Active DNA demethylation: many roads lead to Rome

[1]  Yi Zhang,et al.  Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification , 2010, Nature.

[2]  Tyson A. Clark,et al.  Direct detection of DNA methylation during single-molecule, real-time sequencing , 2010, Nature Methods.

[3]  Swati Kadam,et al.  Examination of the specificity of DNA methylation profiling techniques towards 5-methylcytosine and 5-hydroxymethylcytosine , 2010, Nucleic acids research.

[4]  M. Pellegrini,et al.  Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency , 2010, Nature.

[5]  Helen M. Blau,et al.  Reprogramming towards pluripotency requires AID-dependent DNA demethylation , 2010, Nature.

[6]  Julie A. Law,et al.  Establishing, maintaining and modifying DNA methylation patterns in plants and animals , 2010, Nature Reviews Genetics.

[7]  Yi Zhang,et al.  A role for elongator in zygotic paternal genome demethylation , 2010, Nature.

[8]  Sascha Karberg Switching on Epigenetic Therapy , 2009, Cell.

[9]  J. Soulier,et al.  Mutation in TET2 in myeloid cancers. , 2009, The New England journal of medicine.

[10]  Jian‐Kang Zhu Active DNA demethylation mediated by DNA glycosylases. , 2009, Annual review of genetics.

[11]  Jeroen S. van Zon,et al.  Direct cell reprogramming is a stochastic process amenable to acceleration , 2009, Nature.

[12]  H. Shibuya,et al.  DNA demethylation in hormone-induced transcriptional derepression , 2009, Nature.

[13]  D. Birnbaum,et al.  TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs). , 2009, Blood.

[14]  Zhiguo Zhang,et al.  The Elongator Complex Interacts with PCNA and Modulates Transcriptional Silencing and Sensitivity to DNA Damage Agents , 2009, PLoS genetics.

[15]  S. Goodman,et al.  Sensitive digital quantification of DNA methylation in clinical samples , 2009, Nature Biotechnology.

[16]  W. Vainchenker,et al.  Analysis of the ten-eleven translocation 2 (TET2) gene in familial myeloproliferative neoplasms. , 2009, Blood.

[17]  G. Mufti,et al.  Novel TET2 mutations associated with UPD4q24 in myelodysplastic syndrome. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[18]  M. Saitou Germ cell specification in mice. , 2009, Current opinion in genetics & development.

[19]  D. Gilliland,et al.  Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies. , 2009, Blood.

[20]  A. Hagemeijer,et al.  Acquired mutations in TET2 are common in myelodysplastic syndromes , 2009, Nature Genetics.

[21]  Jungwon Huh,et al.  Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasms. , 2009, Blood.

[22]  Steven Henikoff,et al.  Extensive Demethylation of Repetitive Elements During Seed Development Underlies Gene Imprinting , 2009, Science.

[23]  Z. Liutkevičiūtė,et al.  Cytosine-5-methyltransferases add aldehydes to DNA. , 2009, Nature chemical biology.

[24]  N. Heintz,et al.  The Nuclear DNA Base 5-Hydroxymethylcytosine Is Present in Purkinje Neurons and the Brain , 2009, Science.

[25]  Y. Yamauchi,et al.  Asynchronous DNA replication and origin licensing in the mouse one‐cell embryo , 2009, Journal of cellular biochemistry.

[26]  H. Ohta,et al.  A Signaling Principle for the Specification of the Germ Cell Lineage in Mice , 2009, Cell.

[27]  I. Pogribny,et al.  DNA hypomethylation in the origin and pathogenesis of human diseases , 2009, Cellular and Molecular Life Sciences.

[28]  D. Gilliland,et al.  Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML , 2009, Leukemia.

[29]  G. Ming,et al.  Neuronal Activity–Induced Gadd45b Promotes Epigenetic DNA Demethylation and Adult Neurogenesis , 2009, Science.

[30]  C. Sapienza,et al.  Conserved DNA methylation in Gadd45a-/- mice , 2009, Epigenetics.

[31]  U. Hoffmann‐Rohrer,et al.  TAF12 recruits Gadd45a and the nucleotide excision repair complex to the promoter of rRNA genes leading to active DNA demethylation. , 2009, Molecular cell.

[32]  M. Marshall,et al.  JBP1 and JBP2 are two distinct thymidine hydroxylases involved in J biosynthesis in genomic DNA of African trypanosomes , 2009, Nucleic acids research.

