The causes of cancer revisited: "mitochondrial malignancy" and ROS-induced oncogenic transformation - why mitochondria are targets for cancer therapy.
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Emma Saavedra | R. Moreno-Sánchez | E. Saavedra | S. Rodríguez-Enríquez | J. Neuzil | S. Ralph | Rafael Moreno-Sánchez | Stephen J Ralph | Jiri Neuzil | Sara Rodríguez-Enríquez
[1] M. Fernö,et al. c‐myc amplification is an independent prognostic factor in postmenopausal breast cancer , 1992, International journal of cancer.
[2] R. G. Allen,et al. Effects of oxygen on the antioxidant responses of normal and transformed cells. , 2003, Experimental cell research.
[3] Alexander V. Zhdanov,et al. PGC-1α is coupled to HIF-1α-dependent gene expression by increasing mitochondrial oxygen consumption in skeletal muscle cells , 2009, Proceedings of the National Academy of Sciences.
[4] U. Moll,et al. p53 and Nur77/TR3 – transcription factors that directly target mitochondria for cell death induction , 2006, Oncogene.
[5] K. Smolková,et al. Distinctions and similarities of cell bioenergetics and the role of mitochondria in hypoxia, cancer, and embryonic development. , 2010, The international journal of biochemistry & cell biology.
[6] C. Hoppel,et al. Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria. , 2008, American journal of physiology. Cell physiology.
[7] B. Spiegelman,et al. Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. , 2006, Endocrine reviews.
[8] B. Viollet,et al. Hypoxic activation of AMPK is dependent on mitochondrial ROS but independent of an increase in AMP/ATP ratio. , 2009, Free radical biology & medicine.
[9] Fionnuala Morrish,et al. c-MYC apoptotic function is mediated by NRF-1 target genes. , 2003, Genes & development.
[10] P. Puigserver,et al. Metabolic adaptations through the PGC‐1α and SIRT1 pathways , 2008 .
[11] K. Eckardt,et al. HIF-1 or HIF-2 induction is sufficient to achieve cell cycle arrest in NIH3T3 mouse fibroblasts independent from hypoxia , 2009, Cell cycle.
[12] P. Meltzer,et al. Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[13] C. Stournaras,et al. Colorectal carcinoma cells--regulation of survival and growth by SGK1. , 2010, The international journal of biochemistry & cell biology.
[14] U. Dirnagl,et al. Mitochondrial free radical production induced by glucose deprivation in cerebellar granule neurons , 2008 .
[15] Xiu-fang Wang,et al. Molecular mechanism of ‘mitocan’‐induced apoptosis in cancer cells epitomizes the multiple roles of reactive oxygen species and Bcl‐2 family proteins , 2006, FEBS letters.
[16] James E. Klaunig,et al. Oxidative Stress and Oxidative Damage in Carcinogenesis , 2010, Toxicologic pathology.
[17] D. Wolters,et al. Activation of the lifespan regulator p66Shc through reversible disulfide bond formation , 2008, Proceedings of the National Academy of Sciences.
[18] E. Giannoni,et al. Redox-based escape mechanism from death: the cancer lesson. , 2009, Antioxidants & redox signaling.
[19] L. Huang,et al. HIF‐1α induces cell cycle arrest by functionally counteracting Myc , 2004 .
[20] S. Rhee. Cell signaling. H2O2, a necessary evil for cell signaling. , 2006, Science.
[21] M. Ott,et al. The ups and downs of SIRT1. , 2008, Trends in biochemical sciences.
[22] J. Tillement,et al. Effects of resveratrol on the rat brain respiratory chain. , 1999, Drugs under experimental and clinical research.
[23] Robin A. J. Smith,et al. Selective Targeting of a Redox-active Ubiquinone to Mitochondria within Cells , 2001, The Journal of Biological Chemistry.
[24] V. Sartorelli,et al. Comparing and contrasting the roles of AMPK and SIRT1 in metabolic tissues , 2008, Cell cycle.
[25] C. Holterman,et al. Human cancers converge at the HIF-2α oncogenic axis , 2009, Proceedings of the National Academy of Sciences.
[26] N. Chandel,et al. Mitochondrial complex III regulates hypoxic activation of HIF , 2008, Cell Death and Differentiation.
[27] D. Spitz,et al. Mitochondrial electron transport chain blockers enhance 2-deoxy-D-glucose induced oxidative stress and cell killing in human colon carcinoma cells , 2009, Cancer biology & therapy.
