Veterinary Drug Residues in Foods

Abstract: A residue may be defined as a trace of a substance present in a matrix (e.g. meat, urine, etc.) after some kind of administration (e.g. within the framework of veterinary practice or illegal use) to an animal. This chapter deals with the broader issues associated with residues of veterinary drugs in food products of animal origin. Topics such as risk assessment, risk management, major causes of residues and major classes of drug residues are treated. Current and future analytical strategies and results obtained in the national residue programme of Belgium are highlighted.

[1]  J. Mcevoy,et al.  Monensin carry-over into unmedicated broiler feeds. , 1998, The Analyst.

[2]  A. Posyniak,et al.  Rapid method for the determination of tranquilizers and a beta-blocker in porcine and bovine kidney by liquid chromatography with tandem mass spectrometry. , 2009, Analytica chimica acta.

[3]  J. Boison,et al.  Determination of the performance characteristics of a new multi-residue method for non-steroidal anti-inflammatory drugs, corticosteroids and anabolic steroids in food animal tissues , 2008, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

[4]  J. Blondeau Current Issues in the Management of Urinary Tract Infections , 2012, Drugs.

[5]  M. Danaher,et al.  Determination of nitroxynil residues in tissues and bovine milk by immunobiosensor , 2013, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

[6]  M. Brewer,et al.  Effects of subtherapeutic concentrations of antimicrobials on gene acquisition events in Yersinia, Proteus, Shigella, and Salmonella recipient organisms in isolated ligated intestinal loops of swine. , 2013, American journal of veterinary research.

[7]  A. Surleva,et al.  Simultaneous Determination of Nine Quinolones in Food by Liquid Chromatography with Fluorescence Detection , 2013, Food Analytical Methods.

[8]  C. Elliott,et al.  Carry-over of sulphadimidine in the faeces and urine of pigs fed medicated feed , 1990, Veterinary Record.

[9]  F. Monteau,et al.  Multi-residue analysis for β-agonistic drugs in urine of meat-producing animals by gas chromatography—mass spectrometry , 1993 .

[10]  X. Xia,et al.  Validation of a method for simultaneous determination of nitroimidazoles, benzimidazoles and chloramphenicols in swine tissues by ultra-high performance liquid chromatography-tandem mass spectrometry. , 2013, Journal of chromatography. A.

[11]  L. Vanhaecke,et al.  High resolution Orbitrap mass spectrometry in comparison with tandem mass spectrometry for confirmation of anabolic steroids in meat. , 2013, Analytica chimica acta.

[12]  H. D. De brabander,et al.  A downscaled multi-residue strategy for detection of anabolic steroids in bovine urine using gas chromatography tandem mass spectrometry (GC-MS3). , 2007, Analytica chimica acta.

[13]  D. Durden Positive and negative electrospray LC-MS-MS methods for quantitation of the antiparasitic endectocide drugs, abamectin, doramectin, emamectin, eprinomectin, ivermectin, moxidectin and selamectin in milk. , 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[14]  Willem Haasnoot,et al.  Immunofiltration as sample cleanup for the immunochemical detection of beta-agonists in urine. , 2002, The Analyst.

[15]  A. Sanquer,et al.  Critical review on the withdrawal period calculation for injection site residues. , 2006, Journal of veterinary pharmacology and therapeutics.

[16]  F. André,et al.  Withdrawal time of four pharmaceutical formulations of enrofloxacin in poultry according to different maximum residues limits. , 2009, Journal of veterinary pharmacology and therapeutics.

[17]  F. Monteau,et al.  Gas chromatography/combustion/isotope ratio mass spectrometry to control the misuse of androgens in breeding animals: new derivatisation method applied to testosterone metabolites and precursors in urine samples. , 2001, Rapid communications in mass spectrometry : RCM.

[18]  F. Vinci,et al.  Confirmatory identification of sixteen non-steroidal anti-inflammatory drug residues in raw milk by liquid chromatography coupled with ion trap mass spectrometry. , 2008, Rapid communications in mass spectrometry : RCM.

