Expression of active recombinant human alpha 1-antitrypsin in transgenic rabbits.

[1]  A. Balland,et al.  Characterization of recombinant human factor IX expressed in transgenic mice and in derived trans‐immortalized hepatic cell lines. , 1990, The EMBO journal.

[2]  M. Perricaudet,et al.  Expression of human α1‐antitrypsin using a recombinant adenovirus vector , 1990 .

[3]  A. Archibald,et al.  High-level expression of biologically active human alpha 1-antitrypsin in the milk of transgenic mice. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[4]  K. Bürki,et al.  Rabbit β-Casein Promoter Directs Secretion of Human Interleukin-2 into the Milk of Transgenic Rabbits , 1990, Bio/Technology.

[5]  L. Houdebine,et al.  An improvement of the single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. , 1990, BioTechniques.

[6]  A. Sepulveda,et al.  Development of a transgenic mouse system for the analysis of stages in liver carcinogenesis using tissue-specific expression of SV40 large T-antigen controlled by regulatory elements of the human alpha-1-antitrypsin gene. , 1989, Cancer research.

[7]  R. Lathe,et al.  Recombinant Proteins of Therapeutic Interest Expressed by Lymphoid Cell Lines Derived from Transgenic Mice , 1989, Nature Biotechnology.

[8]  R. Crystal,et al.  Recombinant DNA-produced alpha 1-antitrypsin administered by aerosol augments lower respiratory tract antineutrophil elastase defenses in individuals with alpha 1-antitrypsin deficiency. , 1989, The Journal of clinical investigation.

[9]  M. Mahmoudi,et al.  Comparison of two different hybridization systems in northern transfer analysis. , 1989, BioTechniques.

[10]  R. Shen,et al.  Tissue-Specific Regulation of Human α1-Antitrypsin Gene Expression in Transgenic Mice , 1989 .

[11]  S. Hauser,et al.  A simple method for DNA purification from peripheral blood. , 1988, Analytical biochemistry.

[12]  J. Carlson,et al.  Multiple tissues express alpha 1-antitrypsin in transgenic mice and man. , 1988, The Journal of clinical investigation.

[13]  V. Oi,et al.  Transgenic rabbits with lymphocytic leukemia induced by the c-myc oncogene fused with the immunoglobulin heavy chain enhancer. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[14]  R. Lathe,et al.  Gene Transfer into Sheep , 1988, Bio/Technology.

[15]  M. Casolaro,et al.  Augmentation of lung antineutrophil elastase capacity with recombinant human alpha-1-antitrypsin. , 1987, Journal of applied physiology.

[16]  E. Wagner,et al.  The human alpha-1-antitrypsin gene is efficiently expressed from two tissue-specific promotors in transgenic mice. , 1987, Nucleic acids research.

[17]  R. Crystal,et al.  Replacement therapy for alpha 1-antitrypsin deficiency associated with emphysema. , 1987, The New England journal of medicine.

[18]  R. Lovell-Badge,et al.  Species- and tissue-specific expression of human alpha 1-antitrypsin in transgenic mice. , 1987, Genes & development.

[19]  F. DeMayo,et al.  Tissue specific expression of the human alpha-1-antitrypsin gene in transgenic mice. , 1987, Nucleic acids research.

[20]  R. Palmiter,et al.  Genetic engineering of mammalian embryos. , 1986, Journal of animal science.

[21]  R. Crystal,et al.  Synthesis in E. coli of α1-antitrypsin variants of therapeutic potential for emphysema and thrombosis , 1985, Nature.

[22]  R. Lathe,et al.  High-level production of biologically active human alpha 1-antitrypsin in Escherichia coli. , 1984, Proceedings of the National Academy of Sciences of the United States of America.

[23]  R. Carrell,et al.  Structure and variation of human α1–antitrypsin , 1982, Nature.

[24]  R. Crystal The α1-antitrypsin gene and its deficiency states , 1989 .

[25]  R. Lovell-Badge,et al.  Widespread expression of human alpha 1-antitrypsin in transgenic mice revealed by in situ hybridization. , 1989, Genes & development.

[26]  R. Crystal,et al.  Fate of aerosolized recombinant DNA-produced alpha 1-antitrypsin: use of the epithelial surface of the lower respiratory tract to administer proteins of therapeutic importance. , 1989, Proceedings of the National Academy of Sciences of the United States of America.