Neural Interactions That Give Rise to Musical Pleasure

Music is arguably one of the most potent rewards, existing in all cultures as far back as history dates, and currently reported to be among the most pleasurable stimuli by most individuals. In this review, we summarize the literature to investigate how a mere sequence of sound events can become so pleasurable. We examine the role of the brain’s mesolimbic reward and reinforcement circuitry in processing of rewards, and how the connectivity of this system has become more integrated with higher-order brain regions involved in complex thought to give rise to abstract pleasures. We suggest an integrative role for complex cortical processes with long-existing reinforcement circuits and an interaction between sensory processing and decoding mechanisms and affective processing.

[1]  D. Västfjäll,et al.  Emotional responses to music: the need to consider underlying mechanisms. , 2008, The Behavioral and brain sciences.

[2]  I. Peretz,et al.  Impaired recognition of scary music following unilateral temporal lobe excision. , 2005, Brain : a journal of neurology.

[3]  E. Newport,et al.  WORD SEGMENTATION : THE ROLE OF DISTRIBUTIONAL CUES , 1996 .

[4]  L. Shatin The influence of rhythmic drumbeat stimuli upon the pulse rate and general activity of long-term schizophrenics. , 1957, The Journal of mental science.

[5]  Elizabeth Hellmuth Margulis,et al.  Timbre priming effects and expectation in melody , 2006 .

[6]  M. Laruelle Imaging Synaptic Neurotransmission with in Vivo Binding Competition Techniques: A Critical Review , 2000, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[7]  G. Sedvall,et al.  Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects. , 1992, Archives of general psychiatry.

[8]  Daniel J. Levitin,et al.  The rewards of music listening: Response and physiological connectivity of the mesolimbic system , 2005, NeuroImage.

[9]  Jay A. Gottfried,et al.  Neurobiology of Sensation and Reward , 2011 .

[10]  P. Janata,et al.  Characterisation of music-evoked autobiographical memories , 2007, Memory.

[11]  Justin S. Feinstein,et al.  Increased amygdala and insula activation during emotion processing in anxiety-prone subjects. , 2007, The American journal of psychiatry.

[12]  J. Wallis Orbitofrontal cortex and its contribution to decision-making. , 2007, Annual review of neuroscience.

[13]  I. Peretz,et al.  Music and emotion: perceptual determinants, immediacy, and isolation after brain damage , 1998, Cognition.

[14]  H. Heinze,et al.  Mesolimbic Functional Magnetic Resonance Imaging Activations during Reward Anticipation Correlate with Reward-Related Ventral Striatal Dopamine Release , 2008, The Journal of Neuroscience.

[15]  A. Goldstein Opioid peptides endorphins in pituitary and brain. , 1976, Science.

[16]  Klaus-Ernst Behne,et al.  The development of "Musikerleben" in adolescence: How and why young people listen to music. , 1997 .

[17]  J. Panksepp The emotional sources of "chills" induced by music. , 1995 .

[18]  A. Gabrielsson Emotions in strong experiences with music. , 2001 .

[19]  R. Zatorre,et al.  When the brain plays music: auditory–motor interactions in music perception and production , 2007, Nature Reviews Neuroscience.

[20]  S. Koelsch Towards a neural basis of music-evoked emotions , 2010, Trends in Cognitive Sciences.

[21]  Elizabeth K. Johnson,et al.  Statistical learning of tone sequences by human infants and adults , 1999, Cognition.

[22]  M. Bradley,et al.  Measuring emotion: Behavior, feeling, and physiology , 2000 .

[23]  P. Fox,et al.  Differential limbic–cortical correlates of sadness and anxiety in healthy subjects: implications for affective disorders , 2000, Biological Psychiatry.

[24]  A. Routtenberg,et al.  Effects of the availability of rewarding septal and hypothalamic stimulation on bar pressing for food under conditions of deprivation. , 1965, Journal of comparative and physiological psychology.

[25]  L. Jäncke Music, memory and emotion , 2008, Journal of biology.

[26]  J. Bharucha,et al.  Reaction time and musical expectancy: priming of chords. , 1986, Journal of experimental psychology. Human perception and performance.

[27]  K. Henke A model for memory systems based on processing modes rather than consciousness , 2010, Nature Reviews Neuroscience.