[19]  C. V. Van Peteghem,et al.  Investigation into the possible natural occurence of semicarbazide in Macrobrachium rosenbergii prawns. , 2011, Journal of agricultural and food chemistry.

[20]  A. Cepeda,et al.  Application of molecularly imprinted polymers in food analysis: clean-up and chromatographic improvements , 2012 .

[21]  P. Toutain,et al.  Plasma terminal half-life. , 2004, Journal of veterinary pharmacology and therapeutics.

[22]  Nathalie Gillard,et al.  Rapid multi-residue and multi-class qualitative screening for veterinary drugs in foods of animal origin by UHPLC-MS/MS , 2013, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

[23]  A. Bhalla,et al.  Toxicity of maduramicin , 2005, Emergency Medicine Journal.

[24]  E. Daeseleire,et al.  Determination of flunixin and ketoprofen in milk by liquid chromatography–tandem mass spectrometry , 2003 .

[25]  W. Andersen,et al.  Multi-class, multi-residue liquid chromatography/tandem mass spectrometry screening and confirmation methods for drug residues in milk. , 2008, Rapid communications in mass spectrometry : RCM.

[26]  C. Stachel,et al.  In-house validation and factorial effect analysis of a liquid chromatography–tandem mass spectrometry method for the determination of corticosteroids in bovine and porcine muscle tissue , 2013, Analytical and Bioanalytical Chemistry.

[27]  C. V. Van Peteghem,et al.  Incidence of residues of nine anticoccidials in eggs , 2005, Food additives and contaminants.

[28]  U. Brinkman,et al.  Analytical strategies for residue analysis of veterinary drugs and growth-promoting agents in food-producing animals--a review. , 2005, Journal of chromatography. A.

[29]  M. Churchwell,et al.  Multiresidue confirmation of beta-agonists in bovine retina and liver using LC-ES/MS/MS. , 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[30]  Terry J. Dutko,et al.  Development and validation of a streamlined method designed to detect residues of 62 veterinary drugs in bovine kidney using ultra-high performance liquid chromatography--tandem mass spectrometry. , 2012, Drug testing and analysis.

[31]  E. Malone,et al.  Analytical strategy for the determination of non-steroidal anti-inflammatory drugs in plasma and improved analytical strategy for the determination of authorised and non-authorised non-steroidal anti-inflammatory drugs in milk by LC–MS/MS , 2010, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

[32]  G. Theodoridis,et al.  Rapid multi-method for the determination of growth promoters in bovine milk by liquid chromatography-tandem mass spectrometry. , 2013, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[33]  F. Vinci,et al.  Determination of fourteen non-steroidal anti-inflammatory drugs in animal serum and plasma by liquid chromatography/mass spectrometry. , 2006, Rapid communications in mass spectrometry : RCM.

[34]  Marilena E. Dasenaki,et al.  Multi-residue determination of seventeen sulfonamides and five tetracyclines in fish tissue using a multi-stage LC-ESI-MS/MS approach based on advanced mass spectrometric techniques. , 2010, Analytica chimica acta.

[35]  R. Galarini,et al.  Determination of macrocyclic lactones in food and feed , 2013, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

[36]  P. Gowik,et al.  Validation of a multi-residue method for the determination of several antibiotic groups in honey by LC-MS/MS , 2012, Analytical and Bioanalytical Chemistry.

[37]  M. Urioste,et al.  Methimazole in animal feed and congenital aplasia cutis , 1992, The Lancet.

[38]  B. Shao,et al.  Multi-residual analysis of 16 β-agonists in pig liver, kidney and muscle by ultra performance liquid chromatography tandem mass spectrometry. , 2009 .

[39]  J. Shim,et al.  Determination of sedatives and adrenergic blockers in blood meal using accelerated solvent extraction and Orbitrap mass spectrometry. , 2012, Journal of chromatography. A.

[40]  L. Stolker,et al.  Evidence of natural occurrence of the banned antibiotic chloramphenicol in herbs and grass , 2010, Analytical and bioanalytical chemistry.