[33]  L. Selth,et al.  An Iron-Sulfur Cluster Domain in Elp3 Important for the Structural Integrity of Elongator* , 2009, Journal of Biological Chemistry.

[34]  B. Cairns,et al.  DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45 , 2008, Cell.

[35]  P. Leder,et al.  A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints. , 2008, Developmental cell.

[36]  T. Mikkelsen,et al.  Dissecting direct reprogramming through integrative genomic analysis , 2008, Nature.

[37]  T. Bestor,et al.  The Colorful History of Active DNA Demethylation , 2008, Cell.

[38]  S. Conticello The AID/APOBEC family of nucleic acid mutators , 2008, Genome Biology.

[39]  R. Jaenisch,et al.  Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development. , 2008, Genes & development.

[40]  J. Christman,et al.  Characterization of Dnmt3b:thymine-DNA glycosylase interaction and stimulation of thymine glycosylase-mediated repair by DNA methyltransferase(s) and RNA. , 2008, Journal of molecular biology.

[41]  Florian Nolte,et al.  Myelodysplastic syndromes: molecular pathogenesis and genomic changes , 2008, Annals of Hematology.

[42]  R. R. Ariza,et al.  Arabidopsis DEMETER-LIKE proteins DML2 and DML3 are required for appropriate distribution of DNA methylation marks , 2008, Plant Molecular Biology.

[43]  R. Lister,et al.  Highly Integrated Single-Base Resolution Maps of the Epigenome in Arabidopsis , 2008, Cell.

[44]  S. Nelson,et al.  Shotgun bisulphite sequencing of the Arabidopsis genome reveals DNA methylation patterning , 2008, Nature.

[45]  Vladimir Benes,et al.  Transient cyclical methylation of promoter DNA , 2008, Nature.

[46]  V. Beneš,et al.  Cyclical DNA methylation of a transcriptionally active promoter , 2008, Nature.

[47]  G. Pfeifer,et al.  GADD45A Does Not Promote DNA Demethylation , 2008, PLoS genetics.

[48]  H. Schöler,et al.  Pluripotential Reprogramming of the Somatic Genome in Hybrid Cells Occurs with the First Cell Cycle , 2008, Stem cells.

[49]  Peter A. Jones,et al.  Cancer epigenetics: modifications, screening, and therapy. , 2008 .

[50]  T. Ichisaka,et al.  Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors , 2007, Cell.

[51]  E. Li,et al.  Synergistic Function of DNA Methyltransferases Dnmt3a and Dnmt3b in the Methylation of Oct4 and Nanog , 2007, Molecular and Cellular Biology.

[52]  William Stafford Noble,et al.  Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project , 2007, Nature.

[53]  S. Henikoff,et al.  DNA demethylation in the Arabidopsis genome , 2007, Proceedings of the National Academy of Sciences.

[54]  M. Esteller Cancer epigenomics: DNA methylomes and histone-modification maps , 2007, Nature Reviews Genetics.

[55]  R. Hausinger,et al.  The protein that binds to DNA base J in trypanosomatids has features of a thymidine hydroxylase , 2007, Nucleic acids research.

[56]  Yi Zhang,et al.  Regulation of histone methylation by demethylimination and demethylation , 2007, Nature Reviews Molecular Cell Biology.

[57]  S. Yagi,et al.  Epigenetic regulation of Nanog gene in embryonic stem and trophoblast stem cells , 2007, Genes to cells : devoted to molecular & cellular mechanisms.

[58]  M. Waterman,et al.  Sterol 14α-Demethylase Cytochrome P450 (CYP51), a P450 in all Biological Kingdoms , 2007 .

[59]  Christof Niehrs,et al.  Gadd45a promotes epigenetic gene activation by repair-mediated DNA demethylation , 2007, Nature.

[60]  L. Sowers,et al.  Endogenous cytosine damage products alter the site selectivity of human DNA maintenance methyltransferase DNMT1. , 2007, Cancer research.

[61]  C. Walsh,et al.  Association of Dnmt3a and thymine DNA glycosylase links DNA methylation with base-excision repair , 2006, Nucleic acids research.

[62]  M. Bycroft,et al.  Solution structure of the nonmethyl‐CpG‐binding CXXC domain of the leukaemia‐associated MLL histone methyltransferase , 2006, The EMBO journal.

[63]  M. Rodgers,et al.  Specificity of human thymine DNA glycosylase depends on N-glycosidic bond stability. , 2006, Journal of the American Chemical Society.

