Biological dosimetry of complex ion radiation fields.

We report on a set of cell survival experiments performed in complex field combinations of therapeutic 12C ion beams. CHO cells were exposed to the superposition of two or three fields of 12C ions arranged in a similar way to real patient treatments. Two-dimensional survival distributions were measured and compared with the predictions of the TRiP98 treatment planning system. Good agreement was found in general. In particular the method of tissue sparing using dose ramps could be verified.

[1]  G Kraft,et al.  Tumortherapy with ion beams , 2000 .

[2]  M Scholz,et al.  Treatment planning for heavy-ion radiotherapy: calculation and optimization of biologically effective dose. , 2000, Physics in medicine and biology.

[3]  G. Kraft,et al.  Tumor therapy with heavy charged particles , 2000 .

[4]  O Jäkel,et al.  Quality management of medical physics issues at the German heavy ion therapy project. , 2000, Medical physics.

[5]  O Jäkel,et al.  Treatment planning for heavy-ion radiotherapy: physical beam model and dose optimization. , 2000, Physics in medicine and biology.

[6]  O Jäkel,et al.  A system for three-dimensional dosimetric verification of treatment plans in intensity-modulated radiotherapy with heavy ions. , 1999, Medical physics.

[7]  O Jäkel,et al.  Treatment planning for heavy ion radiotherapy: clinical implementation and application. , 2001, Physics in medicine and biology.

[8]  M. Scholz,et al.  Computation of cell survival in heavy ion beams for therapy , 1997, Radiation and environmental biophysics.

[9]  M. Krämer Treatment planning for heavy-ion radiotherapy: biological optimization of multiple beam ports. , 2001, Journal of radiation research.

[10]  J. Debus,et al.  Radiotherapy for chordomas and low-grade chondrosarcomas of the skull base with carbon ions. , 2002, International journal of radiation oncology, biology, physics.

[11]  M Scholz,et al.  RBE for carbon track-segment irradiation in cell lines of differing repair capacity. , 1999, International journal of radiation biology.

[12]  G. Kraft,et al.  Biological verification of heavy ion treatment planning , 1998, Radiation and environmental biophysics.

[13]  D. Schardt,et al.  Magnetic scanning system for heavy ion therapy , 1993 .