[41]  B. Le Bizec,et al.  Use of isotope ratio mass spectrometry to differentiate between endogenous steroids and synthetic homologues in cattle: a review. , 2013, Analytica chimica acta.

[42]  M. Kitayama,et al.  Simultaneous Determination of Residual Veterinary Drugs in Bovine, Porcine, and Chicken Muscle Using Liquid Chromatography Coupled with Electrospray Ionization Tandem Mass Spectrometry , 2006, Bioscience, biotechnology, and biochemistry.

[43]  A. Sanquer,et al.  Qualitative assessment of human exposure to consumption of injection site residues. , 2006, Journal of Veterinary Pharmacology and Therapeutics.

[44]  J. Barbosa,et al.  Comparative study of the LC-MS/MS and UPLC-MS/MS for the multi-residue analysis of quinolones, penicillins and cephalosporins in cow milk, and validation according to the regulation 2002/657/EC. , 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[45]  C. V. Van Peteghem,et al.  Determination of the ionophoric coccidiostats narasin, monensin, lasalocid and salinomycin in eggs by liquid chromatography/tandem mass spectrometry. , 2005, Rapid communications in mass spectrometry : RCM.

[46]  M. Hernández-Córdoba,et al.  Dispersive liquid-liquid microextraction for the determination of macrocyclic lactones in milk by liquid chromatography with diode array detection and atmospheric pressure chemical ionization ion-trap tandem mass spectrometry. , 2013, Journal of chromatography. A.

[47]  D. Heller,et al.  Development of multiclass methods for drug residues in eggs: hydrophilic solid-phase extraction cleanup and liquid chromatography/tandem mass spectrometry analysis of tetracycline, fluoroquinolone, sulfonamide, and beta-lactam residues. , 2006, Journal of agricultural and food chemistry.

[48]  G. Palleschi,et al.  Development of an electrochemical ELISA for the screening of 17 beta-estradiol and application to bovine serum. , 2000, The Analyst.

[49]  T. S. Thompson,et al.  Determination of ionophores in raw bovine milk using LC–MS/MS: Application to residue surveillance , 2011 .

[50]  J. Żmudzki,et al.  Determination of non-steroidal anti-inflammatory drugs residues in animal muscles by liquid chromatography-tandem mass spectrometry. , 2010, Analytica chimica acta.

[51]  B. Shao,et al.  Determination of the residues of 50 anabolic hormones in muscle, milk and liver by very-high-pressure liquid chromatography-electrospray ionization tandem mass spectrometry. , 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[52]  M. Moloney,et al.  Detection of banned nitrofuran metabolites in animal plasma samples using UHPLC-MS/MS. , 2011, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[53]  J. Beechinor,et al.  Prevalence and public health significance of blemishes in cuts of Irish beef , 2001, Veterinary Record.

[54]  J. Vercammen,et al.  Recent developments in the use and abuse of growth promoters , 2002 .

[55]  K. Granelli,et al.  Rapid multi-residue screening of antibiotics in muscle and kidney by liquid chromatography-electrospray ionization-tandem mass spectrometry. , 2007, Analytica chimica acta.

[56]  C. V. Van Peteghem,et al.  Multiresidue analysis of anabolic agents in muscle tissues and urines of cattle by GC-MS. , 1992, Journal of chromatographic science.

[57]  S. Croubels,et al.  Residue analysis: Future trends from a historical perspective. , 2009, Journal of chromatography. A.

[58]  V. Sharma,et al.  Quantitative determination of corticosteroids in bovine milk using mixed-mode polymeric strong cation exchange solid-phase extraction and liquid chromatography-tandem mass spectrometry. , 2010, Journal of pharmaceutical and biomedical analysis.

[59]  F. Aarestrup,et al.  Evaluation of eight different cephalosporins for detection of cephalosporin resistance in Salmonella enterica and Escherichia coli. , 2010, Microbial drug resistance.

