Site-specific aspartic acid isomerization regulates self-assembly and neurotoxicity of amyloid-β

[1]  M. Moss,et al.  Unraveling the Early Events of Amyloid-β Protein (Aβ) Aggregation: Techniques for the Determination of Aβ Aggregate Size , 2012, International journal of molecular sciences.

[2]  S. Lesné,et al.  Soluble Aβ oligomer production and toxicity , 2012, Journal of neurochemistry.

[3]  J. Cho,et al.  Protein L-isoaspartyl O-methyltransferase inhibits amyloid beta fibrillogenesis in vitro. , 2011, Die Pharmazie.

[4]  G. Bitan,et al.  Photo-induced cross-linking of unmodified proteins (PICUP) applied to amyloidogenic peptides. , 2009, Journal of visualized experiments : JoVE.

[5]  T. Shirasawa,et al.  Isomerization and/or racemization at Asp23 of Abeta42 do not increase its aggregative ability, neurotoxicity, and radical productivity in vitro. , 2008, Biochemical and biophysical research communications.

[6]  Wim Jiskoot,et al.  Extrinsic Fluorescent Dyes as Tools for Protein Characterization , 2008, Pharmaceutical Research.

[7]  K. Sakai-Kato,et al.  Racemization of the amyloidal beta Asp1 residue blocks the acceleration of fibril formation caused by racemization of the Asp23 residue. , 2007, Biochemical and biophysical research communications.

[8]  S. G. Bolder,et al.  Thioflavin T and birefringence assays to determine the conversion of proteins into fibrils. , 2007, Langmuir : the ACS journal of surfaces and colloids.

[9]  T. Shirasawa,et al.  Verification of the turn at positions 22 and 23 of the beta-amyloid fibrils with Italian mutation using solid-state NMR. , 2005, Bioorganic & medicinal chemistry.

[10]  L. Juliano,et al.  Controlling {beta}-amyloid oligomerization by the use of naphthalene sulfonates: trapping low molecular weight oligomeric species. , 2005, The Journal of biological chemistry.

[11]  Fabrizio Chiti,et al.  Prefibrillar Amyloid Protein Aggregates Share Common Features of Cytotoxicity* , 2004, Journal of Biological Chemistry.

[12]  Y. Cordeiro,et al.  Modulation of Prion Protein Oligomerization, Aggregation, and β-sheet Conversion by 4,4′-Dianilino-1,1′-binaphthyl-5,5′-sulfonate (bis-ANS)* , 2004, Journal of Biological Chemistry.

[13]  J. J. Balbach,et al.  Supramolecular Structure in Full-Length Alzheimer's β-Amyloid Fibrils: Evidence for a Parallel β-Sheet Organization from Solid-State Nuclear Magnetic Resonance , 2002 .

[14]  Stefanie Ritz-Timme,et al.  Racemization of aspartic acid in human proteins , 2002, Ageing Research Reviews.

[15]  T. Grabowski,et al.  Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy , 2001, Annals of neurology.

[16]  T. Shirasawa,et al.  Isoaspartate formation and neurodegeneration in Alzheimer's disease. , 2000, Archives of biochemistry and biophysics.

[17]  M. Benson,et al.  Induction of beta-sheet structure in amyloidogenic peptides by neutralization of aspartate: a model for amyloid nucleation. , 1999, Journal of molecular biology.

[18]  T. Shirasawa,et al.  Synthesis, aggregation, and neurotoxicity of the Alzheimer's Abeta1-42 amyloid peptide and its isoaspartyl isomers. , 1999, Bioorganic & medicinal chemistry letters.

[19]  J. Reed,et al.  A set of constructed type spectra for the practical estimation of peptide secondary structure from circular dichroism. , 1997, Analytical biochemistry.

[20]  M J Ball,et al.  beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[21]  M J Ball,et al.  Structural alterations in the peptide backbone of beta-amyloid core protein may account for its deposition and stability in Alzheimer's disease. , 1993, The Journal of biological chemistry.

[22]  C. Finch,et al.  The neurobiology of Alzheimer's disease. , 1989, Journal of neurosurgery.

[23]  H. Braak,et al.  Occurrence of neuropil threads in the senile human brain and in Alzheimer's disease: A third location of paired helical filaments outside of neurofibrillary tangles and neuritic plaques , 1986, Neuroscience Letters.

[24]  S. Clarke,et al.  Methylation at D-aspartyl residues in erythrocytes: possible step in the repair of aged membrane proteins. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[25]  S. Gandy,et al.  Amyloid-beta oligomers: possible roles as key neurotoxins in Alzheimer's Disease. , 2010, The Mount Sinai journal of medicine, New York.

[26]  N. Greenfield.  Using circular dichroism spectra to estimate protein secondary structure , 2007, Nature Protocols.

[27]  G. Bitan,et al.  Amyloid (cid:1) -Protein Oligomerization PRENUCLEATION INTERACTIONS REVEALED BY PHOTO-INDUCED CROSS-LINKING OF UNMODIFIED PROTEINS* , 2001 .