EpiGauss: Spatio-temporal Characterization of Epiletogenic Activity Applied to Hypothalamic Hamartomas

EpiGauss is a method that combines single dipole model with dipole clustering to characterize active brain generators in space and time related to EEG events. EpiGauss was applied to study epileptogenic activity in 4 patients suffering of hypothalamic hamartoma related epilepsy, a rare syndrome with a unique epileptogenic source – the hamartoma lesion – and natural propagation hypothesis – from hamartoma to the surface EEG focus. The results are compared to Rap-MUSIC and Single Moving Dipole methods over the same patients.

[1]  Jean Gotman,et al.  Negative BOLD responses to epileptic spikes , 2006, Human brain mapping.

[2]  Philippe Kahane,et al.  From hypothalamic hamartoma to cortex: what can be learnt from depth recordings and stimulation? , 2003, Epileptic disorders : international epilepsy journal with videotape.

[3]  J Vieth,et al.  The dipole density plot (DDP), a technique to show concentrations of dipoles. , 1993, Physiological measurement.

[4]  Pedro Augusto do Amaral,et al.  Multimodal application for visualization and manipulation of Electrocorticography data , 2021 .

[5]  C. Michel,et al.  Noninvasive Localization of Electromagnetic Epileptic Activity. I. Method Descriptions and Simulations , 2004, Brain Topography.

[6]  A. Leal,et al.  Interictal spike EEG source analysis in hypothalamic hamartoma epilepsy , 2002, Clinical Neurophysiology.

[7]  D. Schwartz,et al.  Evaluation of a New MEG-EEG Spatio-Temporal Localization Approach Using a Realistic Source Model , 2004, Brain Topography.

[8]  B. Dijk,et al.  The localization of spontaneous brain activity: first results in patients with cerebral tumors , 2001, Clinical Neurophysiology.

[9]  J.C. Mosher,et al.  Recursive MUSIC: A framework for EEG and MEG source localization , 1998, IEEE Transactions on Biomedical Engineering.

[10]  R. Kristeva-Feige,et al.  Localization of Interictal Delta and Epileptiform EEG Activity Associated with Focal Epileptogenic Brain Lesions , 2001, NeuroImage.

[11]  Jean Gotman,et al.  The BOLD Response to Interictal Epileptiform Discharges , 2002, NeuroImage.

[12]  F Andermann,et al.  Human Epileptogenesis and Hypothalamic Hamartomas: New Lessons from an Experiment of Nature , 1997, Epilepsia.

[13]  Karl J. Friston,et al.  To Smooth or Not to Smooth? Bias and Efficiency in fMRI Time-Series Analysis , 2000, NeuroImage.

[14]  Jonathan Marchini,et al.  Comparing methods of analyzing fMRI statistical parametric maps , 2004, NeuroImage.

[15]  Mark D'Esposito,et al.  Variation of BOLD hemodynamic responses across subjects and brain regions and their effects on statistical analyses , 2004, NeuroImage.

[16]  P. Chauvel,et al.  Neuromagnetic source localization of auditory evoked fields and intracerebral evoked potentials: a comparison of data in the same patients , 2001, Clinical Neurophysiology.

[17]  C. Michel,et al.  Noninvasive Localization of Electromagnetic Epileptic Activity. II. Demonstration of Sublobar Accuracy in Patients with Simultaneous Surface and Depth Recordings , 2004, Brain Topography.

[18]  João Paulo da Silva Cunha,et al.  A Grid Framework for Non-Linear Brain fMRI Analysis , 2007, HealthGrid.

[19]  M Hoke,et al.  Possibilities and limitations of magnetic source imaging of methohexital-induced epileptiform patterns in temporal lobe epilepsy patients. , 1997, Electroencephalography and clinical neurophysiology.

[20]  Richard M. Leahy,et al.  Electromagnetic brain mapping - IEEE Signal Processing Magazine , 2001 .

