Neuroligin-mediated neurodevelopmental defects are induced by mitochondrial dysfunction and prevented by lutein in C. elegans

[1]  Dean P. Jones,et al.  Defective metabolic programming impairs early neuronal morphogenesis in neural cultures and an organoid model of Leigh syndrome , 2021, Nature Communications.

[2]  N. Ventura,et al.  Dietary and environmental factors have opposite AhR-dependent effects on C. elegans healthspan , 2020, Aging.

[3]  M. Zeviani,et al.  A Single Intravenous Injection of AAV-PHP.B-hNDUFS4 Ameliorates the Phenotype of Ndufs4−/− Mice , 2020, Molecular therapy. Methods & clinical development.

[4]  F. Calon,et al.  Neuroligin-1 is altered in the hippocampus of Alzheimer’s disease patients and mouse models, and modulates the toxicity of amyloid-beta oligomers , 2020, Scientific Reports.

[5]  Rafael Porto Ineu,et al.  Influence of nanoencapsulated lutein on acetylcholinesterase activity: In vitro determination, kinetic parameters, and in silico docking simulations. , 2020, Food chemistry.

[6]  A. Poenar,et al.  Spectroscopy , 2020, Encyclopedic Dictionary of Archaeology.

[7]  V. Böhm Carotenoids , 2019, Antioxidants.

[8]  Muhammad A. Hagras,et al.  Mutations in NDUFS1 Cause Metabolic Reprogramming and Disruption of the Electron Transfer , 2019, Cells.

[9]  N. Ventura,et al.  Mitochondrial bioenergetic changes during development as an indicator of C. elegans health-span , 2019, Aging.

[10]  M. Stagi,et al.  Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysis , 2019, Autophagy.

[11]  L. Sazanov,et al.  Mammalian Mitochondrial Complex I Structure and Disease-Causing Mutations. , 2018, Trends in cell biology.

[12]  Kavita Babu,et al.  Pentylenetetrazole (PTZ)-induced Convulsion Assay to Determine GABAergic Defects in Caenorhabditis elegans. , 2018, Bio-protocol.

[13]  Nektarios Tavernarakis,et al.  Regulation and Roles of Autophagy at Synapses. , 2018, Trends in cell biology.

[14]  T. Südhof,et al.  Autism-associated neuroligin-4 mutation selectively impairs glycinergic synaptic transmission in mouse brainstem synapses , 2018, The Journal of experimental medicine.

[15]  Marni J. Falk,et al.  Mitochondrial Disease: Advances in Clinical Diagnosis, Management, Therapeutic Development, and Preventative Strategies , 2018, Current Genetic Medicine Reports.

[16]  Marni J. Falk,et al.  N-acetylcysteine and vitamin E rescue animal longevity and cellular oxidative stress in pre-clinical models of mitochondrial complex I disease. , 2018, Molecular genetics and metabolism.

[17]  Michael J. Devine,et al.  Mitochondria at the neuronal presynapse in health and disease , 2018, Nature Reviews Neuroscience.

[18]  E. Heiss,et al.  Activation of Nrf2 signaling by natural products-can it alleviate diabetes? , 2017, Biotechnology advances.

[19]  Joel N Meyer,et al.  Mitochondrial fusion, fission, and mitochondrial toxicity. , 2017, Toxicology.

[20]  Hongkyun Kim,et al.  Aldicarb-induced Paralysis Assay to Determine Defects in Synaptic Transmission in Caenorhabditis elegans. , 2017, Bio-protocol.

[21]  Joel N. Meyer,et al.  Deficiencies in mitochondrial dynamics sensitize Caenorhabditis elegans to arsenite and other mitochondrial toxicants by reducing mitochondrial adaptability. , 2017, Toxicology.

[22]  N. Ventura,et al.  C. elegans as a model organism for human mitochondrial associated disorders. , 2016, Mitochondrion.

[23]  C. Hommet,et al.  Pharmacological treatments of behavioral and psychological symptoms of dementia in Alzheimer's disease: role of acetylcholinesterase inhibitors and memantine. , 2016, Geriatrie et psychologie neuropsychiatrie du vieillissement.

