Towards Novel Biomimetic In Vitro Models of the Blood–Brain Barrier for Drug Permeability Evaluation
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[1] P. Ertl,et al. Bioinspired human stomach-on-a-chip with in vivo like function and architecture. , 2023, Lab on a chip.
[2] Bingjie Han,et al. Recent advances in drug delivery systems for targeting brain tumors , 2023, Drug delivery.
[3] Benjamin S. Freedman,et al. Glucose absorption drives cystogenesis in a human organoid-on-chip model of polycystic kidney disease , 2022, Nature communications.
[4] K. Kurabayashi,et al. A tissue chip with integrated digital immunosensors: In situ brain endothelial barrier cytokine secretion monitoring. , 2022, Biosensors & bioelectronics.
[5] Clayton M. Britt,et al. Application of a Human Blood Brain Barrier Organ-on-a-Chip Model to Evaluate Small Molecule Effectiveness against Venezuelan Equine Encephalitis Virus , 2022, Viruses.
[6] Yinghong Zhou,et al. Current Advances in 3D Dynamic Cell Culture Systems , 2022, Gels.
[7] R. Tekade,et al. Current Update on Transcellular Brain Drug Delivery , 2022, Pharmaceutics.
[8] P. Young,et al. In vitro interactions of aerosol formulations with human nasal epithelium using real-time monitoring of drug transport in a nasal mucosa-on-a-chip. , 2022, Biosensors & bioelectronics.
[9] Anup D. Shah,et al. Altered Blood–Brain Barrier Dynamics in the C9orf72 Hexanucleotide Repeat Expansion Mouse Model of Amyotrophic Lateral Sclerosis , 2022, Pharmaceutics.
[10] Joana Saavedra,et al. Key brain cell interactions and contributions to the pathogenesis of Alzheimer’s disease , 2022, Frontiers in Cell and Developmental Biology.
[11] P. Janmey,et al. Recombinant human plasma gelsolin reverses increased permeability of the blood–brain barrier induced by the spike protein of the SARS-CoV-2 virus , 2022, Journal of Neuroinflammation.
[12] Kyung-Yil Lee. Common immunopathogenesis of central nervous system diseases: the protein-homeostasis-system hypothesis , 2022, Cell & Bioscience.
[13] Ian C. Harding,et al. Developing a transwell millifluidic device for studying blood-brain barrier endothelium. , 2022, Lab on a chip.
[14] R. Menon,et al. Testing of drugs using human feto-maternal interface organ-on-chips provide insights into pharmacokinetics and efficacy , 2022, Lab on a chip.
[15] Diming Zhang,et al. Recent Advances of Organ-on-a-Chip in Cancer Modeling Research , 2022, Biosensors.
[16] Peisheng Xu,et al. Strategies to overcome/penetrate the BBB for systemic nanoparticle delivery to the brain/brain tumor. , 2022, Advanced drug delivery reviews.
[17] Yuki Hattori. The Multiple Roles of Pericytes in Vascular Formation and Microglial Functions in the Brain , 2022, Life.
[18] E. Jacotot,et al. Impact of Neurons on Patient-Derived Cardiomyocytes Using Organ-On-A-Chip and iPSC Biotechnologies , 2022, bioRxiv.
[19] Zhuhao Wu,et al. Engineering human spinal microphysiological systems to model opioid-induced tolerance , 2022, bioRxiv.
[20] K. Ino,et al. Electrochemical sensing of oxygen metabolism for a three-dimensional cultured model with biomimetic vascular flow. , 2022, Biosensors & bioelectronics.
[21] A. Iwasaki,et al. The neurobiology of long COVID , 2022, Neuron.
[22] U. Marx,et al. A Human Stem Cell-Derived Brain-Liver Chip for Assessing Blood-Brain-Barrier Permeation of Pharmaceutical Drugs , 2022, Cells.
[23] A. Calvo,et al. Markers of blood-brain barrier disruption increase early and persistently in COVID-19 patients with neurological manifestations , 2022, Frontiers in Immunology.
[24] Z. Berneman,et al. A Microfluidic In Vitro Three-Dimensional Dynamic Model of the Blood–Brain Barrier to Study the Transmigration of Immune Cells , 2022, Brain sciences.
[25] Lin Gan,et al. The barrier and interface mechanisms of the brain barrier, and brain drug delivery , 2022, Brain Research Bulletin.
[26] Z. Hong,et al. Construction of a novel blood brain barrier-glioma microfluidic chip model: Applications in the evaluation of permeability and anti-glioma activity of traditional Chinese medicine components. , 2022, Talanta.
