In vitro ocular metabolism and bioactivation of ketoconazole in rat, rabbit and human.
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[1] Christine E. Dunne,et al. Ocular Metabolism of Levobunolol: Historic and Emerging Metabolic Pathways , 2016, Drug Metabolism and Disposition.
[2] U. Argikar,et al. An in vitro approach to investigate ocular metabolism of a topical, selective β1-adrenergic blocking agent, betaxolol , 2015, Xenobiotica; the fate of foreign compounds in biological systems.
[3] P. Thomas,et al. Mycotic keratitis: epidemiology, diagnosis and management. , 2013, Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
[4] P. Asbell,et al. Therapeutic Dilemmas in External Ocular Diseases , 1991, Drugs.
[5] R. N. Brogden,et al. Ketoconazole: A Review of its Therapeutic Efficacy in Superficial and Systemic Fungal Infections , 2012, Drugs.
[6] U. Argikar,et al. An experimental approach to enhance precursor ion fragmentation for metabolite identification studies: application of dual collision cells in an orbital trap. , 2011, Rapid communications in mass spectrometry : RCM.
[7] L. P. Mašič. Role of cyclic tertiary amine bioactivation to reactive iminium species: structure toxicity relationship. , 2011, Current drug metabolism.
[8] U. Argikar,et al. Identification of a Novel N-Carbamoyl Glucuronide: In Vitro, In Vivo, and Mechanistic Studies , 2010, Drug Metabolism and Disposition.
[9] S. Kocsubé,et al. Infectious Keratitis Caused by Aspergillus tubingensis , 2009, Cornea.
[10] Yuan Chen,et al. Revisiting the metabolism of ketoconazole using accurate mass. , 2009, Drug metabolism letters.
[11] Huiyun Xia,et al. Ocular pharmacokinetics of topically-applied ketoconazole solution containing hydroxypropyl beta-cyclodextrin to rabbits. , 2008, Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.
[12] N. Scheinfeld. Ketoconazole: a review of a workhorse antifungal molecule with a focus on new foam and gel formulations. , 2008, Drugs of Today.
[13] H. Yamazaki,et al. Comparison of kinetic parameters for drug oxidation rates and substrate inhibition potential mediated by cytochrome P450 3A4 and 3A5. , 2008, Current drug metabolism.
[14] P. Crooks,et al. Phase I and phase II ocular metabolic activities and the role of metabolism in ophthalmic prodrug and codrug design and delivery. , 2007, Molecules.
[15] R. Obach,et al. METABOLISM OF NOMIFENSINE TO A DIHYDROISOQUINOLINIUM ION METABOLITE BY HUMAN MYELOPEROXIDASE, HEMOGLOBIN, MONOAMINE OXIDASE A, AND CYTOCHROME P450 ENZYMES , 2006, Drug Metabolism and Disposition.
[16] R. Riley,et al. Comparative analysis of substrate and inhibitor interactions with CYP3A4 and CYP3A5 , 2006, Xenobiotica; the fate of foreign compounds in biological systems.
[17] Kayo Nakamura,et al. Age, gender and region-specific differences in drug metabolising enzymes in rat ocular tissues. , 2005, Experimental eye research.
[18] Li Liang,et al. Cyanide trapping of iminium ion reactive intermediates followed by detection and structure identification using liquid chromatography-tandem mass spectrometry (LC-MS/MS). , 2005, Chemical research in toxicology.
[19] Sapna Sharma,et al. Clinical and experimental mycotic corneal ulcer caused by Aspergillus fumigatus and the effect of oral ketoconazole in the treatment , 1989, Mycopathologia.
[20] E. Oji. Study of ketoconazole toxiciy in rabbit cornea and conjuctiva , 1982, International Ophthalmology.
[21] Darlene Miller,et al. Advanced Fusarium Keratitis Progressing to Endophthalmitis , 2003, Cornea.
[22] C. Miranda,et al. Isoform specificity of N-deacetyl ketoconazole by human and rabbit flavin-containing monooxygenases. , 2000, Drug metabolism and disposition: the biological fate of chemicals.
[23] D. Acosta,et al. Metabolism of ketoconazole and deacetylated ketoconazole by rat hepatic microsomes and flavin-containing monooxygenases. , 1997, Drug metabolism and disposition: the biological fate of chemicals.
[24] J. Zamecnik,et al. Mouse hepatic metabolites of ketoconazole: isolation and structure elucidation. , 1994, Journal of pharmaceutical and biomedical analysis.
[25] R. H. Rosa,et al. The changing spectrum of fungal keratitis in south Florida. , 1994, Ophthalmology.
[26] Fitzke Fw,et al. The diagnosis of visual field progression in glaucoma. , 1994 .
[27] L. Martínez,et al. Topical ketoconazole for fungal keratitis. , 1985, American journal of ophthalmology-glaucoma.
[28] J. Shock,et al. Treatment of Aspergillus fumigatus keratitis in rabbits with oral and topical ketoconazole. , 1985, American journal of ophthalmology.
[29] Y. Ishibashi. Oral ketoconazole therapy for keratomycosis. , 1983, American journal of ophthalmology.
[30] C. Foster,et al. Ocular toxicity of topical antifungal agents. , 1981, Archives of ophthalmology.