Calmodulin Antagonist W‐7 Prevents Sparfloxacin‐Induced Early Afterdepolarizations (EADs) in Isolated Rabbit Purkinje Fibers: Importance of Beat‐to‐Beat Instability of the Repolarization

Introduction: The occurrence of early afterdepolarizations (EADs) has been related to the incidence of torsades de pointes in drug‐induced long QT (LQT). The generation of EADs may be facilitated by Ca2+/calmodulin‐dependent protein kinase II (CaM kinase).

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