[60]  M. Morita,et al.  Fatal rhabdomyolysis after acute sodium monensin (Rumensin) toxicity: case report. , 2001, Arquivos de neuro-psiquiatria.

[61]  Haiyang Jiang,et al.  Development of a simple method for simultaneous determination of nine subclasses of non-steroidal anti-inflammatory drugs in milk and dairy products by ultra-performance liquid chromatography with tandem mass spectrometry. , 2013, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[62]  B. Le Bizec,et al.  Analysis of thyreostats: a history of 35 years. , 2009, Analytica chimica acta.

[63]  D. Lamaison,et al.  Collective human food poisonings by clenbuterol residues in veal liver. , 1991, Veterinary and human toxicology.

[64]  Robert Boyd John Herbert Beynon. , 2004, Rapid communications in mass spectrometry : RCM.

[65]  P. T. Reeves Residues of veterinary drugs at injection sites. , 2007, Journal of veterinary pharmacology and therapeutics.

[66]  R. Hoff,et al.  Bioactivity-based screening methods for antibiotics residues: a comparative study of commercial and in-house developed kits , 2012, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

[67]  Y. Tao,et al.  Development of a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the quantification of glucocorticoid residues in edible tissues of swine, cattle, sheep, and chicken , 2010, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

[68]  B. Foley,et al.  Rapid multi-class multi-residue method for the confirmation of chloramphenicol and eleven nitroimidazoles in milk and honey by liquid chromatography-tandem mass spectrometry (LC-MS) , 2010, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

[69]  M. Papich,et al.  A study of the disposition of procaine penicillin G in feedlot steers following intramuscular and subcutaneous injection. , 1993, Journal of veterinary pharmacology and therapeutics.

[70]  J. Żmudzki,et al.  Determination of stilbenes and resorcylic acid lactones in bovine, porcine and poultry muscle tissue by liquid chromatography-negative ion electrospray mass spectrometry and QuEChERS for sample preparation. , 2013, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[71]  P. Salvà,et al.  Epidemiologic study of an outbreak of clenbuterol poisoning in Catalonia, Spain. , 1995, Public health reports.

[72]  P. de Backer,et al.  Control of the keto-enol tautomerism of chlortetracycline for its straightforward quantitation in pig tissues by liquid chromatography-electrospray ionization tandem mass spectrometry. , 2006, Journal of chromatography. A.

[73]  P. Jedziniak,et al.  Multi-residue confirmatory method for the determination of twelve coccidiostats in chicken liver using liquid chromatography tandem mass spectrometry. , 2009, Journal of chromatography. A.

[74]  R. Curini,et al.  Development and validation of two multiresidue liquid chromatography tandem mass spectrometry methods based on a versatile extraction procedure for isolating non-steroidal anti-inflammatory drugs from bovine milk and muscle tissue , 2012, Analytical and Bioanalytical Chemistry.

[75]  B. Le Bizec,et al.  Determination of thyreostats in urine and thyroid gland by ultra high performance liquid chromatography tandem mass spectrometry. , 2009, Journal of chromatography. A.

[76]  G. Stubbings,et al.  The development and validation of a multiclass liquid chromatography tandem mass spectrometry (LC-MS/MS) procedure for the determination of veterinary drug residues in animal tissue using a QuEChERS (QUick, Easy, CHeap, Effective, Rugged and Safe) approach. , 2009, Analytica chimica acta.

[77]  A Kaufmann,et al.  Development of an improved high resolution mass spectrometry based multi-residue method for veterinary drugs in various food matrices. , 2011, Analytica chimica acta.

[78]  Steven J Lehotay,et al.  Ruggedness testing and validation of a practical analytical method for >100 veterinary drug residues in bovine muscle by ultrahigh performance liquid chromatography-tandem mass spectrometry. , 2012, Journal of chromatography. A.

[79]  P. Zöllner,et al.  Determination of zeranol, taleranol, zearalenone, α- and β-zearalenol in urine and tissue by high-performance liquid chromatography-tandem mass spectrometry , 2000 .

