Recent advances in the effects of microwave radiation on brains

This study concerns the effects of microwave on health because they pervade diverse fields of our lives. The brain has been recognized as one of the organs that is most vulnerable to microwave radiation. Therefore, in this article, we reviewed recent studies that have explored the effects of microwave radiation on the brain, especially the hippocampus, including analyses of epidemiology, morphology, electroencephalograms, learning and memory abilities and the mechanisms underlying brain dysfunction. However, the problem with these studies is that different parameters, such as the frequency, modulation, and power density of the radiation and the irradiation time, were used to evaluate microwave radiation between studies. As a result, the existing data exhibit poor reproducibility and comparability. To determine the specific dose-effect relationship between microwave radiation and its biological effects, more intensive studies must be performed.

[1]  Peter Achermann,et al.  Sleep EEG alterations: effects of pulsed magnetic fields versus pulse‐modulated radio frequency electromagnetic fields , 2012, Journal of sleep research.

[2]  Per Hall,et al.  Long-term mobile phone use and brain tumor risk. , 2005, American journal of epidemiology.

[3]  R. Peng,et al.  Identification of a Novel Rat NR2B Subunit Gene Promoter Region Variant and Its Association with Microwave-Induced Neuron Impairment , 2015, Molecular Neurobiology.

[4]  P. Boer,et al.  Raised glucose levels enhance scopolamine-induced acetylcholine overflow from the hippocampus: an in vivo microdialysis study in the rat , 1992, Behavioural Brain Research.

[5]  Hiie Hinrikus,et al.  Effect of low frequency modulated microwave exposure on human EEG: Individual sensitivity , 2008, Bioelectromagnetics.

[6]  B. Costall,et al.  Mobile phone use facilitates memory in male, but not female, subjects , 2003, Neuroreport.

[7]  P. Kenny,et al.  MicroRNAs in neuronal function and dysfunction , 2012, Trends in Neurosciences.

[8]  Niels Kuster,et al.  Whole-body exposure to 2.45 GHz electromagnetic fields does not alter radial-maze performance in rats , 2004, Behavioural Brain Research.

[9]  Kavindra Kumar Kesari,et al.  Fifty-gigahertz Microwave Exposure Effect of Radiations on Rat Brain , 2009, Applied biochemistry and biotechnology.

[10]  R. Chizhenkova Slow potentials and spike unit activity of the cerebral cortex of rabbits exposed to microwaves. , 1988, Bioelectromagnetics.

[11]  Kristen M Harris,et al.  Structure, development, and plasticity of dendritic spines , 1999, Current Opinion in Neurobiology.

[12]  J. Moreau,et al.  A Radio Frequency Electric Current Enhances Antibiotic Efficacy against Bacterial Biofilms , 2004, Antimicrobial Agents and Chemotherapy.

[13]  N. Edelstyn,et al.  The acute effects of exposure to the electromagnetic field emitted by mobile phones on human attention , 2002, Neuroreport.

[14]  S. P. Singh,et al.  2.45 GHz Microwave Radiation Impairs Learning and Spatial Memory via Oxidative/Nitrosative Stress Induced p53-Dependent/Independent Hippocampal Apoptosis: Molecular Basis and Underlying Mechanism. , 2015, Toxicological sciences : an official journal of the Society of Toxicology.

[15]  A. Neugut,et al.  Handheld cellular telephone use and risk of brain cancer. , 2000, JAMA.

[16]  Elisabeth Cardis,et al.  Brain tumour risk in relation to mobile telephone use: results of the INTERPHONE international case-control study. , 2010, International journal of epidemiology.

[17]  S. Szmigielski,et al.  Cancer morbidity in subjects occupationally exposed to high frequency (radiofrequency and microwave) electromagnetic radiation. , 1996, The Science of the total environment.

[18]  N. Dehghan,et al.  Human short-term exposure to electromagnetic fields emitted by mobile phones decreases computer-assisted visual reaction time , 2012, Acta Neurologica Belgica.

[19]  John D Boice,et al.  Cellular telephone use and cancer risk: update of a nationwide Danish cohort. , 2006, Journal of the National Cancer Institute.

[20]  R. Peng,et al.  Alterations of cognitive function and 5-HT system in rats after long term microwave exposure , 2015, Physiology & Behavior.

[21]  P. E. Gold Acetylcholine modulation of neural systems involved in learning and memory , 2003, Neurobiology of Learning and Memory.

