Impact of climate change on atopic dermatitis: A review by the International Eczema Council

Atopic dermatitis (AD), the most burdensome skin condition worldwide, is influenced by climatic factors and air pollution; however, the impact of increasing climatic hazards on AD remains poorly characterized. Leveraging an existing framework for 10 climatic hazards related to greenhouse gas emissions, we identified 18 studies with evidence for an impact on AD through a systematic search. Most climatic hazards had evidence for aggravation of AD the impact ranged from direct effects like particulate matter‐induced AD exacerbations from wildfires to the potential for indirect effects like drought‐induced food insecurity and migration. We then created maps comparing the past, present, and future projected burden of climatic hazards to global AD prevalence data. Data are lacking, especially from those regions most likely to experience more climatic hazards. We highlight gaps important for future research: understanding the synergistic impacts of climatic hazards on AD, long‐term disease activity, the differential impact on vulnerable populations, and how basic mechanisms explain population‐level trends.

[1]  N. Nassikas,et al.  Climate change is a health crisis with opportunities for healthcare action: A focus on healthcare providers, patients with asthma and allergic immune diseases, their families and neighbors. , 2023, Journal of Allergy and Clinical Immunology.

[2]  E. Goleva,et al.  The impact of temperature on the skin barrier and atopic dermatitis. , 2023, Annals of Allergy, Asthma & Immunology.

[3]  I. Agache,et al.  The One Health approach for allergic diseases and asthma , 2023, Allergy.

[4]  Jinlyu Sun,et al.  Impact of Air Pollution on Atopic Dermatitis: A Comprehensive Review , 2023, Clinical Reviews in Allergy & Immunology.

[5]  Maria L. Wei,et al.  Air Pollution and Atopic Dermatitis, from Molecular Mechanisms to Population-Level Evidence: A Review , 2023, International journal of environmental research and public health.

[6]  M. Yadav,et al.  Exposure to isocyanates predicts atopic dermatitis prevalence and disrupts therapeutic pathways in commensal bacteria , 2023, Science advances.

[7]  S. Langan,et al.  Atopic dermatitis across the life course. , 2022, British Journal of Dermatology.

[8]  A. Alexis,et al.  The Impact of Global Health Disparities on Atopic Dermatitis in Displaced Populations: Narrowing the Health Equity Gap for Patients with Skin of Color , 2022, Dermatology and Therapy.

[9]  Maria L. Wei,et al.  Association of Exposure to Wildfire Air Pollution With Exacerbations of Atopic Dermatitis and Itch Among Older Adults , 2022, JAMA network open.

[10]  C. Akdis,et al.  Human and planetary health on fire , 2022, Nature Reviews Immunology.

[11]  C. Mora,et al.  Over half of known human pathogenic diseases can be aggravated by climate change , 2022, Nature Climate Change.

[12]  R. Fadadu,et al.  246 Environmental injustice and risk for wildfire-associated skin flares , 2022, Journal of Investigative Dermatology.

[13]  Maria L. Wei,et al.  Associations between wildfire air pollution and online search interest for skin diseases and symptoms , 2022, JAAD international.

[14]  D. Margolis,et al.  Adult atopic eczema and the risk of dementia: A population-based cohort study. , 2022, Journal of the American Academy of Dermatology.

[15]  D. Leung,et al.  Transient Receptor Potential Vanilloid 1 Plays a Major Role in Low Temperature-Mediated Skin Barrier Dysfunction. , 2022, The Journal of allergy and clinical immunology.

[16]  J. Silverberg,et al.  AAD Guidelines: awareness of comorbidities associated with atopic dermatitis in adults. , 2022, Journal of the American Academy of Dermatology.

[17]  B. Dégboé,et al.  Comorbidities and Environmental Factors Associated with Atopic Dermatitis in Children and Adults in Dermatology-Venereology in Cotonou, Benin , 2021, Dermatology research and practice.

