Early Detection, Curative Treatment, and Survival Rates for Hepatocellular Carcinoma Surveillance in Patients with Cirrhosis: A Meta-analysis

Amit Singal and colleagues conducted a systematic review of the evidence that surveillance for hepatocellular carcinoma in patients with cirrhosis improves early detection, receipt of curative treatment, and overall survival. Please see later in the article for the Editors' Summary

[1]  A. Singal,et al.  Factors that affect accuracy of α-fetoprotein test in detection of hepatocellular carcinoma in patients with cirrhosis. , 2014, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[2]  P. Tugwell,et al.  The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses , 2014 .

[3]  Rohit Loomba,et al.  The global NAFLD epidemic , 2013, Nature Reviews Gastroenterology &Hepatology.

[4]  J. Marrero,et al.  Machine Learning Algorithms Outperform Conventional Regression Models in Predicting Development of Hepatocellular Carcinoma , 2013, The American Journal of Gastroenterology.

[5]  A. Singal,et al.  Meta‐analysis: underutilisation and disparities of treatment among patients with hepatocellular carcinoma in the United States , 2013, Alimentary pharmacology & therapeutics.

[6]  Jasmin A. Tiro,et al.  Improving hepatocellular carcinoma screening: applying lessons from colorectal cancer screening. , 2013, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[7]  Mariel S. Lavieri,et al.  Improving screening for hepatocellular carcinoma by incorporating data on levels of α-fetoprotein, over time. , 2013, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[8]  William M. Lee,et al.  Detection of Hepatocellular Carcinoma at Advanced Stages Among Patients in the HALT-C Trial: Where Did Surveillance Fail? , 2013, The American Journal of Gastroenterology.

[9]  A. Haydon,et al.  Improved survival trend of patients with hepatocellular carcinoma at an Australian tertiary hospital between 1995–2009 , 2013, Internal medicine journal.

[10]  H. El‐Serag,et al.  Association between nonalcoholic fatty liver disease and risk for hepatocellular cancer, based on systematic review. , 2012, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[11]  J. Bruix,et al.  Screening for Liver Cancer: The Rush to Judgment , 2012, Annals of Internal Medicine.

[12]  Mingyi Chen,et al.  Hepatocellular carcinoma screening practices and impact on survival among hepatitis B‐infected Asian Americans , 2012, Journal of viral hepatitis.

[13]  Jasmin A. Tiro,et al.  Failure Rates in the Hepatocellular Carcinoma Surveillance Process , 2012, Cancer Prevention Research.

[14]  H. Sørensen,et al.  Risk for Hepatocellular Carcinoma in Patients With Alcoholic Cirrhosis , 2012, Annals of Internal Medicine.

[15]  H. El‐Serag,et al.  Epidemiology of viral hepatitis and hepatocellular carcinoma. , 2012, Gastroenterology.

[16]  M. Vergara,et al.  Factors related to survival in hepatocellular carcinoma in the geographic area of Sabadell (Catalonia, Spain). , 2012, Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva.

[17]  J. Marrero,et al.  Effectiveness of Hepatocellular Carcinoma Surveillance in Patients with Cirrhosis , 2012, Cancer Epidemiology, Biomarkers & Prevention.

[18]  William M. Lee,et al.  Utilization of Hepatocellular Carcinoma Surveillance Among American Patients: A Systematic Review , 2012, Journal of General Internal Medicine.

[19]  H. Poustchi,et al.  Feasibility of conducting a randomized control trial for liver cancer screening: Is a randomized controlled trial for liver cancer screening feasible or still needed? , 2011, Hepatology.

[20]  F. Brunello,et al.  Changing aetiological factors of hepatocellular carcinoma and their potential impact on the effectiveness of surveillance. , 2011, Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver.

[21]  T. A. Varasa,et al.  Características clínicas, estadificación y tratamiento de los pacientes con carcinoma hepatocelular en la práctica clínica. Estudio prospectivo de una serie de 136 pacientes , 2011 .

[22]  J. Marrero,et al.  Patient Involvement in Healthcare is Associated With Higher Rates of Surveillance for Hepatocellular Carcinoma , 2011, Journal of clinical gastroenterology.

[23]  T. Therneau,et al.  Factors that affect risk for hepatocellular carcinoma and effects of surveillance. , 2011, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[24]  J. Bruix,et al.  Management of hepatocellular carcinoma: An update , 2011, Hepatology.

[25]  H. El‐Serag,et al.  Effectiveness of AFP and ultrasound tests on hepatocellular carcinoma mortality in HCV-infected patients in the USA , 2011, Gut.

[26]  K. Lindor,et al.  The value of observational research in liver diseases , 2011, Hepatology.

[27]  R. G. Gómez Rodríguez,et al.  [Clinical characteristics, staging and treatment of patients with hepatocellular carcinoma in clinical practice. Prospective study of 136 patients]. , 2011, Gastroenterologia y hepatologia.

[28]  A. Muir,et al.  Rates of Surveillance and Management of Hepatocellular Carcinoma in Patients Evaluated at a Liver Transplant Center , 2010, Digestive Diseases and Sciences.

[29]  A. Castiella,et al.  Are hepatocellular carcinoma surveillance programs effective at improving the therapeutic options. , 2010, Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva.

[30]  Xianglin L. Du,et al.  Use of surveillance for hepatocellular carcinoma among patients with cirrhosis in the United States , 2010, Hepatology.

[31]  J. Marrero,et al.  Recent advances in the treatment of hepatocellular carcinoma , 2010, Current opinion in gastroenterology.

[32]  Sheng-Nan Lu,et al.  Hepatocellular carcinoma surveillance and appropriate treatment options improve survival for patients with liver cirrhosis. , 2010, European journal of cancer.

[33]  Johnny C. Hong,et al.  Survival in Asian Americans After Treatments for Hepatocellular Carcinoma: A Seven-year Experience at UCLA , 2010, Journal of clinical gastroenterology.

[34]  D. Moher,et al.  Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. , 2010, International journal of surgery.

[35]  D. Lu,et al.  Surveillance for Hepatocellular Carcinoma Improves Survival in Asian-American Patients with Hepatitis B: Results from a Community-Based Clinic , 2010, Digestive Diseases and Sciences.

[36]  D. Lieberman,et al.  Clinical practice. Screening for colorectal cancer. , 2009, The New England journal of medicine.

[37]  J. Marrero,et al.  Meta‐analysis: surveillance with ultrasound for early‐stage hepatocellular carcinoma in patients with cirrhosis , 2009, Alimentary pharmacology & therapeutics.

[38]  N. Hiraga,et al.  Regular surveillance by imaging for early detection and better prognosis of hepatocellular carcinoma in patients infected with hepatitis C virus , 2009, Journal of Gastroenterology.

[39]  Ayako Suzuki,et al.  Surveillance for hepatocellular carcinoma in patients with primary biliary cirrhosis , 2008, Hepatology.

[40]  T. Hassanein,et al.  The role of consensus interferon in the current treatment of chronic hepatitis C viral infection. , 2008, Gastroenterology & hepatology.

[41]  S. Duffy,et al.  Correcting for lead time and length bias in estimating the effect of screen detection on cancer survival. , 2008, American journal of epidemiology.

[42]  P. Zapater,et al.  Usefulness of surveillance programmes for early diagnosis of hepatocellular carcinoma in clinical practice , 2008, Liver international : official journal of the International Association for the Study of the Liver.

[43]  S. Fan,et al.  Changing Paradigm in the Management of Hepatocellular Carcinoma Improves the Survival Benefit of Early Detection by Screening , 2008, Annals of surgery.

[44]  Singal Amit,et al.  Screening for hepatocellular carcinoma. , 2008, Gastroenterology & hepatology.

[45]  R. Fisher,et al.  Surveillance for hepatocellular carcinoma in patients with cirrhosis improves outcome. , 2008, The American journal of medicine.

[46]  V. Wong,et al.  Surveillance programme for hepatocellular carcinoma improves the survival of patients with chronic viral hepatitis , 2007, Liver international : official journal of the International Association for the Study of the Liver.

[47]  H. El‐Serag,et al.  Utilization of screening for hepatocellular carcinoma in the United States. , 2008, Journal of clinical gastroenterology.

[48]  Jung-Hwan Yoon,et al.  Do young hepatocellular carcinoma patients with relatively good liver function have poorer outcomes than elderly patients? , 2007, Journal of Gastroenterology and Hepatology.

[49]  M. Levy,et al.  Hepatocellular carcinoma in Sydney South West: late symptomatic presentation and poor outcome for most , 2007, Internal medicine journal.

[50]  Luci K. Leykum,et al.  Screening for hepatocellular carcinoma among veterans with hepatitis C on disease stage, treatment received, and survival. , 2007, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[51]  J. Nousbaum,et al.  Epidemiology of hepatocellular carcinoma in Finistère. Prospective study from June 2002 to May 2003. , 2007, Gastroenterologie clinique et biologique.

[52]  H. Toyoda,et al.  Impact of surveillance on survival of patients with initial hepatocellular carcinoma: a study from Japan. , 2006, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[53]  M. Yuen,et al.  Clinical features, biochemical parameters, and virological profiles of patients with hepatocellular carcinoma in Hong Kong , 2006, Alimentary pharmacology & therapeutics.