[28] L. Ghibelli,et al. Oxidative Bax dimerization promotes its translocation to mitochondria independently of apoptosis , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[29] P. Pelicci,et al. The Life Span Determinant p66Shc Localizes to Mitochondria Where It Associates with Mitochondrial Heat Shock Protein 70 and Regulates Trans-membrane Potential* , 2004, Journal of Biological Chemistry.
[30] D. Fan,et al. Expression of delayed rectifier potassium channels and their possible roles in proliferation of human gastric cancer cells , 2005, Cancer biology & therapy.
[31] Yau-Huei Wei,et al. Somatic mutations in the D-loop and decrease in the copy number of mitochondrial DNA in human hepatocellular carcinoma. , 2004, Mutation research.
[32] M. Matthay,et al. Prolonged Hypoxia Differentially Regulates Hypoxia-inducible Factor (HIF)-1α and HIF-2α Expression in Lung Epithelial Cells , 2004, Journal of Biological Chemistry.
[33] B. Liu,et al. ROS and p53: a versatile partnership. , 2008, Free radical biology & medicine.
[34] Yan Zhao,et al. Vitamin E analogues as anticancer agents: lessons from studies with alpha-tocopheryl succinate. , 2006, Molecular nutrition & food research.
[35] Tsung-Cheng Chang,et al. c-Myc suppression of miR-23 enhances mitochondrial glutaminase and glutamine metabolism , 2009, Nature.
[36] K. Kinzler,et al. Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells , 2009, Science.
[37] Jinsong Liu,et al. Intrinsic oxidative stress in cancer cells: a biochemical basis for therapeutic selectivity , 2004, Cancer Chemotherapy and Pharmacology.
[38] D. Leibfritz,et al. Free radicals and antioxidants in normal physiological functions and human disease. , 2007, The international journal of biochemistry & cell biology.
[39] N. Neretti,et al. The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry , 2008, Cell cycle.
[40] J. Neuzil,et al. Mitocans: mitochondrial targeted anti-cancer drugs as improved therapies and related patent documents. , 2006, Recent patents on anti-cancer drug discovery.
[41] R. Moreno-Sánchez,et al. Bioenergetic pathways in tumor mitochondria as targets for cancer therapy and the importance of the ROS-induced apoptotic trigger. , 2010, Molecular aspects of medicine.
[42] A. Chatterjee,et al. Mitochondrial DNA mutations in human cancer , 2006, Oncogene.
[43] T. Noda,et al. ARF Tumor Suppressor Induces Mitochondria-dependent Apoptosis by Modulation of Mitochondrial Bcl-2 Family Proteins* , 2003, Journal of Biological Chemistry.
[44] S. Naylor,et al. A heteroplasmic, not homoplasmic, mitochondrial DNA mutation promotes tumorigenesis via alteration in reactive oxygen species generation and apoptosis. , 2009, Human molecular genetics.
[45] K. Fukuzawa,et al. Superoxide is responsible for apoptosis in rat vascular smooth muscle cells induced by alpha-tocopheryl hemisuccinate. , 2001, Biochimica et biophysica acta.
[46] R. Chen,et al. Regulation of Hypoxia-Inducible Factor 2α Signaling by the Stress-Responsive Deacetylase Sirtuin 1 , 2009, Science.
[47] S. Wölfl,et al. Expression of voltage-gated potassium channels Kv1.3 and Kv1.5 in human gliomas , 2003, Neuroscience Letters.
[48] A. Hubbard,et al. Increase in mitochondrial biogenesis, oxidative stress, and glycolysis in murine lymphomas. , 2009, Free radical biology & medicine.
[49] B. Dörken,et al. Bak functionally complements for loss of Bax during p14ARF-induced mitochondrial apoptosis in human cancer cells , 2006, Oncogene.
[50] D. Golde,et al. Vitamin C enters mitochondria via facilitative glucose transporter 1 (Gluti) and confers mitochondrial protection against oxidative injury , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[51] B. Dörken,et al. Adenovirus-mediated overexpression of p14ARF induces p53 and Bax-independent apoptosis , 2002, Oncogene.
[52] T. Kawamoto,et al. Human mismatch repair gene, MLH1, is transcriptionally repressed by the hypoxia-inducible transcription factors, DEC1 and DEC2 , 2008, Oncogene.
[53] U. Moll,et al. p53's mitochondrial translocation and MOMP action is independent of Puma and Bax and severely disrupts mitochondrial membrane integrity , 2008, Cell Research.
[54] Xiu-fang Wang,et al. Vitamin E analogs trigger apoptosis in HER2/erbB2-overexpressing breast cancer cells by signaling via the mitochondrial pathway. , 2005, Biochemical and biophysical research communications.
