Hilar cholangiocarcinoma with intratumoral calcification: A case report.

This report describes a rare case of hilar cholangiocarcinoma with intratumoral calcification that mimicked hepatolithiasis. A 73-year-old man presented to a local hospital with a calcified lesion in the hepatic hilum. At first, hepatolithiasis was diagnosed, and he underwent endoscopic stone extraction via the trans-papillary route. This treatment strategy failed due to biliary stricture. He was referred to our hospital, and further examination suggested the existence of cholangiocarcinoma. He underwent left hepatectomy with caudate lobectomy and extrahepatic bile duct resection. Pathological examination revealed hilar cholangiocarcinoma with intratumoral calcification, while no stones were found. To the best of our knowledge, only one case of calcified hilar cholangiocarcinoma has been previously reported in the literature. Here, we report a rare case of calcified hilar cholangiocarcinoma and reveal its clinicopathologic features.

[1]  D. Das.  Psammoma body: A product of dystrophic calcification or of a biologically active process that aims at limiting the growth and spread of tumor? , 2009, Diagnostic cytopathology.

[2]  S. Gallinger,et al.  Recurrent Pyogenic Cholangitis with Hepatolithiasis—The Role of Surgical Therapy in North America , 2008, Journal of Gastrointestinal Surgery.

[3]  H. Ha,et al.  CT differentiation of mucinous and nonmucinous colorectal carcinoma. , 2007, AJR. American journal of roentgenology.

[4]  B. Choi,et al.  CT Differentiation of cholangiocarcinoma from periductal fibrosis in patients with hepatolithiasis. , 2006, AJR. American journal of roentgenology.

[5]  S. H. Kim,et al.  Calcified Klatskin tumor mimicking intrahepatic stone: case report , 2004, Abdominal Imaging.

[6]  T. Terada,et al.  Are hepatolithiasis and cholangiocarcinoma aetiologically related? , 1985, Virchows Archiv A.

[7]  P. Vock,et al.  The Rocky liver: radiologic-pathologic correlation of calcified hepatic masses. , 1998, Radiographics : a review publication of the Radiological Society of North America, Inc.

[8]  P. Watanapa,et al.  Hepatolithiasis: epidemiology and classification. , 1997, Hepato-gastroenterology.

[9]  M. Nagino,et al.  A clinicopathologic study of primary cholesterol hepatolithiasis. , 1995, Hepato-gastroenterology.

[10]  T. Hwang,et al.  A reappraisal of cholangiocarcinoma in patient with hepatolithiasis , 1993, Cancer.

[11]  F. Chan,et al.  Evaluation of recurrent pyogenic cholangitis with CT: analysis of 50 patients. , 1989, Radiology.

[12]  P. R. Ros,et al.  Intrahepatic cholangiocarcinoma: radiologic-pathologic correlation. , 1988, Radiology.

[13]  Batlan Le.  Calcification within the stomach wall in gastric malignancy; case report and review of literature. , 1954 .

[14]  L. E. Batlan.  Calcification within the stomach wall in gastric malignancy; case report and review of literature. , 1954, The American journal of roentgenology, radium therapy, and nuclear medicine.