Inhibitors of hepatitis C virus NS3.4A protease 2. Warhead SAR and optimization.
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B. G. Rao | Chao Lin | S. Harbeson | R. Perni | Kai Lin | J. V. Van Drie | D. Deininger | J. Thomson | E. O'Malley | R. Tung | Yunyi Wei | Y. Luong | J. Pitlik | L. F. Courtney | C. Gates | Y. Moon | J. Court | L. Farmer | S. Britt | R. B. Levin | E. O'malley | B. Rao | John J. Court | Luc J. Farmer | Rhonda B. Levin | John A. Thomson
[1] B. G. Rao,et al. Inhibitors of hepatitis C virus NS3.4A protease 1. Non-charged tetrapeptide variants. , 2003, Bioorganic & medicinal chemistry letters.
[2] C. Decicco,et al. Glycine α-Ketoamides as HCV NS3 Protease Inhibitors , 2003 .
[3] U. Koch,et al. Recent developments in the discovery of hepatitis C virus serine protease inhibitors – towards a new class of antiviral agents? , 2003, Expert opinion on investigational drugs.
[4] A. Basso,et al. Short synthesis of protease inhibitors via modified Passerini condensation of N-Boc-α-aminoaldehydes , 2002 .
[5] J. Concellón,et al. Enantiopure preparation of the two enantiomers of the pseudo-C(2)-symmetric N,N-dibenzyl-1,2:4,5-diepoxypentan-3-amine. , 2001, The Journal of organic chemistry.
[6] L. W. Spruce,et al. Development of orally active nonpeptidic inhibitors of human neutrophil elastase. , 2001, Journal of medicinal chemistry.
[7] N. Jennings,et al. The identification of α-ketoamides as potent inhibitors of hepatitis c virus nS3-4a proteinase , 2001 .
[8] R. De Francesco,et al. Inhibition of the Hepatitis C Virus NS3/4A Protease , 2000, The Journal of Biological Chemistry.
[9] U. Koch,et al. Alpha-ketoacids are potent slow binding inhibitors of the hepatitis C virus NS3 protease. , 2000, Biochemistry.
[10] J. Silver,et al. Replication of Subgenomic Hepatitis C Virus Rnas in a Hepatoma Cell Line , 1999 .
[11] D. Lamarre,et al. Studies on the C-terminal of hexapeptide inhibitors of the hepatitis C virus serine protease. , 1998, Bioorganic & medicinal chemistry letters.
[12] S. Raybuck,et al. Mechanistic role of an NS4A peptide cofactor with the truncated NS3 protease of hepatitis C virus: elucidation of the NS4A stimulatory effect via kinetic analysis and inhibitor mapping. , 1997, Biochemistry.
[13] A Tramontano,et al. Substrate Specificity of the Hepatitis C Virus Serine Protease NS3* , 1997, The Journal of Biological Chemistry.
[14] J. Ellman,et al. Expedient method for the solid-phase synthesis of aspartic acid protease inhibitors directed toward the generation of libraries. , 1995, Journal of medicinal chemistry.
[15] E. Huber,et al. Inhibition of human neutrophil elastase with peptidyl electrophilic ketones. 2. Orally active PG-Val-Pro-Val pentafluoroethyl ketones. , 1994, Journal of medicinal chemistry.
[16] S. Harbeson,et al. Stereospecific synthesis of peptidyl alpha-keto amides as inhibitors of calpain. , 1994, Journal of medicinal chemistry.
[17] R A Mueller,et al. Discovery of a novel class of potent HIV-1 protease inhibitors containing the (R)-(hydroxyethyl)urea isostere. , 1993, Journal of medicinal chemistry.
[18] P. Edwards. A method for the stereoselective synthesis of peptidyl trifluoromethyl ketones , 1992 .
[19] N. Peet,et al. Efficient preparation of peptidyl pentaflouroethly ketones , 1992 .
[20] J F Morrison,et al. Kinetics of the reversible inhibition of enzyme-catalysed reactions by tight-binding inhibitors. , 1969, Biochimica et biophysica acta.
[21] A. Berger,et al. On the size of the active site in proteases. I. Papain. , 1967, Biochemical and biophysical research communications.
[22] N. Peet,et al. Synthesis of peptidyl fluoromethyl ketones and peptidyl alpha-keto esters as inhibitors of porcine pancreatic elastase, human neutrophil elastase, and rat and human neutrophil cathepsin G. , 1990, Journal of medicinal chemistry.
[23] R. W. Lang,et al. Fluorine-containing organozinc reagents. IV.: Reformatskii-type reactions of chlorodifluoroacet1c acid derivatives , 1988 .