[24]  Jae-Seong Yang,et al.  OASIS 2: online application for survival analysis 2 with features for the analysis of maximal lifespan and healthspan in aging research , 2016, Oncotarget.

[25]  Joel N. Meyer,et al.  In Vivo Determination of Mitochondrial Function Using Luciferase‐Expressing Caenorhabditis elegans: Contribution of Oxidative Phosphorylation, Glycolysis, and Fatty Acid Oxidation to Toxicant‐Induced Dysfunction , 2016, Current protocols in toxicology.

[26]  T. Manivasagam,et al.  Lutein protects dopaminergic neurons against MPTP-induced apoptotic death and motor dysfunction by ameliorating mitochondrial disruption and oxidative stress , 2016, Nutritional neuroscience.

[27]  N. Ventura,et al.  C. elegans screening strategies to identify pro-longevity interventions , 2016, Mechanisms of Ageing and Development.

[28]  Michele L Lemons,et al.  An Inquiry-Based Approach to Study the Synapse: Student-Driven Experiments Using C. elegans. , 2016, Journal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience.

[29]  Xiaoming Gong,et al.  Lutein, But Not Other Carotenoids, Selectively Inhibits Breast Cancer Cell Growth Through Several Molecular Mechanisms , 2016, The FASEB Journal.

[30]  J. Blumberg,et al.  Bioavailability and biodistribution of nanodelivered lutein. , 2016, Food chemistry.

[31]  D. Hu,et al.  Management of Ocular Diseases Using Lutein and Zeaxanthin: What Have We Learned from Experimental Animal Studies? , 2015, Journal of ophthalmology.

[32]  N. Ventura,et al.  An automated phenotype-based microscopy screen to identify pro-longevity interventions acting through mitochondria in C. elegans. , 2015, Biochimica et biophysica acta.

[33]  Nektarios Tavernarakis,et al.  Iron-Starvation-Induced Mitophagy Mediates Lifespan Extension upon Mitochondrial Stress in C. elegans , 2015, Current Biology.

[34]  T. Hirata,et al.  Biodegradable Poly (Lactic-co-Glycolic Acid)-Polyethylene Glycol Nanocapsules: An Efficient Carrier for Improved Solubility, Bioavailability, and Anticancer Property of Lutein. , 2015, Journal of pharmaceutical sciences.

[35]  Nektarios Tavernarakis,et al.  Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans , 2015, Nature.

[36]  E. Holme,et al.  Broad phenotypic variability in patients with complex I deficiency due to mutations in NDUFS1 and NDUFV1. , 2015, Mitochondrion.

[37]  B. Viollet,et al.  Mitochondrial dysfunction in primary human fibroblasts triggers an adaptive cell survival program that requires AMPK-α. , 2015, Biochimica et biophysica acta.

[38]  Matthew E. Ritchie,et al.  limma powers differential expression analyses for RNA-sequencing and microarray studies , 2015, Nucleic acids research.

[39]  Chris Li,et al.  Use of Caenorhabditis elegans as a model to study Alzheimer’s disease and other neurodegenerative diseases , 2014, Front. Genet..

[40]  N. Ventura,et al.  Mitochondrial stress extends lifespan in C. elegans through neuronal hormesis , 2014, Experimental Gerontology.

[41]  J. Auwerx,et al.  A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. elegans , 2014, Scientific Reports.

[42]  G. Silverman,et al.  C. elegans in high-throughput drug discovery. , 2014, Advanced drug delivery reviews.

[43]  G. Ruvkun,et al.  Caenorhabditis elegans pathways that surveil and defend mitochondria , 2014, Nature.

[44]  M. Kaeberlein,et al.  Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans , 2014, Nature Communications.

[45]  W. B. Derry,et al.  CEP-1, the Caenorhabditis elegans p53 Homolog, Mediates Opposing Longevity Outcomes in Mitochondrial Electron Transport Chain Mutants , 2014, PLoS genetics.