[18]  F. Godlee,et al.  Call for emergency action to limit global temperature increases, restore biodiversity and protect health , 2021, BMJ Open.

[19]  Y. Guo,et al.  Emergency room visits for childhood atopic dermatitis are associated with floods? , 2021, The Science of the total environment.

[20]  Sarah J Coates,et al.  Climate change, human migration, and skin disease: is there a link? , 2021, International journal of dermatology.

[21]  Maria L. Wei,et al.  Association of Wildfire Air Pollution and Health Care Use for Atopic Dermatitis and Itch. , 2021, JAMA dermatology.

[22]  C. Akdis Does the epithelial barrier hypothesis explain the increase in allergy, autoimmunity and other chronic conditions? , 2021, Nature Reviews Immunology.

[23]  H. Randeva,et al.  Erythroderma (exfoliative dermatitis). Part 1: underlying causes, clinical presentation and pathogenesis , 2021, Clinical and experimental dermatology.

[24]  G. Valacchi,et al.  Evaluating the effect of Ozone in UV induced skin damage. , 2020, Toxicology letters.

[25]  M. Maslin,et al.  The 2020 report of the Lancet Countdown on health and climate change: responding to converging crises , 2020, The Lancet.

[26]  Hung-Ming Tu,et al.  Effects of flood and flood-control engineering on morbidity , 2020 .

[27]  J. Silverberg,et al.  What are the highest yielding search strategy terms for systematic reviews in atopic dermatitis? A systematic review , 2020, Archives of Dermatological Research.

[28]  A. Gershunov,et al.  Wildfire smoke impacts respiratory health more than fine particles from other sources: observational evidence from Southern California , 2020, Nature Communications.

[29]  J. Samet,et al.  Wildfires, Global Climate Change, and Human Health. , 2020, The New England journal of medicine.

[30]  R. Dellavalle,et al.  The global burden of atopic dermatitis: lessons from the Global Burden of Disease Study 1990–2017 * , 2020, The British journal of dermatology.

[31]  E. Mayo-Wilson,et al.  The PRISMA 2020 statement: an updated guideline for reporting systematic reviews , 2020, BMJ.

[32]  R. Fathy,et al.  Climate Change and Inpatient Dermatology , 2020, Current Dermatology Reports.

[33]  M. Boguniewicz,et al.  The infectious complications of atopic dermatitis , 2020, Annals of Allergy, Asthma & Immunology.

[34]  J. Bousquet,et al.  Atopic dermatitis severity during exposure to air pollutants and weather changes with an Artificial Neural Network (ANN) analysis , 2020, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[35]  J. Bae,et al.  Seasonality of allergic diseases: Real‐world evidence from a nationwide population‐based study , 2020, Immunity, Inflammation and Disease.

[36]  S. Koh,et al.  Bidirectional relationship between atopic dermatitis and inflammatory bowel disease: a systematic review and meta-analysis. , 2020, Journal of the American Academy of Dermatology.

[37]  B. Olabi,et al.  Skin disease profile of Syrian refugees in Jordan: a field‐mission assessment , 2020, Journal of the European Academy of Dermatology and Venereology : JEADV.

[38]  V. Shi,et al.  The impact of airborne pollution on atopic dermatitis: a literature review , 2019, The British journal of dermatology.

[39]  F. Liang,et al.  The interactive effects between air pollution and meteorological factors on the hospital outpatient visits for atopic dermatitis in Beijing, China: a time‐series analysis , 2019, Journal of the European Academy of Dermatology and Venereology : JEADV.

[40]  I. Annesi-Maesano,et al.  Influence of residential land cover on childhood allergic and respiratory symptoms and diseases: Evidence from 9 European cohorts. , 2019, Environmental research.

[41]  Melike Kibar Öztürk Skin diseases in rural Nyala, Sudan (in a rural hospital, in 12 orphanages, and in two refugee camps) , 2019, International journal of dermatology.

