ANTIBIOTIC RESISTANCE MECHANISMS OF UROGENITAL MYCOPLASMAS

Urogenital mycoplasmas (Mycoplasma genitalium, Mycoplasma hominis and Ureaplasma spp.) currently prevail in the etiology of infections of the urogenital tract and are characterized by a high level of genetic polymorphism responsible for the occurrence of their antibiotic resistance. The review presents the data of domestic and foreign researchers on the resistance mechanisms of mycoplasmas and ureaplasmas to antibiotics and considers the acquisition by mycoplasmas of antibiotic resistance determinants. New knowledge of resistance mechanisms is important theoretical basis for improving measures to limit and prevent the spread of antibiotic resistant bacteria.

[1]  M. Unemo,et al.  Prevalence of macrolide and fluoroquinolone resistance-mediating mutations in Mycoplasma genitalium in five cities in Russia and Estonia , 2017, PloS one.

[2]  N. Xin,et al.  Prevalence and antibiotic susceptibility of Ureaplasma urealyticum and Mycoplasma hominis in Xi’an, China , 2016, European Journal of Clinical Microbiology & Infectious Diseases.

[3]  Woo-In Lee,et al.  Prevalence and Antibiotic Susceptibility of Mycoplasma hominis and Ureaplasma urealyticum in Pregnant Women , 2016, Yonsei medical journal.

[4]  V. Chernov,et al.  Mycoplasmas and Their Antibiotic Resistance: The Problems and Prospects in Controlling Infections , 2016, Acta naturae.

[5]  J. Jóźwiak,et al.  Prevalence of Urogenital Mycoplasmas Among Men with NGU in Upper Silesia, Poland. Preliminary Study , 2016, Polish journal of microbiology.

[6]  Sima Azizmohammadi,et al.  Antimicrobial Susceptibility Patterns of Ureaplasma urealyticum and Mycoplasma hominis Isolated From Pregnant Women , 2015, Iranian Red Crescent medical journal.

[7]  V. Chalker,et al.  Antibiotic Resistance among Clinical Ureaplasma Isolates Recovered from Neonates in England and Wales between 2007 and 2013 , 2015, Antimicrobial Agents and Chemotherapy.

[8]  M. Nakayama,et al.  In Vitro Activity of Five Quinolones and Analysis of the Quinolone Resistance-Determining Regions of gyrA, gyrB, parC, and parE in Ureaplasma parvum and Ureaplasma urealyticum Clinical Isolates from Perinatal Patients in Japan , 2015, Antimicrobial Agents and Chemotherapy.

[9]  T. A. Ivanova,et al.  Significance of genital mycoplasmas (U. parvum, U. urealyticum, M. hominis, M. genitalium) in the development of infectious complications of pregnancy, labor, and postpartum and early neonatal periods , 2015 .

[10]  V. Chernov,et al.  Mycoplasma Contamination of Cell Cultures: Vesicular Traffic in Bacteria and Control over Infectious Agents , 2014, Acta naturae.

[11]  L. Fernández,et al.  Adaptive and Mutational Resistance: Role of Porins and Efflux Pumps in Drug Resistance , 2012, Clinical Microbiology Reviews.

[12]  D. Powell Genital Mycoplasmas (Mycoplasma hominis, Mycoplasma genitalium, and Ureaplasma urealyticum) , 2011 .

[13]  M. Bayraktar,et al.  Prevalence and antibiotic susceptibility of Mycoplasma hominis and Ureaplasma urealyticum in pregnant women. , 2010, International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases.