Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits

Gabriëlle H S Buitendijk | Alan M. Kwong | R. T. Smith | Terrie E. Kitchner | Chelsea E. Myers | G. Abecasis | J. Haines | M. Pericak-Vance | Mingyao Li | D. Weeks | I. Chowers | T. Léveillard | J. Sahel | P. Campochiaro | D. Zack | C. Curcio | I. Constable | Cindy Wen | W. Scott | K. Stark | K. Doheny | L. Farrer | E. Chew | M. Hauser | A. Agarwal | E. Postel | I. Heid | M. Brilliant | A. D. den Hollander | Xiaowei Zhan | C. V. van Duijn | A. Swaroop | Jie-Jin Wang | C. Kiel | J. Blangero | Kristine E. Lee | B. Klein | D. Mackey | F. Grassmann | T. Langmann | H. Blanché | T. Kitchner | N. Katsanis | C. Hayward | E. Souied | S. Meuer | R. Guymer | L. Fritsche | M. Othman | S. Hebbring | S. Sengupta | J. Bragg-Gresham | C. Brandl | M. Klein | R. Ratnapriya | J. Heckenlively | G. Liew | R. Laux | Matthew P Johnson | Jane M. Romm | W. Igl | M. Gorin | M. Gorski | A. Hewitt | C. Hoyng | D. Schaumberg | S. Fauser | M. Brantley | J. Deleuze | J. C. Bailey | E. Souzeau | J. Craig | K. Burdon | V. Cipriani | A. Moore | R. Allikmets | Zhenglin Yang | J. Yates | M. Morrison | M. DeAngelis | A. Brucker | I. McAllister | S. Iyengar | Ken Flagg | Danni Lin | Z. Su | G. Silvestri | K. Branham | A. Lotery | Veronika Grassmann | P. Baird | E. D. de Jong | A. Cree | N. Peachey | A. Orlin | M. Brooks | S. Hagstrom | K. Park | C. Klaver | Kang Zhang | J. Merriam | A. Richardson | J. Khan | H. Shahid | M. Schu | R. Igo | I. Audo | M. Benchaboune | M. Cain | H. Ferreyra | Frank G. Holz | Ivana K. Kim | Jaclyn L Kovach | S. Mohand-Saïd | Denise J. Morgan | G. Rudolph | S. G. Schwartz | E. Tsironi | Monique D. Courtenay | L. Gieser | B. Gopinath | B. Vote | T. Isaacs | J. Merriam | F. Blond | A. Tan | S. Goverdhan | Jeeyun Ahn | Johanna R. Foerster | David Cho | E. Bala | Joshua D Hoffman | T. Schick | Yingda Jiang | Chloe M. Stanton | Alexis Boleda | H. Liang | Janette Hall | Hongrong Luo | Daniel Chen | H. Ouyang | Guanping Mao | C. V. von Strachwitz | A. Wolf | C. Rennie | Michelle Grunin | Shira Hagbi-Levi | E. Moore | J. McGrath | L. Ersoy | A. Caramoy | Nicole T. M. Saksens | T. Martin | Baldev Dhillon | D. Stambolian | R. Sardell | R. Klein | D. J. Hunter | P. Mitchell | Y. Lechanteur | B. H. Weber | Barbara J. Truitt | M. Olden | M. Zimmermann | Stewart R. Lake | Lars G. Wilmar Jessica N. Cooke Felix Sebanti Jennifer Fritsche Igl Bailey Grassmann Sengupta Bragg | Joanna E. Merriam | John C. Merriam | Hendrik P. N. Scholl | K. Zhang | K. Zhang | Kang Zhang | B. Weber | M. Grunin | B. Dhillon | A. Moore | Mathias Gorski | F. Holz | Sebanti Sengupta | Helena H. Liang | Barbara Truitt | Ouyang Hong | Alan Kwong | C. V. van Duijn | W. Scott | Paul Mitchell | Felix Grassmann | Mathias Gorski | Klaus Stark | H. Scholl | shira Hagbi-levi | Iris M. Heid | Emily L. Moore | Bernhard H.F. Weber | Klaus J. Stark | Paul A. Mitchell | Klaus Stark | J. Haines | Klaus Stark | Iris M. Heid | Emmanuelle Souzeau | Lebriz Ersoy | I. M. Heid | Klaus Stark | Klaus Stark | I. Heid | Klaus Stark | Klaus Stark

[1]  Gabriëlle H S Buitendijk,et al.  Genetic pleiotropy between age-related macular degeneration and 16 complex diseases and traits , 2017, Genome Medicine.