[42]  C. Flohr,et al.  The exposome in atopic dermatitis , 2019, Allergy.

[43]  A. Siafarikas,et al.  Direct infant UV light exposure is associated with eczema and immune development , 2019, The Journal of allergy and clinical immunology.

[44]  P. Ibekwe,et al.  Impact of Weather Conditions on Atopic Dermatitis Prevalence in Abuja, Nigeria. , 2019, Journal of the National Medical Association.

[45]  A. Haines,et al.  The Imperative for Climate Action to Protect Health , 2019, The New England journal of medicine.

[46]  Naota Hanasaki,et al.  Broad threat to humanity from cumulative climate hazards intensified by greenhouse gas emissions , 2018, Nature Climate Change.

[47]  M. Davis,et al.  Impact of climate change on dermatological conditions related to flooding: update from the International Society of Dermatology Climate Change Committee , 2018, International journal of dermatology.

[48]  H. Na,et al.  Glyoxal-induced exacerbation of pruritus and dermatitis is associated with staphylococcus aureus colonization in the skin of a rat model of atopic dermatitis. , 2018, Journal of dermatological science.

[49]  J. Silverberg,et al.  The effects of season and weather on healthcare utilization among patients with atopic dermatitis , 2018, Journal of the European Academy of Dermatology and Venereology : JEADV.

[50]  F. Farabegoli,et al.  Phycotoxins in Marine Shellfish: Origin, Occurrence and Effects on Humans , 2018, Marine drugs.

[51]  A. Oudin,et al.  High burden of atopy in immigrant families in substandard apartments in Sweden – on the contribution of bad housing to poor health in vulnerable populations , 2018, The World Allergy Organization journal.

[52]  Youngshin Han,et al.  Short-term effects of weather and air pollution on atopic dermatitis symptoms in children: A panel study in Korea , 2017, PloS one.

[53]  Der-Yuan Chen,et al.  Adult atopic dermatitis and exposure to air pollutants-a nationwide population-based study. , 2017, Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology.

[54]  Qihong Deng,et al.  Preconceptional and perinatal exposure to traffic-related air pollution and eczema in preschool children. , 2017, Journal of dermatological science.

[55]  Jeong Hee Kim,et al.  Effects of Indoor Air Pollutants on Atopic Dermatitis , 2016, International journal of environmental research and public health.

[56]  M. Maes,et al.  The Gut-Brain Axis, Including the Microbiome, Leaky Gut and Bacterial Translocation: Mechanisms and Pathophysiological Role in Alzheimer's Disease. , 2016, Current pharmaceutical design.

[57]  K. Ahn,et al.  Airborne formaldehyde causes skin barrier dysfunction in atopic dermatitis , 2016, The British journal of dermatology.

[58]  J. Silverberg,et al.  Association of pollution and climate with atopic eczema in US children , 2016, Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology.

[59]  D. Exeter,et al.  Does urban extent from satellite images relate to symptoms of asthma, rhinoconjunctivitis and eczema in children? A cross-sectional study from ISAAC Phase Three , 2016, The Journal of asthma : official journal of the Association for the Care of Asthma.

[60]  S. Kežić,et al.  The effect of environmental humidity and temperature on skin barrier function and dermatitis , 2016, Journal of the European Academy of Dermatology and Venereology : JEADV.

[61]  M. Meinke,et al.  Birch pollen influence the severity of atopic eczema – prospective clinical cohort pilot study and ex vivo penetration study , 2015, Clinical, cosmetic and investigational dermatology.

[62]  S. Norton,et al.  The Infectious and Noninfectious Dermatological Consequences of Flooding: A Field Manual for the Responding Provider , 2015, American Journal of Clinical Dermatology.

[63]  N. Krug,et al.  Exacerbation of atopic dermatitis on grass pollen exposure in an environmental challenge chamber. , 2015, The Journal of allergy and clinical immunology.