[64]  Y. Yamauchi,et al.  Sperm Chromatin Remodeling after Intracytoplasmic Sperm Injection Differs from That of In Vitro Fertilization1 , 2006, Biology of reproduction.

[65]  Yi Zhang,et al.  JmjC-domain-containing proteins and histone demethylation , 2006, Nature Reviews Genetics.

[66]  S. Yamanaka,et al.  Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors , 2006, Cell.

[67]  Jian-Kang Zhu,et al.  Role of the Arabidopsis DNA glycosylase/lyase ROS1 in active DNA demethylation. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[68]  R. R. Ariza,et al.  DEMETER and REPRESSOR OF SILENCING 1 encode 5-methylcytosine DNA glycosylases. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[69]  H. Erdjument-Bromage,et al.  Histone demethylation by a family of JmjC domain-containing proteins , 2006, Nature.

[70]  Jon Penterman,et al.  DEMETER DNA Glycosylase Establishes MEDEA Polycomb Gene Self-Imprinting by Allele-Specific Demethylation , 2006, Cell.

[71]  P. Brick,et al.  The Elongator subunit Elp3 contains a Fe4S4 cluster and binds S‐adenosylmethionine , 2006, Molecular microbiology.

[72]  S. Muller,et al.  Asymmetry in Histone H3 variants and lysine methylation between paternal and maternal chromatin of the early mouse zygote , 2005, Mechanisms of Development.

[73]  T. Bestor,et al.  Eukaryotic cytosine methyltransferases. , 2005, Annual review of biochemistry.

[74]  J. Smiley,et al.  Genes of the thymidine salvage pathway: thymine-7-hydroxylase from a Rhodotorula glutinis cDNA library and iso-orotate decarboxylase from Neurospora crassa. , 2005, Biochimica et biophysica acta.

[75]  W. Reik,et al.  Dynamic chromatin modifications characterise the first cell cycle in mouse embryos. , 2005, Developmental biology.

[76]  Q. Zhan Gadd45a, a p53- and BRCA1-regulated stress protein, in cellular response to DNA damage. , 2005, Mutation research.

[77]  J. Fulka,et al.  DNA methylation pattern in human zygotes and developing embryos. , 2004, Reproduction.

[78]  Albert Jeltsch,et al.  The Dnmt1 DNA-(cytosine-C5)-methyltransferase Methylates DNA Processively with High Preference for Hemimethylated Target Sites* , 2004, Journal of Biological Chemistry.

[79]  A. Sancar,et al.  Molecular mechanisms of mammalian DNA repair and the DNA damage checkpoints. , 2004, Annual review of biochemistry.

[80]  W. Dean,et al.  Epigenetic reprogramming during early development in mammals. , 2004, Reproduction.

[81]  A. Bird,et al.  The effect of interspecific oocytes on demethylation of sperm DNA. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[82]  F. Aoki,et al.  Regulation of histone H3 lysine 9 methylation in oocytes and early pre-implantation embryos , 2004, Development.

[83]  Satoshi Tanaka,et al.  Epigenetic Control of Mouse Oct-4 Gene Expression in Embryonic Stem Cells and Trophoblast Stem Cells* , 2004, Journal of Biological Chemistry.

[84]  I. Wilmut,et al.  Non-conservation of mammalian preimplantation methylation dynamics , 2004, Current Biology.

[85]  A. Feinberg,et al.  The history of cancer epigenetics , 2004, Nature Reviews Cancer.

[86]  M. Surani,et al.  stella Is a Maternal Effect Gene Required for Normal Early Development in Mice , 2003, Current Biology.

[87]  Daisuke Hattori,et al.  DNA Methylation-Related Chromatin Remodeling in Activity-Dependent Bdnf Gene Regulation , 2003, Science.

[88]  P. Chambon,et al.  T:G Mismatch-specific Thymine-DNA Glycosylase Potentiates Transcription of Estrogen-regulated Genes through Direct Interaction with Estrogen Receptor α* , 2003, Journal of Biological Chemistry.

[89]  Y. Yamazaki,et al.  Reprogramming of primordial germ cells begins before migration into the genital ridge, making these cells inadequate donors for reproductive cloning , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[90]  Andrew J. Bannister,et al.  Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development , 2003, Development.

[91]  S. Mathew,et al.  TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23) , 2003, Leukemia.

[92]  A. Bird,et al.  Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals , 2003, Nature Genetics.