[46]  J. Knowles,et al.  Regulation of Synaptic nlg-1/Neuroligin Abundance by the skn-1/Nrf Stress Response Pathway Protects against Oxidative Stress , 2014, PLoS genetics.

[47]  J. Olesen,et al.  Animal Migraine Models for Drug Development: Status and Future Perspectives , 2013, CNS Drugs.

[48]  P. Mcquary,et al.  The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans , 2013, Nature Communications.

[49]  R. Rodenburg,et al.  A guide to diagnosis and treatment of Leigh syndrome , 2013, Journal of Neurology, Neurosurgery & Psychiatry.

[50]  J. Auwerx,et al.  Pharmacological approaches to restore mitochondrial function , 2013, Nature Reviews Drug Discovery.

[51]  Michael O. Hengartner,et al.  Mitochondria as a Target of Environmental Toxicants , 2013, Toxicological sciences : an official journal of the Society of Toxicology.

[52]  C. Link,et al.  Alzheimer's disease drug discovery: in vivo screening using Caenorhabditis elegans as a model for β-amyloid peptide-induced toxicity. , 2013, Drug discovery today. Technologies.

[53]  L. Holden-Dye,et al.  Pharmacological assays reveal age-related changes in synaptic transmission at the Caenorhabditis elegans neuromuscular junction that are modified by reduced insulin signalling , 2013, Journal of Experimental Biology.

[54]  Nektarios Tavernarakis,et al.  Autophagy induction extends lifespan and reduces lipid content in response to frataxin silencing in C. elegans , 2013, Experimental Gerontology.

[55]  Bernhard Mlecnik,et al.  CluePedia Cytoscape plugin: pathway insights using integrated experimental and in silico data , 2013, Bioinform..

[56]  P. Fowler,et al.  Impact of Sublethal Levels of Environmental Pollutants Found in Sewage Sludge on a Novel Caenorhabditis elegans Model Biosensor , 2012, PloS one.

[57]  G. Aramuni,et al.  Neurexin and Neuroligin Mediate Retrograde Synaptic Inhibition in C. elegans , 2012, Science.

[58]  F. Calahorro,et al.  Functional Phenotypic Rescue of Caenorhabditis elegans Neuroligin-Deficient Mutants by the Human and Rat NLGN1 Genes , 2012, PloS one.

[59]  George M Whitesides,et al.  A microfluidic device for whole-animal drug screening using electrophysiological measures in the nematode C. elegans. , 2012, Lab on a chip.

[60]  S. Dimauro,et al.  Mitochondrial Diseases , 2012, Journal of epilepsy research.

[61]  Nooreen Dabbish,et al.  GABAergic Synaptic Plasticity during a Developmentally Regulated Sleep-Like State in C. elegans , 2011, The Journal of Neuroscience.

[62]  D. Moerman,et al.  Determining the Sub-Cellular Localization of Proteins within Caenorhabditis elegans Body Wall Muscle , 2011, PloS one.

[63]  Rafael A. Irizarry,et al.  A framework for oligonucleotide microarray preprocessing , 2010, Bioinform..

[64]  Joel N. Meyer,et al.  The QPCR assay for analysis of mitochondrial DNA damage, repair, and relative copy number. , 2010, Methods.

[65]  M. Chalfie,et al.  Enhanced neuronal RNAi in C. elegans using SID-1 , 2010, Nature Methods.

[66]  G. P. Mullen,et al.  Neuroligin-deficient mutants of C. elegans have sensory processing deficits and are hypersensitive to oxidative stress and mercury toxicity , 2010, Disease Models & Mechanisms.

[67]  Kunihiro Matsumoto,et al.  Phosphorylation of the Conserved Transcription Factor ATF-7 by PMK-1 p38 MAPK Regulates Innate Immunity in Caenorhabditis elegans , 2010, PLoS genetics.

[68]  Hugh J. Byrne,et al.  Resonant Mie scattering (RMieS) correction of infrared spectra from highly scattering biological samples. , 2010, The Analyst.