[27] C. Yi,et al. Near-Infrared Photothermally Enhanced Photo-Oxygenation for Inhibition of Amyloid-β Aggregation Based on RVG-Conjugated Porphyrinic Metal–Organic Framework and Indocyanine Green Nanoplatform , 2022, International journal of molecular sciences.
[28] A. Luch,et al. Micropatterned Neurovascular Interface to Mimic the Blood–Brain Barrier’s Neurophysiology and Micromechanical Function: A BBB-on-CHIP Model , 2022, Cells.
[29] B. Popescu,et al. In Vitro Modeling of the Blood–Brain Barrier for the Study of Physiological Conditions and Alzheimer’s Disease , 2022, Biomolecules.
[30] Benjamin C. Shaw,et al. Targetability of the neurovascular unit in inflammatory diseases of the central nervous system , 2022, Immunological reviews.
[31] S. Scaglione,et al. A multi-organ-on-chip to recapitulate the infiltration and the cytotoxic activity of circulating NK cells in 3D matrix-based tumor model , 2022, Frontiers in Bioengineering and Biotechnology.
[32] T. Davis,et al. Transport Mechanisms at the Blood–Brain Barrier and in Cellular Compartments of the Neurovascular Unit: Focus on CNS Delivery of Small Molecule Drugs , 2022, Pharmaceutics.
[33] T. Fujie,et al. Recreating cellular barriers in human microphysiological systems in-vitro , 2022, 2022 44th Annual International Conference of the IEEE Engineering in Medicine & Biology Society (EMBC).
[34] A. Sapkota,et al. The impact of genetic manipulation of laminin and integrins at the blood–brain barrier , 2022, Fluids and barriers of the CNS.
[35] A. Sapkota,et al. The impact of genetic manipulation of laminin and integrins at the blood–brain barrier , 2022, Fluids and Barriers of the CNS.
[36] D. Borderie,et al. Exposure of human cerebral microvascular endothelial cells hCMEC/D3 to laminar shear stress induces vascular protective responses , 2022, Fluids and barriers of the CNS.
[37] D. Beebe,et al. A role for microfluidic systems in precision medicine , 2022, Nature Communications.
[38] J. Samitier,et al. Biosensors Integration in Blood–Brain Barrier-on-a-Chip: Emerging Platform for Monitoring Neurodegenerative Diseases , 2022, ACS sensors.
[39] H. S. Rho,et al. A guide to the organ-on-a-chip , 2022, Nature Reviews Methods Primers.
[40] V. Gupta,et al. Advances in Hydrogel-Based Microfluidic Blood–Brain-Barrier Models in Oncology Research , 2022, Pharmaceutics.
[41] Seung‐Woo Cho,et al. Blood-brain barrier-on-a-chip for brain disease modeling and drug testing , 2022, BMB reports.
[42] S. Kaushalya,et al. Human iPSC-derived brain endothelial microvessels in a multi-well format enable permeability screens of anti-inflammatory drugs. , 2022, Biomaterials.
[43] G. Paul,et al. Microvascular Changes in Parkinson’s Disease- Focus on the Neurovascular Unit , 2022, Frontiers in Aging Neuroscience.
[44] G. Dai,et al. Interstitial flow enhances the formation, connectivity, and function of 3D brain microvascular networks generated within a microfluidic device. , 2021, Lab on a chip.
[45] P. Vulto,et al. Modeling ischemic stroke in a triculture neurovascular unit on-a-chip , 2021, Fluids and Barriers of the CNS.
[46] G. Bix,et al. Basal lamina changes in neurodegenerative disorders , 2021, Molecular neurodegeneration.
[47] A. Andrews,et al. SARS-CoV-2 Spike Protein Disrupts Blood–Brain Barrier Integrity via RhoA Activation , 2021, Journal of Neuroimmune Pharmacology.
[48] F. Dehghani,et al. Dynamic flow and shear stress as key parameters for intestinal cells morphology and polarization in an organ-on-a-chip model , 2021, Biomedical Microdevices.
[49] O. Gobbo,et al. Advances in Non-Animal Testing Approaches towards Accelerated Clinical Translation of Novel Nanotheranostic Therapeutics for Central Nervous System Disorders , 2021, Nanomaterials.
[50] Joo H. Kang,et al. Condensed ECM-based nanofilms on highly permeable PET membranes for robust cell-to-cell communications with improved optical clarity , 2021, Biofabrication.
[51] U. Bickel,et al. A Quasi-Physiological Microfluidic Blood-Brain Barrier Model for Brain Permeability Studies , 2021, Pharmaceutics.