[22]  T. Myhrer Neurotransmitter systems involved in learning and memory in the rat: a meta-analysis based on studies of four behavioral tasks , 2003, Brain Research Reviews.

[23]  T Berman,et al.  Cancer in Radar Technicians Exposed to Radiofrequency/Microwave Radiation: Sentinel Episodes , 2000, International journal of occupational and environmental health.

[24]  Jianhong Luo,et al.  Chronic exposure to GSM 1800-MHz microwaves reduces excitatory synaptic activity in cultured hippocampal neurons , 2006, Neuroscience Letters.

[25]  M. Otto,et al.  Electromagnetic fields (EMF): do they play a role in children's environmental health (CEH)? , 2007, International journal of hygiene and environmental health.

[26]  James R Jauchem,et al.  Radial arm maze performance of rats following repeated low level microwave radiation exposure , 2004, Bioelectromagnetics.

[27]  Henry Rusinek,et al.  Quantitation, regional vulnerability, and kinetic modeling of brain glucose metabolism in mild Alzheimer’s disease , 2007, European Journal of Nuclear Medicine and Molecular Imaging.

[28]  C. Ouimet,et al.  Protein synthesis is necessary for dendritic spine proliferation in adult brain slices , 2004, Brain Research.

[29]  M. Wong-Riley,et al.  Is nuclear respiratory factor 2 a master transcriptional coordinator for all ten nuclear-encoded cytochrome c oxidase subunits in neurons? , 2005, Gene.

[30]  Tore Tynes,et al.  Predictors and overestimation of recalled mobile phone use among children and adolescents. , 2011, Progress in biophysics and molecular biology.

[31]  W. Joines,et al.  The effects of hyperthermia and hyperthermia plus microwaves on rat brain energy metabolism. , 1984, Bioelectromagnetics.

[32]  M. Mailankot,et al.  Spatial Memory Perfomance of Wistar Rats Exposed to Mobile Phone , 2009, Clinics.

[33]  C. Yardin,et al.  Apoptosis is Induced by Radiofrequency Fields through the Caspase-Independent Mitochondrial Pathway in Cortical Neurons , 2008, Radiation research.

[34]  G. Kızıl,et al.  Effect of 900 MHz Radio Frequency Radiation on Beta Amyloid Protein, Protein Carbonyl, and Malondialdehyde in the Brain , 2012, Electromagnetic biology and medicine.

[35]  R. Peng,et al.  Abnormality of synaptic vesicular associated proteins in cerebral cortex and hippocampus after microwave exposure , 2009, Synapse.

[36]  Anssi Auvinen,et al.  Location of gliomas in relation to mobile telephone use: a case-case and case-specular analysis. , 2011, American journal of epidemiology.

[37]  S. Cull-Candy,et al.  Role of Distinct NMDA Receptor Subtypes at Central Synapses , 2004, Science's STKE.

[38]  Catrin Bauréus Koch,et al.  Exposure of rat brain to 915 MHz GSM microwaves induces changes in gene expression but not double stranded DNA breaks or effects on chromatin conformation , 2006, Bioelectromagnetics.

[39]  Jaeseung Jeong EEG dynamics in patients with Alzheimer's disease , 2004, Clinical Neurophysiology.

[40]  G. Thuröczy,,et al.  Simultaneous Response of Brain Electrical Activity (EEG) and Cerebral Circulation (REG) to Microwave Exposure in Rats , 1994, Reviews on environmental health.

[41]  R. Peng,et al.  Reduction of Phosphorylated Synapsin I (Ser-553) Leads to Spatial Memory Impairment by Attenuating GABA Release after Microwave Exposure in Wistar Rats , 2014, PloS one.

[42]  Frank J. Slack,et al.  The Role of MicroRNAs in Cancer , 2006, The Yale journal of biology and medicine.

[43]  Naser Dehghan,et al.  Adverse health effects of occupational exposure to radiofrequency radiation in airport surveillance radar operators , 2013, Indian journal of occupational and environmental medicine.

[44]  J. Olsen,et al.  Cellular telephones and cancer--a nationwide cohort study in Denmark. , 2001, Journal of the National Cancer Institute.

[45]  Giuseppina Raciti,et al.  Reactive oxygen species levels and DNA fragmentation on astrocytes in primary culture after acute exposure to low intensity microwave electromagnetic field , 2010, Neuroscience Letters.