[55] R. Moreno-Sánchez,et al. Suppression of Tumor Growth In vivo by the Mitocan α-tocopheryl Succinate Requires Respiratory Complex II , 2009, Clinical Cancer Research.
[56] D. Bostwick,et al. Detection of c-myc oncogene amplification and chromosomal anomalies in metastatic prostatic carcinoma by fluorescence in situ hybridization. , 1997, Cancer research.
[57] H. Schramek,et al. Replicative senescence of human fibroblasts: the role of Ras-dependent signaling and oxidative stress , 2002, Experimental Gerontology.
[58] N. Colburn,et al. p53 translocation to mitochondria precedes its nuclear translocation and targets mitochondrial oxidative defense protein-manganese superoxide dismutase. , 2005, Cancer research.
[59] T. Tong,et al. Irreversible cellular senescence induced by prolonged exposure to H2O2 involves DNA-damage-and-repair genes and telomere shortening. , 2005, The international journal of biochemistry & cell biology.
[60] J. Fish,et al. Discovery of a Major D-Loop Replication Origin Reveals Two Modes of Human mtDNA Synthesis , 2004, Science.
[61] Emelyn H. Shroff,et al. Hyperoxia‐induced premature senescence requires p53 and pRb, but not mitochondrial matrix ROS , 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[62] J. Chávez,et al. Mitochondria and Hypoxia‐induced Gene Expression Mediated by Hypoxia‐inducible Factors , 2008, Annals of the New York Academy of Sciences.
[63] S. Minucci,et al. A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis , 2002, Oncogene.
[64] C. Thompson,et al. HIF and c-Myc: sibling rivals for control of cancer cell metabolism and proliferation. , 2007, Cancer cell.
[65] Qin M. Chen,et al. Replicative Senescence and Oxidant‐Induced Premature Senescence: Beyond the Control of Cell Cycle Checkpoints , 2000, Annals of the New York Academy of Sciences.
[66] E. Condom,et al. Voltage-dependent potassium channels Kv1.3 and Kv1.5 in human cancer. , 2009 .
[67] K. Liu,et al. Effects of glucose concentration on redox status in rat primary cortical neurons under hypoxia , 2006, Neuroscience Letters.
[68] R. Balaban,et al. The Mammalian Longevity-associated Gene Product p66shc Regulates Mitochondrial Metabolism* , 2006, Journal of Biological Chemistry.
[69] B. Mignotte,et al. Mitochondrial localization of the low level p53 protein in proliferative cells. , 2009, Biochemical and biophysical research communications.
[70] A. Diokno,et al. A 12 Week, Open Label, Phase I/IIa Study Using Apatone® for the Treatment of Prostate Cancer Patients Who Have Failed Standard Therapy , 2008, International journal of medical sciences.
[71] M. Valko,et al. Free radicals, metals and antioxidants in oxidative stress-induced cancer. , 2006, Chemico-biological interactions.
[72] M. García-Díaz,et al. Mitochondrial transcription , 2011, Transcription.
[73] C. Klein,et al. BclxL Changes Conformation upon Binding to Wild-type but Not Mutant p53 DNA Binding Domain* , 2009, The Journal of Biological Chemistry.
[74] D. Gutterman,et al. Oxidative Stress And Potassium Channel Function , 2002, Clinical and experimental pharmacology & physiology.
[75] E. Gilson,et al. Senescence-associated oxidative DNA damage promotes the generation of neoplastic cells. , 2009, Cancer research.
[76] Pier Giuseppe Pelicci,et al. Mitochondrial DNA copy number is regulated by cellular proliferation: a role for Ras and p66(Shc). , 2006, Biochimica et biophysica acta.
[77] J. Maris,et al. Treatment of mitochondrial myopathy due to complex III deficiency with vitamins K3 and C: A 31P‐NMR follow‐up study , 1986, Annals of neurology.
[78] S. Minucci,et al. Protein Kinase C ß and Prolyl Isomerase 1 Regulate Mitochondrial Effects of the Life-Span Determinant p66Shc , 2007, Science.
[79] Yan Zhao,et al. Vitamin E analogues as anticancer agents: Lessons from studies with α‐tocopheryl succinate , 2006 .
[80] S. Rhee,et al. H2O2, a Necessary Evil for Cell Signaling , 2006, Science.
[81] A. Leslie,et al. Mechanism of inhibition of bovine F1-ATPase by resveratrol and related polyphenols , 2007, Proceedings of the National Academy of Sciences.
[82] V. Mootha,et al. Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1 , 1999, Cell.