[69]  Joel N. Meyer QPCR: a tool for analysis of mitochondrial and nuclear DNA damage in ecotoxicology , 2010, Ecotoxicology.

[70]  T. Kooistra,et al.  Tissue-specific activities of an immune signaling module regulate physiological responses to pathogenic and nutritional bacteria in C. elegans. , 2009, Cell host & microbe.

[71]  C. Link,et al.  What have worm models told us about the mechanisms of neuronal dysfunction in human neurodegenerative diseases? , 2009, Molecular Neurodegeneration.

[72]  R. Testi,et al.  p53/CEP‐1 increases or decreases lifespan, depending on level of mitochondrial bioenergetic stress , 2009, Aging cell.

[73]  L. A. Glover,et al.  Rapid sublethal toxicity assessment using bioluminescent Caenorhabditis elegans, a novel whole-animal metabolic biosensor. , 2009, Toxicological sciences : an official journal of the Society of Toxicology.

[74]  Michael P. Cary,et al.  A Regulated Response to Impaired Respiration Slows Behavioral Rates and Increases Lifespan in Caenorhabditis elegans , 2009, PLoS genetics.

[75]  Jonathan T. Pierce-Shimomura,et al.  Genetic analysis of crawling and swimming locomotory patterns in C. elegans , 2008, Proceedings of the National Academy of Sciences.

[76]  K. Caldwell,et al.  Paradigms for pharmacological characterization of C. elegans synaptic transmission mutants. , 2008, Journal of visualized experiments : JoVE.

[77]  R. Rodenburg,et al.  Mitochondrial complex I deficiency: from organelle dysfunction to clinical disease. , 2008, Brain : a journal of neurology.

[78]  W. Watt,et al.  Mice with mitochondrial complex I deficiency develop a fatal encephalomyopathy. , 2008, Cell metabolism.

[79]  L. A. Glover,et al.  Bridging the phenotypic gap: Real-time assessment of mitochondrial function and metabolism of the nematode Caenorhabditis elegans , 2008, BMC Physiology.

[80]  T. Johnson,et al.  Relationship Between Mitochondrial Electron Transport Chain Dysfunction, Development, and Life Extension in Caenorhabditis elegans , 2007, PLoS biology.

[81]  S. Rea,et al.  Caenorhabditis elegans mitochondrial mutants as an investigative tool to study human neurodegenerative diseases associated with mitochondrial dysfunction. , 2007, Biotechnology journal.

[82]  Massimo Zeviani,et al.  Increased longevity and refractoriness to Ca(2+)-dependent neurodegeneration in Surf1 knockout mice. , 2007, Human molecular genetics.

[83]  S. Mango,et al.  The C. elegans pharynx: a model for organogenesis. , 2007, WormBook : the online review of C. elegans biology.

[84]  Harald Hutter,et al.  Axon guidance genes identified in a large-scale RNAi screen using the RNAi-hypersensitive Caenorhabditis elegans strain nre-1(hd20) lin-15b(hd126) , 2007, Proceedings of the National Academy of Sciences.

[85]  D. Fedeli,et al.  Influence of astaxanthin, zeaxanthin and lutein on DNA damage and repair in UVA-irradiated cells. , 2006, Journal of photochemistry and photobiology. B, Biology.

[86]  Nektarios Tavernarakis,et al.  Caenorhabditis elegans: A versatile platform for drug discovery , 2006, Biotechnology journal.

[87]  Timothy R Mahoney,et al.  Analysis of synaptic transmission in Caenorhabditis elegans using an aldicarb-sensitivity assay , 2006, Nature Protocols.

[88]  R. Testi,et al.  Long-lived C. elegans Mitochondrial mutants as a model for human mitochondrial-associated diseases , 2006, Experimental Gerontology.

[89]  J. Bessereau,et al.  UNC-13 and UNC-10/Rim Localize Synaptic Vesicles to Specific Membrane Domains , 2006, The Journal of Neuroscience.

[90]  D. Wilkes,et al.  The Caenorhabditis elegans Choline Transporter CHO-1 Sustains Acetylcholine Synthesis and Motor Function in an Activity-Dependent Manner , 2006, The Journal of Neuroscience.