[93]  Wendy Dean,et al.  Epigenetic reprogramming in early mammalian development and following somatic nuclear transfer. , 2003, Seminars in cell & developmental biology.

[94]  W. Reik,et al.  Resistance of IAPs to methylation reprogramming may provide a mechanism for epigenetic inheritance in the mouse , 2003, Genesis.

[95]  Ronald H. Schwartz,et al.  Selective, stable demethylation of the interleukin-2 gene enhances transcription by an active process , 2003, Nature Immunology.

[96]  A. Shearn,et al.  The ubiquitin ligase Hyperplastic discs negatively regulates hedgehog and decapentaplegic expression by independent mechanisms , 2002, Development.

[97]  R. R. Ariza,et al.  ROS1, a Repressor of Transcriptional Gene Silencing in Arabidopsis, Encodes a DNA Glycosylase/Lyase , 2002, Cell.

[98]  Peter A. Jones,et al.  Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2'-deoxycytidine (decitabine) treatment. , 2002, Blood.

[99]  Y. Bergman,et al.  A Unique Developmental Pattern of Oct-3/4DNA Methylation Is Controlled by a cis-demodification Element* , 2002, The Journal of Biological Chemistry.

[100]  Erling Seeberg,et al.  AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli , 2002, Nature.

[101]  Robert P. Hausinger,et al.  Oxidative demethylation by Escherichia coli AlkB directly reverts DNA base damage , 2002, Nature.

[102]  M. Siegmann,et al.  Estradiol receptor potentiates, in vitro, the activity of 5‐methylcytosine DNA glycosylase , 2002, FEBS letters.

[103]  M. Surani,et al.  Epigenetic reprogramming in mouse primordial germ cells , 2002, Mechanisms of Development.

[104]  A. Bird,et al.  Enhanced CpG Mutability and Tumorigenesis in MBD4-Deficient Mice , 2002, Science.

[105]  Y. Hayashi,et al.  LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23). , 2002, Cancer research.

[106]  S. Jacobsen,et al.  DEMETER, a DNA Glycosylase Domain Protein, Is Required for Endosperm Gene Imprinting and Seed Viability in Arabidopsis , 2002, Cell.

[107]  Peter A. Jones,et al.  The fundamental role of epigenetic events in cancer , 2002, Nature Reviews Genetics.

[108]  J. Holland,et al.  Randomized controlled trial of azacitidine in patients with the myelodysplastic syndrome: a study of the cancer and leukemia group B. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[109]  Tony Kouzarides,et al.  Histone methylation defines epigenetic asymmetry in the mouse zygote. , 2002, The International journal of developmental biology.

[110]  N. Ogonuki,et al.  Erasing genomic imprinting memory in mouse clone embryos produced from day 11.5 primordial germ cells. , 2002, Development.

[111]  D. Gilbert,et al.  Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals , 2002, Chromosoma.

[112]  D. Reinberg,et al.  Human Elongator facilitates RNA polymerase II transcription through chromatin , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[113]  H. Erdjument-Bromage,et al.  Purification and Characterization of the Human Elongator Complex* , 2002, The Journal of Biological Chemistry.

[114]  M. Surani,et al.  Genome-wide methylation patterns in normal and uniparental early mouse embryos. , 2001, Human molecular genetics.

[115]  W Dean,et al.  Conservation of methylation reprogramming in mammalian development: Aberrant reprogramming in cloned embryos , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[116]  Stuart M. Brown,et al.  Definitive Identification of Mammalian 5-Hydroxymethyluracil DNAN-Glycosylase Activity as SMUG1* , 2001, The Journal of Biological Chemistry.

[117]  Norio Nakatsuji,et al.  Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells , 2001, Current Biology.

[118]  C. Allis,et al.  Translating the Histone Code , 2001, Science.

[119]  A. Bird,et al.  Closely related proteins MBD2 and MBD3 play distinctive but interacting roles in mouse development. , 2001, Genes & development.

[120]  M. Siegmann,et al.  5-Methylcytosine DNA glycosylase activity is also present in the human MBD4 (G/T mismatch glycosylase) and in a related avian sequence. , 2000, Nucleic acids research.

[121]  A. Fischer,et al.  Activation-Induced Cytidine Deaminase (AID) Deficiency Causes the Autosomal Recessive Form of the Hyper-IgM Syndrome (HIGM2) , 2000, Cell.

[122]  T. Honjo,et al.  Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme , 2000, Cell.

