Selective inhibition of HDAC8 decreases neuroblastoma growth in vitro and in vivo and enhances retinoic acid-mediated differentiation

[1]  Ted Natoli,et al.  An Unbiased Approach To Identify Endogenous Substrates of “Histone” Deacetylase 8 , 2014, ACS chemical biology.

[2]  F. Westermann,et al.  GRHL1 acts as tumor suppressor in neuroblastoma and is negatively regulated by MYCN and HDAC3. , 2014, Cancer research.

[3]  M. Kool,et al.  Histone deacetylase 10 promotes autophagy-mediated cell survival , 2013, Proceedings of the National Academy of Sciences.

[4]  K. Nishio,et al.  SOX4 is a direct target gene of FRA-2 and induces expression of HDAC8 in adult T-cell leukemia/lymphoma. , 2013, Blood.

[5]  F. Westermann,et al.  MYCN and HDAC2 cooperate to repress miR-183 signaling in neuroblastoma , 2013, Nucleic acids research.

[6]  Steven J. M. Jones,et al.  The genetic landscape of high-risk neuroblastoma , 2013, Nature Genetics.

[7]  Gabriele Gillessen-Kaesbach,et al.  HDAC8 mutations in Cornelia de Lange Syndrome affect the cohesin acetylation cycle , 2012, Nature.

[8]  Rani E. George,et al.  Promising Therapeutic Targets in Neuroblastoma , 2012, Clinical Cancer Research.

[9]  D. Gisselsson,et al.  Copy number defects of G1‐Cell cycle genes in neuroblastoma are frequent and correlate with high expression of E2F target genes and a poor prognosis , 2012, Genes, chromosomes & cancer.

[10]  H. Arai.  [Sympathetic nervous system]. , 2011, Nihon rinsho. Japanese journal of clinical medicine.

[11]  P. Northcott,et al.  HDAC5 and HDAC9 in Medulloblastoma: Novel Markers for Risk Stratification and Role in Tumor Cell Growth , 2010, Clinical Cancer Research.

[12]  V. Lefebvre,et al.  Sequential requirement of Sox4 and Sox11 during development of the sympathetic nervous system , 2010, Development.

[13]  James E. Bradner,et al.  Chemical Phylogenetics of Histone Deacetylases , 2010, Nature chemical biology.

[14]  M. Mann,et al.  Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions , 2009, Science.

[15]  J. Buggy,et al.  Isoform-specific histone deacetylase inhibitors: the next step? , 2009, Cancer letters.

[16]  F. Speleman,et al.  The emerging molecular pathogenesis of neuroblastoma: implications for improved risk assessment and targeted therapy , 2009, Genome Medicine.

[17]  E. Olson,et al.  Epigenetic control of skull morphogenesis by histone deacetylase 8. , 2009, Genes & development.

[18]  O. Witt,et al.  HDAC family: What are the cancer relevant targets? , 2009, Cancer letters.

[19]  O. Witt,et al.  Targeting histone deacetylases in neuroblastoma. , 2009, Current pharmaceutical design.

[20]  H. Xia,et al.  Inactivation of CREB mediated gene transcription by HDAC8 bound protein phosphatase. , 2009, Biochemical and biophysical research communications.

[21]  Barbara Hero,et al.  Histone Deacetylase 8 in Neuroblastoma Tumorigenesis , 2009, Clinical Cancer Research.

[22]  E. Olson,et al.  Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice. , 2008, The Journal of clinical investigation.

[23]  J. Lahti,et al.  Retinoic acid induces caspase-8 transcription via phospho-CREB and increases apoptotic responses to death stimuli in neuroblastoma cells. , 2008, Biochimica et biophysica acta.

[24]  J. Buggy,et al.  Interferon-α is able to maintain complete molecular remission induced by imatinib after its discontinuation , 2008, Leukemia.