[91]  M. Beal,et al.  The role of mitochondria in inherited neurodegenerative diseases , 2006, Journal of neurochemistry.

[92]  G. Ruvkun,et al.  A genetic interaction between the vesicular acetylcholine transporter VAChT/UNC-17 and synaptobrevin/SNB-1 in C. elegans , 2006, Nature Neuroscience.

[93]  M. Huynen,et al.  Tracing the evolution of a large protein complex in the eukaryotes, NADH:ubiquinone oxidoreductase (Complex I). , 2005, Journal of molecular biology.

[94]  F. Urano,et al.  Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperones , 2004, Journal of Cell Science.

[95]  B. Lemire,et al.  Caenorhabditis elegans development requires mitochondrial function in the nervous system. , 2004, Biochemical and biophysical research communications.

[96]  J. Smeitink,et al.  Differences in assembly or stability of complex I and other mitochondrial OXPHOS complexes in inherited complex I deficiency. , 2004, Human molecular genetics.

[97]  R. Kamath,et al.  Genome-wide RNAi screening in Caenorhabditis elegans. , 2003, Methods.

[98]  Andrew G Fraser,et al.  Rates of Behavior and Aging Specified by Mitochondrial Function During Development , 2002, Science.

[99]  B. Lemire,et al.  Mitochondrial genome content is regulated during nematode development. , 2002, Biochemical and biophysical research communications.

[100]  E. Kayser,et al.  Mitochondrial mutations differentially affect aging, mutability and anesthetic sensitivity in Caenorhabditis elegans , 2001, Mechanisms of Ageing and Development.

[101]  P. Mazurek,et al.  Lutein and zeaxanthin as protectors of lipid membranes against oxidative damage: the structural aspects. , 1999, Archives of biochemistry and biophysics.

[102]  E A Barnard,et al.  Caenorhabditis elegans Levamisole Resistance Geneslev-1, unc-29, and unc-38 Encode Functional Nicotinic Acetylcholine Receptor Subunits , 1997, The Journal of Neuroscience.

[103]  T. Leslie Youd,et al.  Structural Aspects , 1995 .

[104]  S. Beatty,et al.  The impact of supplemental macular carotenoids in Alzheimer's disease: a randomized clinical trial. , 2015, Journal of Alzheimer's disease : JAD.

[105]  E. H. Howlett,et al.  PCR based determination of mitochondrial DNA copy number in multiple species. , 2015, Methods in molecular biology.

[106]  Bao Zhang,et al.  Lutein and zeaxanthin supplementation and association with visual function in age-related macular degeneration. , 2014, Investigative ophthalmology & visual science.

[107]  H. Arai,et al.  Significance of lutein in red blood cells of Alzheimer's disease patients. , 2012, Journal of Alzheimer's disease : JAD.

[108]  V. Venegas,et al.  Measurement of mitochondrial DNA copy number. , 2012, Methods in molecular biology.

[109]  B. Van Houten,et al.  Analysis of DNA damage and repair in nuclear and mitochondrial DNA of animal cells using quantitative PCR. , 2012, Methods in molecular biology.

[110]  M. Aschner,et al.  Utility of Caenorhabditis elegans in high throughput neurotoxicological research. , 2010, Neurotoxicology and teratology.

[111]  G. Silverman,et al.  Modeling Molecular and Cellular Aspects of Human Disease Using the Nematode Caenorhabditis elegans , 2009, Pediatric Research.

[112]  B. Van Houten,et al.  Quantitative PCR-based measurement of nuclear and mitochondrial DNA damage and repair in mammalian cells. , 2006, Methods in molecular biology.

[113]  E. Glaser The randomized clinical trial. , 1972, The New England journal of medicine.

[114]  D. Turnbull,et al.  This Work Is Licensed under a Creative Commons Attribution 4.0 International License Perceived Fatigue Is Highly Prevalent and Debilitating in Patients with Mitochondrial Disease , 2022 .