[54]  Y. Shiratori,et al.  Surveillance of hepatocellular carcinoma in patients with hepatitis C virus infection may improve patient survival , 2006, Liver international : official journal of the International Association for the Study of the Liver.

[55]  R. Kumashiro,et al.  Surveillance program for early detection of hepatocellular carcinoma in Japan: results of specialized department of liver disease. , 2006, Journal of clinical gastroenterology.

[56]  K. Eguchi,et al.  Clinical benefits of hepatocellular carcinoma surveillance: a single-center, hospital-based study. , 2005, Oncology reports.

[57]  I. Colle,et al.  The HepCar registry: report on a one-year registration program of hepatocellular carcinoma (HCC) in Belgium. What is daily practice in HCC? , 2005, Acta gastro-enterologica Belgica.

[58]  F. Durand,et al.  Screening of hepatocellular carcinoma in French patients , 1995, Digestive Diseases and Sciences.

[59]  Francesco Donato,et al.  Hepatocellular carcinoma in cirrhosis: incidence and risk factors. , 2004, Gastroenterology.

[60]  T. Chen,et al.  Does Screening or Surveillance for Primary Hepatocellular Carcinoma with Ultrasonography Improve the Prognosis of Patients? , 2004, Cancer journal.

[61]  Zhao-You Tang,et al.  Randomized controlled trial of screening for hepatocellular carcinoma , 2004, Journal of Cancer Research and Clinical Oncology.

[62]  Outcomes of 116 patients with hepatocellular carcinoma , 2004, Cancer Chemotherapy and Pharmacology.

[63]  D. Parkin,et al.  Screening for liver cancer: results of a randomised controlled trial in Qidong, China , 2003, Journal of medical screening.

[64]  K. McGlynn,et al.  The Continuing Increase in the Incidence of Hepatocellular Carcinoma in the United States: An Update , 2003, Annals of Internal Medicine.

[65]  D. Altman,et al.  Measuring inconsistency in meta-analyses , 2003, BMJ : British Medical Journal.

[66]  S. Thompson,et al.  Quantifying heterogeneity in a meta‐analysis , 2002, Statistics in medicine.

[67]  M. Zoli,et al.  Semiannual and annual surveillance of cirrhotic patients for hepatocellular carcinoma: effects on cancer stage and patient survival (Italian experience) , 2002, American Journal of Gastroenterology.

[68]  R. Hayward,et al.  Which colon cancer screening test? A comparison of costs, effectiveness, and compliance. , 2001, The American journal of medicine.

[69]  L Pagliaro,et al.  Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. European Association for the Study of the Liver. , 2001, Journal of hepatology.

[70]  J Q Shi,et al.  A sensitivity analysis for publication bias in systematic reviews , 2001, Statistical methods in medical research.

[71]  M. Sherman,et al.  Surveillance programme of cirrhotic patients for early diagnosis and treatment of hepatocellular carcinoma: a cost effectiveness analysis , 2001, Gut.

[72]  R. Testa,et al.  Does surveillance for hepatocellular carcinoma in HCV cirrhotic patients improve treatment outcome mainly due to better clinical status at diagnosis? , 2000, Hepato-gastroenterology.

[73]  R. Severino,et al.  Improved survival with screening for hepatocellular carcinoma , 2000, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

[74]  A. Sonnenberg,et al.  Colorectal cancer prevention 2000: screening recommendations of the American College of Gastroenterology , 2000, American Journal of Gastroenterology.

[75]  ndrea,et al.  Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. , 1996, The New England journal of medicine.

[76]  M. Sherman,et al.  Screening for hepatocellular carcinoma , 2007, Hepatology research : the official journal of the Japan Society of Hepatology.

[77]  J. Bruix,et al.  Natural history of untreated nonsurgical hepatocellular carcinoma: Rationale for the design and evaluation of therapeutic trials , 1999, Hepatology.

[78]  M. J. Soria de la Cruz,et al.  [Usefulness of ultrasonography in the early diagnosis of hepatocarcinoma in patients with liver cirrhosis]. , 1995, Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva.

[79]  C. Guarner,et al.  [Value of ultrasonography in the early diagnosis of hepatocellular carcinoma]. , 1993, Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva.

[80]  M. Yanagi,et al.  High-risk groups and screening strategies for early detection of hepatocellular carcinoma in patients with chronic liver disease. , 1993, Hepato-gastroenterology.

[81]  S. Tanaka,et al.  Effectiveness of periodic checkup by ultrasonography for the early diagnosis of hepatocellular carcinoma , 1990, Cancer.