Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components.

[1]  C. Der,et al.  GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors , 2005, Nature Reviews Molecular Cell Biology.

[2]  Gregory P Tochtrop,et al.  Target identification strategies in chemical genetics. , 2004, Combinatorial chemistry & high throughput screening.

[3]  Mingsheng Zhang,et al.  Ubistatins Inhibit Proteasome-Dependent Degradation by Binding the Ubiquitin Chain , 2004, Science.

[4]  E. Brown,et al.  Multicopy suppressors for novel antibacterial compounds reveal targets and drug efflux susceptibility. , 2004, Chemistry & biology.

[5]  S. Gygi,et al.  Toca-1 Mediates Cdc42-Dependent Actin Nucleation by Activating the N-WASP-WIP Complex , 2004, Cell.

[6]  M. Kirschner,et al.  Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation , 2004, Nature Structural &Molecular Biology.

[7]  L. Machesky,et al.  Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex. , 2004, The Biochemical journal.

[8]  L. Burdine,et al.  Target identification in chemical genetics: the (often) missing link. , 2004, Chemistry & biology.

[9]  Timothy J Mitchison,et al.  Small molecules, big impact: a history of chemical inhibitors and the cytoskeleton. , 2002, Chemistry & biology.

[10]  John Sondek,et al.  A crystallographic view of interactions between Dbs and Cdc42: PH domain‐assisted guanine nucleotide exchange , 2002, The EMBO journal.

[11]  M. Kirschner,et al.  A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[12]  B. Stockwell Chemical genetics: ligand-based discovery of gene function , 2000, Nature Reviews Genetics.

[13]  B. Hinz,et al.  Actin-dependent lamellipodia formation and microtubule-dependent tail retraction control-directed cell migration. , 2000, Molecular biology of the cell.

[14]  Yi Zheng,et al.  The Role of Mg2+ Cofactor in the Guanine Nucleotide Exchange and GTP Hydrolysis Reactions of Rho Family GTP-binding Proteins* , 2000, The Journal of Biological Chemistry.

[15]  Gregory R. Hoffman,et al.  Structure of the Rho Family GTP-Binding Protein Cdc42 in Complex with the Multifunctional Regulator RhoGDI , 2000, Cell.

[16]  G. Bokoch,et al.  Characterization of Rac and Cdc42 Activation in Chemoattractant-stimulated Human Neutrophils Using a Novel Assay for Active GTPases* , 1999, The Journal of Biological Chemistry.

[17]  M. Kirschner,et al.  The Interaction between N-WASP and the Arp2/3 Complex Links Cdc42-Dependent Signals to Actin Assembly , 1999, Cell.

[18]  Paul A. Janmey,et al.  Corequirement of Specific Phosphoinositides and Small GTP-binding Protein Cdc42 in Inducing Actin Assembly in Xenopus Egg Extracts , 1998, The Journal of cell biology.

[19]  G. Bokoch,et al.  Requirements for Both Rac1 and Cdc42 in Membrane Ruffling and Phagocytosis in Leukocytes , 1997, The Journal of experimental medicine.

[20]  Anne J. Ridley,et al.  The small GTP-binding protein rac regulates growth factor-induced membrane ruffling , 1992, Cell.

[21]  J. Rothman,et al.  Purification of an N-ethylmaleimide-sensitive protein catalyzing vesicular transport. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[22]  Mark Stamnes,et al.  Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro , 2006, Nature chemical biology.

[23]  Peter G Schultz,et al.  A genome-wide overexpression screen in yeast for small-molecule target identification. , 2005, Chemistry & biology.

[24]  P. Schultz,et al.  Identification of a novel protein regulating microtubule stability through a chemical approach. , 2004, Chemistry & biology.

[25]  A. Murray,et al.  The use of Xenopus egg extracts to study mitotic spindle assembly and function in vitro. , 1999, Methods in cell biology.