Bioactive properties of native Australian medicinal plants.

Due to their biogeographic isolation the Australian flora has evolved in a distinctive and often unique ways to a vast repository of secondary metabolites many of which are not found elsewhere in the world. Furthermore, the particularly long history of Aboriginal settlement and empirical traditional medicine has provided useful ethnopharmacological leads for biomedical research. In this chapter we examine bioactivities associated with compounds isolated from key plant species of established economic and commercial importance as well as providing a summary of recent research identifying Correspondence/Reprint request: Dr. G. L. Jones, Human Biology, School of Biological Biomedical and Molecular Science University of New England, Armidale, New South Wales 2351, Australia. E-mail: gjones2@une.edu.au G. L. Jones, J. E. Smith & K. Watson 2 compounds of future therapeutic potential using indigenous medical ethnobotany as a primary lead in plant selection.

[1]  L. Webb The Use of Plant Medicines and Poisons by Australian Aborigines , 2009 .

[2]  R. J. Chinnock,et al.  Seed germination of the Australian desert shrubEremophila (Myoporaceae) , 1994, The Botanical Review.

[3]  E. Ghisalberti,et al.  The Australian desert shrubEremophila (myoporaceae): Mmedicinal, cultural, horticultural and phytochemical uses , 2008, Economic Botany.

[4]  C. Barnard The duboisias of Australia , 2008, Economic Botany.

[5]  H. Nagata,et al.  Inhibitory effects of macrocarpals on the biological activity of Porphyromonas gingivalis and other periodontopathic bacteria. , 2006, Oral microbiology and immunology.

[6]  N. Bharti,et al.  Isolation and in vitro antiamoebic activity of iridoids isolated from Kigelia pinnata , 2006 .

[7]  Ki Yong Lee,et al.  Acteoside of Callicarpa dichotoma attenuates scopolamine-induced memory impairments. , 2006, Biological & pharmaceutical bulletin.

[8]  C. Dwivedi,et al.  Chemopreventive effects of various concentrations of &agr;-santalol on skin cancer development in CD-1 mice , 2005, European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation.

[9]  E. Palombo,et al.  Characterisation of antibacterial Australian medicinal plant extracts by investigation of the mechanism of action and the effect of interfering substances , 2005, Journal of basic microbiology.

[10]  J. Wilkinson,et al.  Antibacterial activity of essential oils from Australian native plants , 2005, Phytotherapy research : PTR.

[11]  Lucie Kienow,et al.  Interesting biological activities from plants traditionally used by Native Australians. , 2005, Journal of ethnopharmacology.

[12]  K. A. Reynertson PhytoChem Australia: A Database on Australian Plant Chemistry 1940–2000 , 2004 .

[13]  E. Palombo,et al.  Identification of the antibacterial component of an ethanolic extract of the Australian medicinal plant, Eremophila duttonii , 2004, Phytotherapy research : PTR.

[14]  R. Olson,et al.  Essential oil of Australian lemon myrtle (Backhousia citriodora) in the treatment of molluscum contagiosum in children. , 2004, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[15]  N. Garbett,et al.  Extending nature's leads: the anticancer agent ellipticine. , 2004, Current medicinal chemistry. Anti-cancer agents.

[16]  T. Kato,et al.  A comparison of the antibacterial efficacies of essential oils against oral pathogens. , 2004, Oral microbiology and immunology.

[17]  G. Leach,et al.  Anti‐inflammatory activity, cytotoxicity and active compounds of Tinospora smilacina Benth. , 2004, Phytotherapy research : PTR.

[18]  B. Markovic,et al.  Toxicity of Australian essential oil Backhousia citriodora (lemon myrtle). Part 2. Absorption and histopathology following application to human skin. , 2003, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[19]  J. Brophy,et al.  Melaleuca teretifolia Chemovars: New Australian Sources of Citral and 1,8-Cineole , 2003 .

[20]  K. Rogers,et al.  Isolation of two phenylethanoid glycosides from Eremophila gilesii. , 2003, Journal of ethnopharmacology.

[21]  A. Cassone,et al.  In vitro and in vivo activity of tea tree oil against azole-susceptible and -resistant human pathogenic yeasts. , 2003, The Journal of antimicrobial chemotherapy.

[22]  K. Svoboda Lemon scented plants , 2003 .

[23]  S. Colledge Plants and People , 2003 .

[24]  J. Wilkinson,et al.  Bioactivity of Backhousia citriodora: antibacterial and antifungal activity. , 2003, Journal of agricultural and food chemistry.

