUTION * , 1969 .

[3]  S. Ruddy,et al.  Structural polymorphism of the fourth component of human complement. , 1969, The Journal of clinical investigation.

[4]  S. Ruddy,et al.  Complement metabolism in man: hypercatabolism of the fourth (C4) and third (C3) components in patients with renal allograft rejection and hereditary angioedema (HAE) , 1969 .

[5]  K. Brandt,et al.  Studies of immune deposits in synovial membranes and corresponding synovial fluids. , 1968, The Journal of laboratory and clinical medicine.

[6]  P. Schur,et al.  Reactions of aggregated mercaptoethanol treated gamma globulin with rheumatoid factor--precipitin and complement fixation studies. , 1968, Arthritis and rheumatism.

[7]  I. Gigli,et al.  Complement dependent immune phagocytosis. I. Requirements for C'1, C'4, C'2, C'3. , 1968, Experimental cell research.

[8]  J. Vaughan,et al.  Relation of intracytoplasmic inclusions in joint fluid leukocytes to anti-γG globulins , 1968 .

[9]  J. Vaughan,et al.  Intracytoplasmic inclusions of immunoglobulins in rheumatoid arthritis and other diseases. , 1968, Arthritis and rheumatism.

[10]  J. Leddy,et al.  Direct antiglobulin (Coombs) reactions in patients with connective tissue diseases. , 1967, Arthritis and rheumatism.

[11]  F. Delbarre,et al.  Haemolytic complement level and ragocyte (R A cell) concentration in synovial fluid. , 1967, Annals of the rheumatic diseases.

[12]  P. Schur,et al.  IMMUNOLOGICAL STUDIES CONCERNING THE NEPHRITIS OF SYSTEMIC LUPUS ERYTHEMATOSUS , 1967, The Journal of experimental medicine.

[13]  K. Ishizaka,et al.  Biologic activities of aggregated gamma-globulin. 8. Aggregated immunoglobulins of different classes. , 1967, Journal of immunology.

[14]  L. Hanauer,et al.  Clinical studies of hemolytic complement and the 11S component. , 1967, The American journal of medicine.

[15]  Healey La,et al.  The nonspecificity of synovial leukocyte inclusions. , 1966 .

[16]  A. Michael,et al.  Immunopathologic changes in rheumatoid arthritis synovium , 1966 .

[17]  D. Mccarty,et al.  STUDIES ON THE PATHOGENESIS OF RHEUMATOID JOINT INFLAMMATION. I. THE "R.A. CELL" AND A WORKING HYPOTHESIS. , 1965, Annals of internal medicine.

[18]  J. Fahey,et al.  QUANTITATIVE DETERMINATION OF SERUM IMMUNOGLOBULINS IN ANTIBODY-AGAR PLATES. , 1965, Journal of immunology.

[19]  B. Amor,et al.  [THE SYNOVIAL RAISIN CELL. ITS VALUE IN THE DIAGNOSIS OF RHEUMATIC DISEASES]. , 1964, La Presse medicale.

[20]  H. Grey,et al.  H CHAIN SUBGROUPS OF MYELOMA PROTEINS AND NORMAL 7S γ-GLOBULIN , 1964, The Journal of experimental medicine.

[21]  R. Heimer,et al.  INHIBITION OF COMPLEMENT FIXATION BY HUMAN SERUM. II. THE ACTIVITY OF A GAMMA-LM GLOBULIN AND RHEUMATOID FACTOR IN COMPLEMENT FIXATION REACTIONS. , 1963, Journal of immunology.

[22]  J. F. Kent,et al.  Precise standardization of reagents for complement fixation. , 1963, The American journal of tropical medicine and hygiene.

[23]  R. Heimer,et al.  CELLULAR ORIGIN OF RHEUMATOID FACTOR , 1959, The Journal of experimental medicine.

[24]  G. Edelman,et al.  INTERACTION OF THE RHEUMATOID FACTOR WITH ANTIGEN-ANTIBODY COMPLEXES AND AGGREGATED GAMMA GLOBULIN , 1958, The Journal of experimental medicine.

[25]  T. B. Bayles,et al.  The latex agglutination and inhibition reactions; clinical experience in the diagnosis of rheumatoid arthritis. , 1958, The New England journal of medicine.

[26]  J. Scheidegger.  Une micro-méthode de l’immuno-électrophorèse , 1955 .

[27]  O. Ouchterlony,et al.  Antigen-antibody reactions in gels. IV. Types of reactions in coordinated systems of diffusion. , 2009, Acta pathologica et microbiologica Scandinavica.