The novel lipid mediator PD1n-3 DPA: An overview of the structural elucidation, synthesis, biosynthesis and bioactions.

[1]  C. Serhan.  Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms , 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[2]  M. Perretti,et al.  Protectin D1n-3 DPA and resolvin D5n-3 DPA are effectors of intestinal protection , 2017, Proceedings of the National Academy of Sciences.

[3]  B. Levy,et al.  DHA- and EPA-derived resolvins, protectins, and maresins in airway inflammation. , 2016, European journal of pharmacology.

[4]  P. Calder,et al.  Immunopharmacology of fatty acids. , 2016, European journal of pharmacology.

[5]  Derek W. Gilroy,et al.  Resolution of inflammation: a new therapeutic frontier , 2016, Nature Reviews Drug Discovery.

[6]  Trevor A. Mori,et al.  Specialised pro-resolving mediators of inflammation in inflammatory arthritis. , 2016, Prostaglandins, leukotrienes, and essential fatty acids.

[7]  C. Serhan,et al.  The Protectin PCTR1 Is Produced by Human M2 Macrophages and Enhances Resolution of Infectious Inflammation. , 2016, The American journal of pathology.

[8]  C. Serhan,et al.  Selective identification of specialized pro-resolving lipid mediators from their biosynthetic double di-oxygenation isomers. , 2016, RSC advances.

[9]  A. Sinclair,et al.  Short update on docosapentaenoic acid: a bioactive long-chain n-3 fatty acid , 2016, Current opinion in clinical nutrition and metabolic care.

[10]  C. Serhan,et al.  Synthesis of the 16S,17S-Epoxyprotectin Intermediate in the Biosynthesis of Protectins by Human Macrophages. , 2015, Journal of natural products.

[11]  D. Prvulovic,et al.  Omega 3 Fatty Acids: Novel Neurotherapeutic Targets for Cognitive Dysfunction in Mood Disorders and Schizophrenia? , 2015, Current neuropharmacology.

[12]  C. Serhan,et al.  Protectins and maresins: New pro-resolving families of mediators in acute inflammation and resolution bioactive metabolome. , 2015, Biochimica et biophysica acta.

[13]  C. Serhan,et al.  Novel proresolving and tissue‐regenerative resolvin and protectin sulfido‐conjugated pathways , 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[14]  C. Serhan,et al.  Identification of 14-series sulfido-conjugated mediators that promote resolution of infection and organ protection , 2014, Proceedings of the National Academy of Sciences.

[15]  C. Serhan,et al.  Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue. , 2014, American journal of physiology. Cell physiology.

[16]  Charles N. Serhan,et al.  Pro-resolving lipid mediators are leads for resolution physiology , 2014, Nature.

[17]  D. Gilroy,et al.  Proresolving lipid mediators and mechanisms in the resolution of acute inflammation. , 2014, Immunity.

[18]  M. Aursnes,et al.  Stereoselective synthesis of protectin D1: a potent anti-inflammatory and proresolving lipid mediator. , 2014, Organic & biomolecular chemistry.

[19]  C. Serhan,et al.  Resolution phase lipid mediators of inflammation: agonists of resolution. , 2013, Current opinion in pharmacology.

[20]  J. Haeggström,et al.  The novel 13S,14S ‐epoxy‐maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype , 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[21]  C. Serhan,et al.  Novel n-3 Immunoresolvents: Structures and Actions , 2013, Scientific Reports.

[22]  P. Calder.  Omega-3 polyunsaturated fatty acids and inflammatory processes: nutrition or pharmacology? , 2013, British journal of clinical pharmacology.

[23]  T. Hansen,et al.  Concise syntheses of three ω-3 polyunsaturated fatty acids , 2012 .

[24]  Charles N. Serhan,et al.  Infection Regulates Pro-Resolving Mediators that Lower Antibiotic Requirements , 2012, Nature.

[25]  B. Samuelsson.  Role of Basic Science in the Development of New Medicines: Examples from the Eicosanoid Field , 2012, The Journal of Biological Chemistry.

[26]  S. Proudman,et al.  The Role of Fish Oils in the Treatment of Rheumatoid Arthritis , 2012, Drugs.

[27]  C. Serhan,et al.  Resolvins and protectins in inflammation resolution. , 2011, Chemical reviews.

[28]  J. Haeggström,et al.  Lipoxygenase and leukotriene pathways: biochemistry, biology, and roles in disease. , 2011, Chemical reviews.

[29]  M. Fornage,et al.  Genetic Loci Associated with Plasma Phospholipid n-3 Fatty Acids: A Meta-Analysis of Genome-Wide Association Studies from the CHARGE Consortium , 2011, PLoS genetics.

[30]  C. Serhan,et al.  Pro-resolving actions and stereoselective biosynthesis of 18S E-series resolvins in human leukocytes and murine inflammation. , 2011, The Journal of clinical investigation.

[31]  M. Garg,et al.  Docosapentaenoic acid (22:5n-3): a review of its biological effects. , 2011, Progress in lipid research.

[32]  P. Mukherjee,et al.  Neuroprotectin D1/protectin D1 stereoselective and specific binding with human retinal pigment epithelial cells and neutrophils. , 2010, Prostaglandins, leukotrienes, and essential fatty acids.

