Loss of capacity to elevate plasma cortisol in rainbow trout (Oncorhynchus mykiss) treated with a single injection of o,p′‐dichlorodiphenyldichloroethane

The organochlorine o,p′‐ dichlorodiphenyldichloroethane (o,p′‐DDD) is a metabolite of dichlorodiphenyltrichloroethane (DDT), known for its adrenolytic actions in birds and mammals. The effects of o,p′‐DDD on the cortisol stress response were investigated in rainbow trout, Oncorhynchus mykiss, in a dose‐response study in vivo. A dose‐dependent decrease in plasma cortisol levels was observed on days 7 and 14 after a single i.p. injection of o,p′‐DDD. Treatment with o,p′‐DDD had no effect on weight gain, hematocrit, and gonado‐ or hepatosomatic index but decreased liver glycogen reserves. The results indicate that o,p′‐DDD is an adrenotoxic compound in rainbow trout and that its effects can be detected even 14 d postinjection.

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