[2]  P. Mitchell,et al.  Assessment of polygenic effects links primary open-angle glaucoma and age-related macular degeneration , 2016, Scientific Reports.

[3]  F. Grassmann,et al.  Multiallelic copy number variation in the complement component 4A (C4A) gene is associated with late-stage age-related macular degeneration (AMD) , 2016, Journal of Neuroinflammation.

[4]  C. Spencer,et al.  A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects: CNV Analysis Group and the Schizophrenia Working Group of the Psychiatric Genomics Consortium , 2016, bioRxiv.

[5]  Yara T. E. Lechanteur,et al.  Nature Genetics Advance Online Publication , 2022 .

[6]  Robert N Weinreb,et al.  Genome-wide association analysis identifies TXNRD2, ATXN2 and FOXC1 as susceptibility loci for primary open angle glaucoma , 2015, Nature Genetics.

[7]  Daniel L. Chao,et al.  Refractive Error and the Risk of Age-Related Macular Degeneration in the South Korean Population , 2016, Asia-Pacific journal of ophthalmology.

[8]  M. Goldacre,et al.  ASSOCIATIONS BETWEEN AGE-RELATED MACULAR DEGENERATION, OSTEOARTHRITIS AND RHEUMATOID ARTHRITIS: Record Linkage Study , 2015, Retina.

[9]  A. D. den Hollander,et al.  Genetic Variants and Systemic Complement Activation Levels Are Associated With Serum Lipoprotein Levels in Age-Related Macular Degeneration. , 2015, Investigative ophthalmology & visual science.

[10]  Thomas Ach,et al.  What Does Genetics Tell Us About Age-Related Macular Degeneration? , 2015, Annual review of vision science.

[11]  David M. Evans,et al.  Multi-ethnic genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis , 2015, Nature Genetics.

[12]  J. Rioux,et al.  Genetic association analyses implicate aberrant regulation of innate and adaptive immunity genes in the pathogenesis of systemic lupus erythematosus , 2015, Nature Genetics.

[13]  Jennifer G. Robinson,et al.  Association between vitamin D status and age-related macular degeneration by genetic risk. , 2015, JAMA ophthalmology.

[14]  Marko Hočevar,et al.  Genome-wide meta-analysis identifies five new susceptibility loci for cutaneous malignant melanoma , 2015, Nature Genetics.

[15]  Herng‐Ching Lin,et al.  Association between psoriasis and neovascular age-related macular degeneration: A population-based study. , 2015, Journal of the American Academy of Dermatology.

[16]  Aung Ko Win,et al.  A new GWAS and meta-analysis with 1000Genomes imputation identifies novel risk variants for colorectal cancer , 2015, Scientific Reports.

[17]  E. Chew,et al.  Clinical and Genetic Factors Associated with Progression of Geographic Atrophy Lesions in Age-Related Macular Degeneration , 2015, PloS one.

[18]  Mario Roederer,et al.  The Genetic Architecture of the Human Immune System: A Bioresource for Autoimmunity and Disease Pathogenesis , 2015, Cell.

[19]  M. Daly,et al.  An Atlas of Genetic Correlations across Human Diseases and Traits , 2015, Nature Genetics.

[20]  Patrick Neven,et al.  Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer , 2015 .

[21]  Adriana I. Iglesias,et al.  Meta‐analysis of Genome‐Wide Association Studies Identifies Novel Loci Associated With Optic Disc Morphology , 2015, Genetic epidemiology.

[22]  Ross M. Fraser,et al.  Genetic studies of body mass index yield new insights for obesity biology , 2015, Nature.

[23]  Tamara S. Roman,et al.  New genetic loci link adipose and insulin biology to body fat distribution , 2014, Nature.

[24]  Weidinger,et al.  Genetics (AAGC) (2015). Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis. , 2015 .

[25]  T. Lumley,et al.  gplots: Various R Programming Tools for Plotting Data , 2015 .

[26]  Blue Mountains Eye Study-GWAS groupw,et al.  Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process , 2014 .

[27]  Adriana I. Iglesias,et al.  Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process , 2014, Nature Communications.

[28]  Peter Kraft,et al.  A meta-analysis of 87,040 individuals identifies 23 new susceptibility loci for prostate cancer , 2014, Nature Genetics.

[29]  G. Abecasis,et al.  Age-related macular degeneration: genetics and biology coming together. , 2014, Annual review of genomics and human genetics.

[30]  Gabriëlle H S Buitendijk,et al.  Lipids, lipid genes, and incident age-related macular degeneration: the three continent age-related macular degeneration consortium. , 2014, American journal of ophthalmology.