[25]  S. Semple,et al.  Antibacterial activity of Australian plant extracts against methicillin‐resistant Staphylococcus aureus (MRSA) and vancomycin‐resistant enterococci (VRE) , 2002, Journal of basic microbiology.

[26]  P. Hart,et al.  Tea tree oil reduces histamine‐induced skin inflammation , 2002, The British journal of dermatology.

[27]  Takuji Tanaka,et al.  A bitter diterpenoid furanolactone columbin from Calumbae Radix inhibits azoxymethane-induced rat colon carcinogenesis. , 2002, Cancer letters.

[28]  J. Vazquez,et al.  Efficacy of Alcohol-Based and Alcohol-Free Melaleuca Oral Solution for the Treatment of Fluconazole-Refractory Oropharyngeal Candidiasis in Patients with AIDS , 2002, HIV clinical trials.

[29]  B. Markovic,et al.  Toxicity of Australian essential oil Backhousia citriodora (Lemon myrtle). Part 1. Antimicrobial activity and in vitro cytotoxicity. , 2002, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[30]  S. Arikan,et al.  Comparison of Microdilution and Disc Diffusion Methods in Assessing the in vitro Activity of Fluconazole and Melaleuca alternifolia (Tea Tree) Oil Against Vaginal Candida Isolates , 2002, Journal of chemotherapy.

[31]  M. Abubakar,et al.  Inhibition of Naja Nigricolis Venom Acidic Phospholipase A 2 Catalysed Hydrolysis of Ghost Red Blood Cells by Columbin , 2002, Journal of Enzyme Inhibition and Medicinal Chemistry.

[32]  S. Semple,et al.  Antibacterial activity of traditional Australian medicinal plants. , 2001, Journal of ethnopharmacology.

[33]  A. House,et al.  Backhousia citriodora F. Muell.—Rediscovery and chemical characterization of the L-citronellal form and aspects of its breeding system , 2001 .

[34]  J. Markham,et al.  Interactions between components of the essential oil of Melaleuca alternifolia , 2001, Journal of applied microbiology.

[35]  H. Yamaguchi,et al.  Antibacterial activity of essential oils and their major constituents against respiratory tract pathogens by gaseous contact. , 2001, The Journal of antimicrobial chemotherapy.

[36]  S. Wyllie,et al.  Xanthine oxidase inhibitory activity of selected Australian native plants. , 2001, Journal of ethnopharmacology.

[37]  J. Reichling,et al.  Antiviral activity of Australian tea tree oil and eucalyptus oil against herpes simplex virus in cell culture. , 2001, Die Pharmazie.

[38]  P. Hart,et al.  The water-soluble components of the essential oil of Melaleuca alternifolia (tea tree oil) suppress the production of superoxide by human monocytes, but not neutrophils, activated in vitro , 2001, Inflammation Research.

[39]  S. Pyke,et al.  In vitro antiviral activity of the anthraquinone chrysophanic acid against poliovirus. , 2001, Antiviral research.

[40]  Abimael D Rodríguez,et al.  Serrulatane diterpenes with antimycobacterial activity isolated from the West Indian sea whip Pseudopterogorgia elisabethae. , 2001, Journal of natural products.

[41]  M. Luyckx,et al.  Neurosedative and Antioxidant Activities of Phenylpropanoids from Ballota nigra , 2000, Arzneimittelforschung.

[42]  J. Jamie,et al.  Antibacterial compounds from Carissa lanceolata R.Br. , 2000, Phytochemistry.

[43]  C F Carson,et al.  Tea tree oil as an alternative topical decolonization agent for methicillin-resistant Staphylococcus aureus. , 2000, The Journal of hospital infection.

[44]  P. Hart,et al.  Terpinen-4-ol, the main component of the essential oil of Melaleuca alternifolia (tea tree oil), suppresses inflammatory mediator production by activated human monocytes , 2000, Inflammation Research.

[45]  K. Kato,et al.  Effects of sesquiterpenoids from "Oriental incenses" on acetic acid-induced writhing and D2 and 5-HT2A receptors in rat brain. , 2000, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[46]  D. Devanesen Traditional Aboriginal medicine practice in the Northern Territory , 2000 .

[47]  K. Rogers,et al.  Inhibition of platelet aggregation and 5-HT release by extracts of Australian plants used traditionally as headache treatments. , 2000, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[48]  J. Warmington,et al.  The mode of antimicrobial action of the essential oil of Melaleuca alternifolia (tea tree oil) , 2000, Journal of applied microbiology.

[49]  S. Griffin Aspects of antimicrobial activity of terpenoids and the relationship to their molecular structure , 2000 .

