Suppression of proinvasive RGS4 by mTOR inhibition optimizes glioma treatment
暂无分享,去创建一个
M. Weller | W. Wick | J. Gronych | A. Deimling | M. Bendszus | S. Combs | L. Jestaedt | M. Jugold | M. Plattén | M. Weiler | M. Bendszus | M. Weller | M. Kosch | A. Thiepold | J. Blaes | Philipp-Niclas Pfenning | L. Dittmann | W. Wick | B. Berger | S. Combs | A. Deimling | Markus Kosch | Leonie Jestaedt
[1] T. Chenevert,et al. Perifosine and CCI 779 Co-Operate to Induce Cell Death and Decrease Proliferation in PTEN-Intact and PTEN-Deficient PDGF-Driven Murine Glioblastoma , 2011, PloS one.
[2] D. Amelio,et al. Patterns of failure and comparison of different target volume delineations in patients with glioblastoma treated with conformal radiotherapy plus concomitant and adjuvant temozolomide. , 2010, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.
[3] K. Hunter,et al. Making a Case , 2010 .
[4] J. Sarkaria,et al. Combination of Temsirolimus (CCI-779) with Chemoradiation in Newly Diagnosed Glioblastoma Multiforme (GBM) (NCCTG trial N027D) Is Associated with Increased Infectious Risks , 2010, Clinical Cancer Research.
[5] R. Neubig,et al. Reversible, Allosteric Small-Molecule Inhibitors of Regulator of G Protein Signaling Proteins , 2010, Molecular Pharmacology.
[6] J. Hurst,et al. Regulator of G-protein signaling (RGS) proteins in cancer biology. , 2009, Biochemical pharmacology.
[7] B. Coiffier,et al. Phase III study to evaluate temsirolimus compared with investigator's choice therapy for the treatment of relapsed or refractory mantle cell lymphoma. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[8] T. Wei,et al. Breast cancer migration and invasion depend on proteasome degradation of regulator of G-protein signaling 4. , 2009, Cancer research.
[9] M. Cotton,et al. G protein-coupled receptors stimulation and the control of cell migration. , 2009, Cellular signalling.
[10] K. Murthy,et al. Upregulation of RGS4 expression by IL-1beta in colonic smooth muscle is enhanced by ERK1/2 and p38 MAPK and inhibited by the PI3K/Akt/GSK3beta pathway. , 2009, American journal of physiology. Cell physiology.
[11] M. Weller,et al. Antagonism of the mammalian target of rapamycin selectively mediates metabolic effects of epidermal growth factor receptor inhibition and protects human malignant glioma cells from hypoxia-induced cell death. , 2009, Brain : a journal of neurology.
[12] R. Mirimanoff,et al. Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. , 2009, The Lancet. Oncology.
[13] D. Guertin,et al. The Pharmacology of mTOR Inhibition , 2009, Science Signaling.
[14] M. Weller,et al. Toll‐Like Receptor Engagement Enhances the Immunosuppressive Properties of Human Bone Marrow‐Derived Mesenchymal Stem Cells by Inducing Indoleamine‐2,3‐dioxygenase‐1 via Interferon‐β and Protein Kinase R , 2009, Stem cells.
[15] D. Yee. Faculty Opinions recommendation of Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. , 2009 .
[16] Masahiro Inoue,et al. Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis. , 2009, Cancer cell.
[17] Gerard Manning,et al. TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2. , 2009, Cancer research.
[18] D. Alessi,et al. mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1). , 2008, The Biochemical journal.
[19] M. Weller,et al. Enzastaurin‐induced apoptosis in glioma cells is caspase‐dependent and inhibited by BCL‐XL , 2008, Journal of neurochemistry.
[20] C. James,et al. PTEN Loss Does Not Predict for Response to RAD001 (Everolimus) in a Glioblastoma Orthotopic Xenograft Test Panel , 2008, Clinical Cancer Research.
[21] Zhihui Xie,et al. R4 RGS proteins: regulation of G-protein signaling and beyond. , 2007, Pharmacology & therapeutics.
[22] R. Motzer,et al. Phase I/II trial of temsirolimus combined with interferon alfa for advanced renal cell carcinoma. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[23] David M Sabatini,et al. Defining the role of mTOR in cancer. , 2007, Cancer cell.
