Wireless telesurveillance system for detecting dementia

Objective We hypothesized path tortuosity (an index of casual locomotor variability) measured by a movement telesurveillance system would be suitable for assisted living facility residents clinically diagnosed with dementia. Background We examined the relationship of dementia to path tortuosity and to movement speed and path length variability, both of which increase in dementia. Methods Daytime movements of 25 elders (19 female; 14 with dementia; average age 80.6) were monitored for 30 days using radio transponders measuring location with a maximum accuracy of 20 cm. After 30 days, the Mini Mental State Exam (MMSE) and Revised Algase Wandering Scale-Community Version (RAWS-CV) were administered. Results Fractal Dimension (Fractal D), a measure of path tortuosity, correctly classified all but 2 residents with dementia; sensitivity 0.857, specificity 0.818 while the MMSE had 6 misclassifications, a sensitivity of 0.857 and a specificity of 0.727. Individual logistic regressions of dementia diagnosis on predictors MMSE and Fractal D were significant, but a logistic regression using both predictors found Fractal D marginally predictive of dementia (p=0.055) while the MMSE was not (p=0.168). Although significantly correlated with Fractal D, rate of travel and mean path distance were not predictive of dementia. Fractal D correlated negatively with overall MMSE (r= -0.44, n=25, p<0.05) but the relationship was mediated by MMSE Geographical Orientation items. Fractal D was unrelated to the RAWS-CV. Conclusions Telesurveillance-measured path tortuosity is greater in persons diagnosed with dementia. Persons with dementia have relatively more impaired spatial memory which is required for successful navigation. Application Automatic monitoring of direction, length and speed of unconstrained movements.

[1]  Andre Gustavo Adami,et al.  Unobtrusive Assessment of Mobility , 2006, 2006 International Conference of the IEEE Engineering in Medicine and Biology Society.

[2]  Jeffrey M. Hausdorff,et al.  The role of executive function and attention in gait , 2008, Movement disorders : official journal of the Movement Disorder Society.

[3]  W. Kearns,et al.  Tortuosity in Movement Paths Is Related to Cognitive Impairment , 2010, Methods of Information in Medicine.

[4]  Donna L. Algase,et al.  The Interrelatedness of Wandering and Wayfinding in a Community Sample of Persons with Dementia , 2004, Dementia and Geriatric Cognitive Disorders.

[5]  Vilis O Nams,et al.  Improving Accuracy and Precision in Estimating Fractal Dimension of Animal movement paths , 2006, Acta biotheoretica.

[6]  Herman Buschke,et al.  Abnormality of gait as a predictor of non-Alzheimer's dementia. , 2002, The New England journal of medicine.

[7]  W. Kearns,et al.  Evaluation of Wandering by Residents in an Assisted Living Facility (ALF) Using Ultra Wideband Radio RTLS , 2009 .

[8]  J. Morris,et al.  Longitudinal study of the transition from healthy aging to Alzheimer disease. , 2009, Archives of neurology.

[9]  R. Lipton,et al.  Quantitative gait markers and incident fall risk in older adults. , 2009, The journals of gerontology. Series A, Biological sciences and medical sciences.

[10]  Amy E. Sanders,et al.  Egocentric and exocentric navigation skills in older adults. , 2008, The journals of gerontology. Series A, Biological sciences and medical sciences.

[11]  William D. Kearns,et al.  Ultra wideband radio: A novel method for measuring wandering in persons with dementia , 2008 .

[12]  Jeffrey M. Hausdorff Gait dynamics, fractals and falls: finding meaning in the stride-to-stride fluctuations of human walking. , 2007, Human movement science.

[13]  J. Kaye,et al.  Motor slowing precedes cognitive impairment in the oldest old , 1998, Neurology.

[14]  L. Nyberg,et al.  Fall and Injury Prevention in Residential Care—Effects in Residents with Higher and Lower Levels of Cognition , 2003, Journal of the American Geriatrics Society.

[15]  D. Gavin-Dreschnack,et al.  Mapping the maze of terms and definitions in dementia-related wandering , 2007, Aging & mental health.

[16]  R. Passini,et al.  Wayfinding in dementia of the Alzheimer type: planning abilities. , 1995, Journal of clinical and experimental neuropsychology.

[17]  T. Zandi,et al.  Graphomotor Perseveration and Wandering in Alzheimer's Disease , 1995, Journal of geriatric psychiatry and neurology.

[18]  M J de Leon,et al.  Wandering and parietal signs in senile dementia of Alzheimer's type. , 1984, Neuropsychobiology.

[19]  Kate E Webster,et al.  Quantitative gait analysis in patients with dementia with Lewy bodies and Alzheimer's disease. , 2007, Gait & posture.

[20]  L. Rubenstein Falls in older people: epidemiology, risk factors and strategies for prevention. , 2006, Age and ageing.

[21]  A. Buse The Likelihood Ratio, Wald, and Lagrange Multiplier Tests: An Expository Note , 1982 .

[22]  M. Pavel,et al.  An unobtrusive in-home monitoring system for detection of key motor changes preceding cognitive decline , 2004, The 26th Annual International Conference of the IEEE Engineering in Medicine and Biology Society.

[23]  N. A. Bernshteĭn The co-ordination and regulation of movements , 1967 .

[24]  Jeff Craighead Using fractal dimension to assess robot operator search skill , 2009, 2009 IEEE International Workshop on Safety, Security & Rescue Robotics (SSRR 2009).

[25]  J. Jolles,et al.  Symptoms of Preclinical Dementia in General Practice up to Five Years before Dementia Diagnosis , 2007, Dementia and Geriatric Cognitive Disorders.

[26]  Vilis O. Nams,et al.  Fractal analysis measures habitat use at different spatial scales: an example with American marten , 2004 .

[27]  E. Revilla,et al.  A movement ecology paradigm for unifying organismal movement research , 2008, Proceedings of the National Academy of Sciences.

[28]  Jelle Jolles,et al.  Symptoms of preclinical dementia in general practice up to five years before dementia diagnosis. , 2008, Dementia and geriatric cognitive disorders.