Regulation of CSF‐1 receptor expression

Cells of the mononuclear phagocyte lineage possess receptors for macrophage colony‐stimulating factor (CSF‐1) encoded by the c‐fms protooncogene and respond to CSF‐1 with increased survival, growth, differentiation, and reversible changes in function. The c‐fms gene is itself a macrophage differentiation marker. In whole mount analyses of mRNA expression in embryos, c‐fms is expressed at very high levels on placental trophoblasts. It is detectable on individual cells in the yolk sac around 8.5 to 9 days postcoitus, appears on isolated cells in the head of the embryo around 9.5 dpc, and appears on numerous cells throughout the embryo by day 10.5. The extent of c‐fms expression is much greater than for other macrophage‐specific genes including lysozyme and a macrophage‐specific protein tyrosine phosphatase.

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