LOCAL USE OF SULFATHIAZOLE IN MANAGEMENT OF SIMPLE MASTOIDECTOMY WOUNDS

Within the past few years there has accumulated a voluminous literature concerning the oral and parenteral administration of sulfanilamide and its derivatives, but the local use of these drugs has received little prominence. The excellent results obtained by Jensen and his associates 1 in the treatment of compound fractures with powdered sulfanilamide have served to arouse considerable interest in this type of therapy, and the work of Thomson 2 as well as that of Key and his co-workers 3 along similar lines has tended to place such therapy on a firm footing. Sulfanilamide has been found to be of value also in the local treatment of gonorrheal ophthalmia 4 and of chancroid. 5 Mueller, 6 in a recent communication to The Journal of the American Medical Association , described the local employment of this drug in cases of peritonitis with gratifying results. The rapid healing of purulent, sloughing mastoidectomy wounds after the local application of sulfathiazole (2-[paraaminobenzenesulfon-amido]-thiazole)