[80]  E. Dubreil-Chéneau,et al.  Development and validation of a confirmatory method for the determination of 12 non steroidal anti-inflammatory drugs in milk using liquid chromatography-tandem mass spectrometry. , 2011, Journal of chromatography. A.

[81]  J. Dorne,et al.  Risk assessment of coccidostatics during feed cross-contamination: animal and human health aspects. , 2013, Toxicology and applied pharmacology.

[82]  A. Nasi,et al.  The Use of Bovine Serum Albumin as a Ligand in Affinity Chromatographic Clean-up of Non-Steroidal Anti-Inflammatory Drugs from Bovine Plasma , 2004 .

[83]  E. Malone,et al.  Analytical strategy for the confirmatory analysis of the non-steroidal anti-inflammatory drugs firocoxib, propyphenazone, ramifenazone and piroxicam in bovine plasma by liquid chromatography tandem mass spectrometry. , 2011, Journal of pharmaceutical and biomedical analysis.

[84]  M. Danaher,et al.  Review of methodology for the determination of benzimidazole residues in biological matrices. , 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[85]  K. Miura,et al.  6 The Nitrofurans , 1967 .

[86]  H. Mol,et al.  Full scan MS in comprehensive qualitative and quantitative residue analysis in food and feed matrices: How much resolving power is required? , 2009 .

[87]  C. Dass,et al.  Structural characterization of methionine and leucine enkephalins by hydrogen/deuterium exchange and electrospray ionization tandem mass spectrometry. , 2005, Rapid communications in mass spectrometry : RCM.

[88]  B. Le Bizec,et al.  Options for veterinary drug analysis using mass spectrometry. , 2009, Journal of chromatography. A.

[89]  Limin He,et al.  Simultaneous Determination of Tranquilizers and Carazolol Residues in Swine Tissues by Liquid Chromatography-Tandem Mass Spectrometry , 2012 .

[90]  F. Franconi,et al.  Clinical and pharmacological profile in a clenbuterol epidemic poisoning of contaminated beef meat in Italy. , 2000, Toxicology letters.

[91]  M. Lafontan,et al.  Les agonistes bêta-adrénergiques. Mécanismes d'action : lipomobilisation et anabolisme , 1988 .

[92]  D. Donoghue,et al.  Multiresidue analysis of fluoroquinolone antibiotics in chicken tissue using liquid chromatography-fluorescence-multiple mass spectrometry. , 2002, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[93]  X. Xia,et al.  Simultaneous determination of thirty non-steroidal anti-inflammatory drug residues in swine muscle by ultra-high-performance liquid chromatography with tandem mass spectrometry. , 2012, Journal of chromatography. A.

[94]  Katia De Wasch,et al.  Screening and confirmation of chloramphenicol in shrimp tissue using ELISA in combination with , 2003 .

[95]  A. Gentili LC-MS methods for analyzing anti-inflammatory drugs in animal-food products , 2007 .

[96]  P. Gowik,et al.  Validation of a method for the detection and confirmation of nitroimidazoles and corresponding hydroxy metabolites in turkey and swine muscle by means of gas chromatography-negative ion chemical ionization mass spectrometry. , 2001, Journal of chromatography. B, Biomedical sciences and applications.

[97]  Supalax Srijaranai,et al.  Surfactant–Solvent-Based Quaternary Component Emulsification Microextraction Followed by High-Performance Liquid Chromatography for the Simultaneous Analysis of Benzimidazole Anthelmintics in Milk Samples , 2014, Food Analytical Methods.

[98]  J. Riviere,et al.  Tabulation of FARAD Comparative and Veterinary Pharmacokinetic Data , 2006 .

[99]  M. Curatolo,et al.  Development and validation of a liquid chromatography-tandem mass spectrometry method for the simultaneous determination of nine corticosteroid residues in bovine liver samples. , 2011, Analytica chimica acta.

[100]  M. Galceran,et al.  Ultra-high performance liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry for the analysis of benzimidazole compounds in milk samples. , 2013, Journal of chromatography. A.