[28]  R. Heath Pleasure response of human subjects to direct stimulation of the brain: Physiologic and psychodynamic considerations , 1964 .

[29]  R. Wise Catecholamine theories of reward: A critical review , 1978, Brain Research.

[30]  Malgorzata Kopacz Personality and music preferences: the influence of personality traits on preferences regarding musical elements. , 2005, Journal of music therapy.

[31]  James M. Kilner,et al.  Brain systems for assessing facial attractiveness , 2007, Neuropsychologia.

[32]  Michael J. Martinez,et al.  Passive music listening spontaneously engages limbic and paralimbic systems , 2004, Neuroreport.

[33]  A. Phillips,et al.  Sexual behavior increases dopamine transmission in the nucleus accumbens and striatum of male rats: comparison with novelty and locomotion. , 1992 .

[34]  P. Janicak,et al.  Molecular Neuropharmacology: A Foundation for Clinical Neuroscience , 2002 .

[35]  J. Sloboda,et al.  Emotions in everyday listening to music. , 2001 .

[36]  M. Goldsmith,et al.  Statistical Learning by 8-Month-Old Infants , 1996 .

[37]  E. Newport,et al.  Computation of Conditional Probability Statistics by 8-Month-Old Infants , 1998 .

[38]  Sylvia M. L. Cox,et al.  Striatal Dopamine Responses to Intranasal Cocaine Self-Administration in Humans , 2009, Biological Psychiatry.

[39]  Barbara Tillmann,et al.  Effects of Global and Local Contexts on Harmonic Expectancy , 1998 .

[40]  Antonio Damasio,et al.  The somatic marker hypothesis: A neural theory of economic decision , 2005, Games Econ. Behav..

[41]  J. Sloboda,et al.  Music and emotion: Theory and research , 2001 .

[42]  P. Gomez,et al.  Relationships between musical structure and psychophysiological measures of emotion. , 2007, Emotion.

[43]  C. Darwin The Descent of Man and Selection in Relation to Sex: INDEX , 1871 .

[44]  S. Wise,et al.  Interactions between orbital prefrontal cortex and amygdala: advanced cognition, learned responses and instinctive behaviors , 2010, Current Opinion in Neurobiology.

[45]  Kent C. Berridge,et al.  Pleasures of the brain , 2003, Brain and Cognition.

[46]  Alan C. Evans,et al.  Emotional responses to pleasant and unpleasant music correlate with activity in paralimbic brain regions , 1999, Nature Neuroscience.

[47]  Mitul A. Mehta,et al.  The dopaminergic basis of human behaviors: A review of molecular imaging studies , 2009, Neuroscience & Biobehavioral Reviews.

[48]  J. Panksepp,et al.  Emotional sounds and the brain: the neuro-affective foundations of musical appreciation , 2002, Behavioural Processes.

[49]  Yul-Wan Sung,et al.  Functional magnetic resonance imaging , 2004, Scholarpedia.

[50]  H. Fibiger,et al.  Sexual activity increases dopamine transmission in the nucleus accumbens and striatum of female rats , 1995, Brain Research.

[51]  Monique Ernst,et al.  Increased Occupancy of Dopamine Receptors in Human Striatum during Cue-Elicited Cocaine Craving , 2007, Neuropsychopharmacology.

[52]  Brian Knutson,et al.  Linking nucleus accumbens dopamine and blood oxygenation , 2007, Psychopharmacology.

[53]  E. Bigand,et al.  Global context effects on musical expectancy , 1997, Perception & psychophysics.

[54]  R. Wise Brain Reward Circuitry Insights from Unsensed Incentives , 2002, Neuron.

[55]  Jean Logan,et al.  Imaging endogenous dopamine competition with [11C]raclopride in the human brain , 1994, Synapse.

[56]  C. Cannon,et al.  Is dopamine required for natural reward? , 2004, Physiology & Behavior.

[57]  J. Bharucha Tonality and expectation. , 1994 .

[58]  Alberto Fernández,et al.  Activation of the prefrontal cortex in the human visual aesthetic perception. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[59]  A. Dagher,et al.  Alcohol promotes dopamine release in the human nucleus accumbens , 2003, Synapse.

[60]  P. Sedlmeier,et al.  The functions of music and their relationship to music preference in India and Germany. , 2012, International journal of psychology : Journal international de psychologie.

[61]  Carol Krumhansl,et al.  Psychophysiology of Musical Emotions , 1997, ICMC.

[62]  H. P. Weld,et al.  An Experimental Study of Musical Enjoyment , 1912 .

[63]  L. Hazrati,et al.  Functional anatomy of the basal ganglia , 1995 .

[64]  Marcus E Raichle,et al.  Glucose metabolism in the amygdala in depression: Relationship to diagnostic subtype and plasma cortisol levels , 2002, Pharmacology Biochemistry and Behavior.

[65]  P. Glimcher,et al.  Midbrain Dopamine Neurons Encode a Quantitative Reward Prediction Error Signal , 2005, Neuron.

[66]  M. Zentner,et al.  Mapping Aesthetic Musical Emotions in the Brain , 2011, Cerebral cortex.

[67]  Walter A. Siebel,et al.  Opinion TRENDS in Cognitive Sciences Vol.9 No.12 December 2005 Towards , 2022 .

[68]  J. Russell A circumplex model of affect. , 1980 .

[69]  John A. Sloboda,et al.  Empirical studies of emotional response to music. , 1992 .

[70]  K. Scherer,et al.  Emotions evoked by the sound of music: characterization, classification, and measurement. , 2008, Emotion.

[71]  J. O'Doherty,et al.  Evidence for a Common Representation of Decision Values for Dissimilar Goods in Human Ventromedial Prefrontal Cortex , 2009, The Journal of Neuroscience.

[72]  A. Ettenberg,et al.  Sexually conditioned incentives: Attenuation of motivational impact during dopamine receptor antagonism , 2002, Pharmacology Biochemistry and Behavior.

[73]  G. Schlaug,et al.  Amygdala activity can be modulated by unexpected chord functions during music listening , 2008, Neuroreport.

[74]  S. Vanderark,et al.  Biochemical and Galvanic Skin Responses to Music Stimuli by College Students in Biology and Music , 1992, Perceptual and motor skills.

[75]  E. Newport,et al.  PSYCHOLOGICAL SCIENCE Research Article INCIDENTAL LANGUAGE LEARNING: Ustening (and Learning) out of the Comer of Your Ear , 2022 .

[76]  D. Yves von Cramon,et al.  Brain correlates of aesthetic judgment of beauty , 2006, NeuroImage.

[77]  Mari Riess Jones,et al.  Cognitive Bases of Musical Communication , 1992 .

[78]  J. Korf,et al.  The Neurobiology of dopamine , 1979 .

[79]  James L Olds Drives and reinforcements : behavioral studies of hypothalamic functions / by James Olds , 1977 .

[80]  N. Rickard Intense emotional responses to music: a test of the physiological arousal hypothesis , 2004 .

[81]  H. Critchley,et al.  Cerebral correlates of autonomic cardiovascular arousal: a functional neuroimaging investigation in humans , 2000, The Journal of physiology.

[82]  C. Stevens,et al.  Aquaporin 4 and glymphatic flow have central roles in brain fluid homeostasis , 2021, Nature Reviews Neuroscience.

[83]  Thomas Suddendorf,et al.  Foresight and Evolution of the Human Mind , 2006, Science.

[84]  J. Sloboda Music Structure and Emotional Response: Some Empirical Findings , 1991 .

[85]  F. Bloom,et al.  Brain, Mind, and Behavior , 1985 .

[86]  P. Janata,et al.  Activation of the inferior frontal cortex in musical priming. , 2003, Annals of the New York Academy of Sciences.

[87]  D. Brooks,et al.  Evidence for striatal dopamine release during a video game , 1998, Nature.

[88]  J. Yelnik Functional anatomy of the basal ganglia , 2002, Movement disorders : official journal of the Movement Disorder Society.

[89]  Leonard B. Meyer Emotion and Meaning in Music , 1957 .

[90]  A. Goldstein Thrills in response to music and other stimuli , 1980 .

[91]  G. Di Chiara,et al.  Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[92]  Stefan Koelsch,et al.  The Role of Harmonic Expectancy Violations in Musical Emotions: Evidence from Subjective, Physiological, and Neural Responses , 2006, Journal of Cognitive Neuroscience.

