CpG directly induces T-bet expression and inhibits IgG1 and IgE switching in B cells

[1]  I. Boldogh,et al.  In Vivo Role of p38 Mitogen-Activated Protein Kinase in Mediating the Anti-inflammatory Effects of CpG Oligodeoxynucleotide in Murine Asthma1 , 2002, The Journal of Immunology.

[2]  S. Akira,et al.  Differential involvement of IFN-beta in Toll-like receptor-stimulated dendritic cell activation. , 2002, International immunology.

[3]  L. Kwak,et al.  Mammalian defensins in immunity: more than just microbicidal. , 2002, Trends in immunology.

[4]  R. Modlin Mammalian toll-like receptors. , 2002, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[5]  T. Decker,et al.  IFNs and STATs in innate immunity to microorganisms. , 2002, The Journal of clinical investigation.

[6]  S. Szabo,et al.  T-bet regulates IgG class switching and pathogenic autoantibody production , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[7]  M. J. Cody,et al.  TLR4, but not TLR2, mediates IFN-β–induced STAT1α/β-dependent gene expression in macrophages , 2002, Nature Immunology.

[8]  Shizuo Akira,et al.  Toll-like receptors as adjuvant receptors. , 2002, Biochimica et biophysica acta.

[9]  Jianfei Yang,et al.  T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells , 2002, Nature Immunology.

[10]  I. Boldogh,et al.  In Vivo Role of p 38 Mitogen-Activated Protein Kinase in Mediating the Anti-inflammatory Effects of CpG Oligodeoxynucleotide in Murine Asthma 1 , 2002 .

[11]  A. Sher,et al.  T-bet is rapidly induced by interferon-γ in lymphoid and myeloid cells , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[12]  S. Sur,et al.  CpG oligonucleotide modulation of allergic inflammation , 2001, Allergy.

[13]  H. Asnagli,et al.  Stability and commitment in T helper cell development. , 2001, Current opinion in immunology.

[14]  B. Bohle,et al.  Oligodeoxynucleotides Containing CpG Motifs Induce Low Levels of TNF-α in Human B Lymphocytes: Possible Adjuvants for Th1 Responses1 , 2001, The Journal of Immunology.

[15]  K. Ishii,et al.  Human Peripheral Blood Cells Differentially Recognize and Respond to Two Distinct CpG Motifs , 2001 .

[16]  S. Akira,et al.  A Toll-like receptor recognizes bacterial DNA , 2000, Nature.

[17]  S. Fujieda,et al.  Synthetic oligodeoxynucleotides inhibit IgE induction in human lymphocytes. , 2000, American journal of respiratory and critical care medicine.

[18]  Laurie H Glimcher,et al.  A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment , 2000, Cell.

[19]  Gunther Hartmann,et al.  Mechanism and Function of a Newly Identified CpG DNA Motif in Human Primary B Cells1 , 2000, The Journal of Immunology.

[20]  A. Ullrich,et al.  Cell type‐specific activation of mitogen‐activated protein kinases by CpG‐DNA controls interleukin‐12 release from antigen‐presenting cells , 1999, The EMBO journal.

[21]  F. Annunziato,et al.  Phosphorothioate oligodeoxynucleotides promote the in vitro development of human allergen-specific CD4+ T cells into Th1 effectors. , 1999, Journal of immunology.

[22]  B. Bohle,et al.  Oligodeoxynucleotides containing CpG motifs induce IL‐12, IL‐18 and IFN‐γ production in cells from allergic individuals and inhibit IgE synthesis in vitro , 1999, European journal of immunology.

[23]  D. Klinman,et al.  Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides. , 1999, Journal of immunology.

[24]  S. Szabo,et al.  T helper differentiation proceeds through Stat1-dependent, Stat4-dependent and Stat4-independent phases. , 1999, Current topics in microbiology and immunology.

[25]  P. Thompson,et al.  STAT6 is required for IL-4-induced germline Ig gene transcription and switch recombination. , 1998, Journal of immunology.

[26]  J. Kline,et al.  Cutting Edge: Modulation of Airway Inflammation by CpG Oligodeoxynucleotides in a Murine Model of Asthma , 1998, The Journal of Immunology.

[27]  J. Kline,et al.  Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma. , 1998, Journal of immunology.

[28]  D. Richman,et al.  Immunostimulatory DNA sequences function as T helper-1-promoting adjuvants , 1997, Nature Medicine.

[29]  D. Hume,et al.  Macrophages ingest and are activated by bacterial DNA. , 1996, Journal of immunology.

[30]  A. Krieg,et al.  Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA. , 1996, Journal of immunology.

[31]  D. Carvajal,et al.  IL-12-Deficient Mice Are Defective in IFNγ Production and Type 1 Cytokine Responses , 1996 .

[32]  W. Paul,et al.  Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene , 1996, Nature.

[33]  S. Akira,et al.  Essential role of Stat6 in IL-4 signalling , 1996, Nature.

[34]  S. Beaucage,et al.  CpG motifs present in bacteria DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[35]  R. Schreiber,et al.  Targeted Disruption of the Stat1 Gene in Mice Reveals Unexpected Physiologic Specificity in the JAK–STAT Signaling Pathway , 1996, Cell.

[36]  A. Krieg,et al.  IFN-gamma promotes IL-6 and IgM secretion in response to CpG motifs in bacterial DNA and oligodeoxynucleotides. , 1996, Journal of immunology.

[37]  D. Pisetsky,et al.  Bacterial DNA Induces Murine Interferon-γ Production by Stimulation of Interleukin-12 and Tumor Necrosis Factor-α , 1996 .

[38]  G. Bishop,et al.  CpG motifs in bacterial DNA trigger direct B-cell activation , 1995, Nature.

[39]  F. Alt,et al.  Mitogen plus interleukin 4 induction of C epsilon transcripts in B lymphoid cells , 1988, The Journal of experimental medicine.

[40]  T. Tokunaga,et al.  A SYNTHETIC SINGLE‐STRANDED DNA, POLY(dG, dC), INDUCES TNTERFERON‐α/β AND ‐γ, AUGMENTS NATURAL KILLER ACTIVITY, AND SUPPRESSES TUMOR GROWTH , 1988, Japanese journal of cancer research : Gann.

[41]  Y. Fujisawa,et al.  Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity. , 1984, Journal of the National Cancer Institute.