[101]  Y. Picó,et al.  Multi-class determination of antimicrobials in meat by pressurized liquid extraction and liquid chromatography-tandem mass spectrometry. , 2008, Journal of chromatography. A.

[102]  Y X Wang,et al.  Multi residue determination of the penicillins regulated by the European Union, in bovine, porcine and chicken muscle, by LC-MS/MS. , 2012, Food chemistry.

[103]  J. O'mahony,et al.  Determination of 20 coccidiostats in egg and avian muscle tissue using ultra high performance liquid chromatography-tandem mass spectrometry. , 2012, Journal of chromatography. A.

[104]  Linus Sandegren,et al.  Selection of Resistant Bacteria at Very Low Antibiotic Concentrations , 2011, PLoS pathogens.

[105]  J. Guiteras,et al.  Development and validation of a multiclass method for the analysis of antibiotic residues in eggs by liquid chromatography-tandem mass spectrometry. , 2011, Journal of chromatography. A.

[106]  P. Kootstra,et al.  Multi-residue screening of a minimum package of anabolic steroids in urine with GC-MS. , 2007, Analytica chimica acta.

[107]  V. Sharma,et al.  Confirmatory analysis of stanozolol metabolites in bovine, pig and sheep urines using an optimized clean-up and liquid chromatography-tandem mass spectrometry. , 2014, Journal of pharmaceutical and biomedical analysis.

[108]  J. Miranda,et al.  A sensitive and validated HPLC–MS/MS method for simultaneous determination of seven coccidiostats in bovine whole milk , 2012 .

[109]  Martindale : the extra pharmacopoeia , 1996 .

[110]  H. D. De brabander,et al.  Multi-residue liquid chromatography/tandem mass spectrometry method for the detection of non-steroidal anti-inflammatory drugs in bovine muscle: optimisation of ion trap parameters. , 2004, Rapid communications in mass spectrometry : RCM.

[111]  P. Delahaut,et al.  Efficient and sensitive detection of residues of nine coccidiostats in egg and muscle by liquid chromatography-electrospray tandem mass spectrometry. , 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[112]  S. Biselli,et al.  A multi-class, multi-analyte method for routine analysis of 84 veterinary drugs in chicken muscle using simple extraction and LC-MS/MS , 2013, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

[113]  J. Riviere,et al.  Application of risk assessment and management principles to the extralabel use of drugs in food-producing animals. , 2006, Journal of veterinary pharmacology and therapeutics.

[114]  D. Kennedy,et al.  Depletion of four nitrofuran antibiotics and their tissue-bound metabolites in porcine tissues and determination using LC-MS/MS and HPLC-UV , 2005, Food additives and contaminants.

[115]  N. Bilandžić,et al.  Validation of a multi-residue enzyme-linked immunosorbent assay for qualitative screening of corticosteroids in liver, urine and milk , 2011, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

[116]  R. Grabic,et al.  Simultaneous determination of 32 antibiotics in aquaculture products using LC-MS/MS , 2013, Chemical Papers.

[117]  M. N. Haouet,et al.  ELISA qualitative screening of chloramphenicol in muscle, eggs, honey and milk: method validation according to the Commission Decision 2002/657/EC criteria , 2005 .

[118]  B. Shao,et al.  Simultaneous detection of residues of beta-adrenergic receptor blockers and sedatives in animal tissues by high-performance liquid chromatography/tandem mass spectrometry. , 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[119]  B. Le Bizec,et al.  Fast and multiresidue determination of twenty glucocorticoids in bovine milk using ultra high performance liquid chromatography-tandem mass spectrometry. , 2013, Journal of chromatography. A.

[120]  J. Żmudzki,et al.  Determination of zeranol, taleranol, zearalanone, α-zearalenol, β-zearalenol and zearalenone in urine by LC-MS/MS , 2013, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

[121]  Eric Gremaud,et al.  Multi-screening approach to monitor and quantify 42 antibiotic residues in honey by liquid chromatography-tandem mass spectrometry. , 2008, Journal of chromatography. A.

