Studies in an Early Development Window Unveils a Severe HSC Defect in both Murine and Human Fanconi Anemia

[1]  Minoru Takata,et al.  Biallelic mutations in the ubiquitin ligase RFWD3 cause Fanconi anemia , 2017, The Journal of clinical investigation.

[2]  S. Cantor,et al.  Impairment of fetal hematopoietic stem cell function in the absence of Fancd2. , 2017, Experimental hematology.

[3]  M. Bellani,et al.  Fanconi Anemia: A DNA repair disorder characterized by accelerated decline of the hematopoietic stem cell compartment and other features of aging , 2017, Ageing Research Reviews.

[4]  P. Kurre,et al.  Endogenous DNA Damage Leads to p53-Independent Deficits in Replicative Fitness in Fetal Murine Fancd2−/− Hematopoietic Stem and Progenitor Cells , 2016, Stem cell reports.

[5]  J. Soulier,et al.  Biallelic inactivation of REV7 is associated with Fanconi anemia. , 2016, The Journal of clinical investigation.

[6]  A. Jankowska,et al.  Complementation of hypersensitivity to DNA interstrand crosslinking agents demonstrates that XRCC2 is a Fanconi anaemia gene , 2016, Journal of Medical Genetics.

[7]  J. Soulier,et al.  TGF-β Inhibition Rescues Hematopoietic Stem Cell Defects and Bone Marrow Failure in Fanconi Anemia. , 2016, Cell stem cell.

[8]  P. Andreassen,et al.  Fancb deficiency impairs hematopoietic stem cell function , 2015, Scientific Reports.

[9]  E. Bruford,et al.  Update of the human and mouse Fanconi anemia genes , 2015, Human Genomics.

[10]  K. Kim,et al.  Assaying Cell Cycle Status Using Flow Cytometry , 2015, Current protocols in molecular biology.

[11]  Derrick J. Rossi,et al.  Epigenetic Control of Stem Cell Potential during Homeostasis, Aging, and Disease. , 2015, Cell stem cell.

[12]  David A. Williams,et al.  Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells , 2015, Nature.

[13]  S. Kato,et al.  Oxymetholone Therapy of Fanconi Anemia Suppresses Osteopontin Transcription and Induces Hematopoietic Stem Cell Cycling , 2014, Stem cell reports.

[14]  P. Frenette,et al.  Hematopoietic stem cell niche maintenance during homeostasis and regeneration , 2014, Nature Medicine.

[15]  G. Nalepa,et al.  Fanconi anemia and the cell cycle: new perspectives on aneuploidy , 2014, F1000prime reports.

[16]  K. J. Patel,et al.  Why does the bone marrow fail in Fanconi anemia? , 2014, Blood.

[17]  R. Porcher,et al.  Allogeneic hematopoietic stem cell transplantation in Fanconi anemia: the European Group for Blood and Marrow Transplantation experience. , 2013, Blood.

[18]  G. Kupfer.  Fanconi Anemia: A Signal Transduction and DNA Repair Pathway , 2013, The Yale journal of biology and medicine.

[19]  J. Shim,et al.  Olfactory Control of Blood Progenitor Maintenance , 2013, Cell.

[20]  H. Deeg,et al.  Allogeneic hematopoietic cell transplantation for fanconi anemia in patients with pretransplantation cytogenetic abnormalities, myelodysplastic syndrome, or acute leukemia. , 2013, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[21]  P. Kurre,et al.  Fetal origins of hematopoietic failure in a murine model of Fanconi anemia. , 2013, Blood.

[22]  Molly C. Kottemann,et al.  Fanconi anaemia and the repair of Watson and Crick DNA crosslinks , 2013, Nature.

[23]  H. Eich,et al.  Evaluation of Different Biomarkers to Predict Individual Radiosensitivity in an Inter-Laboratory Comparison–Lessons for Future Studies , 2012, PloS one.

[24]  L. Hays.  A mismatched life in the stem cell pool. , 2012, Blood.

[25]  Nicola K. Wilson,et al.  Signaling from the Sympathetic Nervous System Regulates Hematopoietic Stem Cell Emergence during Embryogenesis , 2012, Cell stem cell.

[26]  B. Dumitriu,et al.  Damage control and its costs: BM failure in Fanconi anemia stems from overactive p53/p21. , 2012, Cell stem cell.

[27]  J. Soulier,et al.  Bone marrow failure in Fanconi anemia is triggered by an exacerbated p53/p21 DNA damage response that impairs hematopoietic stem and progenitor cells. , 2012, Cell stem cell.

