Naturally occurring infections in non-human primates (NHP) and immunotoxicity implications: Discussion sessions

Non-human primates (NHP) are used to best understand and address pharmacology and toxicology obligations for human patients with highest and/or unmet need. In order to ensure the most appropriate care and use of NHP, it is important to understand the normal micro flora and fauna of NHP and ensure their utmost health to generate the most valuable and applicable data. There are many infections, including viral, bacterial, parasitic, and fungal that may perturb physiologic endpoints relevant to human health, and are essential to monitor and/or eradicate for NHP health. This publication captures a discussion involving the experience, knowledge and opinion from academic, industry and government experts regarding emerging and normal infections in NHP as they relate to immunotoxicity, and treatment and consequences of known infections.

[1]  K. Price.  Bacterial infections in cynomolgus monkeys given small molecule immunomodulatory antagonists , 2010, Journal of immunotoxicology.

[2]  Joe H. Simmons,et al.  Herpesvirus infections of laboratory macaques , 2010, Journal of immunotoxicology.

[3]  N. Lerche.  Simian retroviruses: Infection and disease—implications for immunotoxicology research in primates , 2010, Journal of immunotoxicology.

[4]  D. Hutto.  Opportunistic infections in non-human primates exposed to immunomodulatory biotherapeutics: considerations and case examples , 2010, Journal of immunotoxicology.

[5]  K. Mansfield,et al.  Overview of known non-human primate pathogens with potential to affect colonies used for toxicity testing , 2009, Journal of immunotoxicology.

[6]  K. Taylor.  Clinical veterinarian's perspective of non-human primate (NHP) use in drug safety studies. , 2009, Journal of immunotoxicology.

[7]  M. Deac,et al.  THE IMMUNE RECONSTITUTION INFLAMMATORY SYNDROME (IRIS) , 2010 .

[8]  G. Breton.  [Immune reconstitution inflammatory syndrome or IRIS]. , 2010, Medecine sciences : M/S.

[9]  N. Lerche,et al.  Beyond specific pathogen-free: biology and effect of common viruses in macaques. , 2008, Comparative medicine.

[10]  R. Grant,et al.  Specific pathogen-free macaques: definition, history, and current production. , 2008, ILAR journal.

[11]  Mansfield Keith.  CHAPTER 15 – Development of Specific Pathogen Free Nonhuman Primate Colonies , 2005 .

[12]  J. Kutok,et al.  Experimental rhesus lymphocryptovirus infection in immunosuppressed macaques: an animal model for Epstein-Barr virus pathogenesis in the immunosuppressed host. , 2004, Blood.

[13]  R. Ward,et al.  Infectious Agent and Immune Response Characteristics of Chronic Enterocolitis in Captive Rhesus Macaques , 2003, Infection and Immunity.

[14]  S. Shelburne,et al.  The immune reconstitution inflammatory syndrome. , 2003, AIDS reviews.

[15]  Z. Grossman,et al.  CD4+ T-cell depletion in HIV infection: Are we closer to understanding the cause? , 2002, Nature Medicine.

[16]  P. Bucsky,et al.  PATIENTS AT RISK FOR DEVELOPMENT OF POSTTRANSPLANT LYMPHOPROLIFERATIVE DISORDER: PLASMA VERSUS PERIPHERAL BLOOD MONONUCLEAR CELLS AS MATERIAL FOR QUANTIFICATION OF EPSTEIN-BARR VIRAL LOAD BY USING REAL-TIME QUANTITATIVE POLYMERASE CHAIN REACTION1,2 , 2001, Transplantation.

[17]  A. Limaye,et al.  Quantitation of BK virus load in serum for the diagnosis of BK virus-associated nephropathy in renal transplant recipients. , 2001, The Journal of infectious diseases.

[18]  J. McCune,et al.  The dynamics of CD4+ T-cell depletion in HIV disease , 2001, Nature.

[19]  A. Caliendo,et al.  Clinical utility of quantitative cytomegalovirus viral load determination for predicting cytomegalovirus disease in liver transplant recipients. , 1999, Transplantation.

[20]  N. Haigwood,et al.  Plasma viremia in macaques infected with simian immunodeficiency virus: plasma viral load early in infection predicts survival , 1997, Journal of virology.

[21]  L Timmermann,et al.  The mechanism of action of cyclosporin A and FK506. , 1996, Clinical immunology and immunopathology.

[22]  John W. Mellors,et al.  Prognosis in HIV-1 Infection Predicted by the Quantity of Virus in Plasma , 1996, Science.

[23]  Anderson Jh,et al.  Diarrhea rates and risk factors for developing chronic diarrhea in infant and juvenile rhesus monkeys. , 1992 .

[24]  VandeWoude Sj,et al.  The role of Branhamella catarrhalis in the "bloody-nose syndrome" of cynomolgus macaques. , 1991 .

[25]  S. Vandewoude,et al.  The role of Branhamella catarrhalis in the "bloody-nose syndrome" of cynomolgus macaques. , 1991, Laboratory animal science.

[26]  N. Lerche,et al.  Electrolyte abnormalities associated with diarrhea in rhesus monkeys: 100 cases (1986-1987). , 1990, Journal of the American Veterinary Medical Association.

[27]  R. Steinman,et al.  EVIDENCE THAT CYCLOSPORINE INHIBITS CELL‐MEDIATED IMMUNITY PRIMARILY AT THE LEVEL OF THE T LYMPHOCYTE RATHER THAN THE ACCESSORY CELL , 1988, Transplantation.

[28]  Anderson Jh,et al.  Diarrhea in nonhuman primates: a survey of primate colonies for incidence rates and clinical opinion. , 1984 .

[29]  D. Hird,et al.  Diarrhea in nonhuman primates: a survey of primate colonies for incidence rates and clinical opinion. , 1984, Laboratory animal science.

[30]  J. Vickers.  DISEASES OF PRIMATES AFFECTING THE CHOICE OF SPECIES FOR TOXICOLOGIC STUDIES , 1969, Annals of the New York Academy of Sciences.