[46]  Keisuke Ito,et al.  Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells , 2006, Nature Medicine.

[47]  S. Condello,et al.  Modulation of heat shock protein response in SH-SY5Y by mobile phone microwaves. , 2012, World journal of biological chemistry.

[48]  Peter Kan,et al.  Cellular phone use and brain tumor: a meta-analysis , 2007, Journal of Neuro-Oncology.

[49]  Ruiyun Peng,et al.  Impairment of long-term potentiation induction is essential for the disruption of spatial memory after microwave exposure , 2013, International journal of radiation biology.

[50]  K. Yeğin,et al.  Effects of 2.4 GHz radiofrequency radiation emitted from Wi-Fi equipment on microRNA expression in brain tissue , 2015, International journal of radiation biology.

[51]  C. Koch,et al.  The function of dendritic spines: devices subserving biochemical rather than electrical compartmentalization , 1993, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[52]  R. Peng,et al.  The relationship between NMDA receptors and microwave-induced learning and memory impairment: A long-term observation on Wistar rats , 2015, International journal of radiation biology.

[53]  P. E. Gold,et al.  Hippocampal acetylcholine release during memory testing in rats: augmentation by glucose. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[54]  V. Vorobyov,et al.  Repeated exposure to low-level extremely low frequency-modulated microwaves affects cortex-hypothalamus interplay in freely moving rats: EEG study , 2010, International journal of radiation biology.

[55]  Kjell Hansson Mild,et al.  Case-control study on the use of mobile and cordless phones and the risk for malignant melanoma in the head and neck region. , 2011, Pathophysiology : the official journal of the International Society for Pathophysiology.

[56]  C. Vakalopoulos The EEG as an index of neuromodulator balance in memory and mental illness , 2014, Front. Neurosci..

[57]  Evaluation of Psychologic Parameters in People Occupationally Exposed to Radiofrequencies and Microwave , 1994 .

[58]  R. Peng,et al.  MicroRNAs: Novel Mechanism Involved in the Pathogenesis of Microwave Exposure on Rats’ Hippocampus , 2014, Journal of Molecular Neuroscience.

[59]  Eric J. Murphy,et al.  Mitochondrial Lipid Abnormality and Electron Transport Chain Impairment in Mice Lacking α-Synuclein , 2005, Molecular and Cellular Biology.

[60]  Matti Laine,et al.  Effects of 902 MHz electromagnetic field emitted by cellular telephones on response times in humans , 2000, Neuroreport.

[61]  C. Plass,et al.  Genome-wide epigenetic regulation of miRNAs in cancer. , 2013, Cancer research.

[62]  Konstantinos Vougas,et al.  Brain proteome response following whole body exposure of mice to mobile phone or wireless DECT base radiation , 2012, Electromagnetic biology and medicine.

[63]  R. Ahmed,et al.  Low intensity microwave radiation induced oxidative stress, inflammatory response and DNA damage in rat brain. , 2015, Neurotoxicology.

[64]  Stanislaw Szmigielski,et al.  Cancer risks related to low-level RF/MW exposures, including cell phones , 2013, Electromagnetic biology and medicine.

[65]  S. Rapoport,et al.  Decreased expression of nuclear and mitochondrial DNA-encoded genes of oxidative phosphorylation in association neocortex in Alzheimer disease. , 1997, Brain research. Molecular brain research.

[66]  B. Eickholt,et al.  Defective actin dynamics in dendritic spines: cause or consequence of age-induced cognitive decline? , 2016, Biological chemistry.

[67]  E. Richter,et al.  Brain Cancer with Induction Periods of Less Than 10 Years in Young Military Radar Workers , 2002, Archives of environmental health.

[68]  M. Kumar,et al.  Chronic Nonmodulated Microwave Radiations in Mice Produce Anxiety-like and Depression-like Behaviours and Calcium- and NO-related Biochemical Changes in the Brain , 2016, Experimental neurobiology.

[69]  I. N. Krylova,et al.  Effect of microwave radiation on learning and memory , 1992, Bulletin of Experimental Biology and Medicine.

[70]  A W Preece,et al.  Effect of a 915-MHz simulated mobile phone signal on cognitive function in man. , 1999, International journal of radiation biology.

[71]  M. Sakly,et al.  Postnatal development and behavior effects of in-utero exposure of rats to radiofrequency waves emitted from conventional WiFi devices. , 2017, Environmental toxicology and pharmacology.