[28]  A. D’Andrea,et al.  Regulation of Rev1 by the Fanconi Anemia Core Complex , 2011, Nature Structural &Molecular Biology.

[29]  Stephen C. West,et al.  DNA interstrand crosslink repair and cancer , 2011, Nature Reviews Cancer.

[30]  F. Sigaux,et al.  Myelodysplasia and leukemia of Fanconi anemia are associated with a specific pattern of genomic abnormalities that includes cryptic RUNX1/AML1 lesions. , 2011, Blood.

[31]  S. Rybtsov,et al.  Embryonic origin of the adult hematopoietic system: advances and questions , 2011, Development.

[32]  E. Domany,et al.  A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal. , 2010, Cell stem cell.

[33]  K. Ottersbach,et al.  The placenta as a haematopoietic organ. , 2010, The International journal of developmental biology.

[34]  M. Ueno,et al.  Hematopoietic stem cell development in the placenta. , 2010, The International journal of developmental biology.

[35]  G. Daley,et al.  Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage. , 2010, Blood.

[36]  P. Dedon,et al.  Endogenous DNA Damage , 2010 .

[37]  David A. Williams,et al.  Finding the needle in the hay stack: hematopoietic stem cells in Fanconi anemia. , 2009, Mutation research.

[38]  A. D’Andrea,et al.  Mouse models of Fanconi anemia. , 2009, Mutation research.

[39]  T. Vulliamy,et al.  Inherited aplastic anaemias/bone marrow failure syndromes. , 2008, Blood reviews.

[40]  Elaine Dzierzak,et al.  Of lineage and legacy: the development of mammalian hematopoietic stem cells , 2008, Nature Immunology.

[41]  M. Souyri,et al.  Dual role of Mpl receptor during the establishment of definitive hematopoiesis , 2007, Development.

[42]  T. Mikkelsen,et al.  Genome-wide maps of chromatin state in pluripotent and lineage-committed cells , 2007, Nature.

[43]  S. Orkin,et al.  The journey of developing hematopoietic stem cells , 2006, Development.

[44]  S. Ramkissoon,et al.  G protein-coupled receptors in haematopoietic disruption , 2006, Expert opinion on biological therapy.

[45]  Pablo Tamayo,et al.  Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[46]  K. Ottersbach,et al.  The murine placenta contains hematopoietic stem cells within the vascular labyrinth region. , 2005, Developmental cell.

[47]  S. Orkin,et al.  The placenta is a niche for hematopoietic stem cells. , 2004, Developmental cell.

[48]  M. Tischkowitz,et al.  Fanconi anaemia and leukaemia – clinical and molecular aspects , 2004, British journal of haematology.

[49]  Marianne Berwick,et al.  A 20-year perspective on the International Fanconi Anemia Registry (IFAR). , 2003, Blood.

[50]  A. M. Morrison,et al.  Quantitative developmental anatomy of definitive haematopoietic stem cells/long-term repopulating units (HSC/RUs): role of the aorta-gonad-mesonephros (AGM) region and the yolk sac in colonisation of the mouse embryonic liver. , 2002, Development.

[51]  H. Joenje,et al.  Reduced fertility and hypersensitivity to mitomycin C characterize Fancg/Xrcc9 null mice. , 2002, Human molecular genetics.

[52]  C. Lewis,et al.  Association of complementation group and mutation type with clinical outcome in fanconi anemia. European Fanconi Anemia Research Group. , 2000, Blood.

[53]  H. Nakauchi,et al.  Expansion of hematopoietic stem cells in the developing liver of a mouse embryo. , 2000, Blood.

[54]  E. Dzierzak,et al.  Characterization of the first definitive hematopoietic stem cells in the AGM and liver of the mouse embryo. , 1996, Immunity.

[55]  I. Weissman,et al.  The purification and characterization of fetal liver hematopoietic stem cells. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[56]  I. Lemischka,et al.  Long-term repopulating abilities of enriched fetal liver stem cells measured by competitive repopulation. , 1995, Experimental hematology.

[57]  K. Nagata,et al.  Reproducible establishment of hemopoietic supportive stromal cell lines from murine bone marrow. , 1989, Experimental hematology.

[58]  V. Barroca,et al.  Impaired functionality and homing of Fancg-deficient hematopoietic stem cells. , 2012, Human molecular genetics.

[59]  J. Soulier.  Fanconi anemia. , 2011, Hematology. American Society of Hematology. Education Program.

[60]  David A. Williams,et al.  Stem Cell Collection and Gene Transfer in Fanconi Anemia. , 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

[61]  B. Péault,et al.  Embryonic development of the human hematopoietic system. , 2005, The International journal of developmental biology.