A Convenient and Stable Synthon for Ethyl Azide and Its Evaluation in a [3 + 2]-Cycloaddition Reaction under Continuous-Flow Conditions

Azidoethyl phenyl sulfide, a readily accessible and reasonably stable synthon for ethyl azide with acceptable thermal safety properties, was investigated in a preliminary design space evaluation of a [3 + 2]-cycloaddition with cyanoacetamide under continuous-flow conditions in the Syrris AFRICA flow reactor.