[31]  C. Spencer,et al.  Biological Insights From 108 Schizophrenia-Associated Genetic Loci , 2014, Nature.

[32]  Correction: Age-Related Macular Degeneration and the Incidence of Cardiovascular Disease: A Systematic Review and Meta-Analysis , 2014, PLoS ONE.

[33]  Chuong B. Do,et al.  Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson’s disease , 2014, Nature Genetics.

[34]  Lorna M. Lopez,et al.  Genome-wide association analysis identifies six new loci associated with forced vital capacity , 2014, Nature Genetics.

[35]  S. Camelo Potential Sources and Roles of Adaptive Immunity in Age-Related Macular Degeneration: Shall We Rename AMD into Autoimmune Macular Disease? , 2014, Autoimmune diseases.

[36]  Ronald Klein,et al.  Markers of inflammation, oxidative stress, and endothelial dysfunction and the 20-year cumulative incidence of early age-related macular degeneration: the Beaver Dam Eye Study. , 2014, JAMA ophthalmology.

[37]  D. Schaumberg,et al.  Age-Related Macular Degeneration and the Incidence of Cardiovascular Disease: A Systematic Review and Meta-Analysis , 2014, PloS one.

[38]  P. Barberger‐Gateau,et al.  Elevated High-Density Lipoprotein Cholesterol and Age-Related Macular Degeneration: The Alienor Study , 2014, PloS one.

[39]  Y. Li,et al.  Refractive Error and Risk of Early or Late Age-Related Macular Degeneration: A Systematic Review and Meta-Analysis , 2014, PloS one.

[40]  Tanya M. Teslovich,et al.  Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility , 2014, Nature Genetics.

[41]  R. Klein,et al.  Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. , 2014, The Lancet. Global health.

[42]  Jun S. Liu,et al.  Genetics of rheumatoid arthritis contributes to biology and drug discovery , 2013 .

[43]  Daniel R. Zerbino,et al.  Ensembl 2014 , 2013, Nucleic Acids Res..

[44]  Aneela Majid,et al.  A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia , 2013, Nature Genetics.

[45]  R Core Team,et al.  R: A language and environment for statistical computing. , 2014 .

[46]  Tanya M. Teslovich,et al.  Discovery and refinement of loci associated with lipid levels , 2013, Nature Genetics.

[47]  Margaret A. Pericak-Vance,et al.  Identification of a Rare Coding Variant in Complement 3 Associated with Age-related Macular Degeneration , 2013, Nature Genetics.

[48]  Sivakumar Gowrisankar,et al.  Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration , 2013, Nature Genetics.

[49]  Lorna M. Lopez,et al.  Meta-Analysis of Genome-Wide Association Studies Identifies Six New Loci for Serum Calcium Concentrations , 2013, PLoS genetics.

[50]  Chuong B. Do,et al.  A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci , 2013, Nature Genetics.

[51]  Thomas Meitinger,et al.  Genome-wide meta-analysis identifies new susceptibility loci for migraine , 2013, Nature Genetics.

[52]  Paolo Vineis,et al.  Genome-wide Association Study Identifies Multiple Risk Loci for Chronic Lymphocytic Leukemia , 2013, Nature Genetics.

[53]  Simon G. Coetzee,et al.  Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. , 2013, Gastroenterology.

[54]  Marko Hočevar,et al.  A variant in FTO shows association with melanoma risk not due to BMI , 2013, Nature Genetics.

[55]  P. Mitchell,et al.  Differential associations of myopia with major age-related eye diseases: the Singapore Indian Eye Study. , 2013, Ophthalmology.

[56]  Tin Aung,et al.  Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus , 2013, Nature Genetics.

[57]  Suzanne Chambers,et al.  A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease. , 2013, Human molecular genetics.

[58]  Fabian J Theis,et al.  Genome-wide association analyses identify 18 new loci associated with serum urate concentrations , 2012, Nature Genetics.

[59]  Peter Kraft,et al.  Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array , 2013, Nature Genetics.

[60]  Chuong B. Do,et al.  Genome-Wide Analysis Points to Roles for Extracellular Matrix Remodeling, the Visual Cycle, and Neuronal Development in Myopia , 2012, PLoS genetics.

[61]  C. Keilhauer,et al.  Age-related macular degeneration and coronary heart disease: evaluation of genetic and environmental associations. , 2012, European journal of medical genetics.

[62]  J. Danesh,et al.  Large-scale association analysis identifies new risk loci for coronary artery disease , 2013 .

