Api m 10, a genuine A. mellifera venom allergen, is clinically relevant but underrepresented in therapeutic extracts

To cite this article: Blank S, Seismann H, Michel Y, McIntyre M, Cifuentes L, Braren I, Grunwald T, Darsow U, Ring J, Bredehorst R, Ollert M, Spillner E. Api m 10, a genuine A. mellifera venom allergen, is clinically relevant but underrepresented in therapeutic extracts. Allergy 2011; 66: 1322–1329.

[1]  S. Blank,et al.  Dissecting cross-reactivity in hymenoptera venom allergy by circumvention of alpha-1,3-core fucosylation. , 2010, Molecular immunology.

[2]  Y. Le Dréan,et al.  Purification of Proteins Fused to Either the Amino or Carboxy Terminus of the Mycobacterium xenopi Gyrase A Intein , 1999 .

[3]  D. D. de Graaf,et al.  Molecular cloning and expression of icarapin, a novel IgE‐binding bee venom protein , 2006, FEBS letters.

[4]  S. Blank,et al.  Generation of human monoclonal allergen-specific IgE and IgG antibodies from synthetic antibody libraries. , 2007, Clinical chemistry.

[5]  J. Ring,et al.  Identification, Recombinant Expression, and Characterization of the 100 kDa High Molecular Weight Hymenoptera Venom Allergens Api m 5 and Ves v 3 , 2010, The Journal of Immunology.

[6]  W. Hemmer,et al.  Identification by immunoblot of venom glycoproteins displaying immunoglobulin E‐binding N‐glycans as cross‐reactive allergens in honeybee and yellow jacket venom , 2004, Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology.

[7]  D. Kemeny,et al.  Superior biologic activity of the recombinant bee venom allergen hyaluronidase expressed in baculovirus-infected insect cells as compared with Escherichia coli. , 1998, The Journal of allergy and clinical immunology.

[8]  J. V. Van Beeumen,et al.  The protein composition of honeybee venom reconsidered by a proteomic approach. , 2005, Biochimica et biophysica acta.

[9]  R. Reisman,et al.  Allergenic potency of bee antigens measured by RAST inhibition , 1976, Clinical allergy.

[10]  K. Struhl,et al.  Current Protocols in Molecular Biology (New York: Greene Publishing Associates and Wiley-Interscience). Host-Range Shuttle System for Gene Insertion into the Chromosomes of Gram-negative Bacteria. , 1988 .

[11]  J. Ring,et al.  Molecular cloning and expression in insect cells of honeybee venom allergen acid phosphatase (Api m 3). , 2006, The Journal of allergy and clinical immunology.

[12]  J. Ring,et al.  In vitro basophil activation using CD63 expression in patients with bee and wasp venom allergy. , 2006, Journal of investigational allergology & clinical immunology.

[13]  A. Helbling,et al.  Immunotherapy with honeybee venom and yellow jacket venom is different regarding efficacy and safety. , 1992, The Journal of allergy and clinical immunology.

[14]  R. Aalberse,et al.  Serologic aspects of IgG4 antibodies. I. Prolonged immunization results in an IgG4-restricted response. , 1983, Journal of immunology.

[15]  E Habermann,et al.  Bee and wasp venoms. , 1972, Science.

[16]  R. Van Ree,et al.  Cross‐reactivity of IgE antibodies to allergens , 2001, Allergy.

[17]  A. Enk,et al.  In vitro hymenoptera venom allergy diagnosis: improved by screening for cross‐reactive carbohydrate determinants and reciprocal inhibition , 2006, Allergy.

[18]  H. Mosbech,et al.  The sting challenge test in Hymenoptera venom allergy Position paper of the subcommittee on Insect Venom Allergy of the European Academy of Allergology and Clinical Immunology , 1996, Allergy.