[83] G. Pani,et al. The p53-p66shc-Manganese Superoxide Dismutase (MnSOD) network: a mitochondrial intrigue to generate reactive oxygen species. , 2009, The international journal of biochemistry & cell biology.
[84] Yau-Huei Wei,et al. Mitochondrial DNA Instability and Metabolic Shift in Human Cancers , 2009, International journal of molecular sciences.
[85] H. Jacobs,et al. Alterations to the expression level of mitochondrial transcription factor A, TFAM, modify the mode of mitochondrial DNA replication in cultured human cells , 2006, Nucleic acids research.
[86] S. Lowe,et al. Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a , 1997, Cell.
[87] Pier Paolo Pandolfi,et al. The p66shc adaptor protein controls oxidative stress response and life span in mammals , 1999, Nature.
[88] G. Filomeni,et al. trans-Resveratrol induces apoptosis in human breast cancer cells MCF-7 by the activation of MAP kinases pathways , 2007, Genes & Nutrition.
[89] Yidong Bai,et al. Implications of mitochondrial DNA mutations and mitochondrial dysfunction in tumorigenesis , 2009, Cell Research.
[90] R. Gutala,et al. Quinone oxidoreductases and vitamin K metabolism. , 2008, Vitamins and hormones.
[91] E. Zalckvar,et al. A short mitochondrial form of p19ARF induces autophagy and caspase-independent cell death. , 2006, Molecular cell.
[92] R. Bryan,et al. H2O2 activates redox- and 4-aminopyridine-sensitive Kv channels in coronary vascular smooth muscle. , 2007, American journal of physiology. Heart and circulatory physiology.
[93] D. S. St. Clair,et al. Suppression of fibrosarcoma metastasis by elevated expression of manganese superoxide dismutase. , 1994, Cancer research.
[94] N. Hamasaki,et al. Mitochondrial transcription factor A (TFAM): roles in maintenance of mtDNA and cellular functions. , 2007, Mitochondrion.
[95] J. Stamler,et al. Redox-based regulation of signal transduction: principles, pitfalls, and promises. , 2008, Free radical biology & medicine.
[96] Lewis A. Chodosh,et al. Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis , 2007, Nature Cell Biology.
[97] P. Witting,et al. α-Tocopheryl Succinate Inhibits Malignant Mesothelioma by Disrupting the Fibroblast Growth Factor Autocrine Loop , 2005, Journal of Biological Chemistry.
[98] Takeshi Akiyoshi,et al. The potential of vitamin K3 as an anticancer agent against breast cancer that acts via the mitochondria-related apoptotic pathway , 2009, Cancer Chemotherapy and Pharmacology.
[99] M. Barbacid,et al. Tumour biology: Senescence in premalignant tumours , 2005, Nature.
[100] U. Moll,et al. The mitochondrial p53 pathway. , 2009, Biochimica et biophysica acta.
[101] F. Sesti,et al. Oxidation of potassium channels by ROS: a general mechanism of aging and neurodegeneration? , 2010, Trends in cell biology.
[102] P. Daleau,et al. Hydrogen peroxide modulates the Kv1.5 channel expressed in a mammalian cell line , 2003, Naunyn-Schmiedeberg's Archives of Pharmacology.
[103] J. Hancock. The Role of Redox Mechanisms in Cell Signalling , 2009, Molecular biotechnology.
[104] B. Spiegelman. Transcriptional control of mitochondrial energy metabolism through the PGC1 coactivators. , 2007, Novartis Foundation symposium.
[105] K. Fukuzawa,et al. High cytotoxicity of alpha-tocopheryl hemisuccinate to cancer cells is due to failure of their antioxidative defense systems. , 2002, Cancer letters.
[106] L. Andĕra,et al. α‐Tocopheryl succinate induces DR4 and DR5 expression by a p53‐dependent route: Implication for sensitisation of resistant cancer cells to TRAIL apoptosis , 2006, FEBS letters.
[107] Anthony Mancuso,et al. Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction , 2008, Proceedings of the National Academy of Sciences.
[108] Xiu-fang Wang,et al. Vitamin E analogues as a novel group of mitocans: anti-cancer agents that act by targeting mitochondria. , 2007, Molecular aspects of medicine.
[109] L. Penn,et al. Reflecting on 25 years with MYC , 2008, Nature Reviews Cancer.
[110] G. Shadel,et al. Loss of p53 causes mitochondrial DNA depletion and altered mitochondrial reactive oxygen species homeostasis. , 2009, Biochimica et biophysica acta.