[72]  Yan-wen Zhang,et al.  Elevation of plasma corticosterone levels and hippocampal glucocorticoid receptor translocation in rats: a potential mechanism for cognition impairment following chronic low-power-density microwave exposure. , 2008, Journal of radiation research.

[73]  Kumar Vyonkesh Mani,et al.  Effect of occupational EMF exposure from radar at two different frequency bands on plasma melatonin and serotonin levels , 2015, International journal of radiation biology.

[74]  H. Chiang,et al.  Effects of GSM 1800 MHz on dendritic development of cultured hippo-campal neurons , 2007, Acta Pharmacologica Sinica.

[75]  T. Motawi,et al.  Biochemical Modifications and Neuronal Damage in Brain of Young and Adult Rats After Long-Term Exposure to Mobile Phone Radiations , 2014, Cell Biochemistry and Biophysics.

[76]  R. Verma,et al.  Radioprotective role of Amaranthus gangeticus Linn.: a biochemical study on mouse brain. , 2002, Journal of medicinal food.

[77]  M. Sakly,et al.  Effects of prenatal exposure to WIFI signal (2.45GHz) on postnatal development and behavior in rat: Influence of maternal restraint , 2017, Behavioural Brain Research.

[78]  J P McNamee,et al.  Microarray Gene Expression Profiling of a Human Glioblastoma Cell Line Exposed In Vitro to a 1.9 GHz Pulse-Modulated Radiofrequency Field , 2006, Radiation research.

[79]  Seung-Kwon Myung,et al.  Mobile phone use and risk of tumors: a meta-analysis. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[80]  S. Dasdag,et al.  Does 900 MHZ GSM Mobile Phone Exposure Affect Rat Brain? , 2004 .

[81]  A. Björklund,et al.  Regional changes in brain glucose metabolism reflect cognitive impairments in aged rats , 1984, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[82]  E. Gouaux,et al.  Subunit arrangement and function in NMDA receptors , 2005, Nature.

[83]  T. Ozben Oxidative stress and apoptosis: impact on cancer therapy. , 2007, Journal of pharmaceutical sciences.

[84]  Z. Bolaman,et al.  Neurologic and Biochemical Findings and CD4/CD8 Ratio in People Occupationally Exposed to RF and Microwave , 1992 .

[85]  B. Platt,et al.  Glutamate receptor function in learning and memory , 2003, Behavioural Brain Research.

[86]  Lennart Hardell,et al.  Cell phones and brain tumors: a review including the long-term epidemiologic data. , 2009, Surgical neurology.

[87]  Matti Laine,et al.  The effects of electromagnetic field emitted by GSM phones on working memory , 2000, Neuroreport.

[88]  Shui-ming Wang,et al.  Relationship between cognition function and hippocampus structure after long-term microwave exposure. , 2012, Biomedical and environmental sciences : BES.

[89]  Kanako Wake,et al.  Effects of electromagnetic fields emitted from W‐CDMA‐like mobile phones on sleep in humans , 2013, Bioelectromagnetics.

[90]  W. Staines,et al.  Glucose transporter plasticity during memory processing , 2005, Neuroscience.

[91]  Hiie Hinrikus,et al.  Effect of microwave radiation on human EEG at two different levels of exposure , 2013, Bioelectromagnetics.

[92]  Chetwyn C. H. Chan,et al.  Effect on human attention of exposure to the electromagnetic field emitted by mobile phones , 2001, Neuroreport.

[93]  N. Meiran,et al.  Effects of radiofrequency radiation emitted by cellular telephones on the cognitive functions of humans , 2006, Bioelectromagnetics.

[94]  D. Bhatnagar,et al.  Spatial memory and learning performance and its relationship to protein synthesis of Swiss albino mice exposed to 10 GHz microwaves , 2014, International journal of radiation biology.

[95]  A. Melloni,et al.  Using a $\hbox{Si}_{3}\hbox{N}_{4}$ Ring Resonator Notch Filter for Optical Carrier Reduction and Modulation Depth Enhancement in Radio-Over-Fiber Links , 2013, IEEE Photonics Journal.

[96]  H. Çelik,et al.  Effect of Long Term Mobile Phone Exposure on Oxidative-Antioxidative Processes and Nitric Oxide in Rats , 2008 .