[21]  A. Vortmeyer,et al.  Hypothalamic hamartomas: with special reference to gelastic epilepsy and surgery. , 1994, Neurosurgery.

[22]  Jean Gotman,et al.  EEG‐fMRI of focal epileptic spikes: Analysis with multiple haemodynamic functions and comparison with gadolinium‐enhanced MR angiograms , 2004, Human brain mapping.

[23]  J. Csicsvari,et al.  Accuracy of tetrode spike separation as determined by simultaneous intracellular and extracellular measurements. , 2000, Journal of neurophysiology.

[24]  Jan C. de Munck,et al.  The localization of spontaneous brain activity: an efficient way to analyze large data sets , 2001, IEEE Transactions on Biomedical Engineering.

[25]  Richard M. Leahy,et al.  Electromagnetic brain mapping , 2001, IEEE Signal Process. Mag..

[26]  H Kober,et al.  Functional 3D localization of cerebrovascular accidents by magnetoencephalography (MEG). , 1992, Neurological research.

[27]  J. -P. Vignal,et al.  Non-supervised spatio-temporal analysis of interictal magnetic spikes: comparison with intracerebral recordings , 2003, Clinical Neurophysiology.

[28]  C. Rorden,et al.  Stereotaxic display of brain lesions. , 2000, Behavioural neurology.

[29]  J. Gotman.  Noninvasive Methods for Evaluating the Localization and Propagation of Epileptic Activity , 2003, Epilepsia.

[30]  J. Kassubek,et al.  Time course of focal slow wave activity in transient ischemic attacks and transient global amnesia as measured by magnetoencephalography , 2000, Neuroreport.

[31]  Karl J. Friston,et al.  Studying spontaneous EEG activity with fMRI , 2003, Brain Research Reviews.

[32]  V Diekmann,et al.  Localisation of epileptic foci with electric, magnetic and combined electromagnetic models. , 1998, Electroencephalography and clinical neurophysiology.

[33]  R. Turner,et al.  Event-Related fMRI: Characterizing Differential Responses , 1998, NeuroImage.

[34]  J. Gotman,et al.  Correspondence between EEG-fMRI and EEG dipole localisation of interictal discharges in focal epilepsy , 2006, NeuroImage.

[35]  Alberto Leal,et al.  The BOLD Effect of Interictal Spike Activity in Childhood Occipital Lobe Epilepsy , 2006, Epilepsia.

[36]  Alberto Fernández,et al.  Dipole Density of Low-Frequency and Spike Magnetic Activity: A Reliable Procedure in Presurgical Evaluation of Temporal Lobe Epilepsy , 2004, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[37]  S. Spencer,et al.  Hypothalamic hamartomas: seven cases and review of the literature , 2003, Epilepsy & Behavior.

[38]  J. Gotman,et al.  Combining EEG and fMRI in Epilepsy: Methodological Challenges and Clinical Results , 2004, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[39]  Johannes Kornhuber,et al.  Spontaneous slow and fast MEG activity in male schizophrenics treated with clozapine , 2002 .

[40]  C. Michel,et al.  Propagation of Interictal Epileptiform Activity Can Lead to Erroneous Source Localizations: A 128-Channel EEG Mapping Study , 2003, Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society.

[41]  W Sperling,et al.  Spontaneous, slow and fast magnetoencephalographic activity in patients with schizophrenia , 2002, Schizophrenia Research.

[42]  A. Leal,et al.  Different Electroclinical Manifestations of the Epilepsy Associated with Hamartomas Connecting to the Middle or Posterior Hypothalamus , 2003, Epilepsia.

[43]  B. Rockstroh,et al.  Source distribution of neuromagnetic slow waves and MEG-delta activity in schizophrenic patients , 2001, Biological Psychiatry.

[44]  S. Baillet,et al.  Automated interictal spike detection and source localization in magnetoencephalography using independent components analysis and spatio-temporal clustering , 2004, Clinical Neurophysiology.

[45]  M. Murray,et al.  EEG source imaging , 2004, Clinical Neurophysiology.