[123]  M. Siegmann,et al.  5-methylcytosine-DNA glycosylase activity is present in a cloned G/T mismatch DNA glycosylase associated with the chicken embryo DNA demethylation complex. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[124]  W. Reik,et al.  Active demethylation of the paternal genome in the mouse zygote , 2000, Current Biology.

[125]  J. Walter,et al.  Embryogenesis: Demethylation of the zygotic paternal genome , 2000, Nature.

[126]  D. Haber,et al.  DNA Methyltransferases Dnmt3a and Dnmt3b Are Essential for De Novo Methylation and Mammalian Development , 1999, Cell.

[127]  A. Bird,et al.  The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites , 1999, Nature.

[128]  Paul Tempst,et al.  MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex , 1999, Nature Genetics.

[129]  F. Fuller-Pace,et al.  A chicken embryo protein related to the mammalian DEAD box protein p68 is tightly associated with the highly purified protein-RNA complex of 5-MeC-DNA glycosylase. , 1999, Nucleic acids research.

[130]  R. Schultz,et al.  DNA replication in the 1-cell mouse embryo: stimulatory effect of histone acetylation , 1999, Zygote.

[131]  M. Szyf,et al.  A mammalian protein with specific demethylase activity for mCpG DNA , 1999, Nature.

[132]  H. Cedar,et al.  Analysis of putative RNase sensitivity and protease insensitivity of demethylation activity in extracts from rat myoblasts. , 1998, Nucleic acids research.

[133]  M Plachot,et al.  Chromosome methylation patterns during mammalian preimplantation development. , 1998, Genes & development.

[134]  E. Li,et al.  Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases , 1998, Nature Genetics.

[135]  Jörn Walter,et al.  The pre-implantation ontogeny of the H19 methylation imprint , 1997, Nature Genetics.

[136]  C. Bouniol-Baly,et al.  Dynamic organization of DNA replication in one-cell mouse embryos: relationship to transcriptional activation. , 1997, Experimental cell research.

[137]  M. Siegmann,et al.  Demethylation of DNA by purified chick embryo 5-methylcytosine-DNA glycosylase requires both protein and RNA. , 1997, Nucleic acids research.

[138]  M. Carmo-Fonseca,et al.  Genome replication in early mouse embryos follows a defined temporal and spatial order. , 1997, Journal of cell science.

[139]  F. Aoki,et al.  Regulation of transcriptional activity during the first and second cell cycles in the preimplantation mouse embryo. , 1997, Developmental biology.

[140]  P. O'Connor,et al.  Antisense GADD45 expression results in decreased DNA repair and sensitizes cells to u.v.-irradiation or cisplatin. , 1996, Oncogene.

[141]  A. Razin,et al.  DNA Demethylation In Vitro: Involvement of RNA , 1996, Cell.

[142]  A. Yang,et al.  Methylation inhibitors can increase the rate of cytosine deamination by (cytosine-5)-DNA methyltransferase. , 1996, Nucleic acids research.

[143]  J. Morrison,et al.  Apolipoprotein B RNA editing enzyme-deficient mice are viable despite alterations in lipoprotein metabolism. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[144]  L. Sowers,et al.  Photochemical deamination and demethylation of 5-methylcytosine. , 1996, Chemical research in toxicology.

[145]  Robert V Farese,et al.  Targeted Disruption of the Mouse apobec-1 Gene Abolishes Apolipoprotein B mRNA Editing and Eliminates Apolipoprotein B48 (*) , 1996, The Journal of Biological Chemistry.

[146]  A. Bhagwat,et al.  A cytosine methyltransferase converts 5-methylcytosine in DNA to thymine. , 1995, Biochemistry.

[147]  M. Wyszynski,et al.  HpaII methyltransferase is mutagenic in Escherichia coli , 1995, Journal of bacteriology.

[148]  M. Siegmann,et al.  Mechanisms of DNA Demethylation in Chicken Embryos , 1995, The Journal of Biological Chemistry.

[149]  P. O'Connor,et al.  Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen. , 1994, Science.

[150]  M. Wyszynski,et al.  Cytosine deaminations catalyzed by DNA cytosine methyltransferases are unlikely to be the major cause of mutational hot spots at sites of cytosine methylation in Escherichia coli. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[151]  J. Morrison,et al.  The p27 catalytic subunit of the apolipoprotein B mRNA editing enzyme is a cytidine deaminase. , 1993, The Journal of biological chemistry.