[122]  C T Elliott,et al.  Development of a rapid, multi-class method for the confirmatory analysis of anti-inflammatory drugs in bovine milk using liquid chromatography tandem mass spectrometry. , 2009, Journal of chromatography. A.

[123]  J. Glennon,et al.  Supercritical fluid extraction (SFE) as a multi-residue extraction procedure for beta-agonists in bovine liver tissue. , 1999, The Analyst.

[124]  Siska Croubels,et al.  Quantitative multi-residue analysis of tetracyclines and their 4-epimers in pig tissues by high-performance liquid chromatography combined with positive-ion electrospray ionization mass spectrometry , 2003 .

[125]  C. Peteghem,et al.  Development and validation of a multi-analyte method for the detection of anabolic steroids in bovine urine with liquid chromatography-tandem mass spectrometry. , 2002 .

[126]  P. Delahaut,et al.  Simultaneous detection of five coccidiostats in eggs by liquid chromatography-tandem mass spectrometry , 2003 .

[127]  B. Le Bizec,et al.  Determination of MRL regulated corticosteroids in liver from various species using ultra high performance liquid chromatography-tandem mass spectrometry (UHPLC). , 2011, Analytica chimica acta.

[128]  G. Terplan,et al.  [Biological demonstration of inhibitors in foodstuff of animal origin]. , 1959, Archiv fur lebensmittelhygiene.

[129]  S. Ehling,et al.  Liquid chromatography-mass spectrometry method for the quantitative determination of residues of selected veterinary hormones in powdered ingredients derived from bovine milk. , 2013, Journal of agricultural and food chemistry.

[130]  B. Le Bizec,et al.  Toward a criterion for suspect thiouracil administration in animal husbandry , 2011, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

[131]  H. Meyer,et al.  A sensitive enzyme immunoassay (EIA) for the determination of melengestrol acetate (MGA) in adipose and muscle tissues , 2001, Food additives and contaminants.

[132]  F. Ramos,et al.  Development and validation of a multi-residue and multiclass ultra-high-pressure liquid chromatography-tandem mass spectrometry screening of antibiotics in milk , 2013 .

[133]  C. Elliott,et al.  Development of an ELISA screening test for nitroimidazoles in egg and chicken muscle , 2005 .

[134]  P. Mulder,et al.  The derivatisation of avermectins and milbemycins in milk: new insights and improvement of the procedure. , 2007, Analytica chimica acta.

[135]  P. de Backer,et al.  Quantitative determination of chlortetracycline content in animal plasma at controlled keto-enol tautomerism by liquid chromatography-electrospray ionization-tandem mass spectrometry. , 2006, Journal of chromatography. A.

[136]  J. Blondeau Fluoroquinolones: mechanism of action, classification, and development of resistance. , 2004, Survey of ophthalmology.

[137]  D. Donoghue,et al.  Multiresidue determination of fluoroquinolone antibiotics in eggs using liquid chromatography-fluorescence-mass spectrometryn , 2003 .

[138]  A. González-Bulnes,et al.  Influence of vehicle on kinetics of exogenous progesterone administered either by subcutaneous and intramuscular routes to sheep. , 2008, Research in veterinary science.

[139]  H. Senyuva,et al.  Quantitative multi-residue method for determination antibiotics in chicken meat using turbulent flow chromatography coupled to liquid chromatography-tandem mass spectrometry. , 2013, Journal of chromatography. A.

[140]  Steven J. Lehotay,et al.  Evaluation of a multi-class, multi-residue liquid chromatography-tandem mass spectrometry method for analysis of 120 veterinary drugs in bovine kidney. , 2012, Drug testing and analysis.

[141]  M. Bordignon-Luiz,et al.  Multiclass analysis of antibacterial residues in milk using RP-liquid chromatography with photodiode array and fluorescence detection and tandem mass spectrometer confirmation. , 2012, Talanta.

