Measurements of temperature during thermal ablation treatments on ex vivo liver tissue using fiber Bragg grating sensors

In this work, we propose the use of fiber Bragg grating (FBG) sensor arrays for real-time temperature monitoring during RadioFrequency Thermal Ablation (RFTA) tumor treatment. Real-time temperature monitoring of RF-treatment to the tumors lesion of an organ could prove to be highly beneficial for intra-operative surgical planning and subsequently ensure a successful outcome of a thermo-ablation procedure. An adequate configuration was designed in order to create a thermal multipoint map. In particular, the RF probe of a commercial medical device was properly packaged with FBG sensors. In order to discern the treatment areas as accurately as possible, a second 3.5 cm long array, consisting of several FBGs was also employed. The experiments were conducted on ex vivo animal liver tissues and results confirm that we were successfully able to conduct a multipoint measurement and to distinguish between different and consecutive RF discharges with a temperature resolution of 0.1 °C and a minimum spatial resolution of 5mm.

[1]  Nick Todd,et al.  In vivo evaluation of multi‐echo hybrid PRF/T1 approach for temperature monitoring during breast MR‐guided focused ultrasound surgery treatments , 2014, Magnetic resonance in medicine.

[2]  Emiliano Schena,et al.  Assessment of temperature measurement error and its correction during Nd:YAG laser ablation in porcine pancreas , 2014, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[3]  Sergio Silvestri,et al.  CT-based thermometry: An overview , 2014, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[4]  S L Dawson,et al.  Tissue ablation with radiofrequency: effect of probe size, gauge, duration, and temperature on lesion volume. , 1995, Academic radiology.

[5]  Elfed Lewis,et al.  Fiber Optic Sensors for Temperature Monitoring during Thermal Treatments: An Overview , 2016, Sensors.

[6]  K. Hill,et al.  Fiber Bragg grating technology fundamentals and overview , 1997 .

[7]  Emiliano Schena,et al.  Multipoint temperature monitoring in liver undergoing computed tomography-guided radiofrequency ablation with fiber Bragg grating probes , 2016, 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

[8]  Agostino Iadicicco,et al.  Temperature monitoring during thermal ablation on ex-vivo organs by Fiber Bragg gratings , 2016, 2016 IEEE SENSORS.

[9]  D. Gervais,et al.  Renal cell carcinoma: clinical experience and technical success with radio-frequency ablation of 42 tumors. , 2003, Radiology.

[10]  Luigi Solbiati,et al.  Treatment of focal liver tumors with percutaneous radio-frequency ablation: complications encountered in a multicenter study. , 2003, Radiology.

[11]  Elfed Lewis,et al.  Monitoring of radiofrequency thermal ablation in liver tissue through fibre Bragg grating sensors array , 2014 .

[12]  Huacai Chen,et al.  Study on Optical Fiber Bragg Grating Temperature Sensors for Human Body Temperature Monitoring , 2012, 2012 Symposium on Photonics and Optoelectronics.

[13]  Emiliano Schena,et al.  Endoscopic ultrasound-guided Nd:YAG laser ablation of recurrent pancreatic neuroendocrine tumor: a promising revolution? , 2014, Endoscopy.

[14]  Massimo Della Pietra,et al.  Strain measurements of a multilayer panel via Fiber Bragg gratings as novel approach for deflection monitoring of tracking particle detectors , 2015, Europe Optics + Optoelectronics.

[15]  E Schena,et al.  Temperature monitoring during microwave ablation in ex vivo porcine livers. , 2015, European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology.

[16]  M D Sherar,et al.  Temperature measurement artefacts of thermocouples and fluoroptic probes during laser irradiation at 810 nm. , 2001, Physics in medicine and biology.

[17]  Agostino Iadicicco,et al.  Temperature profile of ex-vivo organs during radio frequency thermal ablation by fiber Bragg gratings , 2016, Journal of biomedical optics.

[18]  Sergio Silvestri,et al.  Theoretical Analysis and Experimental Evaluation of Laser-Induced Interstitial Thermotherapy in Ex Vivo Porcine Pancreas , 2012, IEEE Transactions on Biomedical Engineering.

[19]  Emiliano Schena,et al.  Experimental validation of MWA effects on biological tissue by sensorized needles based on FBG technology , 2016, 2016 IEEE International Symposium on Medical Measurements and Applications (MeMeA).

[20]  D. Dupuy,et al.  Thermal ablation of tumours: biological mechanisms and advances in therapy , 2014, Nature Reviews Cancer.

[21]  Sergio Silvestri,et al.  Temperature monitoring and lesion volume estimation during double-applicator laser-induced thermotherapy in ex vivo swine pancreas: a preliminary study , 2014, Lasers in Medical Science.

[22]  Emiliano Schena,et al.  Error of a Temperature Probe for Cancer Ablation Monitoring Caused by Respiratory Movements: Ex Vivo and In Vivo Analysis , 2016, IEEE Sensors Journal.

[23]  Sergio Silvestri,et al.  Techniques for temperature monitoring during laser-induced thermotherapy: An overview , 2013, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[24]  Agostino Iadicicco,et al.  Fiber Bragg Grating for Temperature Monitoring During Medical Radiofrequency Treatments , 2016 .

[25]  Esra Neufeld,et al.  Simulation techniques in hyperthermia treatment planning , 2013, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[26]  Haim Azhari,et al.  Feasibility study of ultrasonic computed tomography-guided high-intensity focused ultrasound. , 2012, Ultrasound in medicine & biology.

[27]  Gregor Bruggmoser,et al.  Some aspects of quality management in deep regional hyperthermia , 2012, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[28]  N. Habib,et al.  Liver resection with bipolar radiofrequency device: Habib 4X. , 2008, HPB : the official journal of the International Hepato Pancreato Biliary Association.

[29]  Agostino Iadicicco,et al.  Fiber Bragg grating sensors as a tool to evaluate the influence of filler on shrinkage of geopolymer matrices , 2015, Europe Optics + Optoelectronics.

[30]  Michael A. Davis,et al.  Fiber grating sensors , 1997 .