Phenome-wide association study of genetically predicted B vitamins and homocysteine biomarkers with multiple health and disease outcomes: analysis of the UK Biobank.

[1]  Gary D Bader,et al.  The reactome pathway knowledgebase 2022 , 2021, Nucleic Acids Res..

[2]  K. Kalantar-Zadeh,et al.  Chronic kidney disease , 2021, The Lancet.

[3]  Y. Kim,et al.  Causal Effects of Homocysteine, Folate, and Cobalamin on Kidney Function: A Mendelian Randomization Study , 2021, Nutrients.

[4]  Nadezhda T. Doncheva,et al.  The STRING database in 2021: customizable protein–protein networks, and functional characterization of user-uploaded gene/measurement sets , 2020, Nucleic Acids Res..

[5]  Ling Wang,et al.  Association Between Folate and Health Outcomes: An Umbrella Review of Meta-Analyses , 2020, Frontiers in Public Health.

[6]  S. Peterson,et al.  B Vitamins and Their Role in Immune Regulation and Cancer , 2020, Nutrients.

[7]  P. Saravanan,et al.  Investigating vitamin B12 deficiency , 2019, BMJ.

[8]  H. Jakubowski.  Homocysteine Modification in Protein Structure/Function and Human Disease. , 2019, Physiological reviews.

[9]  P. Donnelly,et al.  The UK Biobank resource with deep phenotyping and genomic data , 2018, Nature.

[10]  B. Neale,et al.  Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases , 2018, Nature Genetics.

[11]  Valeriia Haberland,et al.  The MR-Base platform supports systematic causal inference across the human phenome , 2018, eLife.

[12]  Greg S Garrett,et al.  A public health approach for preventing neural tube defects: folic acid fortification and beyond , 2018, Annals of the New York Academy of Sciences.

[13]  G. Gambaro,et al.  Vitamin B6 intake and the risk of incident kidney stones , 2018, Urolithiasis.

[14]  G. Hankey,et al.  B vitamins in stroke prevention: time to reconsider , 2017, The Lancet Neurology.

[15]  R. Green.  Vitamin B12 deficiency from the perspective of a practicing hematologist. , 2017, Blood.

[16]  M. Ritchie,et al.  A simulation study investigating power estimates in phenome-wide association studies , 2017, bioRxiv.

[17]  C. Schooling,et al.  Homocysteine-reducing B vitamins and ischemic heart disease: a separate-sample Mendelian randomization analysis , 2017, European Journal of Clinical Nutrition.

[18]  Joshua D Rabinowitz,et al.  One-Carbon Metabolism in Health and Disease. , 2017, Cell metabolism.

[19]  A. Khera,et al.  Mendelian Randomization. , 2017, JAMA.

[20]  C. Zheng,et al.  Causal mediation analysis in the context of clinical research. , 2016, Annals of translational medicine.

[21]  A. Smith,et al.  Homocysteine, B Vitamins, and Cognitive Impairment. , 2016, Annual review of nutrition.

[22]  Tsippi Iny Stein,et al.  The GeneCards Suite: From Gene Data Mining to Disease Genome Sequence Analyses , 2016, Current protocols in bioinformatics.

[23]  G. Davey Smith,et al.  Consistent Estimation in Mendelian Randomization with Some Invalid Instruments Using a Weighted Median Estimator , 2016, Genetic epidemiology.

[24]  Dana C. Crawford,et al.  Unravelling the human genome–phenome relationship using phenome-wide association studies , 2016, Nature Reviews Genetics.

[25]  G. Davey Smith,et al.  Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression , 2015, International journal of epidemiology.

[26]  Joshua C. Denny,et al.  R PheWAS: data analysis and plotting tools for phenome-wide association studies in the R environment , 2014, Bioinform..

[27]  O. Devine,et al.  Population red blood cell folate concentrations for prevention of neural tube defects: bayesian model , 2014, BMJ : British Medical Journal.

[28]  Melissa A. Basford,et al.  Systematic comparison of phenome-wide association study of electronic medical record data and genome-wide association study data , 2013, Nature Biotechnology.

[29]  Andrew D. Johnson,et al.  Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease. , 2013, The American journal of clinical nutrition.

[30]  D. Gudbjartsson,et al.  Genetic Architecture of Vitamin B12 and Folate Levels Uncovered Applying Deeply Sequenced Large Datasets , 2013, PLoS genetics.

[31]  Ellen T. Gelfand,et al.  The Genotype-Tissue Expression (GTEx) project , 2013, Nature Genetics.

[32]  S. Stabler.  Clinical practice. Vitamin B12 deficiency. , 1996, The New England journal of medicine.

[33]  M. Jardine,et al.  The effect of folic acid based homocysteine lowering on cardiovascular events in people with kidney disease: systematic review and meta-analysis , 2012, BMJ : British Medical Journal.

[34]  S. Brunak,et al.  Mining electronic health records: towards better research applications and clinical care , 2012, Nature Reviews Genetics.

[35]  François Mariotti,et al.  Dose‐response analyses using restricted cubic spline functions in public health research , 2010, Statistics in medicine.

[36]  Marylyn D. Ritchie,et al.  PheWAS: demonstrating the feasibility of a phenome-wide scan to discover gene–disease associations , 2010, Bioinform..

[37]  S. Chanock,et al.  Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway. , 2009, Human molecular genetics.

[38]  S. Berg,et al.  Heritabilities for fifteen routine biochemical values: findings in 215 Swedish twin pairs 82 years of age or older , 2009, Scandinavian journal of clinical and laboratory investigation.

[39]  S. Vollset,et al.  Homocysteine, cysteine, and body composition in the Hordaland Homocysteine Study: does cysteine link amino acid and lipid metabolism? , 2008, The American journal of clinical nutrition.

[40]  G. Curhan,et al.  24-h uric acid excretion and the risk of kidney stones. , 2008, Kidney international.

[41]  P. Barter,et al.  Homocysteine and cardiovascular disease: is HDL the link? , 2006, Circulation research.

[42]  Gary M. Shaw,et al.  Neural tube defects and folate: case far from closed , 2006, Nature Reviews Neuroscience.

[43]  A. Devlin,et al.  ApoA-I: a missing link between homocysteine and lipid metabolism? , 2006, Circulation research.

[44]  P. Shannon,et al.  Cytoscape: a software environment for integrated models of biomolecular interaction networks. , 2003, Genome research.

[45]  A. Alver,et al.  Plasma homocysteine and its relationships with atherothrombotic markers in psoriatic patients. , 2003, Clinica chimica acta; international journal of clinical chemistry.

[46]  Susumu Goto,et al.  KEGG: Kyoto Encyclopedia of Genes and Genomes , 2000, Nucleic Acids Res..

[47]  W. Willett,et al.  Intake of vitamins B6 and C and the risk of kidney stones in women. , 1999, Journal of the American Society of Nephrology : JASN.

[48]  E. Rimm,et al.  A prospective study of the intake of vitamins C and B6, and the risk of kidney stones in men. , 1996, The Journal of urology.

[49]  Y. Benjamini,et al.  Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .

[50]  J. Pacala.  Vitamin B12 deficiency. , 1993, The Journal of family practice.

[51]  F. Harrell,et al.  Evaluating the yield of medical tests. , 1982, JAMA.