[111] J. Ku,et al. Role of reactive oxygen species in the induction of apoptosis by α‐tocopheryl succinate , 2004, International journal of cancer.
[112] L. Oberley,et al. Increased levels of superoxide and H2O2 mediate the differential susceptibility of cancer cells versus normal cells to glucose deprivation. , 2009, The Biochemical journal.
[113] P. Ottino,et al. Effect of alpha-tocopherol succinate on free radical and lipid peroxidation levels in BL6 melanoma cells. , 1997, Free radical biology & medicine.
[114] A. Nègre-Salvayre,et al. Mitochondria play a central role in apoptosis induced by alpha-tocopheryl succinate, an agent with antineoplastic activity: comparison with receptor-mediated pro-apoptotic signaling. , 2003, Biochemistry.
[115] P. Lacy. Pancreatic Beta Cell , 2008 .
[116] J. Dolly,et al. Predominant expression of Kv1.3 voltage-gated K+ channel subunit in rat prostate cancer cell lines: electrophysiological, pharmacological and molecular characterisation , 2003, Pflügers Archiv.
[117] Anastasia Kralli,et al. Transcriptional control of mitochondrial biogenesis and function. , 2009, Annual review of physiology.
[118] J. Neuzil,et al. Mitocans, a class of emerging anti-cancer drugs. , 2009, Molecular nutrition & food research.
[119] Peng Huang,et al. Superoxide dismutase as a target for the selective killing of cancer cells , 2000, Nature.
[120] E. Morselli,et al. Targeting p53 to mitochondria for cancer therapy , 2008, Cell cycle.
[121] P. Petit,et al. Cysteine 62 of Bax Is Critical for Its Conformational Activation and Its Proapoptotic Activity in Response to H2O2-induced Apoptosis* , 2008, Journal of Biological Chemistry.
[122] I. Todorov,et al. Multifactorial nature of high frequency of mitochondrial DNA mutations in somatic mammalian cells , 2009, Biochemistry (Moscow).
[123] M. Matthay,et al. Prolonged hypoxia differentially regulates hypoxia-inducible factor (HIF)-1alpha and HIF-2alpha expression in lung epithelial cells: implication of natural antisense HIF-1alpha. , 2004, The Journal of biological chemistry.
[124] A. Marchetti,et al. MDM4 (MDMX) localizes at the mitochondria and facilitates the p53‐mediated intrinsic‐apoptotic pathway , 2009, The EMBO journal.
[125] W. Plunkett,et al. Inhibition of Mitochondrial Respiration , 2003, Journal of Biological Chemistry.
[126] Shu-Chen Lu,et al. Resveratrol is Not a Direct Activator of SIRT1 Enzyme Activity , 2009, Chemical biology & drug design.
[127] Horst Kessler,et al. WT p53, but Not Tumor-derived Mutants, Bind to Bcl2 via the DNA Binding Domain and Induce Mitochondrial Permeabilization* , 2006, Journal of Biological Chemistry.
[128] S. Lowe,et al. Oncogenic ras and p53 Cooperate To Induce Cellular Senescence , 2002, Molecular and Cellular Biology.
[129] William C Hahn,et al. Rules for making human tumor cells. , 2002, The New England journal of medicine.
[130] S. Orrenius,et al. Menadione (2-methyl-1,4-naphthoquinone)-induced Ca2+ release from rat-liver mitochondria is caused by NAD(P)H oxidation. , 1986, Xenobiotica; the fate of foreign compounds in biological systems.
[131] U. Dirnagl,et al. Mitochondrial free radical production induced by glucose deprivation in cerebellar granule neurons , 2008, Biochemistry (Moscow).
[132] J. Milbrandt,et al. Resveratrol stimulates AMP kinase activity in neurons , 2007, Proceedings of the National Academy of Sciences.
[133] G. Haddad,et al. Hypoxia increases BK channel activity in the inner mitochondrial membrane. , 2007, Biochemical and biophysical research communications.
[134] Kjell Hultenby,et al. Mitochondrial transcription factor A regulates mtDNA copy number in mammals. , 2004, Human molecular genetics.
[135] C. Day,et al. Bak activation for apoptosis involves oligomerization of dimers via their alpha6 helices. , 2009, Molecular cell.
[136] G. Ferbeyre,et al. Mitochondrial Dysfunction Contributes to Oncogene-Induced Senescence , 2009, Molecular and Cellular Biology.
[137] A. Cheong,et al. K(v)1.5 potassium channel gene regulation by Sp1 transcription factor and oxidative stress. , 2007, American journal of physiology. Heart and circulatory physiology.
