Cell-specific conditional deletion of interleukin-1 (IL-1) ligands and its receptors: a new toolbox to study the role of IL-1 in health and disease

[1]  A. Maqbool,et al.  Fibroblast-specific deletion of IL-1 receptor-1 reduces adverse cardiac remodeling following myocardial infarction , 2019, JCI insight.

[2]  R. Germain,et al.  Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells , 2019, The Journal of experimental medicine.

[3]  Ling Zhu,et al.  Interleukin-1 causes CNS inflammatory cytokine expression via endothelia-microglia bi-cellular signaling , 2019, Brain, Behavior, and Immunity.

[4]  T. Kiss,et al.  Transfer of complex regional pain syndrome to mice via human autoantibodies is mediated by interleukin-1–induced mechanisms , 2019, Proceedings of the National Academy of Sciences.

[5]  B. Becher,et al.  Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β. , 2019, Immunity.

[6]  C. Garlanda,et al.  Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity. , 2019, Immunity.

[7]  R. Blakely,et al.  Cell‐Type‐Specific Interleukin 1 Receptor 1 Signaling in the Brain Regulates Distinct Neuroimmune Activities , 2019, Immunity.

[8]  N. Rothwell,et al.  Interleukin-1 mediates ischaemic brain injury via distinct actions on endothelial cells and cholinergic neurons , 2019, Brain, Behavior, and Immunity.

[9]  I. Holen,et al.  Endogenous Production of IL1B by Breast Cancer Cells Drives Metastasis and Colonization of the Bone Microenvironment , 2019, Clinical Cancer Research.

[10]  A. Dzutsev,et al.  Cell‐Type‐Specific Responses to Interleukin‐1 Control Microbial Invasion and Tumor‐Elicited Inflammation in Colorectal Cancer , 2019, Immunity.

[11]  G. Kollias,et al.  Innate Sensing through Mesenchymal TLR4/MyD88 Signals Promotes Spontaneous Intestinal Tumorigenesis , 2019, Cell reports.

[12]  J. Wynn,et al.  Cutting Edge: IL-1α and Not IL-1β Drives IL-1R1–Dependent Neonatal Murine Sepsis Lethality , 2018, The Journal of Immunology.

[13]  T. Schlüter,et al.  Regulation of IL-1 signaling by the decoy receptor IL-1R2 , 2018, Journal of Molecular Medicine.

[14]  V. V. Ganusov,et al.  Cutting Edge: IL-1R1 Mediates Host Resistance to Mycobacterium tuberculosis by Trans-Protection of Infected Cells , 2018, The Journal of Immunology.

[15]  R. Blakely,et al.  Pancreatic deletion of the interleukin-1 receptor disrupts whole body glucose homeostasis and promotes islet β-cell de-differentiation , 2018, Molecular metabolism.

[16]  A. Waisman,et al.  Interleukin-1β promotes atheroprotective changes of advanced atherosclerotic lesions in mice , 2018, Nature Medicine.

[17]  P. Galle,et al.  Hepatocyte-specific deletion of IL1-RI attenuates liver injury by blocking IL-1 driven autoinflammation. , 2018, Journal of hepatology.

[18]  C. Dinarello.  Introduction to the interleukin‐1 family of cytokines and receptors: Drivers of innate inflammation and acquired immunity , 2018, Immunological reviews.

[19]  D. Marks,et al.  Interleukin-1β signaling in fenestrated capillaries is sufficient to trigger sickness responses in mice , 2017, Journal of Neuroinflammation.

[20]  A. Blomqvist,et al.  Involvement of interleukin-1 type 1 receptors in lipopolysaccharide-induced sickness responses , 2017, Brain, Behavior, and Immunity.

[21]  J. Martínez-Quiroz,et al.  Interleukin-1β increases neuronal death in the hippocampal dentate gyrus associated with status epilepticus in the developing rat. , 2017 .

[22]  J. Martínez-Quiroz,et al.  Interleukin-1β increases neuronal death in the hippocampal dentate gyrus associated with status epilepticus in the developing rat. , 2017, Neurologia.