[93]  R. Kopiez,et al.  Listening To Music As A Re-Creative Process: Physiological, Psychological, And Psychoacoustical Correlates Of Chills And Strong Emotions , 2007 .

[94]  P. Janata The Neural Architecture of Music-Evoked Autobiographical Memories , 2009, Cerebral cortex.

[95]  J. Hollerman,et al.  Dopamine neurons report an error in the temporal prediction of reward during learning , 1998, Nature Neuroscience.

[96]  L. Heimer The Olfactory Cortex and the Ventral Striatum , 1978 .

[97]  Tuomas Eerola,et al.  The role of mood and personality in the perception of emotions represented by music , 2011, Cortex.

[98]  C. Frith,et al.  Anticipation is the key to understanding music and the effects of music on emotion , 2008 .

[99]  S. Haber,et al.  The Reward Circuit: Linking Primate Anatomy and Human Imaging , 2010, Neuropsychopharmacology.

[100]  S. Haber,et al.  Imaging Human Mesolimbic Dopamine Transmission with Positron Emission Tomography. Part II: Amphetamine-Induced Dopamine Release in the Functional Subdivisions of the Striatum , 2003, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[101]  E. Altenmüller,et al.  Emotions over time: synchronicity and development of subjective, physiological, and facial affective reactions to music. , 2007, Emotion.

[102]  J. O'Doherty,et al.  Reward representations and reward-related learning in the human brain: insights from neuroimaging , 2004, Current Opinion in Neurobiology.

[103]  D. Charney,et al.  Spect imaging of striatal dopamine release after amphetamine challenge in humans: Relationship between subjective effects and dopamine release , 1995, Schizophrenia Research.

[104]  B. Everitt,et al.  Cocaine Seeking Habits Depend upon Dopamine-Dependent Serial Connectivity Linking the Ventral with the Dorsal Striatum , 2008, Neuron.

[105]  R. Dolan,et al.  Dopamine-dependent prediction errors underpin reward-seeking behaviour in humans , 2006, Nature.

[106]  K. Carr Augmentation of drug reward by chronic food restriction Behavioral evidence and underlying mechanisms , 2002, Physiology & Behavior.

[107]  J. W. Papez THE NEUROBIOLOGY OF EMOTION , 2004 .

[108]  Brian Knutson,et al.  Anticipation of Increasing Monetary Reward Selectively Recruits Nucleus Accumbens , 2001, The Journal of Neuroscience.

[109]  Midbrain Dopamine Neurons and Adult Neurogenesis , 2012 .

[110]  R. Zatorre,et al.  Intensely pleasurable responses to music correlate with activity in brain regions implicated in reward and emotion , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[111]  J. Cacioppo,et al.  Handbook Of Psychophysiology , 2019 .

[112]  M. Thaut,et al.  The Influence of Subject-Selected versus Experimenter-Chosen Music on Affect, Anxiety, and Relaxation , 1993 .

[113]  Simon B. Eickhoff,et al.  Naturalizing aesthetics: Brain areas for aesthetic appraisal across sensory modalities , 2011, NeuroImage.

[114]  Talma Hendler,et al.  Eyes Wide Shut: Amygdala Mediates Eyes-Closed Effect on Emotional Experience with Music , 2009, PloS one.

[115]  R. Zatorre,et al.  Individual Differences in Music Reward Experiences , 2013 .

[116]  H. Critchley Neural mechanisms of autonomic, affective, and cognitive integration , 2005, The Journal of comparative neurology.

[117]  Karine Sergerie,et al.  The role of the amygdala in emotional processing: A quantitative meta-analysis of functional neuroimaging studies , 2008, Neuroscience & Biobehavioral Reviews.

[118]  I. Peretz,et al.  Evidence of lateralized anteromedial temporal structures involvement in musical emotion processing , 2008, Neuropsychologia.

[119]  Kae Nakamura,et al.  Predictive Reward Signal of Dopamine Neurons , 2015 .

[120]  R. Wise Dopamine and food reward: back to the elements. , 2004, American journal of physiology. Regulatory, integrative and comparative physiology.

[121]  N. Volkow,et al.  “Nonhedonic” food motivation in humans involves dopamine in the dorsal striatum and methylphenidate amplifies this effect , 2002, Synapse.