[152]  C. Burant,et al.  Molecular cloning of an apolipoprotein B messenger RNA editing protein. , 1993, Science.

[153]  J. Jost,et al.  Nuclear extracts of chicken embryos promote an active demethylation of DNA by excision repair of 5-methyldeoxycytidine. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[154]  Peter A. Jones,et al.  High frequency mutagenesis by a DNA methyltransferase , 1992, Cell.

[155]  T. Bestor,et al.  Properties and localization of DNA methyltransferase in preimplantation mouse embryos: implications for genomic imprinting. , 1992, Genes & development.

[156]  Rudolf Jaenisch,et al.  Targeted mutation of the DNA methyltransferase gene results in embryonic lethality , 1992, Cell.

[157]  W. Reik,et al.  Methylation levels of maternal and paternal genomes during preimplantation development. , 1991, Development.

[158]  V. Ingram,et al.  Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. , 1988, Journal of molecular biology.

[159]  G. Teebor,et al.  5-Hydroxymethylcytosine DNA glycosylase activity in mammalian tissue. , 1988, Biochemical and biophysical research communications.

[160]  S. Lehnert,et al.  Temporal and regional changes in DNA methylation in the embryonic, extraembryonic and germ cell lineages during mouse embryo development. , 1987, Development.

[161]  S. Howlett,et al.  Sequence and regulation of morphological and molecular events during the first cell cycle of mouse embryogenesis. , 1985, Journal of embryology and experimental morphology.

[162]  M. T. Abbott,et al.  Markedly different ascorbate dependencies of the sequential alpha-ketoglutarate dioxygenase reactions catalyzed by an essentially homogeneous thymine 7-hydroxylase from Rhodotorula glutinis. , 1983, The Journal of biological chemistry.

[163]  V. Ingram,et al.  Two DNA methyltransferases from murine erythroleukemia cells: purification, sequence specificity, and mode of interaction with DNA. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[164]  D. Martin,et al.  Presence of a DNA demethylating activity in the nucleus of murine erythroleukemic cells. , 1982, The Journal of biological chemistry.

[165]  R. Kothari,et al.  5-methylcytosine content in the vertebrate deoxyribonucleic acids: Species specificity , 1976, Journal of Molecular Evolution.

[166]  F. Luthardt,et al.  Pronuclear DNA synthesis in mouse eggs. An autoradiographic study. , 1973, Experimental cell research.

[167]  K. Bojanowski,et al.  The presence of 5-hydroxymethylcytosine in animal deoxyribonucleic acid. , 1972, The Biochemical journal.

[168]  A. Alegría Hydroxymethylation of pyrimidine mononucleotides with formaldehyde. , 1967, Biochimica et biophysica acta.

[169]  Albert Jeltsch,et al.  Cyclical DNA methylation of a transcriptionally active promoter , 2008, Nature.

[170]  David R. Liu,et al.  Conversion of 5-Methylcytosine to 5- Hydroxymethylcytosine in Mammalian DNA by the MLL Partner TET1 , 2009 .

[171]  C. Santos-Rebouças,et al.  Implication of abnormal epigenetic patterns for human diseases , 2007, European Journal of Human Genetics.

[172]  Satoshi Tanaka,et al.  PGC7/Stella protects against DNA demethylation in early embryogenesis , 2007, Nature Cell Biology.

[173]  S. Henikoff,et al.  Genome-wide analysis of Arabidopsis thaliana DNA methylation uncovers an interdependence between methylation and transcription , 2007, Nature Genetics.

[174]  H. Ohta,et al.  Epigenetic abnormalities of the mouse paternal zygotic genome associated with microinsemination of round spermatids. , 2006, Developmental biology.

[175]  Andrew J. Bannister,et al.  Dynamic distribution of the replacement histone variant H3.3 in the mouse oocyte and preimplantation embryos. , 2006, The International journal of developmental biology.

[176]  A. Bird,et al.  Oxidative damage to methyl-CpG sequences inhibits the binding of the methyl-CpG binding domain (MBD) of methyl-CpG binding protein 2 (MeCP2). , 2004, Nucleic acids research.

[177]  Wendy Dean,et al.  Dynamic reprogramming of DNA methylation in the early mouse embryo. , 2002, Developmental biology.

[178]  C. Wylie Primordial germ cells , 1980, Nature.

[179]  Identification and Characterization of a Family of Mammalian Methyl-CpG Binding Proteins , 2022 .