[138] R. Wiesner,et al. Transient overexpression of mitochondrial transcription factor A (TFAM) is sufficient to stimulate mitochondrial DNA transcription, but not sufficient to increase mtDNA copy number in cultured cells. , 2004, Nucleic acids research.
[139] Jennifer E. Van Eyk,et al. c-Myc suppression of miR-23 enhances mitochondrial glutaminase and glutamine metabolism , 2009, Nature.
[140] Keshav K. Singh,et al. p53 regulates mtDNA copy number and mitocheckpoint pathway , 2009, Journal of carcinogenesis.
[141] P. Schumacker,et al. Oxygen sensing by mitochondria at complex III: the paradox of increased reactive oxygen species during hypoxia , 2006, Experimental physiology.
[142] R. Bryan,et al. H 2 O 2 activates redox-and 4-aminopyridine-sensitive Kv channels in coronary vascular smooth muscle , 2007 .
[143] Johan Auwerx,et al. PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure , 2009, Current opinion in lipidology.
[144] L. Andĕra,et al. Coenzyme Q blocks biochemical but not receptor‐mediated apoptosis by increasing mitochondrial antioxidant protection , 2001, FEBS letters.
[145] K. Vousden,et al. Savior and slayer: the two faces of p53 , 2005, Nature Medicine.
[146] Y. Rojanasakul,et al. Protection against oxidative injury and permeability alteration in cultured alveolar epithelium by transferrin-catalase conjugate. , 1996, Biochimica et biophysica acta.
[147] P. Chumakov,et al. Homeostatic functions of the p53 tumor suppressor: regulation of energy metabolism and antioxidant defense. , 2009, Seminars in cancer biology.
[148] J. Christodoulou,et al. Respiratory chain complex III deficiency with pruritus: A novel vitamin responsive clinical feature , 1999 .
[149] Sébastien Bonnet,et al. A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. , 2007, Cancer cell.
[150] L. D. Luk’yanova,et al. Antihypoxic effects of some quinones associated with restoration of the electron transport function of the respiratory chain of the isolated rat heart , 1990, Bulletin of Experimental Biology and Medicine.
[151] D. Levy,et al. Mitochondrial STAT3 Supports Ras-Dependent Oncogenic Transformation , 2009, Science.
[152] D. Pipeleers,et al. Glucose Suppresses Superoxide Generation in Metabolically Responsive Pancreatic β Cells* , 2005, Journal of Biological Chemistry.
[153] F. Krempler,et al. Role of Peroxisome Proliferator-Activated Receptor-γ Coactivator-1α in the Transcriptional Regulation of the Human Uncoupling Protein 2 Gene in INS-1E Cells , 2006 .
[154] S. Shirasawa,et al. Ischemia-Induced Kras Mutations in Human Colorectal Cancer Cells : Role of Microenvironmental Regulation of MSH 2 Expression , 2005 .
[155] P. Witting,et al. α‐Tocopheryl succinate selectively induces apoptosis in neuroblastoma cells: potential therapy of malignancies of the nervous system? , 2005, Journal of neurochemistry.
[156] Yidong Bai,et al. Number matters: control of mammalian mitochondrial DNA copy number. , 2009, Journal of genetics and genomics = Yi chuan xue bao.
[157] F. Krempler,et al. Role of peroxisome proliferator-activated receptor-gamma coactivator-1alpha in the transcriptional regulation of the human uncoupling protein 2 gene in INS-1E cells. , 2006, Endocrinology.
[158] J. López-Barneo,et al. Regulation of oxygen sensing by ion channels. , 2004, Journal of applied physiology.
[159] S. Miura,et al. Mechanism for Peroxisome Proliferator-activated Receptor-α Activator-induced Up-regulation of UCP2 mRNA in Rodent Hepatocytes* , 2002, The Journal of Biological Chemistry.
[160] D. Golde,et al. Antioxidants prevent oxidative DNA damage and cellular transformation elicited by the over-expression of c-MYC. , 2006, Mutation research.
[161] R. Moreno-Sánchez,et al. HIF-1alpha modulates energy metabolism in cancer cells by inducing over-expression of specific glycolytic isoforms. , 2009, Mini reviews in medicinal chemistry.
[162] J. Doroshow,et al. Phase I trial of menadiol diphosphate (vitamin K3) in advanced malignancy , 2005, Investigational New Drugs.
[163] A. Cheong,et al. Kv1.5 potassium channel gene regulation by Sp1 transcription factor and oxidative stress , 2007 .
[164] J. Marine,et al. Mdm2-mediated ubiquitylation: p53 and beyond , 2010, Cell Death and Differentiation.
