Electroresponsive Polymer–Carbon Nanotube Hydrogel Hybrids for Pulsatile Drug Delivery In Vivo

Drug release triggered by an external non-invasive stimulus is of great interest for the development of new drug delivery systems. The preparation of an electroresponsive multiwalled carbon nanotube/poly(methylacrylic acid) (MWNT/PMAA)-based hybrid material is reported. The hydrogel hybrids achieve a controlled drug release upon the ON/OFF application of an electric field, giving rise to in vitro and in vivo pulsatile release profiles.

[1]  Brian P. Timko,et al.  Remotely Triggerable Drug Delivery Systems , 2010, Advanced materials.

[2]  Young-Seak Lee,et al.  The effect of carbon nanotubes on drug delivery in an electro-sensitive transdermal drug delivery system. , 2010, Biomaterials.

[3]  R Langer,et al.  Responsive polymeric delivery systems. , 2001, Advanced drug delivery reviews.

[4]  A. Domb,et al.  Polymeric carriers for regional drug therapy. , 1995, Molecular medicine today.

[5]  X. Zhu,et al.  Polymer microspheres for controlled drug release. , 2004, International journal of pharmaceutics.

[6]  Zhiping Luo,et al.  Synthesis and characterization of chitosan-carbon nanotube composites. , 2009, Materials letters.

[7]  Y. Bae,et al.  Electrically credible polymer gel for controlled release of drugs , 1991, Nature.

[8]  Xiaojun Zeng,et al.  A New Transparent Conductor: Silver Nanowire Film Buried at the Surface of a Transparent Polymer , 2010, Advanced materials.

[9]  Constantina Lekakou,et al.  Electrophoresis and orientation of multiple wall carbon nanotubes in polymer solution , 2010 .

[10]  Jun Ge,et al.  Drug release from electric-field-responsive nanoparticles. , 2012, ACS nano.

[11]  Yanling Luo,et al.  Preparation and characterization of PMAA/MWCNTs nanohybrid hydrogels with improved mechanical properties. , 2010, Journal of biomedical materials research. Part B, Applied biomaterials.

[12]  Chen-Yuan Dong,et al.  Multiple release kinetics of targeted drug from gold nanorod embedded polyelectrolyte conjugates induced by near-infrared laser irradiation. , 2010, Journal of the American Chemical Society.

[13]  R. Langer,et al.  Drug delivery and targeting. , 1998, Nature.

[14]  T. Duis.  Acute Electrical Burns , 1995 .

[15]  Y. Luo,et al.  Preparation and characterisation of polyacrylamide/MWCNTs nanohybrid hydrogels with microporous structures , 2009 .

[16]  R. Langer,et al.  Polymers for sustained macromolecule release: procedures to fabricate reproducible delivery systems and control release kinetics. , 1980, Journal of pharmaceutical sciences.

[17]  Robert Langer,et al.  Multi-pulse drug delivery from a resorbable polymeric microchip device , 2003, Nature materials.

[18]  K. Sawahata,et al.  Electrically controlled drug delivery system using polyelectrolyte gels , 1990 .

[19]  Mu-Yi Hua,et al.  Magnetic resonance monitoring of focused ultrasound/magnetic nanoparticle targeting delivery of therapeutic agents to the brain , 2010, Proceedings of the National Academy of Sciences.

[20]  N. Kim,et al.  Heating fluid from aqueous dispersion of metallic to semiconducting particles , 2010 .

[21]  Electrically controlled release of macromolecules from cross-linked hyaluronic acid hydrogels , 1995 .

[22]  Andrew G. Gillies,et al.  Optically-and Thermally-responsive Programmable Materials Based on Carbon Nanotube-hydrogel Polymer Composites , 2022 .

[23]  Yongming Chen,et al.  Supramolecular Hydrogels Hybridized with Single-Walled Carbon Nanotubes , 2007 .

[24]  R. Hoogenboom,et al.  Externally triggered glass transition switch for localized on-demand drug delivery. , 2009, Angewandte Chemie.