[33]  D. Gilroy,et al.  Effects of Low-Dose Aspirin on Acute Inflammatory Responses in Humans1 , 2009, The Journal of Immunology.

[34]  M. Zdanowicz,et al.  Therapeutic potential of n-3 polyunsaturated fatty acids in disease. , 2009, American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists.

[35]  C. Serhan,et al.  Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions , 2009, The Journal of experimental medicine.

[36]  P. Calder.  Immunomodulation by omega-3 fatty acids. , 2007, Prostaglandins, leukotrienes, and essential fatty acids.

[37]  C. Serhan.  Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways. , 2007, Annual review of immunology.

[38]  Katherine B Percarpio,et al.  Resolvin E2: identification and anti-inflammatory actions: pivotal role of human 5-lipoxygenase in resolvin E series biosynthesis. , 2006, Chemistry & biology.

[39]  Yan Lu,et al.  Anti-Inflammatory Actions of Neuroprotectin D1/Protectin D1 and Its Natural Stereoisomers: Assignments of Dihydroxy-Containing Docosatrienes1 , 2006, The Journal of Immunology.

[40]  J. Nettleton,et al.  n-3 long-chain polyunsaturated fatty acids in type 2 diabetes: a review. , 2005, Journal of the American Dietetic Association.

[41]  P. Mukherjee,et al.  Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[42]  Magnus Ingelman-Sundberg,et al.  Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms. , 2004, The American journal of clinical nutrition.

[43]  C. Serhan,et al.  Novel Docosatrienes and 17S-Resolvins Generated from Docosahexaenoic Acid in Murine Brain, Human Blood, and Glial Cells , 2003, The Journal of Biological Chemistry.

[44]  A. Simopoulos.  Omega-3 Fatty Acids in Inflammation and Autoimmune Diseases , 2002, Journal of the American College of Nutrition.

[45]  C. Serhan,et al.  Resolvins , 2002, The Journal of experimental medicine.

[46]  S. Ferdinandusse,et al.  Identification of the peroxisomal beta-oxidation enzymes involved in the biosynthesis of docosahexaenoic acid. , 2001, Journal of lipid research.

[47]  T. A. Jacobson,et al.  The fats of life: the role of omega-3 fatty acids in the prevention of coronary heart disease. , 2001, Archives of internal medicine.

[48]  C. Clish,et al.  Novel Functional Sets of Lipid-Derived Mediators with Antiinflammatory Actions Generated from Omega-3 Fatty Acids via Cyclooxygenase 2–Nonsteroidal Antiinflammatory Drugs and Transcellular Processing , 2000, The Journal of experimental medicine.

[49]  B. Samuelsson.  The discovery of the leukotrienes. , 2000, American journal of respiratory and critical care medicine.

[50]  S. Godtfredsen,et al.  Ullmann ' s Encyclopedia of Industrial Chemistry , 2017 .

[51]  M. Lagarde,et al.  Docosapentaenoic acid (22:5,n-3): metabolism and effect on prostacyclin production in endothelial cells. , 1996, Prostaglandins, leukotrienes, and essential fatty acids.

[52]  C. Serhan.  Lipoxin biosynthesis and its impact in inflammatory and vascular events. , 1994, Biochimica et biophysica acta.

[53]  K. Nicolaou,et al.  Lipoxins and Related Eicosanoids: Biosynthesis, Biological Properties, and Chemical Synthesis , 1991 .

[54]  K. Nicolaou,et al.  Lipoxine und verwandte Eicosanoide: Biosynthese, biologische Eigenschaften und chemische Synthese , 1991 .

[55]  E. Corey,et al.  A Stereoselective and Practical Synthesis of 5,6(S,S)-Epoxy-15(S)-hydroxy-7(E),9(E),11(Z),13(E)-eicosatetraenoic Acid, Possible Precursor of the Lipoxins. , 1987 .

[56]  E. Corey,et al.  A stereoselective and practical synthesis of 5,6(S,S)-epoxy-15(S)-hydroxy-7(E),9(E),11(Z),13(E)-eicosatetraenoic acid (4), possible precursor of the lipoxins , 1986 .

[57]  H. Sprecher,et al.  Synthesis of two hydroxy fatty acids from 7,10,13,16,19-docosapentaenoic acid by human platelets. , 1984, The Journal of biological chemistry.

[58]  M. Hamberg,et al.  Trihydroxytetraenes: a novel series of compounds formed from arachidonic acid in human leukocytes. , 1984, Biochemical and biophysical research communications.

[59]  E. Corey,et al.  Total synthesis of (.+-.)-5,6-oxido-7,9-trans,11,14-cis-eicosapentaenoic acid, a possible precursor of SRSA , 1979 .

[60]  B. Samuelsson,et al.  Arachidonic acid metabolism in polymorphonuclear leukocytes: unstable intermediate in formation of dihydroxy acids. , 1979, Proceedings of the National Academy of Sciences of the United States of America.

[61]  B. Samuelsson,et al.  Arachidonic acid metabolism in polymorphonuclear leukocytes: effects of ionophore A23187. , 1979, Proceedings of the National Academy of Sciences of the United States of America.