[165] M. Bakhanashvili,et al. p53 in mitochondria enhances the accuracy of DNA synthesis , 2008, Cell Death and Differentiation.
[166] A. Fersht,et al. Biophysical characterizations of human mitochondrial transcription factor A and its binding to tumor suppressor p53 , 2009, Nucleic acids research.
[167] F. Domann,et al. α-Tocopheryl succinate induces apoptosis by targeting ubiquinone-binding sites in mitochondrial respiratory complex II , 2008, Oncogene.
[168] Richard Weindruch,et al. Dynamic regulation of PGC-1α localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response , 2008, Aging cell.
[169] P. Yaswen,et al. Oncogene-Induced Senescence Pathways Weave an Intricate Tapestry , 2007, Cell.
[170] D. Trinh,et al. Tid1 is a new regulator of p53 mitochondrial translocation and apoptosis in cancer , 2010, Oncogene.
[171] A. Somlyo,et al. VASCULAR SMOOTH MUSCLE , 1968 .
[172] S. Cortassa,et al. Mitochondrial ion channels: gatekeepers of life and death. , 2005, Physiology.
[173] Stuart Gillies,et al. Menadione-induced Reactive Oxygen Species Generation via Redox Cycling Promotes Apoptosis of Murine Pancreatic Acinar Cells* , 2006, Journal of Biological Chemistry.
[174] Chi V. Dang,et al. The c-Myc target gene PRDX3 is required for mitochondrial homeostasis and neoplastic transformation , 2002, Proceedings of the National Academy of Sciences of the United States of America.
[175] H. C. Lee,et al. Increase of mitochondria and mitochondrial DNA in response to oxidative stress in human cells. , 2000, The Biochemical journal.
[176] G. Haddad,et al. Hypoxia Increases Activity of the BK-Channel in the Inner Mitochondrial Membrane and Reduces Activity of the Permeability Transition Pore , 2008, Cellular Physiology and Biochemistry.
[177] E. Bernhard,et al. Decreased ability of cells overexpressing MYC proteins to reduce peroxide and hydroperoxides. , 1996, The British journal of cancer. Supplement.
[178] R. O. Poyton,et al. Mitochondrial generation of free radicals and hypoxic signaling , 2009, Trends in Endocrinology & Metabolism.
[179] D. Hood,et al. Interactions between ROS and AMP kinase activity in the regulation of PGC-1alpha transcription in skeletal muscle cells. , 2009, American journal of physiology. Cell physiology.
[180] C. Dang,et al. Could MYC Induction of Mitochondrial Biogenesis be linked to ROS Production and Genomic Instability? , 2005, Cell cycle.
[181] J. Christodoulou,et al. Respiratory chain complex III [correction of complex] in deficiency with pruritus: a novel vitamin responsive clinical feature. , 1999, The Journal of pediatrics.
[182] F. Meyskens,et al. UC Irvine UC Irvine Previously Published Works Title Reactive oxygen species : a breath of life or death ? , 2007 .
[183] M. Maitland,et al. Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1alpha-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer. , 2008, American journal of physiology. Heart and circulatory physiology.
[184] F. Villarroya,et al. PPARd, but not PPARa, activates PGC-1a gene transcription in muscle , 2007 .
[185] Lilia Alberghina,et al. Expression of transforming K-Ras oncogene affects mitochondrial function and morphology in mouse fibroblasts. , 2006, Biochimica et biophysica acta.
[186] G. Semenza,et al. Regulation of cancer cell metabolism by hypoxia-inducible factor 1. , 2009, Seminars in cancer biology.
[187] M. Murphy,et al. ARF Induces Autophagy by Virtue of Interaction with Bcl-xl* , 2009, Journal of Biological Chemistry.
[188] K. Sugimura,et al. DNA polymerase γ inhibition by vitamin K3 induces mitochondria‐mediated cytotoxicity in human cancer cells , 2008, Cancer science.
[189] S. Sugano,et al. Novel dimerization mode of the human Bcl-2 family protein Bak, a mitochondrial apoptosis regulator. , 2009, Journal of structural biology.
[190] U. Moll,et al. The mitochondrial p 53 pathway , 2009 .
[191] M. López-Lázaro. Excessive superoxide anion generation plays a key role in carcinogenesis , 2007, International journal of cancer.
[192] Emanuel F Petricoin,et al. Mitochondrial proteome: Altered cytochrome c oxidase subunit levels in prostate cancer , 2003, Proteomics.
[193] D. Bostwick,et al. Loss of p53 and c-myc Overrepresentation in Stage T2-3N1-3M0 Prostate Cancer are Potential Markers for Cancer Progression , 2002, Modern Pathology.
