Functional regulation of the apurinic/apyrimidinic endonuclease 1 by nucleophosmin: impact on tumor biology
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C. Vascotto | G. Tell | M. Poletto | G. Damante | D. Fabbro | E. Colombo | B. Demple | L. Lirussi | M. Tiribelli | D. Damiani | Dora Fabbro | Giuseppe Damante | M. Tiribelli | Daniela Damiani | Bruce Demple | Emanuela Colombo
[1] C. Vascotto,et al. Expression and prognostic significance of APE1/Ref-1 and NPM1 proteins in high-grade ovarian serous cancer. , 2014, American journal of clinical pathology.
[2] C. Vascotto,et al. Role of the unstructured N-terminal domain of the hAPE1 (human apurinic/apyrimidinic endonuclease 1) in the modulation of its interaction with nucleic acids and NPM1 (nucleophosmin). , 2013, The Biochemical journal.
[3] A. Scaloni,et al. Nucleolar accumulation of APE1 depends on charged lysine residues that undergo acetylation upon genotoxic stress and modulate its BER activity in cells , 2012, Molecular biology of the cell.
[4] David M. Wilson,et al. Synthesis, biological evaluation, and structure-activity relationships of a novel class of apurinic/apyrimidinic endonuclease 1 inhibitors. , 2012, Journal of medicinal chemistry.
[5] D. Delneri,et al. Knock-in reconstitution studies reveal an unexpected role of Cys-65 in regulating APE1/Ref-1 subcellular trafficking and function , 2011, Molecular biology of the cell.
[6] Eizadora T Yu,et al. Bioinformatic processing to identify single nucleotide polymorphism that potentially affect Ape1 function. , 2011, Mutation research.
[7] P G Pelicci,et al. Nucleophosmin and its complex network: a possible therapeutic target in hematological diseases , 2011, Oncogene.
[8] Robert W Sobol,et al. Base excision repair and lesion-dependent subpathways for repair of oxidative DNA damage. , 2011, Antioxidants & redox signaling.
[9] M. Gross,et al. Functional analysis of novel analogues of E3330 that block the redox signaling activity of the multifunctional AP endonuclease/redox signaling enzyme APE1/Ref-1. , 2011, Antioxidants & redox signaling.
[10] R. Andrews,et al. Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice , 2011, Nature Genetics.
[11] N. Bolli,et al. Acute myeloid leukemia with mutated nucleophosmin (NPM1): is it a distinct entity? , 2011, Blood.
[12] B. Demple,et al. Distinct Roles of Ape1 Protein in the Repair of DNA Damage Induced by Ionizing Radiation or Bleomycin* , 2010, The Journal of Biological Chemistry.
[13] A. Simeonov,et al. Small molecule inhibitors of DNA repair nuclease activities of APE1 , 2010, Cellular and Molecular Life Sciences.
[14] G. Tell,et al. Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment , 2010, Cellular and Molecular Life Sciences.
[15] L. Vitagliano,et al. Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions , 2010, Nucleic acids research.
[16] Karl-Johan Leuchowius,et al. Proximity ligation assays: a recent addition to the proteomics toolbox , 2010, Expert review of proteomics.
[17] S. Mitra,et al. Age- and tissue-specific changes in mitochondrial and nuclear DNA base excision repair activity in mice: Susceptibility of skeletal muscles to oxidative injury , 2010, Mechanisms of Ageing and Development.
[18] G. Tell,et al. Intrusion of a DNA Repair Protein in the RNome World: Is This the Beginning of a New Era? , 2009, Molecular and Cellular Biology.
[19] M. Kelley,et al. Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress: use of APE1 small molecule inhibitors to delineate APE1 functions. , 2009, DNA repair.
[20] R. Fanin,et al. Two novel NPM1 mutations in a therapy‐responder AML patient , 2009, Hematological oncology.
[21] S. Mitra,et al. Identification of Apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA , 2009, Nucleic acids research.
[22] A. Leonardi,et al. APE1/Ref-1 Interacts with NPM1 within Nucleoli and Plays a Role in the rRNA Quality Control Process , 2009, Molecular and Cellular Biology.
[23] S. Mitra,et al. Long Patch Base Excision Repair in Mammalian Mitochondrial Genomes* , 2008, Journal of Biological Chemistry.
[24] P. Pelicci,et al. A ribosomal protein L23-nucleophosmin circuit coordinates Miz1 function with cell growth , 2008, Nature Cell Biology.
[25] P. Pelicci,et al. Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7γ , 2008, The Journal of cell biology.
[26] G. Martinelli,et al. Increase sensitivity to chemotherapeutical agents and cytoplasmatic interaction between NPM leukemic mutant and NF-κB in AML carrying NPM1 mutations , 2008, Leukemia.
[27] T. Lim,et al. Nucleophosmin interacts with HEXIM1 and regulates RNA polymerase II transcription. , 2008, Journal of molecular biology.
[28] Z. Fan,et al. Granzyme K degrades the redox/DNA repair enzyme Ape1 to trigger oxidative stress of target cells leading to cytotoxicity. , 2008, Molecular immunology.
[29] M. Balbín,et al. A new type of NPM1 gene mutation in AML leading to a C-terminal truncated protein , 2007, Leukemia.
[30] Brunangelo Falini,et al. Acute myeloid leukemia carrying cytoplasmic/mutated nucleophosmin (NPMc+ AML): biologic and clinical features. , 2007, Blood.
