Inhibitors of hepatitis C virus NS3.4A protease 2. Warhead SAR and optimization.

[1]  B. G. Rao,et al.  Inhibitors of hepatitis C virus NS3.4A protease 1. Non-charged tetrapeptide variants. , 2003, Bioorganic & medicinal chemistry letters.

[2]  C. Decicco,et al.  Glycine α-Ketoamides as HCV NS3 Protease Inhibitors , 2003 .

[3]  U. Koch,et al.  Recent developments in the discovery of hepatitis C virus serine protease inhibitors – towards a new class of antiviral agents? , 2003, Expert opinion on investigational drugs.

[4]  A. Basso,et al.  Short synthesis of protease inhibitors via modified Passerini condensation of N-Boc-α-aminoaldehydes , 2002 .

[5]  J. Concellón,et al.  Enantiopure preparation of the two enantiomers of the pseudo-C(2)-symmetric N,N-dibenzyl-1,2:4,5-diepoxypentan-3-amine. , 2001, The Journal of organic chemistry.

[6]  L. W. Spruce,et al.  Development of orally active nonpeptidic inhibitors of human neutrophil elastase. , 2001, Journal of medicinal chemistry.

[7]  N. Jennings,et al.  The identification of α-ketoamides as potent inhibitors of hepatitis c virus nS3-4a proteinase , 2001 .

[8]  R. De Francesco,et al.  Inhibition of the Hepatitis C Virus NS3/4A Protease , 2000, The Journal of Biological Chemistry.

[9]  U. Koch,et al.  Alpha-ketoacids are potent slow binding inhibitors of the hepatitis C virus NS3 protease. , 2000, Biochemistry.

[10]  J. Silver,et al.  Replication of Subgenomic Hepatitis C Virus Rnas in a Hepatoma Cell Line , 1999 .

[11]  D. Lamarre,et al.  Studies on the C-terminal of hexapeptide inhibitors of the hepatitis C virus serine protease. , 1998, Bioorganic & medicinal chemistry letters.

[12]  S. Raybuck,et al.  Mechanistic role of an NS4A peptide cofactor with the truncated NS3 protease of hepatitis C virus: elucidation of the NS4A stimulatory effect via kinetic analysis and inhibitor mapping. , 1997, Biochemistry.

[13]  A Tramontano,et al.  Substrate Specificity of the Hepatitis C Virus Serine Protease NS3* , 1997, The Journal of Biological Chemistry.

[14]  J. Ellman,et al.  Expedient method for the solid-phase synthesis of aspartic acid protease inhibitors directed toward the generation of libraries. , 1995, Journal of medicinal chemistry.

[15]  E. Huber,et al.  Inhibition of human neutrophil elastase with peptidyl electrophilic ketones. 2. Orally active PG-Val-Pro-Val pentafluoroethyl ketones. , 1994, Journal of medicinal chemistry.

[16]  S. Harbeson,et al.  Stereospecific synthesis of peptidyl alpha-keto amides as inhibitors of calpain. , 1994, Journal of medicinal chemistry.

[17]  R A Mueller,et al.  Discovery of a novel class of potent HIV-1 protease inhibitors containing the (R)-(hydroxyethyl)urea isostere. , 1993, Journal of medicinal chemistry.

[18]  P. Edwards A method for the stereoselective synthesis of peptidyl trifluoromethyl ketones , 1992 .

[19]  N. Peet,et al.  Efficient preparation of peptidyl pentaflouroethly ketones , 1992 .

[20]  J F Morrison,et al.  Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors. , 1969, Biochimica et biophysica acta.

[21]  A. Berger,et al.  On the size of the active site in proteases. I. Papain. , 1967, Biochemical and biophysical research communications.

[22]  N. Peet,et al.  Synthesis of peptidyl fluoromethyl ketones and peptidyl alpha-keto esters as inhibitors of porcine pancreatic elastase, human neutrophil elastase, and rat and human neutrophil cathepsin G. , 1990, Journal of medicinal chemistry.

[23]  R. W. Lang,et al.  Fluorine-containing organozinc reagents. IV.: Reformatskii-type reactions of chlorodifluoroacet1c acid derivatives , 1988 .