[194] P. Chumakov,et al. The antioxidant function of the p53 tumor suppressor , 2005, Nature Medicine.
[195] Kathryn A. O’Donnell,et al. Myc Stimulates Nuclearly Encoded Mitochondrial Genes and Mitochondrial Biogenesis , 2005, Molecular and Cellular Biology.
[196] P. Puigserver,et al. Metabolic adaptations through the PGC-1 alpha and SIRT1 pathways. , 2008, FEBS letters.
[197] T. Slater. Studies on the succinate-neotetrazolium reductase system. Activation by vitamin K3. , 1959, The Biochemical journal.
[198] J. Hallinan,et al. Cellular senescence: unravelling complexity , 2009, AGE.
[199] S. Minucci,et al. Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis , 2005, Cell.
[200] P. Witting,et al. Alpha-tocopheryl succinate inhibits malignant mesothelioma by disrupting the fibroblast growth factor autocrine loop: mechanism and the role of oxidative stress. , 2005, The Journal of biological chemistry.
[201] Diana Anderson,et al. Hypoxia and defective apoptosis drive genomic instability and tumorigenesis. , 2004, Genes & development.
[202] J. di Rago,et al. Electron‐transfer restoration by vitamin K3 in a complex III‐deficient mutant of S. cerevisiae and sequence of the corresponding cytochrome b mutation , 1989, FEBS letters.
[203] F. Villarroya,et al. PPARdelta, but not PPARalpha, activates PGC-1alpha gene transcription in muscle. , 2007, Biochemical and biophysical research communications.
[204] M. López-Lázaro,et al. Dual role of hydrogen peroxide in cancer: possible relevance to cancer chemoprevention and therapy. , 2007, Cancer letters.
[205] A. Asai,et al. Adenovirus-mediated overexpression of Fas induces apoptosis of gliomas , 2000, Cancer Gene Therapy.
[206] T. Osawa,et al. Antioxidative Defense Systems Generated by Phenolic Plant Constituents , 1992 .
[207] Pawan Gupta,et al. Concomitant presence of mutations in mitochondrial genome and p53 in cancer development—A study in north Indian sporadic breast and esophageal cancer patients , 2008, International journal of cancer.
[208] P. Puigserver,et al. Resveratrol Improves Mitochondrial Function and Protects against Metabolic Disease by Activating SIRT1 and PGC-1α , 2006, Cell.
[209] P. Pinton,et al. p66Shc, oxidative stress and aging: Importing a lifespan determinant into mitochondria , 2008, Cell cycle.
[210] C. Abbadie,et al. Acquisition of Oxidative DNA Damage during Senescence , 2007, Annals of the New York Academy of Sciences.
[211] B. Salvatore,et al. Vitamin E analogues: a new class of inducers of apoptosis with selective anti-cancer effects. , 2004, Current cancer drug targets.
[212] K. Liu,et al. Cerebral tissue oxygenation and oxidative brain injury during ischemia and reperfusion. , 2007, Frontiers in bioscience : a journal and virtual library.
[213] B. Dörken,et al. Loss of p21 disrupts p14ARF-induced G1 cell cycle arrest but augments p14ARF-induced apoptosis in human carcinoma cells , 2005, Oncogene.
[214] B. Mignotte,et al. Evidence for a mitochondrial localization of the retinoblastoma protein , 2009, BMC Cell Biology.
[215] H. Daniel,et al. Resveratrol induces apoptosis through ROS-dependent mitochondria pathway in HT-29 human colorectal carcinoma cells. , 2008, Journal of agricultural and food chemistry.
[216] M. Murphy,et al. Mitochondria--a neglected drug target. , 2009, Current opinion in investigational drugs.
[217] Lee-Jun C Wong,et al. Comprehensive scanning of somatic mitochondrial DNA mutations in breast cancer. , 2002, Cancer research.
[218] So Yeong Lee,et al. Kv1.3 voltage-gated K(+) channel subunit as a potential diagnostic marker and therapeutic target for breast cancer. , 2009, BMB reports.
[219] D. Wallace,et al. Ancient mtDNA Genetic Variants Modulate mtDNA Transcription and Replication , 2009, PLoS genetics.
[220] S. Shirasawa,et al. Ischemia-induced K-ras mutations in human colorectal cancer cells: role of microenvironmental regulation of MSH2 expression. , 2005, Cancer research.
[221] J. Klaunig,et al. The role of oxidative stress in carcinogenesis. , 2004, Annual review of pharmacology and toxicology.