[63]  Eli Stahl,et al.  High density genetic mapping identifies new susceptibility loci for rheumatoid arthritis , 2012, Nature Genetics.

[64]  M. Guardiola,et al.  Complement system and small HDL particles are associated with subclinical atherosclerosis in SLE patients. , 2012, Atherosclerosis.

[65]  David C. Wilson,et al.  Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease , 2012, Nature.

[66]  Tanya M. Teslovich,et al.  Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes , 2012, Nature Genetics.

[67]  Colm O'Dushlaine,et al.  INRICH: interval-based enrichment analysis for genome-wide association studies , 2012, Bioinform..

[68]  I. Heid,et al.  Modelling the Genetic Risk in Age-Related Macular Degeneration , 2012, PloS one.

[69]  Hideo Tanaka,et al.  Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population , 2012, Nature Genetics.

[70]  Daniel L. Koller,et al.  Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture , 2012, Nature Genetics.

[71]  T. Wong,et al.  Prevalence of and risk factors for age-related macular degeneration in a multiethnic Asian cohort. , 2012, Archives of ophthalmology.

[72]  M. Radic,et al.  Autoimmune biomarkers in age-related macular degeneration: a possible role player in disease development and progression. , 2012, Advances in experimental medicine and biology.

[73]  Christian Gieger,et al.  Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma , 2011, Nature Genetics.

[74]  Jeffrey E. Lee,et al.  Genome-wide association study identifies three new melanoma susceptibility loci , 2011, Nature Genetics.

[75]  Jeffrey E. Lee,et al.  Genome-wide association study identifies a new melanoma susceptibility locus at 1q21.3 , 2011, Nature Genetics.

[76]  Christian Gieger,et al.  Genome-wide association and large scale follow-up identifies 16 new loci influencing lung function , 2011, Nature Genetics.

[77]  Christian Gieger,et al.  Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk , 2011, Nature.

[78]  Constantin Polychronakos,et al.  A Genome-Wide Meta-Analysis of Six Type 1 Diabetes Cohorts Identifies Multiple Associated Loci , 2011, PLoS genetics.

[79]  Suzanne Chambers,et al.  Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study , 2011, Nature Genetics.

[80]  Simon C. Potter,et al.  Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis , 2011, Nature.

[81]  P. Sham,et al.  Evaluating the heritability explained by known susceptibility variants: a survey of ten complex diseases , 2011, Genetic epidemiology.

[82]  Yusuke Nakamura,et al.  The human AIRE gene at chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid arthritis in Japanese population. , 2011, Human molecular genetics.

[83]  Steven Gallinger,et al.  Multiple Common Susceptibility Variants near BMP Pathway Loci GREM1, BMP4, and BMP2 Explain Part of the Missing Heritability of Colorectal Cancer , 2011, PLoS genetics.

[84]  M. Thun,et al.  Genome-wide association study identifies new prostate cancer susceptibility loci. , 2011, Human molecular genetics.

[85]  P. Elliott,et al.  Meta-Analysis of Genome-Wide Association Studies in >80 000 Subjects Identifies Multiple Loci for C-Reactive Protein Levels , 2011, Circulation.

[86]  E. Morrison,et al.  The Role of High-Density Lipoproteins in Reducing the Risk of Vascular Diseases, Neurogenerative Disorders, and Cancer , 2010, Cholesterol.

[87]  R. Mayeux,et al.  Association of higher levels of high-density lipoprotein cholesterol in elderly individuals and lower risk of late-onset Alzheimer disease. , 2010, Archives of neurology.

[88]  R. Guymer,et al.  C-reactive protein levels and complement factor H polymorphism interaction in age-related macular degeneration and its progression. , 2010, Ophthalmology.

[89]  Daniel L. Koller,et al.  Common genetic determinants of vitamin D insufficiency: a genome-wide association study , 2010, The Lancet.

[90]  Uwe Völker,et al.  New loci associated with kidney function and chronic kidney disease , 2010, Nature Genetics.

[91]  Inês Barroso,et al.  Genome-wide association study identifies five loci associated with lung function , 2010, Nature Genetics.

[92]  D. Clayton,et al.  The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes , 2009, Nature Genetics.

[93]  A. Hofman,et al.  Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function , 2010, Nature Genetics.

[94]  D. Clayton,et al.  Genome-wide association study and meta-analysis finds over 40 loci affect risk of type 1 diabetes , 2009, Nature Genetics.

[95]  Santa Jeremy Ono,et al.  Autoimmunity in retinal degeneration: autoimmune retinopathy and age-related macular degeneration. , 2009, Journal of autoimmunity.