[50]  S. Pyke,et al.  Antiviral flavonoid from Pterocaulon sphacelatum, an Australian Aboriginal medicine. , 1999, Journal of ethnopharmacology.

[51]  M. M. Cowan Plant Products as Antimicrobial Agents , 1999, Clinical Microbiology Reviews.

[52]  S. Wyllie,et al.  The role of structure and molecular properties of terpenoids in determining their antimicrobial activity. , 1999 .

[53]  E. Ghisalberti,et al.  Mechanism of action of verbascoside on the isolated rat heart: increases in level of prostacyclin , 1999, Phytotherapy research : PTR.

[54]  J. Markham BIOLOGICAL ACTIVITY OF TEA TREE OIL , 1999 .

[55]  S. Semple,et al.  Screening of Australian medicinal plants for antiviral activity. , 1998, Journal of ethnopharmacology.

[56]  W. Kitching,et al.  Isolation and Structure of Some Constituents of the Australian Medicinal Plant Tinospora smilacina ('Snakevine') , 1998 .

[57]  E. Ghisalberti,et al.  Cardioactive iridoid glycosides from Eremophila species. , 1997, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[58]  E. Ghisalberti,et al.  Cardioactive compounds from Eremophila species. , 1996, Journal of ethnopharmacology.

[59]  E. Ghisalberti,et al.  Cardioactive effects of Eremophila alternifolia extracts. , 1995, Journal of Ethnopharmacology.

[60]  N. Osheroff,et al.  Topoisomerase II Binds to Ellipticine in the Absence or Presence of DNA. , 1995, The Journal of Biological Chemistry.

[61]  V. Rodov,et al.  Preformed antifungal compounds of lemon-fruit: citral and its relation to disease resistance , 1995 .

[62]  S. Torrado,et al.  Effect of dissolution profile and (-)-alpha-bisabolol on the gastrotoxicity of acetylsalicylic acid. , 1995, Pharmazie.

[63]  L. Pannell,et al.  HIV inhibitory natural products. 11. Structure, absolute stereochemistry, and synthesis of conocurvone, a potent, novel HIV-inhibitory naphthoquinone trimer from a Conospermum sp , 1993 .

[64]  R. Massy-Westropp,et al.  Serrulatane diterpenes from Eremophila duttonii , 1993 .

[65]  R. Barnetson,et al.  TEA TREE OIL IN THE TREATMENT OF TINEA PEDIS , 1992, The Australasian journal of dermatology.

[66]  M. Nicoletti,et al.  Pharmacological effects of phenylpropanoid glycosides from Orobanche hederae , 1992 .

[67]  D. M. Jackson,et al.  Alawa ethnobotany : aboriginal plant use from Minyerri, Northern Australia , 1991 .

[68]  N. Smith Ethnobotanical field notes from the Northern Territory, Australia. , 1991 .

[69]  Y. Ohashi,et al.  Macrocarpal A, a Novel Antibacterial Compound from Eucalyptus macrocarpa , 1990 .

[70]  T. Low Bush Medicine: A Pharmacopoeia of Natural Remedies , 1990 .

[71]  J. R. Price,et al.  Plants for medicines: a chemical and pharmacological survey of plants in the Australian Region. , 1990 .

[72]  P. Cox Ethnopharmacology and the search for new drugs. , 1990, Ciba Foundation symposium.

[73]  S. Cane Australian Aboriginal subsistence in the Western desert , 1987 .

[74]  T. Horie,et al.  Antiviral activity of natural occurring flavonoids in vitro. , 1985, Chemical & pharmaceutical bulletin.

[75]  E. V. Lassak,et al.  Australian medicinal plants , 1983 .

[76]  Ken Lyon,et al.  Plants and People: Aboriginal Uses of Plants on Groote Eylandt , 1981 .

[77]  D. J. Collins,et al.  A Survey of Australian Solanum Plants for Potentially Useful Sources of Solasodine , 1978 .

[78]  N. Atkinson Antibacterial substances from flowering plants. 3. Antibacterial activity of dried Australian plants by a rapid direct plate test. , 1956, The Australian journal of experimental biology and medical science.

[79]  N. Atkinson,et al.  Antibacterial substances produced by flowering plants. II. The antibacterial action of essential oils from some Australian plants. , 1955, The Australian journal of experimental biology and medical science.

[80]  N. Atkinson ANTIBIOTICS IN AUSTRALIAN PLANTS AND FUNGI , 1949, The Medical journal of Australia.

[81]  N. Atkinson Antibacterial Activity in Members of the Native Australian Flora , 1946, Nature.