[122]  N. Volkow,et al.  Cocaine Cues and Dopamine in Dorsal Striatum: Mechanism of Craving in Cocaine Addiction , 2006, The Journal of Neuroscience.

[123]  R. Zatorre,et al.  Anatomically distinct dopamine release during anticipation and experience of peak emotion to music , 2011, Nature Neuroscience.

[124]  P. Lang,et al.  Fear and anxiety: animal models and human cognitive psychophysiology. , 2000, Journal of affective disorders.

[125]  S. Gosling,et al.  PERSONALITY PROCESSES AND INDIVIDUAL DIFFERENCES The Do Re Mi’s of Everyday Life: The Structure and Personality Correlates of Music Preferences , 2003 .

[126]  B. Hoebel,et al.  Food reward and cocaine increase extracellular dopamine in the nucleus accumbens as measured by microdialysis. , 1988, Life sciences.

[127]  A. Argiolas,et al.  Dopamine and sexual behavior , 1995, Neuroscience & Biobehavioral Reviews.

[128]  Stefan Koelsch,et al.  Brain and Music , 2012 .

[129]  R. Zatorre,et al.  The Rewarding Aspects of Music Listening Are Related to Degree of Emotional Arousal , 2009, PloS one.

[130]  M. Leyton The neurobiology of desire: Dopamine and the regulation of mood and motivational states in humans. , 2010 .

[131]  A. Parent,et al.  Functional anatomy of the basal ganglia. I. The cortico-basal ganglia-thalamo-cortical loop , 1995, Brain Research Reviews.

[132]  Jeffrey C. Cooper,et al.  Functional magnetic resonance imaging of reward prediction , 2005, Current opinion in neurology.

[133]  Kevin J. Grimm,et al.  Music-evoked nostalgia: affect, memory, and personality. , 2010, Emotion.

[134]  D. Ellis,et al.  Effects of music on respiration- and heart-rate. , 1952, The American journal of psychology.

[135]  S. Haber,et al.  Reward-Related Cortical Inputs Define a Large Striatal Region in Primates That Interface with Associative Cortical Connections, Providing a Substrate for Incentive-Based Learning , 2006, The Journal of Neuroscience.

[136]  A. Friederici,et al.  Investigating emotion with music: An fMRI study , 2006, Human brain mapping.

[137]  Grosvenor W. Cooper,et al.  The Rhythmic Structure of Music , 1971 .

[138]  B. Hoebel,et al.  Feeding and hypothalamic stimulation increase dopamine turnover in the accumbens , 1988, Physiology & Behavior.

[139]  Talma Hendler,et al.  Feeling the real world: limbic response to music depends on related content. , 2007, Cerebral cortex.

[140]  M. Kringelbach The human orbitofrontal cortex: linking reward to hedonic experience , 2005, Nature Reviews Neuroscience.

[141]  S. Hyman,et al.  Acute Effects of Cocaine on Human Brain Activity and Emotion , 1997, Neuron.

[142]  Eckart Altenmüller,et al.  How Does Music Arouse “Chills”? , 2005, Annals of the New York Academy of Sciences.

[143]  D. Stuss,et al.  Principles of frontal lobe function , 2002 .

[144]  A. Furnham,et al.  Personality and music: can traits explain how people use music in everyday life? , 2007, British journal of psychology.

[145]  S. Zeki,et al.  Neural correlates of beauty. , 2004, Journal of neurophysiology.

[146]  Elvira Brattico,et al.  Expertise in folk music alters the brain processing of Western harmony , 2012, Annals of the New York Academy of Sciences.

[147]  D. Kupfer,et al.  Amphetamine-induced dopamine release in human ventral striatum correlates with euphoria , 2001, Biological Psychiatry.

[148]  R. Adolphs,et al.  Amygdala damage impairs emotion recognition from music , 2007, Neuropsychologia.

[149]  Henrik Walter,et al.  Cultural objects modulate reward circuitry , 2002, Neuroreport.

[150]  James L Olds,et al.  Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain. , 1954, Journal of comparative and physiological psychology.

[151]  P. Laukka,et al.  Expression, Perception, and Induction of Musical Emotions: A Review and a Questionnaire Study of Everyday Listening , 2004 .