[52] Weiyu Teng,et al. Function of Astrocytes in Neuroprotection and Repair after Ischemic Stroke , 2021, European Neurology.
[53] F. Russel,et al. Differences in P-glycoprotein activity in human and rodent blood–brain barrier assessed by mechanistic modelling , 2021, Archives of Toxicology.
[54] A. Oliva,et al. Barrier-on-a-Chip with a Modular Architecture and Integrated Sensors for Real-Time Measurement of Biological Barrier Function , 2021, Micromachines.
[55] Kisuk Yang,et al. Fungal brain infection modelled in a human-neurovascular-unit-on-a-chip with a functional blood–brain barrier , 2021, Nature Biomedical Engineering.
[56] B. Brodin,et al. Transendothelial Electrical Resistance Measurement across the Blood–Brain Barrier: A Critical Review of Methods , 2021, Micromachines.
[57] Deok‐Ho Kim,et al. A neurovascular-unit-on-a-chip for the evaluation of the restorative potential of stem cell therapies for ischaemic stroke , 2021, Nature Biomedical Engineering.
[58] D. Baker,et al. Transferrin receptor targeting by de novo sheet extension , 2021, Proceedings of the National Academy of Sciences.
[59] A. Herland,et al. Continuous monitoring reveals protective effects of N-acetylcysteine amide on an isogenic microphysiological model of the neurovascular unit , 2021, bioRxiv.
[60] P. Winter,et al. Flow induces barrier and glycocalyx-related genes and negative surface charge in a lab-on-a-chip human blood-brain barrier model , 2021, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[61] K. Al‐Jamal,et al. Development of Real-Time Transendothelial Electrical Resistance Monitoring for an In Vitro Blood-Brain Barrier System , 2020, Micromachines.
[62] N. Voelcker,et al. In Situ Surface Modification of Microfluidic Blood-Brain-Barriers for Improved Screening of Small Molecules and Nanoparticles. , 2020, ACS applied materials & interfaces.
[63] M. Kaya,et al. Basic physiology of the blood-brain barrier in health and disease: a brief overview , 2020, Tissue barriers.
[64] Wentao Su,et al. Evaluation of hepatic drug-metabolism for glioblastoma using liver-brain chip , 2020, Biotechnology Letters.
[65] Peter A. Galie,et al. The SARS-CoV-2 spike protein alters barrier function in 2D static and 3D microfluidic in-vitro models of the human blood–brain barrier , 2020, Neurobiology of Disease.
[66] J. Wikswo,et al. Advances in blood–brain barrier modeling in microphysiological systems highlight critical differences in opioid transport due to cortisol exposure , 2020, Fluids and Barriers of the CNS.
[67] Valeria Chiono,et al. Modeling Nanocarrier Transport across a 3D In Vitro Human Blood‐Brain–Barrier Microvasculature , 2020, Advanced healthcare materials.
[68] A. Malhotra,et al. The Neurovascular Unit: Effects of Brain Insults During the Perinatal Period , 2020, Frontiers in Neuroscience.
[69] Guixue Wang,et al. Overview of Crosstalk Between Multiple Factor of Transcytosis in Blood Brain Barrier , 2020, Frontiers in Neuroscience.
[70] Jeongmoon J. Choi,et al. Microengineered human blood–brain barrier platform for understanding nanoparticle transport mechanisms , 2020, Nature Communications.
[71] K. Dawson,et al. Ultrathin Silicon Membranes for In Situ Optical Analysis of Nanoparticle Translocation across a Human Blood-Brain Barrier Model. , 2020, ACS nano.
[72] Deepak Choudhury,et al. A pump‐free tricellular blood–brain barrier on‐a‐chip model to understand barrier property and evaluate drug response , 2019, Biotechnology and bioengineering.
[73] Y. Yun,et al. Three-dimensional (3D) brain microphysiological system for organophosphates and neurochemical agent toxicity screening , 2019, PloS one.
[74] Samira M. Azarin,et al. An isogenic hiPSC-derived BBB-on-a-chip. , 2019, Biomicrofluidics.
[75] P. Sansonetti,et al. Bioengineered Human Organ-on-Chip Reveals Intestinal Microenvironment and Mechanical Forces Impacting Shigella Infection. , 2019, Cell host & microbe.
[76] Eunhee Kim,et al. Blood–Brain Barrier Dysfunction in a 3D In Vitro Model of Alzheimer's Disease , 2019, Advanced science.
[77] T. England,et al. A Novel Transwell Blood Brain Barrier Model Using Primary Human Cells , 2019, Front. Cell. Neurosci..