[31] C. Bloomfield,et al. Clinical relevance of mutations and gene-expression changes in adult acute myeloid leukemia with normal cytogenetics: are we ready for a prognostically prioritized molecular classification? , 2007, Blood.
[32] W. Hiddemann,et al. Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML. , 2006, Blood.
[33] Bernd Epe,et al. DNA damage by bromate: mechanism and consequences. , 2006, Toxicology.
[34] P. Pelicci,et al. Delocalization and destabilization of the Arf tumor suppressor by the leukemia-associated NPM mutant. , 2006, Cancer research.
[35] Brian A. Smith,et al. DNA damage disrupts the p14ARF-B23(nucleophosmin) interaction and triggers a transient subnuclear redistribution of p14ARF. , 2005, Cancer research.
[36] B. Falini,et al. Nucleophosmin Is Required for DNA Integrity and p19Arf Protein Stability , 2005, Molecular and Cellular Biology.
[37] N. Bolli,et al. Cell line OCI/AML3 bears exon-12 NPM gene mutation-A and cytoplasmic expression of nucleophosmin , 2005, Leukemia.
[38] C. Sherr,et al. Myeloid Leukemia-Associated Nucleophosmin Mutants Perturb p53-Dependent and Independent Activities of the Arf Tumor Suppressor Protein , 2005, Cell cycle.
[39] P. Hainaut,et al. Roles of thioredoxin reductase 1 and APE/Ref-1 in the control of basal p53 stability and activity , 2005, Oncogene.
[40] L. Ellis,et al. HIF-1α, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas , 2005, Oncogene.
[41] David J. Chen,et al. Two essential but distinct functions of the mammalian abasic endonuclease. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[42] G. Tell,et al. The intracellular localization of APE1/Ref-1: more than a passive phenomenon? , 2005, Antioxidants & redox signaling.
[43] B. Demple,et al. A vital role for Ape1/Ref1 protein in repairing spontaneous DNA damage in human cells. , 2005, Molecular cell.
[44] J. Stubbe,et al. Bleomycins: towards better therapeutics , 2005, Nature Reviews Cancer.
[45] Paola Fazi,et al. Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype. , 2005, The New England journal of medicine.
[46] G. Wilson,et al. Ref‐1/Ape is critical for formation of the hypoxia‐inducible transcriptional complex on the hypoxic response element of the rat pulmonary artery endothelial cell VEGF gene , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[47] K. Bhakat,et al. Role of acetylated human AP‐endonuclease (APE1/Ref‐1) in regulation of the parathyroid hormone gene , 2003, The EMBO journal.
[48] M. Waltham,et al. Human Apurinic/Apyrimidinic Endonuclease (Ape1) and Its N-terminal Truncated Form (AN34) Are Involved in DNA Fragmentation during Apoptosis* , 2003, Journal of Biological Chemistry.
[49] L. Oberley,et al. Redox factor-1 contributes to the regulation of progression from G0/G1 to S by PDGF in vascular smooth muscle cells. , 2003, American journal of physiology. Heart and circulatory physiology.
[50] J. Lieberman,et al. Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A , 2003, Nature Immunology.
[51] B. Jeon,et al. Redox factor-1: an extra-nuclear role in the regulation of endothelial oxidative stress and apoptosis , 2002, Cell Death and Differentiation.
[52] Pier Giuseppe Pelicci,et al. Nucleophosmin regulates the stability and transcriptional activity of p53 , 2002, Nature Cell Biology.
[53] K. Irani,et al. Redox factor‐1/APE suppresses oxidative stress by inhibiting activity of the rac1 GTPase , 2002, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[54] E. Crivellato,et al. Mitochondrial localization of APE/Ref-1 in thyroid cells. , 2001, Mutation research.
[55] J. Yodoi,et al. Thioredoxin nuclear translocation and interaction with redox factor-1 activates the activator protein-1 transcription factor in response to ionizing radiation. , 2000, Cancer research.
[56] J. Tainer,et al. DNA-bound structures and mutants reveal abasic DNA binding by APE1 DNA repair and coordination , 2000, Nature.
[57] T. Sakai,et al. Thioredoxin-dependent Redox Regulation of p53-mediated p21 Activation* , 1999, The Journal of Biological Chemistry.
[58] B. Demple,et al. Dynamics of the Interaction of Human Apurinic Endonuclease (Ape1) with Its Substrate and Product* , 1998, The Journal of Biological Chemistry.
[59] K. Mori,et al. AP-1 transcriptional activity is regulated by a direct association between thioredoxin and Ref-1. , 1997, Proceedings of the National Academy of Sciences of the United States of America.
[60] T. Curran,et al. The redox and DNA-repair activities of Ref-1 are encoded by nonoverlapping domains. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[61] T. Curran,et al. Identification and characterization of Ref‐1, a nuclear protein that facilitates AP‐1 DNA‐binding activity. , 1992, The EMBO journal.
[62] Y. Miki,et al. BRCA2 and nucleophosmin coregulate centrosome amplification and form a complex with the Rho effector kinase ROCK2. , 2011, Cancer research.
[63] M. Christmann,et al. BER, MGMT, and MMR in defense against alkylation-induced genotoxicity and apoptosis. , 2001, Progress in nucleic acid research and molecular biology.