[97]  K. Svoboda,et al.  Structure and function of dendritic spines. , 2002, Annual review of physiology.

[98]  Nancy M Bonini,et al.  MicroRNAs and neurodegeneration: role and impact. , 2013, Trends in cell biology.

[99]  S. Mortazavi,et al.  Looking at the other side of the coin: the search for possible biopositive cognitive effects of the exposure to 900 MHz GSM mobile phone radiofrequency radiation , 2014, Journal of Environmental Health Science and Engineering.

[100]  P. E. Gold Acetylcholine: Cognitive and brain functions , 2003, Neurobiology of Learning and Memory.

[101]  Fabrizio De Vico Fallani,et al.  Resting state cortical EEG rhythms in Alzheimer's disease: toward EEG markers for clinical applications: a review. , 2013, Supplements to Clinical neurophysiology.

[102]  H. Hämäläinen,et al.  GSM Mobile Phone Radiation Suppresses Brain Glucose Metabolism , 2011, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[103]  Ramesh Srinivasan,et al.  Anatomical constraints on source models for high-resolution EEG and MEG derived from MRI. , 2006, Technology in cancer research & treatment.

[104]  R. Morris Developments of a water-maze procedure for studying spatial learning in the rat , 1984, Journal of Neuroscience Methods.

[105]  Gunhild Waldemar,et al.  Risks for Central Nervous System Diseases among Mobile Phone Subscribers: A Danish Retrospective Cohort Study , 2009, PloS one.

[106]  R. Pinto,et al.  Proliferation and apoptosis in a neuroblastoma cell line exposed to 900 MHz modulated radiofrequency field , 2006, Bioelectromagnetics.

[107]  Niels Kuster,et al.  Whole-body exposure to 2.45GHz electromagnetic fields does not alter 12-arm radial-maze with reduced access to spatial cues in rats , 2005, Behavioural Brain Research.

[108]  N. Dehghan,et al.  Alterations of Visual Reaction Time and Short Term Memory in Military Radar Personnel , 2013, Iranian journal of public health.

[109]  S. Magazù,et al.  Inspections of Mobile Phone Microwaves Effects on Proteins Secondary Structure by Means of Fourier Transform Infrared Spectroscopy , 2010 .

[110]  Zhihui Li,et al.  Effects of fetal microwave radiation exposure on offspring behavior in mice , 2014, Journal of radiation research.

[111]  K. Yeğin,et al.  Long term and excessive use of 900 MHz radiofrequency radiation alter microRNA expression in brain , 2015, International journal of radiation biology.

[112]  A. Guy,et al.  Microwave irradiation affects radial-arm maze performance in the rat. , 1994, Bioelectromagnetics.

[113]  Patrizia Frei,et al.  Use of mobile phones and risk of brain tumours: update of Danish cohort study , 2011, BMJ : British Medical Journal.

[114]  N. Seyhan,et al.  Does MW Radiation Affect Gene Expression, Apoptotic Level, and Cell Cycle Progression of Human SH-SY5Y Neuroblastoma Cells? , 2016, Cell Biochemistry and Biophysics.

[115]  R. Peng,et al.  Microwave exposure impairs synaptic plasticity in the rat hippocampus and PC12 cells through over-activation of the NMDA receptor signaling pathway. , 2015, Biomedical and environmental sciences : BES.

[116]  Eric M. Reiman,et al.  Regional cerebral glucose uptake in the 3xTG model of Alzheimer's disease highlights common regional vulnerability across AD mouse models , 2010, Brain Research.

[117]  C. Destrade,et al.  Memory-improving action of glucose: indirect evidence for a facilitation of hippocampal acetylcholine synthesis , 1990, Behavioural Brain Research.

[118]  M. Shabani,et al.  The effect of Wi-Fi electromagnetic waves in unimodal and multimodal object recognition tasks in male rats , 2017, Neurological Sciences.

[119]  N. Hamasaki,et al.  Mitochondrial Transcription Factor A in the Maintenance of Mitochondrial DNA , 2005, Annals of the New York Academy of Sciences.

[120]  J. Blass,et al.  Decreased synthesis of acetylcholine accompanying impaired oxidation of pyruvic acid in rat brain minces. , 1975, The Biochemical journal.

[121]  Keisuke Ito,et al.  Reactive oxygen species act through p 38 MAPK to limit the lifespan of hematopoietic stem cells , 2006 .