[96]  Ali Amin Al Olama,et al.  Multiple loci on 8q24 associated with prostate cancer susceptibility , 2009, Nature Genetics.

[97]  Ali Amin Al Olama,et al.  Identification of seven new prostate cancer susceptibility loci through a genome-wide association study , 2009, Nature Genetics.

[98]  Kari Stefansson,et al.  Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility , 2009, Nature Genetics.

[99]  Yurii S. Aulchenko,et al.  Multiple loci associated with indices of renal function and chronic kidney disease , 2009, Nature Genetics.

[100]  Vincent Plagnol,et al.  Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci , 2008, Nature Genetics.

[101]  L. Smeeth,et al.  Age-related macular degeneration and complement activation-related diseases: a population-based case-control study. , 2008, Ophthalmology.

[102]  Y. Kamatani,et al.  Functional SNPs in CD244 increase the risk of rheumatoid arthritis in a Japanese population , 2008, Nature Genetics.

[103]  Emily W. Gower,et al.  Hospitalized cardiovascular diseases in neovascular age-related macular degeneration. , 2008, Archives of ophthalmology.

[104]  J. Brooks Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer , 2008 .

[105]  J. Carpten,et al.  Evidence for two independent prostate cancer risk–associated loci in the HNF1B gene at 17q12 , 2008, Nature Genetics.

[106]  R. Klein,et al.  Is Age-Related Macular Degeneration Associated with Stroke Among Elderly Americans?§ , 2008, The open ophthalmology journal.

[107]  Ali Amin Al Olama,et al.  Multiple newly identified loci associated with prostate cancer susceptibility , 2008, Nature Genetics.

[108]  Kevin M. Bradley,et al.  Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer , 2008, Nature Genetics.

[109]  Sharon D. Solomon,et al.  Racial differences in the prevalence of age-related macular degeneration: the Salisbury Eye Evaluation (SEE) Project. , 2008, Archives of ophthalmology.

[110]  M. Cesari,et al.  The aging process and potential interventions to extend life expectancy , 2007, Clinical interventions in aging.

[111]  Alan Bensoussan,et al.  Use of calcium or calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years and older: a meta-analysis , 2007, The Lancet.

[112]  Joseph T. Glessner,et al.  A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene , 2007, Nature.

[113]  D. Gudbjartsson,et al.  Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes , 2007, Nature Genetics.

[114]  G. Abecasis,et al.  Genetic susceptibility to age-related macular degeneration: a paradigm for dissecting complex disease traits. , 2007, Human molecular genetics.

[115]  R. A. Bailey,et al.  Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes , 2007, Nature Genetics.

[116]  D. Gudbjartsson,et al.  Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24 , 2007, Nature Genetics.

[117]  R. Klein,et al.  Age-related macular degeneration is associated with incident myocardial infarction among elderly Americans. , 2007, Ophthalmology.

[118]  R. T. Smith,et al.  Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration , 2006, Nature Genetics.

[119]  Ronald Klein,et al.  A simplified severity scale for age-related macular degeneration: AREDS Report No. 18. , 2005, Archives of ophthalmology.

[120]  Jennifer J. Gibson,et al.  Pigmentary characteristics and moles in relation to melanoma risk , 2005, International journal of cancer.

[121]  R. T. Smith,et al.  A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[122]  Leslie Hyman,et al.  A Simplified Severity Scale for Age-Related Macular Degeneration , 2005 .

[123]  B. Munoz,et al.  Racial variations in causes of vision loss in nursing homes: The Salisbury Eye Evaluation in Nursing Home Groups (SEEING) Study. , 2004, Archives of ophthalmology.

[124]  P. Jong Prevalence of age-related macular degeneration in the United States. , 2004 .

[125]  T. Mack,et al.  Skin characteristics and risk of superficial spreading and nodular melanoma (United States) , 2000, Cancer Causes & Control.

[126]  Benita J. O’Colmain,et al.  Prevalence of age-related macular degeneration in the United States. , 2004, Archives of ophthalmology.

[127]  Y. Benjamini,et al.  THE CONTROL OF THE FALSE DISCOVERY RATE IN MULTIPLE TESTING UNDER DEPENDENCY , 2001 .

[128]  George C. Williams,et al.  PLEIOTROPY, NATURAL SELECTION, AND THE EVOLUTION OF SENESCENCE , 1957, Science of Aging Knowledge Environment.

[129]  M. C. Leske,et al.  Hypertension, cardiovascular disease, and age-related macular degeneration. Age-Related Macular Degeneration Risk Factors Study Group. , 2000, Archives of ophthalmology.