[25]  T. Triche,et al.  Histone deacetylase 1 gene expression and sensitization of multidrug-resistant neuroblastoma cell lines to cytotoxic agents by depsipeptide. , 2007, Journal of the National Cancer Institute.

[26]  Eric Verdin,et al.  Design and evaluation of 'Linkerless' hydroxamic acids as selective HDAC8 inhibitors. , 2007, Bioorganic & medicinal chemistry letters.

[27]  Mark J. Smyth,et al.  Analysis of the apoptotic and therapeutic activities of histone deacetylase inhibitors by using a mouse model of B cell lymphoma , 2007, Proceedings of the National Academy of Sciences.

[28]  Wolfgang Wurst,et al.  Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity. , 2007, Nature medicine.

[29]  T. Perlmann,et al.  The establishment of neuronal properties is controlled by Sox4 and Sox11. , 2006, Genes & development.

[30]  S. Fulda,et al.  5-Aza-2′-deoxycytidine and IFN-γ cooperate to sensitize for TRAIL-induced apoptosis by upregulating caspase-8 , 2006, Oncogene.

[31]  Y. Bang,et al.  Histone Deacetylase Inhibitors for Cancer Therapy , 2006, Epigenetics.

[32]  Peter A. Jones,et al.  Epigenetic therapy of cancer: past, present and future , 2006, Nature Reviews Drug Discovery.

[33]  S. Minucci,et al.  Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer , 2006, Nature Reviews Cancer.

[34]  E. Seto,et al.  Acetylation and deacetylation of non-histone proteins. , 2005, Gene.

[35]  L. Schwartz,et al.  Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[36]  J. Armstrong,et al.  13-cis retinoic acid and isomerisation in paediatric oncology--is changing shape the key to success? , 2005, Biochemical Pharmacology.

[37]  F. Berthold,et al.  Reliable transcript quantification by real-time reverse transcriptase-polymerase chain reaction in primary neuroblastoma using normalization to averaged expression levels of the control genes HPRT1 and SDHA. , 2005, The Journal of molecular diagnostics : JMD.

[38]  V. Castronovo,et al.  Expression of histone deacetylase 8, a class I histone deacetylase, is restricted to cells showing smooth muscle differentiation in normal human tissues. , 2004, The American journal of pathology.

[39]  J. R. Somoza,et al.  Structural snapshots of human HDAC8 provide insights into the class I histone deacetylases. , 2004, Structure.

[40]  Y. Kwong,et al.  Differential effects of 9-cis, 13-cis and all-trans retinoic acids on the neuronal differentiation of human neuroblastoma cells , 2003, Neuroreport.

[41]  G. Brodeur.  Neuroblastoma: biological insights into a clinical enigma , 2003, Nature Reviews Cancer.

[42]  D. O’Carroll,et al.  Essential function of histone deacetylase 1 in proliferation control and CDK inhibitor repression , 2002, The EMBO journal.

[43]  Xiao-Fan Wang,et al.  HDAC6 is a microtubule-associated deacetylase , 2002, Nature.

[44]  P. Marks,et al.  Histone deacetylases and cancer: causes and therapies , 2001, Nature Reviews Cancer.

[45]  J. Clark,et al.  Cloning and characterization of a novel human histone deacetylase, HDAC8. , 2000, The Biochemical journal.

[46]  A. Bird,et al.  Histone deacetylases: silencers for hire. , 2000, Trends in biochemical sciences.

[47]  Medeva Ghee,et al.  AP-1, CREB and CBP transcription factors differentially regulate the tyrosine hydroxylase gene. , 1998, Brain research. Molecular brain research.

[48]  A. Cumano,et al.  Defects in cardiac outflow tract formation and pro-B-lymphocyte expansion in mice lacking Sox-4 , 1996, Nature.

[49]  M. Israel,et al.  Decreased expression of N-myc precedes retinoic acid-induced morphological differentiation of human neuroblastoma , 1985, Nature.