[24] P. Levitt,et al. Making the Case for a Candidate Vulnerability Gene in Schizophrenia: Convergent Evidence for Regulator of G-Protein Signaling 4 (RGS4) , 2006, Biological Psychiatry.
[25] M. Weller,et al. Irradiation and hypoxia promote homing of haematopoietic progenitor cells towards gliomas by TGF-β-dependent HIF-1α-mediated induction of CXCL12 , 2006 .
[26] G. Kroemer,et al. Current development of mTOR inhibitors as anticancer agents , 2006, Nature Reviews Drug Discovery.
[27] P. Wen,et al. Pilot study of the combination of EGFR and mTOR inhibitors in recurrent malignant gliomas , 2006, Neurology.
[28] M. Weller,et al. BCL-xL: time-dependent dissociation between modulation of apoptosis and invasiveness in human malignant glioma cells , 2006, Cell Death and Differentiation.
[29] Charles J. Wilson,et al. RGS4-dependent attenuation of M4 autoreceptor function in striatal cholinergic interneurons following dopamine depletion , 2006, Nature Neuroscience.
[30] Thomas D. Wu,et al. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. , 2006, Cancer cell.
[31] Gordon B Mills,et al. mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. , 2006, Cancer research.
[32] B. Scheithauer,et al. Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group Study. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[33] D. Guertin,et al. Phosphorylation and Regulation of Akt/PKB by the Rictor-mTOR Complex , 2005, Science.
[34] R. Loewith,et al. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive , 2004, Nature Cell Biology.
[35] C. Tamminga,et al. Regional expression of RGS4 mRNA in human brain † , 2004, The European journal of neuroscience.
[36] Alona Muzikansky,et al. The prognostic significance of phosphatidylinositol 3-kinase pathway activation in human gliomas. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[37] Werner Paulus,et al. Regulators of G‐Protein Signaling 3 and 4 (RGS3, RGS4) Are Associated with Glioma Cell Motility , 2004, Journal of neuropathology and experimental neurology.
[38] Gordon K Smyth,et al. Statistical Applications in Genetics and Molecular Biology Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments , 2011 .
[39] In-Hyun Park,et al. Regulation of Ribosomal S6 Kinase 2 by Mammalian Target of Rapamycin* , 2002, The Journal of Biological Chemistry.
[40] H. Dohlman. Regulators of G Protein Signaling (RGS Proteins) , 2002 .
[41] J. Blenis,et al. An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/− mice , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[42] Hong Wu,et al. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[43] E. Sausville,et al. Biochemical correlates of mTOR inhibition by the rapamycin ester CCI-779 and tumor growth inhibition. , 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.
[44] A Rimner,et al. Sublethal irradiation promotes migration and invasiveness of glioma cells: implications for radiotherapy of human glioblastoma. , 2001, Cancer research.
[45] B. Geoerger,et al. Antitumor activity of the rapamycin analog CCI-779 in human primitive neuroectodermal tumor/medulloblastoma models as single agent and in combination chemotherapy. , 2001, Cancer research.
[46] Clive N Svendsen,et al. A new method for the rapid and long term growth of human neural precursor cells , 1998, Journal of Neuroscience Methods.
[47] D. Bigner,et al. Characterization of a spontaneous murine astrocytoma and abrogation of its tumorigenicity by cytokine secretion. , 1997, Neurosurgery.
[48] J. Uhm. Updated Response Assessment Criteria for High-Grade Gliomas: Response Assessment in Neuro-Oncology Working Group , 2010 .
[49] R. McLendon,et al. Phase 2 trial of erlotinib plus sirolimus in adults with recurrent glioblastoma , 2009, Journal of Neuro-Oncology.
[50] J. Uhm. Comprehensive genomic characterization defines human glioblastoma genes and core pathways , 2009 .
[51] K. Martemyanov,et al. A role of RGS proteins in drug addiction. , 2008, Biochemical pharmacology.
[52] M. Weller,et al. Irradiation and hypoxia promote homing of haematopoietic progenitor cells towards gliomas by TGF-beta-dependent HIF-1alpha-mediated induction of CXCL12. , 2006, Brain : a journal of neurology.
[53] Alex E. Lash,et al. Gene Expression Omnibus: NCBI gene expression and hybridization array data repository , 2002, Nucleic Acids Res..
[54] M. Farquhar,et al. The regulator of G protein signaling family. , 2000, Annual review of pharmacology and toxicology.