[78] Clive N Svendsen,et al. Human iPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications. , 2019, Cell stem cell.
[79] Hui-fang Huang,et al. Recent Progress in Microfluidic Models of the Blood-Brain Barrier , 2019, Micromachines.
[80] B. Engelhardt,et al. A silicon nanomembrane platform for the visualization of immune cell trafficking across the human blood–brain barrier under flow , 2018, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[81] Yao Yao,et al. Basement membrane and blood–brain barrier , 2018, Stroke and Vascular Neurology.
[82] P. Searson,et al. Benchmarking in vitro tissue-engineered blood–brain barrier models , 2018, Fluids and Barriers of the CNS.
[83] M. Scarpa,et al. Possible strategies to cross the blood–brain barrier , 2018, Italian Journal of Pediatrics.
[84] H. Flyvbjerg,et al. Contributions of the glycocalyx, endothelium, and extravascular compartment to the blood–brain barrier , 2018, Proceedings of the National Academy of Sciences.
[85] Hossein Heidari,et al. Review Article: Capturing the physiological complexity of the brain's neuro-vascular unit in vitro. , 2018, Biomicrofluidics.
[86] Paul Vulto,et al. A perfused human blood–brain barrier on-a-chip for high-throughput assessment of barrier function and antibody transport , 2018, Fluids and Barriers of the CNS.
[87] Sean P Sheehy,et al. A linked organ-on-chip model of the human neurovascular unit reveals the metabolic coupling of endothelial and neuronal cells , 2018, Nature Biotechnology.
[88] Roger D Kamm,et al. 3D self-organized microvascular model of the human blood-brain barrier with endothelial cells, pericytes and astrocytes. , 2018, Biomaterials.
[89] T. Gaborski,et al. Use of porous membranes in tissue barrier and co-culture models. , 2018, Lab on a chip.
[90] Chenghua Gu,et al. Bridging barriers: a comparative look at the blood–brain barrier across organisms , 2018, Genes & development.
[91] P. Searson,et al. Functional brain-specific microvessels from iPSC-derived human brain microvascular endothelial cells: the role of matrix composition on monolayer formation , 2018, Fluids and Barriers of the CNS.
[92] Y. Yun,et al. Three-dimensional (3D) tetra-culture brain on chip platform for organophosphate toxicity screening , 2018, Scientific Reports.
[93] John Buonocore,et al. A Three-Dimensional Arrayed Microfluidic Blood–Brain Barrier Model With Integrated Electrical Sensor Array , 2018, IEEE Transactions on Biomedical Engineering.
[94] S. Gerecht,et al. Engineering the human blood-brain barrier in vitro , 2017, Journal of biological engineering.
[95] R. Davalos,et al. A microfluidic model of the blood-brain barrier to study permeabilization by pulsed electric fields. , 2017, RSC advances.
[96] P. Searson,et al. Effect of shear stress on iPSC-derived human brain microvascular endothelial cells (dhBMECs) , 2017, Fluids and Barriers of the CNS.
[97] Paolo A Netti,et al. Shuttle‐mediated nanoparticle transport across an in vitro brain endothelium under flow conditions , 2017, Biotechnology and bioengineering.
[98] M. Shuler,et al. Microfluidic blood–brain barrier model provides in vivo‐like barrier properties for drug permeability screening , 2017, Biotechnology and bioengineering.
[99] R. Woltjer,et al. The Translational Significance of the Neurovascular Unit* , 2016, The Journal of Biological Chemistry.
[100] Dan Gao,et al. Development of a blood-brain barrier model in a membrane-based microchip for characterization of drug permeability and cytotoxicity for drug screening. , 2016, Analytica chimica acta.
[101] R. Vandenbroucke,et al. Into rather unexplored terrain—transcellular transport across the blood–brain barrier , 2016, Glia.
[102] Donald E. Ingber,et al. Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip , 2016, PloS one.
[103] Qing Yang,et al. Recreating blood-brain barrier physiology and structure on chip: A novel neurovascular microfluidic bioreactor. , 2015, Biomicrofluidics.
[104] D. Beebe,et al. The importance of being a lumen , 2014, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[105] Hanseup Kim,et al. Characterization of a microfluidic in vitro model of the blood-brain barrier (μBBB). , 2012, Lab on a chip.
[106] B. Långström,et al. Species Differences in Blood-Brain Barrier Transport of Three Positron Emission Tomography Radioligands with Emphasis on P-Glycoprotein Transport , 2009, Drug Metabolism and Disposition.