[64]  P. Elias,et al.  Potential role of reduced environmental UV exposure as a driver of the current epidemic of atopic dermatitis. , 2015, The Journal of allergy and clinical immunology.

[65]  P. Elias,et al.  An integrated view of the epidermal environmental interface , 2015 .

[66]  Chiang-Wen Lee,et al.  The impact of urban particulate pollution on skin barrier function and the subsequent drug absorption. , 2015, Journal of dermatological science.

[67]  G. Kaplan,et al.  Air pollution effects on the gut microbiota , 2014, Gut microbes.

[68]  S. Chatproedprai,et al.  Flood‐related skin diseases: a literature review , 2013, International journal of dermatology.

[69]  R Brian Haynes,et al.  Retrieving Clinical Evidence: A Comparison of PubMed and Google Scholar for Quick Clinical Searches , 2013, Journal of medical Internet research.

[70]  D. Margolis,et al.  Warm, Humid, and High Sun Exposure Climates are Associated with Poorly Controlled Eczema: PEER (Pediatric Eczema Elective Registry) Cohort, 2004–2012 , 2013, The Journal of investigative dermatology.

[71]  B. Pyun,et al.  Impacts of Heavy Rain and Typhoon on Allergic Disease , 2013, Osong public health and research perspectives.

[72]  C. Cusack,et al.  The oldest new finding in atopic dermatitis: subclinical miliaria as an origin. , 2013, JAMA dermatology.

[73]  J. Silverberg,et al.  Climatic factors are associated with childhood eczema prevalence in US , 2013, The Journal of investigative dermatology.

[74]  B. Metz The Intergovernmental Panel on Climate Change , 2011 .

[75]  A. Comellas,et al.  Ambient particulate matter affects occludin distribution and increases alveolar transepithelial electrical conductance , 2011, Respirology.

[76]  R. Spijker,et al.  Is there a rural/urban gradient in the prevalence of eczema? A systematic review , 2010, The British journal of dermatology.

[77]  P. Elias,et al.  Biopositive effects of low-dose UVB on epidermis: coordinate upregulation of antimicrobial peptides and permeability barrier reinforcement. , 2008, The Journal of investigative dermatology.

[78]  S. Silva,et al.  Influence of narrow‐band UVB phototherapy on cutaneous microbiota of children with atopic dermatitis , 2006, Journal of the European Academy of Dermatology and Venereology : JEADV.

[79]  D. Strachan,et al.  Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multicountry cross-sectional surveys , 2006, The Lancet.

[80]  Rima R Habib,et al.  Harboring illnesses: On the association between disease and living conditions in a Palestinian refugee camp in Lebanon , 2006, International journal of environmental health research.

[81]  H. Hashizume,et al.  Anxiety accelerates T‐helper 2‐tilted immune responses in patients with atopic dermatitis , 2005, The British journal of dermatology.

[82]  A. Kanwar,et al.  Epidemiology and Clinical Pattern of Atopic Dermatitis in a North Indian Pediatric Population , 1998, Pediatric dermatology.

[83]  O. Larkö,et al.  The in vivo effect of UVB radiation on skin bacteria in patients with atopic dermatitis. , 1992, Acta dermato-venereologica.

[84]  G. Plewig,et al.  Influence of UV irradiation on the composition of human stratum corneum lipids. , 1990, The Journal of investigative dermatology.

[85]  Howard A. Rockman,et al.  Clinical Medicine , 1915, The Indian Medical Gazette.

[86]  C. Miracco,et al.  Skin Damage Mechanisms Related to Airborne Particulate Matter Exposure. , 2016, Toxicological sciences : an official journal of the Society of Toxicology.

[87]  A. El-Gilany,et al.  Pattern of skin diseases among Central African refugees in Chad , 2015 .

[88]  I I Lelis,et al.  [Atopic dermatitis]. , 1980, Vestnik dermatologii i venerologii.

[89]  R. Pinkel,et al.  University of California, San Diego , 1967, Radiocarbon.