Hageman factor, high molecular weight kininogen, and prekallikrein in chronic liver disease.

The activities of Hageman factor, high molecular weight kininogen (HMWK), and prekallikrein were studied in patients who had chronic active hepatitis and cirrhosis. Serum HMWK and prekallikrein activities were decreased in chronic active hepatitis and cirrhosis, but Hageman factor activity was low in cirrhosis only. The reduction of prekallikrein, HMWK, and Hageman factor was dependent on the degree of liver failure. Similar prekallikrein values were found in serum samples, activated or not, with an excess of Hageman factor and HMWK, which suggests that the decrease of prekallikrein in liver disease is not influenced by the simultaneous decrease of Hageman factor and HMWK.

[1]  C. Alessandri,et al.  Prekallikrein and factor VII as prognostic indexes of liver failure. , 1986, American journal of clinical pathology.

[2]  C. Alessandri,et al.  Low Doses of Calcium-Heparin in Liver Cirrhosis , 1985, Thrombosis and Haemostasis.

[3]  C. Alessandri,et al.  Correlation between hepatic blood flow and coagulation indices in chronic active hepatitis and liver cirrhosis patients. , 1985, Haemostasis.

[4]  C. Alessandri,et al.  Prekallikrein behaviour in chronic active hepatitis and in cirrhotic patients. , 1984, Haemostasis.

[5]  G. Claeson,et al.  Determination of prekallikrein in plasma by means of a chromogenic tripeptide substrate for plasma kallikrein. , 1979, Advances in experimental medicine and biology.

[6]  H. Stormorken,et al.  Chromogenic Substrate Assay of Plasma Prekallikrein , 1978 .

[7]  C. Kluft.  Determination of prekallikrein in human plasma: optimal conditions for activating prekallikrein. , 1978, The Journal of laboratory and clinical medicine.

[8]  R. Colman,et al.  Potentiation of the function of Hageman factor fragments by high molecular weight kininogen. , 1977, The Journal of clinical investigation.

[9]  H. Bismuth,et al.  UPPER GASTROINTESTINAL HÆMORRHAGE IN HEPATIC CIRRHOSIS: CAUSES AND RELATION TO HEPATIC FAILURE AND STRESS , 1977, The Lancet.

[10]  R. Waldmann,et al.  Fitzgerald factor (high molecular weight kininogen) clotting activity in human plasma in health and disease in various animal plasmas. , 1976, Blood.

[11]  J. A. Robinson,et al.  Endotoxin, prekallikrein, complement and systemic vascular resistance. Sequential measurements in man. , 1975, The American journal of medicine.

[12]  R. Colman,et al.  Studies on the prekallikrein (kallikreinogen)--kallikrein enzyme system of human plasma. II. Evidence relating the kaolin-activated arginine esterase to plasma kallikrein. , 1969, The Journal of clinical investigation.

[13]  Sol Sierry.  Studies on the Prekallikrein ( Kallikreinogen )-Kallikrein Enzyme System of Human Plasma , 2022 .