Fluorescence, opalescence, and translucency are critical for restorative materials to mimic the optical properties and appearance of natural teeth. This case report describes the restoration of multiple anterior teeth with CAD/CAM-fabricated glass-infiltrated aluminum oxide ceramic (In-Ceram Alumina, Vita Zahnfabrik) crowns and illustrates the technical steps to achieve an adequate amount of fluorescence in the ceramic veneering material. CAD/CAM aluminum oxide ceramic copings and frameworks can be predictable and successful when replacing missing tooth structure and imitating optical properties of natural teeth. A modified layering technique enhances fluorescence within the veneering ceramic and provides an esthetic appearance of glass-infiltrated aluminum oxide ceramic restorations.