[23]  K. Flaherty,et al.  An adaptive signaling network in melanoma inflammatory niches confers tolerance to MAPK signaling inhibition , 2017, The Journal of experimental medicine.

[24]  C. Gabay,et al.  Deficiency in IL-1 Receptor Type 2 Aggravates K/BxN Serum Transfer-Induced Arthritis in Mice but Has No Impact on Systemic Inflammatory Responses , 2017, The Journal of Immunology.

[25]  A. Waisman,et al.  IL‐1 signaling is critical for expansion but not generation of autoreactive GM‐CSF+ Th17 cells , 2017, The EMBO journal.

[26]  A. Waisman,et al.  Generation of a Novel T Cell Specific Interleukin-1 Receptor Type 1 Conditional Knock Out Mouse Reveals Intrinsic Defects in Survival, Expansion and Cytokine Production of CD4 T Cells , 2016, PloS one.

[27]  R. Blakely,et al.  Generation and Characterization of Mice Expressing a Conditional Allele of the Interleukin-1 Receptor Type 1 , 2016, PloS one.

[28]  N. Rothwell,et al.  Characterization of a conditional interleukin‐1 receptor 1 mouse mutant using the Cre/LoxP system , 2016, European journal of immunology.

[29]  Frauke Zipp,et al.  Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System. , 2015, Immunity.

[30]  Y. Iwakura,et al.  IL-1 receptor antagonist-deficient mice develop autoimmune arthritis due to intrinsic activation of IL-17-producing CCR2+Vγ6+γδ T cells , 2015, Nature Communications.

[31]  D. Brough,et al.  Interleukin‐1α and brain inflammation , 2015, IUBMB life.

[32]  Y. Iwakura,et al.  IL-1 Receptor Type 2 Suppresses Collagen-Induced Arthritis by Inhibiting IL-1 Signal on Macrophages , 2015, The Journal of Immunology.

[33]  J. Sheridan,et al.  Interleukin 1 Type 1 Receptor Restore: A Genetic Mouse Model for Studying Interleukin 1 Receptor-Mediated Effects in Specific Cell Types , 2015, The Journal of Neuroscience.

[34]  J. Bugajski,et al.  Cytokines, prostaglandins and nitric oxide in the regulation of stress-response systems , 2013, Pharmacological reports : PR.

[35]  R. Shahar,et al.  IL-1RI participates in normal growth plate development and bone modeling. , 2013, American journal of physiology. Endocrinology and metabolism.

[36]  C. Dinarello,et al.  Non-redundant properties of IL-1α and IL-1β during acute colon inflammation in mice , 2013, Gut.

[37]  J. Qian,et al.  Interleukin-1R3 mediates interleukin-1–induced potassium current increase through fast activation of Akt kinase , 2012, Proceedings of the National Academy of Sciences.

[38]  E. Pinteaux,et al.  Oxygen–glucose deprivation and interleukin‐1α trigger the release of perlecan LG3 by cells of neurovascular unit , 2011, Journal of neurochemistry.

[39]  Y. Iwakura,et al.  IL-1 plays an important role in the bone metabolism under physiological conditions. , 2010, International immunology.

[40]  R. Grencis,et al.  IL‐1‐dependent, IL‐1R1‐independent resistance to gastrointestinal nematodes , 2009, European journal of immunology.

[41]  N. Rothwell,et al.  Differential effects of interleukin-1 alpha and beta on interleukin-6 and chemokine synthesis in neurones , 2008, Molecular and Cellular Neuroscience.

[42]  C. Viebahn,et al.  Focus on Mammalian Embryogenomics Blastocyst elongation, trophoblastic differentiation, and embryonic pattern formation , 2008 .

[43]  David Evans,et al.  Interleukin-1beta and signaling of interleukin-1 in vascular wall and circulating cells modulates the extent of neointima formation in mice. , 2006, The American journal of pathology.

[44]  N. Rothwell,et al.  Neuroprotective actions of endogenous interleukin‐1 receptor antagonist (IL‐1ra) are mediated by glia , 2006, Glia.

[45]  N. Rothwell,et al.  Gene regulation by IL‐1β independent of IL‐1R1 in the mouse brain , 2006, Glia.

