RELATIONSHIP OF THE BIOSYNTHESIS OF α‐FETOPROTEIN, ALBUMIN, HEMOPEXIN, AND HAPTOGLOBIN TO THE GROWTH STATE OF FETAL RAT HEPATOCYTE CULTURES *

AFP and albumin are produced by arginine-synthesizing fetal rat hepatocytes in vitro. AFP and hemopexin production are coupled to hepatocellular proliferation, whereas albumin and haptoglobin production are not. During the cell cycle, AFP is synthesized prior to S and released prior to M. AFP may play a role in regulation of hepatocellular growth through estradiol binding and modulation of the intracellular concentration of lipoprotein (VLDL).

[1]  U. Muller-eberhard,et al.  A radioimmunoassay employing polyethylene glycol (PEG) for measuring dilute concentrations of rat hemopexin, albumin and haptoglobin. , 1975, Immunochemistry.

[2]  F. Becker,et al.  Early Elevation of α1-Fetoprotein in N-2-Fluorenylacetamide Hepatocarcinogenesis , 1974 .

[3]  M. Brown,et al.  Stimulation of the synthesis of very low density lipoproteins in rooster liver by estradiol. , 1974, The Journal of biological chemistry.

[4]  H. Leffert.  GROWTH CONTROL OF DIFFERENTIATED FETAL RAT HEPATOCYTES IN PRIMARY MONOLAYER CULTURE , 1974, The Journal of cell biology.

[5]  H. Leffert,et al.  GROWTH CONTROL OF DIFFERENTIATED FETAL RAT HEPATOCYTES IN PRIMARY MONOLAYER CULTURE , 1974, The Journal of cell biology.

[6]  H. Leffert,et al.  Growth Control of Differentiated Fetal Rat Hepatocytes in Primary Monolayer Culture Vii. Hormonal Control of Dna Synthesis and Its Possible Significance to the Problem of Liver Regeneration , 1974 .

[7]  S. Sell,et al.  Rat Alpha1-Fetoprotein: Appearance After GalactosamineInduced Liver Injury , 1974 .

[8]  O. Stein,et al.  COLCHICINE-INDUCED INHIBITION OF LIPOPROTEIN AND PROTEIN SECRETION INTO THE SERUM AND LACK OF INTERFERENCE WITH SECRETION OF BILIARY PHOSPHOLIPIDS AND CHOLESTEROL BY RAT LIVER IN VIVO , 1974, The Journal of cell biology.

[9]  S. Sell,et al.  Relationship of rat alpha 1-fetoprotein to growth rate and chromosome composition of Morris hepatomas. , 1974, Cancer research.

[10]  S. Sell,et al.  ALPHA1-FETOPROTEIN BIOSYNTHESIS DURING THE GROWTH CYCLE OF DIFFERENTIATED FETAL RAT HEPATOCYTES IN PRIMARY MONOLAYER CULTURE , 1974, The Journal of cell biology.

[11]  S. Sell,et al.  Rat α1F. XI. Immunological control of cell proliferation: Increased growth rate and α1F production by morris hepatoma 5123tc in rats treated with anti‐thymocyte serum , 1974, International journal of cancer.

[12]  F. Becker,et al.  Hepatocyte proliferation and alpha 1-fetoprotein in pregnant, neonatal, and partially hepatectomized rats. , 1974, Cancer research.

[13]  S. Sell.  Alpha-fetoprotein: serum levels in pregnant rats. , 1973, Journal of the National Cancer Institute.

[14]  S. Sell,et al.  Rat α-fetoprotein—III. Refinement of radioimmunoassay for detection of 1 ng rat α1F , 1973 .

[15]  U. Muller-eberhard,et al.  Sites of formation of the serum proteins transferrin and hemopexin. , 1973, The Journal of clinical investigation.

[16]  H. Leffert,et al.  Serum dependent growth of primary cultured differentiated fetal rat hepatocytes in arginine‐deficient medium , 1973, Journal of cellular physiology.

[17]  M. L. Watkins,et al.  Sexual influences on hepatic secretion of triglyceride. , 1972, Biochimica et biophysica acta.

[18]  S. Sell,et al.  Isolation and characterization of rat 1 -fetoprotein. , 1972, Cancer research.

[19]  H. Leffert,et al.  STUDIES ON PRIMARY CULTURES OF DIFFERENTIATED FETAL LIVER CELLS , 1972, The Journal of cell biology.

[20]  J. Uriel,et al.  Estrogen-binding properties of rat, mouse and man fetospecific serum proteins. Demonstration by immuno-autoradiographic methods. , 1972, Biochemical and biophysical research communications.

[21]  D L Young,et al.  Estradiol- and testosterone-induced alterations in phosphatidylcholine and triglyceride synthesis in hepatic endoplasmic reticulum. , 1971, Journal of lipid research.

[22]  J. Uriel,et al.  Antigènes cellulaires transitoires du foie de rat. I. Sécrétion et synthèse des protéines sériques fetospécifiques au cours du développement et de la régénération hépatiques , 1971 .

[23]  R. Freedman,et al.  The effects of aflatoxin B1 on the sex-specific binding of steroid hormones to microsomal membranes of rat liver. , 1971, European journal of biochemistry.

[24]  Abelev Gi.  Alpha-Fetoprotein in Ontogenesis and its Association with Malignant Tumors , 1971 .

[25]  D. Gitlin,et al.  Sites of serum alpha-fetoprotein synthesis in the human and in the rat. , 1967, The Journal of clinical investigation.