Neural generators of ERPs linked with Necker cube reversals.

Multistable perception occurs when a single physical stimulus leads to two or more distinct percepts that spontaneously switch (reverse). Previous ERP studies have reported reversal negativities and late positive components associated with perceptual reversals. The goal of the current study was to localize the neural generators of the reversal ERP components in order to evaluate their correspondence with previous fMRI results and to better understand their functional significance. A Necker-type stimulus was presented for brief intervals while subjects indicated their perceptions. Local auto-regressive average source analyses and dipole modeling indicated that sources for the reversal negativity were located in inferior occipital-temporal cortex. Generators of the late positive component were estimated to reside in inferior temporal and superior parietal regions.

[1]  Michael Bach,et al.  Bistable perception -- along the processing chain from ambiguous visual input to a stable percept. , 2006, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[2]  Daniel Strüber,et al.  EEG gamma-band response during the perception of Necker cube reversals , 2001 .

[3]  N. Squires,et al.  The effect of stimulus sequence on the waveform of the cortical event-related potential. , 1976, Science.

[4]  E. Courchesne,et al.  Stimulus novelty, task relevance and the visual evoked potential in man. , 1975, Electroencephalography and clinical neurophysiology.

[5]  Michael Bach,et al.  The Necker cube—an ambiguous figure disambiguated in early visual processing , 2005, Vision Research.

[6]  Kathryn A. Moores,et al.  Investigating the generators of the scalp recorded visuo‐verbal P300 using cortically constrained source localization , 2003, Human brain mapping.

[7]  C. Rorden,et al.  Cognitive Control Mechanisms Revealed by ERP and fMRI: Evidence from Repeated Task-Switching , 2003, Journal of Cognitive Neuroscience.

[8]  C. Michel,et al.  Noninvasive Localization of Electromagnetic Epileptic Activity. I. Method Descriptions and Simulations , 2004, Brain Topography.

[9]  Tomoharu Kiyuna,et al.  Multiple Dipole Analysis of Visual Event-Related Potentials During Oddball Paradigm with Silent Counting , 2004, Brain Topography.

[10]  Michael Bach,et al.  Discontinuous presentation of ambiguous figures: how interstimulus-interval durations affect reversal dynamics and ERPs. , 2007, Psychophysiology.

[11]  Dennis M Levi,et al.  What limits performance in the amblyopic visual system: seeing signals in noise with an amblyopic brain. , 2008, Journal of vision.

[12]  R. van Ee,et al.  Early interactions between neuronal adaptation and voluntary control determine perceptual choices in bistable vision. , 2008, Journal of vision.

[13]  Jens Schwarzbach,et al.  Control of object-based attention in human cortex. , 2004, Cerebral cortex.

[14]  E. Halgren,et al.  Generators of the late cognitive potentials in auditory and visual oddball tasks. , 1998, Electroencephalography and clinical neurophysiology.

[15]  Michael A. Pitts,et al.  Electrophysiological correlates of perceptual reversals for three different types of multistable images. , 2007, Journal of vision.

[16]  E. Donchin,et al.  Spatiotemporal analysis of the late ERP responses to deviant stimuli. , 2001, Psychophysiology.

[17]  A. Kok.  On the utility of P3 amplitude as a measure of processing capacity. , 2001, Psychophysiology.

[18]  S. Yantis,et al.  Common neural substrates for the control and effects of visual attention and perceptual bistability. , 2005, Brain research. Cognitive brain research.

[19]  J. Ford,et al.  Combined event‐related fMRI and EEG evidence for temporal—parietal cortex activation during target detection , 1997, Neuroreport.

[20]  Laurie A. Miller,et al.  Perceptual flexibility after frontal or temporal lobectomy , 1994, Neuropsychologia.

[21]  Ahmet Ademoglu,et al.  Analysis of the electroencephalographic activity during the Necker cube reversals by means of the wavelet transform , 1998, Biological Cybernetics.

[22]  M. Torrens.  Co-Planar Stereotaxic Atlas of the Human Brain—3-Dimensional Proportional System: An Approach to Cerebral Imaging, J. Talairach, P. Tournoux. Georg Thieme Verlag, New York (1988), 122 pp., 130 figs. DM 268 , 1990 .

[23]  N. Squires,et al.  Visual evoked potentials to illusory reversals of the necker cube. , 1988, Psychophysiology.

[24]  R W Cox,et al.  AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. , 1996, Computers and biomedical research, an international journal.

[25]  Christoph M. Michel,et al.  Electrical neuroimaging based on biophysical constraints , 2004, NeuroImage.

[26]  Sabine Windmann,et al.  Role of the Prefrontal Cortex in Attentional Control over Bistable Vision , 2006 .

[27]  R T Knight,et al.  Anatomic bases of event-related potentials and their relationship to novelty detection in humans. , 1998, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[28]  S. Morand,et al.  Electric source imaging of human brain functions , 2001, Brain Research Reviews.

[29]  N. Logothetis,et al.  Multistable phenomena: changing views in perception , 1999, Trends in Cognitive Sciences.

[30]  E Başar,et al.  Multistable visual perception induces a slow positive EEG wave. , 1993, The International journal of neuroscience.

[31]  Theodor Landis,et al.  Right parietal brain activity precedes perceptual alternation of bistable stimuli. , 2009, Cerebral cortex.

[32]  E. Donchin,et al.  Is the P300 component a manifestation of context updating? , 1988, Behavioral and Brain Sciences.

[33]  T W Picton,et al.  Separation and identification of event-related potential components by brain electric source analysis. , 1991, Electroencephalography and clinical neurophysiology. Supplement.

[34]  R. S. J. Frackowiak,et al.  Human brain activity during spontaneously reversing perception of ambiguous figures , 1998, Proceedings of the Royal Society of London. Series B: Biological Sciences.

[35]  Thomas C. Toppino,et al.  Enduring interest in perceptual ambiguity: alternating views of reversible figures. , 2004, Psychological bulletin.

[36]  M. Scherg,et al.  Localizing P300 Generators in Visual Target and Distractor Processing: A Combined Event-Related Potential and Functional Magnetic Resonance Imaging Study , 2004, The Journal of Neuroscience.

[37]  C. Blundo,et al.  Perception of ambiguous figures after focal brain lesions , 1990, Neuropsychologia.

[38]  Toshio Inui,et al.  Neural substrates for depth perception of the Necker cube; a functional magnetic resonance imaging study in human subjects , 2000, Neuroscience Letters.

[39]  C. Rorden,et al.  Stereotaxic display of brain lesions. , 2000, Behavioural neurology.

[40]  C. Michel,et al.  Noninvasive Localization of Electromagnetic Epileptic Activity. II. Demonstration of Sublobar Accuracy in Patients with Simultaneous Surface and Depth Recordings , 2004, Brain Topography.

[41]  Michael Bach,et al.  Early neural activity in Necker-cube reversal: evidence for low-level processing of a gestalt phenomenon. , 2004, Psychophysiology.

[42]  M. Murray,et al.  EEG source imaging , 2004, Clinical Neurophysiology.

[43]  Michael A. Pitts,et al.  Early top-down influences on bistable perception revealed by event-related potentials , 2008, Brain and Cognition.