[46]  J. Dayer,et al.  Decreased fat mass in interleukin-1 receptor antagonist-deficient mice: impact on adipogenesis, food intake, and energy expenditure. , 2005, Diabetes.

[47]  N. Gérard,et al.  In vivo effect of interleukin-1beta and interleukin-1RA on oocyte cytoplasmic maturation, ovulation, and early embryonic development in the mare , 2005, Reproductive biology and endocrinology : RB&E.

[48]  F. Ohsuzu,et al.  Lack of Interleukin-1 Receptor Antagonist Modulates Plaque Composition in Apolipoprotein E–Deficient Mice , 2004, Arteriosclerosis, thrombosis, and vascular biology.

[49]  YoichiroIwakura,et al.  Lack of Interleukin-1 Receptor Antagonist Modulates Plaque Composition in Apolipoprotein E–Deficient Mice , 2004 .

[50]  Werner Müller,et al.  Keratin 14 Cre transgenic mice authenticate keratin 14 as an oocyte‐expressed protein , 2004, Genesis.

[51]  M. Little,et al.  Psoriasis-like cutaneous inflammation in mice lacking interleukin-1 receptor antagonist. , 2004, The Journal of investigative dermatology.

[52]  A. Martoriati,et al.  The interleukin-1 system and female reproduction. , 2004, The Journal of endocrinology.

[53]  J. Um,et al.  Association of interleukin-1 alpha gene polymorphism with cerebral infarction. , 2003, Brain research. Molecular brain research.

[54]  J. Um,et al.  Interleukin-1 gene cluster polymorphisms in cerebral infarction. , 2003, Cytokine.

[55]  N. Rothwell,et al.  The expanding interleukin-1 family and its receptors , 2003, Molecular Neurobiology.

[56]  M. Bähr,et al.  Interleukin-1β protects neurons via the interleukin-1 (IL-1) receptor-mediated Akt pathway and by IL-1 receptor-independent decrease of transmembrane currents in vivo , 2003, Molecular and Cellular Neuroscience.

[57]  N. Rothwell,et al.  Interleukin-1 Influences Ischemic Brain Damage in the Mouse Independently of the Interleukin-1 Type I Receptor , 2002, The Journal of Neuroscience.

[58]  S. Nakae,et al.  IL-1α, but not IL-1β, is required for contact-allergen-specific T cell activation during the sensitization phase in contact hypersensitivity , 2001 .

[59]  P. Neveu,et al.  Interleukin 1 receptor accessory protein (IL-1RAcP) is necessary for centrally mediated neuroendocrine and immune responses to IL-1β , 2000, Journal of Neuroimmunology.

[60]  R. Dantzer,et al.  Biological activity and brain actions of recombinant rat interleukin-1alpha and interleukin-1beta. , 1998, European cytokine network.

[61]  K. McIntyre,et al.  IL-1 receptor accessory protein is an essential component of the IL-1 receptor. , 1998, Journal of immunology.

[62]  T. Bártfai,et al.  Interleukin-1-mediated febrile responses in mice and interleukin-1 beta activation of NFkappaB in mouse primary astrocytes, involves the interleukin-1 receptor accessory protein. , 1998, European cytokine network.

[63]  Masatoshi Suzuki,et al.  Production of Mice Deficient in Genes for Interleukin (IL)-1α, IL-1β, IL-1α/β, and IL-1 Receptor Antagonist Shows that IL-1β Is Crucial in Turpentine-induced Fever Development and Glucocorticoid Secretion , 1998, The Journal of experimental medicine.

[64]  P. Morrissey,et al.  Phenotypic and functional characterization of mice that lack the type I receptor for IL-1. , 1997, Journal of immunology.

[65]  K. Huebner,et al.  A novel IL‐1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. , 1991, The EMBO journal.

[66]  Jan Born,et al.  Brain-immune interactions in sleep. , 2002, International review of neurobiology.

[67]  S. Nakae,et al.  IL-1 alpha, but not IL-1 beta, is required for contact-allergen-specific T cell activation during the sensitization phase in contact hypersensitivity. , 2001, International immunology.