[152]  R. Adolphs,et al.  Emotional responses to unpleasant music correlates with damage to the parahippocampal cortex. , 2006, Brain : a journal of neurology.

[153]  C. Ramsey,et al.  Τesting models for the beginnings of the Aurignacian and the advent of figurative art and music: the radiocarbon chronology of Geißenklösterle. , 2012, Journal of human evolution.

[154]  Ray Jackendoff,et al.  Toward a Formal Theory of Tonal Music , 1977 .

[155]  Monique Ernst,et al.  Increased Occupancy of Dopamine Receptors in Human Striatum during Cue-Elicited Cocaine Craving , 2006, Neuropsychopharmacology.

[156]  Dolf Zillmann,et al.  Musical taste in adolescence. , 1997 .

[157]  Samuel M. McClure,et al.  Temporal Prediction Errors in a Passive Learning Task Activate Human Striatum , 2003, Neuron.

[158]  P. Silvia,et al.  Shivers and Timbres , 2011 .

[159]  Andreas Schulze-Bonhage,et al.  Response Properties of Human Amygdala Subregions: Evidence Based on Functional MRI Combined with Probabilistic Anatomical Maps , 2007, PloS one.

[160]  C. Benkelfat,et al.  Cocaine craving, euphoria, and self-administration: a preliminary study of the effect of catecholamine precursor depletion. , 2005, Behavioral neuroscience.

[161]  Peter Dayan,et al.  A Neural Substrate of Prediction and Reward , 1997, Science.

[162]  Alain Dagher,et al.  Modeling sensitization to stimulants in humans: an [11C]raclopride/positron emission tomography study in healthy men. , 2006, Archives of general psychiatry.

[163]  S. Vanderark,et al.  Cortisol, Biochemical, and Galvanic Skin Responses to Music Stimuli of Different Preference Values by College Students in Biology and Music , 1993, Perceptual and motor skills.

[164]  A. Dagher,et al.  Amphetamine-Induced Increases in Extracellular Dopamine, Drug Wanting, and Novelty Seeking: A PET/[11C]Raclopride Study in Healthy Men , 2002, Neuropsychopharmacology.

[165]  J. Sloboda The Musical Mind: The Cognitive Psychology of Music , 1987 .

[166]  Richard S. Sutton,et al.  Reinforcement Learning: An Introduction , 1998, IEEE Trans. Neural Networks.

[167]  Michael A. Bozarth,et al.  Brain reward circuitry: Four circuit elements “wired” in apparent series , 1984, Brain Research Bulletin.

[168]  Steven Brown,et al.  The Origins of Music: Edited by Nils L. Wallin, Björn Merker, and Steven Brown, Cambridge, MA: The MIT Press, 2000, xii+ 498 pages, ISBN 0-262-23206-5, US$60.00 , 2000 .

[169]  A. Syrota,et al.  In Vivo Detection of Striatal Dopamine Release during Reward: A PET Study with [11C]Raclopride and a Single Dynamic Scan Approach , 2002, NeuroImage.

[170]  T. Baumgartner,et al.  From emotion perception to emotion experience: emotions evoked by pictures and classical music. , 2006, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[171]  N. Volkow,et al.  Reinforcing effects of psychostimulants in humans are associated with increases in brain dopamine and occupancy of D(2) receptors. , 1999, The Journal of pharmacology and experimental therapeutics.

[172]  G. E. Alexander,et al.  Basal ganglia-thalamocortical circuits: parallel substrates for motor, oculomotor, "prefrontal" and "limbic" functions. , 1990, Progress in brain research.

[173]  Steven C. R. Williams,et al.  A functional MRI study of happy and sad affective states induced by classical music , 2007, Human brain mapping.

[174]  Oshin Vartanian,et al.  Neuroanatomical correlates of aesthetic preference for paintings , 2004, Neuroreport.

[175]  Justyna Humięcka-Jakubowska,et al.  Sweet Anticipation : Music and , 2006 .

[176]  Ivan Izquierdo,et al.  Molecular Mechanisms of Memory Retrieval , 2002, Neurochemical Research.

[177]  A. Gratton,et al.  Electrochemical monitoring of extracellular dopamine in nucleus accumbens of rats lever-pressing for food , 1994, Brain Research.