[142]  H. Oka Chemical analysis for antibiotics used in agriculture , 1995 .

[143]  Limin He,et al.  Multiresidue analysis of nine β-agonists in animal muscles by LC-MS/MS based on a new polymer cartridge for sample cleanup. , 2013, Journal of separation science.

[144]  B. Le Bizec,et al.  Development and validation of an ultra-high performance liquid chromatography tandem mass spectrometry method for quantifying thyreostats in urine without derivatisation. , 2010, Journal of chromatography. A.

[145]  Juan Carlos Moltó,et al.  Review on the toxicity, occurrence, metabolism, detoxification, regulations and intake of zearalenone: an oestrogenic mycotoxin. , 2007, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[146]  A. Kaufmann,et al.  Quantification of anthelmintic drug residues in milk and muscle tissues by liquid chromatography coupled to Orbitrap and liquid chromatography coupled to tandem mass spectrometry. , 2011, Talanta.

[147]  J. Dewulf,et al.  Prophylactic and metaphylactic antimicrobial use in Belgian fattening pig herds. , 2012, Preventive veterinary medicine.

[148]  D. Maume,et al.  Detection and identification of thyreostats in the thyroid gland by gas chromatography-mass spectrometry , 1997 .

[149]  M. Dodd,et al.  THE IN VITRO BACTERIOSTATIC ACTION OF SOME SIMPLE FURAN DERIVATIVES , 1944 .

[150]  G. Font,et al.  Determination of aminoglycoside and macrolide antibiotics in meat by pressurized liquid extraction and LC-ESI-MS. , 2010, Journal of separation science.

[151]  A. G. Frenich,et al.  Development of fast screening methods for the analysis of veterinary drug residues in milk by liquid chromatography-triple quadrupole mass spectrometry , 2010, Analytical and bioanalytical chemistry.

[152]  P. Gallo,et al.  Rapid confirmatory analysis of non-steroidal anti-inflammatory drugs in bovine milk by rapid resolution liquid chromatography tandem mass spectrometry. , 2009, Journal of Chromatography A.

[153]  Y. Tao,et al.  Development of a high-performance liquid chromatography method to monitor the residues of benzimidazoles in bovine milk. , 2010, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[154]  R. Carabias-Martínez,et al.  A fast and reliable method for the quantitative determination of benzimidazoles and metabolites in milk by LC-MS/MS with on-line sample treatment , 2012, Analytical and Bioanalytical Chemistry.

[155]  Yolanda Picó,et al.  Liquid chromatography-mass spectrometry in food safety. , 2010, Journal of chromatography. A.

[156]  H. Rønning,et al.  Determination of chloramphenicol residues in meat, seafood, egg, honey, milk, plasma and urine with liquid chromatography-tandem mass spectrometry, and the validation of the method based on 2002/657/EC. , 2006, Journal of chromatography. A.

[157]  P. Sanders,et al.  Validation of a multi-residue liquid chromatography-tandem mass spectrometry confirmatory method for 10 anticoccidials in eggs according to Commission Decision 2002/657/EC. , 2009, Journal of chromatography. A.

[158]  Brian Kinsella,et al.  Current trends in sample preparation for growth promoter and veterinary drug residue analysis. , 2009, Journal of chromatography. A.

[159]  R. B. Brito,et al.  Optimisation and validation of a quantitative and confirmatory LC-MS method for multi-residue analyses of β-lactam and tetracycline antibiotics in bovine muscle , 2012, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.

[160]  Keita Saito,et al.  Recent advances in SPME techniques in biomedical analysis. , 2011, Journal of pharmaceutical and biomedical analysis.

[161]  X. Xia,et al.  Determination of chloramphenicol, thiamphenicol, florfenicol, and florfenicol amine in poultry and porcine muscle and liver by gas chromatography-negative chemical ionization mass spectrometry. , 2009, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

[162]  M. Danaher,et al.  Anthelmintic drug residues in beef: UPLC-MS/MS method validation, European retail beef survey, and associated exposure and risk assessments , 2012, Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment.