Transcription factor abnormalities as a cause of beta cell dysfunction in diabetes: a hypothesis
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[1] Lee,et al. Pathogenesis of non-insulin-dependent (type II) diabetes mellitus (NIDDM) - genetic predisposition and metabolic abnormalities. , 1999, Advanced drug delivery reviews.
[2] S. Bonner-Weir,et al. Reduced Insulin, GLUT2, and IDX-1 in β-Cells After Partial Pancreatectomy , 1997, Diabetes.
[3] Samuel L. Pfaff,et al. Independent requirement for ISL1 in formation of pancreatic mesenchyme and islet cells , 1997, Nature.
[4] 細川 等. Upregulated hexokinase activity in isolated islets from diabetic 90% pancreatectomized rats , 1997 .
[5] Y. Matsuzawa,et al. PDX-1 Induces Insulin and Glucokinase Gene Expressions in αTC1 Clone 6 Cells in the Presence of Betacellulin , 1996, Diabetes.
[6] P. Meda,et al. The caudal-related Homeodomain Protein Cdx-2/3 Regulates Glucagon Gene Expression in Islet Cells* , 1996, The Journal of Biological Chemistry.
[7] H. Kaneto,et al. The Human Glucokinase Gene β-Cell-Type Promoter: An Essential Role of Insulin Promoter Factor 1/PDX-1 in Its Activation in HIT-T15 Cells , 1996, Diabetes.
[8] G. Waeber,et al. Transcriptional activation of the GLUT2 gene by the IPF-1/STF-1/IDX-1 homeobox factor. , 1996, Molecular endocrinology.
[9] T. Ogihara,et al. Identification of genes regulated by glucose in a pancreatic beta-cell line by a new method for subtraction of mRNA , 1996, Diabetologia.
[10] J. Holst,et al. Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1. , 1996, Proceedings of the National Academy of Sciences of the United States of America.
[11] O. Madsen,et al. mRNA Profiling of Rat Islet Tumors Reveals Nkx 6.1 as a β-Cell-specific Homeodomain Transcription Factor* , 1996, The Journal of Biological Chemistry.
[12] C. Ostenson,et al. Normalization by Insulin Treatment of Low Mitochondrial Glycerol Phosphate Dehydrogenase and Pyruvate Carboxylase in Pancreatic Islets of the GK Rat , 1996, Diabetes.
[13] J. McGarry,et al. Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat. , 1996, The Journal of clinical investigation.
[14] Yun-ping Zhou,et al. A Fatty Acid—Induced Decrease in Pyruvate Dehydrogenase Activity Is an Important Determinant of β-Cell Dysfunction in the Obese Diabetic db/db Mouse , 1996, Diabetes.
[15] D. Drucker,et al. Activation of amylin gene transcription by LIM domain homeobox gene isl-1. , 1996, Molecular endocrinology.
[16] M. Prentki,et al. Are the β-Cell Signaling Molecules Malonyl-CoA and Cystolic Long-Chain Acyl-CoA Implicated in Multiple Tissue Defects of Obesity and NIDDM? , 1996, Diabetes.
[17] L. Olson,et al. Chronic exposure of betaTC-6 cells to supraphysiologic concentrations of glucose decreases binding of the RIPE3b1 insulin gene transcription activator. , 1996, The Journal of clinical investigation.
[18] F M Matschinsky,et al. A Lesson in Metabolic Regulation Inspired by the Glucokinase Glucose Sensor Paradigm , 1996, Diabetes.
[19] M. Stoffel,et al. Evolution of β-Cell Dysfunction in the Male Zucker Diabetic Fatty Rat , 1995, Diabetes.
[20] R. Stein,et al. The role of the insulin control element and RIPE3b1 activators in glucose-stimulated transcription of the insulin gene. , 1995, Molecular endocrinology.
[21] D Pipeleers,et al. Human and rat beta cells differ in glucose transporter but not in glucokinase gene expression. , 1995, The Journal of clinical investigation.
[22] L. Olson,et al. Reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to a supraphysiologic glucose concentration is associated with loss of STF-1 transcription factor expression. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[23] L. Olson,et al. The reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription factor expression. , 1995, Molecular endocrinology.
[24] M. J. MacDonald,et al. Feasibility of a mitochondrial pyruvate malate shuttle in pancreatic islets. Further implication of cytosolic NADPH in insulin secretion. , 1995, The Journal of biological chemistry.
[25] H. Weintraub,et al. Conversion of Xenopus ectoderm into neurons by NeuroD, a basic helix-loop-helix protein. , 1995, Science.
[26] M. Tsai,et al. Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor. , 1995, Genes & development.
[27] Yun-ping Zhou,et al. Palmitate-Induced β-Cell Insensitivity to Glucose is Coupled to Decreased Pyruvate Dehydrogenase Activity and Enhanced Kinase Activity in Rat Pancreatic Islets , 1995, Diabetes.
[28] V. Grill,et al. Palmitate-induced beta-cell insensitivity to glucose is coupled to decreased pyruvate dehydrogenase activity and enhanced kinase activity in rat pancreatic islets. , 1995, Diabetes.
[29] W. Rutter,et al. Pancreatic beta cells express a diverse set of homeobox genes. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[30] G. Asins,et al. Expression of GLUT-2 antisense RNA in beta cells of transgenic mice leads to diabetes. , 1994, The Journal of biological chemistry.
[31] O. Madsen,et al. Transcriptional regulation of the human insulin gene is dependent on the homeodomain protein STF1/IPF1 acting through the CT boxes. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[32] K. Docherty,et al. Glucose modulates the binding activity of the beta-cell transcription factor IUF1 in a phosphorylation-dependent manner. , 1994, The Biochemical journal.
[33] M. Peyton,et al. Two distinct class A helix-loop-helix transcription factors, E2A and BETA1, form separate DNA binding complexes on the insulin gene E box. , 1994, The Journal of biological chemistry.
[34] H. Edlund,et al. Insulin-promoter-factor 1 is required for pancreas development in mice , 1994, Nature.
[35] M. German,et al. The insulin gene contains multiple transcriptional elements that respond to glucose , 1994, Molecular and cellular biology.
[36] R. Stein,et al. XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor. , 1994, Molecular endocrinology.
[37] J. H. Johnson,et al. GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity. , 1994, The Journal of biological chemistry.
[38] G. Weir,et al. Ribozyme-mediated attenuation of pancreatic beta-cell glucokinase expression in transgenic mice results in impaired glucose-induced insulin secretion. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[39] B. Portha,et al. Glucose refractoriness of pancreatic beta-cells in rat models of non-insulin dependent diabetes. , 1994, Diabete & metabolisme.
[40] J. Habener,et al. IDX‐1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene. , 1994, The EMBO journal.
[41] M. J. MacDonald,et al. Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. Potential role in nutrient sensing. , 1994, The Journal of biological chemistry.
[42] R. Stein,et al. Glucose-induced transcription of the insulin gene is mediated by factors required for beta-cell-type-specific expression , 1994, Molecular and cellular biology.
[43] Yun-ping Zhou,et al. Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle. , 1994, The Journal of clinical investigation.
[44] R. Stein,et al. Expression of the trans-active factors that stimulate insulin control element-mediated activity appear to precede insulin gene transcription. , 1994, The Journal of biological chemistry.
[45] H. Yki-Järvinen. Pathogenesis of non-insulin-dependent diabetes mellitus , 1994, The Lancet.
[46] C. Jung,et al. High Km of GLUT-2 glucose transporter does not explain its role in insulin secretion. , 1993, The American journal of physiology.
[47] C. Ostenson,et al. Metabolism of endogenous nutrients in islets of Goto-Kakizaki (GK) rats. , 1993, The Biochemical journal.
[48] L. Baxter,et al. A Second Pathway for Regeneration of Adult Exocrine and Endocrine Pancreas: A Possible Recapitulation of Embryonic Development , 1993, Diabetes.
[49] H. Ohlsson,et al. IPF1, a homeodomain‐containing transactivator of the insulin gene. , 1993, The EMBO journal.
[50] M. Montminy,et al. Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells. , 1993, Molecular endocrinology.
[51] M. Prentki,et al. Glucose regulates acetyl-CoA carboxylase gene expression in a pancreatic beta-cell line (INS-1). , 1993, The Journal of biological chemistry.
[52] R. Casamitjana,et al. Signals Derived From Glucose Metabolism Are Required for Glucose Regulation of Pancreatic Islet GLUT2 mRNA and Protein , 1993, Diabetes.
[53] K. Polonsky,et al. Expression of Calcium Channel mRNAs in Rat Pancreatic Islets and Downregulation After Glucose Infusion , 1993, Diabetes.
[54] L. Olson,et al. Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein. , 1993, The Journal of clinical investigation.
[55] Y. Ben-Neriah,et al. Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and the human insulin promoters. , 1993, Proceedings of the National Academy of Sciences of the United States of America.
[56] G. Weir,et al. The relationship of diabetes, loss of glucose-induced insulin secretion, and GLUT2. , 1993, Journal of diabetes and its complications.
[57] W. Malaisse,et al. Interference of glycogenolysis with glycolysis in pancreatic islets from glucose-infused rats. , 1993, The Journal of clinical investigation.
[58] J. McGarry,et al. What if Minkowski had been ageusic? An alternative angle on diabetes. , 1992, Science.
[59] C. Östenson,et al. Glucocorticoid increases glucose cycling and inhibits insulin release in pancreatic islets of ob/ob mice. , 1992, The American journal of physiology.
[60] H. Lodish,et al. Expression and function of GLUT-1 and GLUT-2 glucose transporter isoforms in cells of cultured rat pancreatic islets. , 1992, The Journal of biological chemistry.
[61] L. G. Moss,et al. Hepatocyte nuclear factor 1 alpha is expressed in a hamster insulinoma line and transactivates the rat insulin I gene. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[62] A. Leiter,et al. Identification of a transcriptional enhancer important for enteroendocrine and pancreatic islet cell-specific expression of the secretin gene , 1992, Molecular and cellular biology.
[63] J. H. Johnson,et al. Roles of insulin resistance and beta-cell dysfunction in dexamethasone-induced diabetes. , 1992, The Journal of clinical investigation.
[64] R. Robertson,et al. Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations. , 1992, The Journal of clinical investigation.
[65] S. Goodison,et al. Control of insulin gene expression by glucose. , 1992, The Biochemical journal.
[66] H. Lodish,et al. [Val12] HRAS downregulates GLUT2 in beta cells of transgenic mice without affecting glucose homeostasis. , 1992, Proceedings of the National Academy of Sciences of the United States of America.
[67] W. Rutter,et al. The insulin and islet amyloid polypeptide genes contain similar cell-specific promoter elements that bind identical beta-cell nuclear complexes , 1992, Molecular and cellular biology.
[68] J. Kaysen,et al. Lack of Glyconeogenesis in Pancreatic Islets: Expression of Gluconeogenic Enzyme Genes in Islets , 1992, Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
[69] J. Leahy,et al. β-Cell Dysfunction Induced by Chronic Hyperglycemia: Current Ideas on Mechanism of Impaired Glucose-Induced Insulin Secretion , 1992, Diabetes Care.
[70] S. Seino,et al. Expression of GLUT1 and GLUT2 Glucose Transporter Isoforms in Rat Islets of Langerhans and Their Regulation by Glucose , 1992, Diabetes.
[71] J. Leahy,et al. Beta-cell dysfunction induced by chronic hyperglycemia. Current ideas on mechanism of impaired glucose-induced insulin secretion. , 1992, Diabetes care.
[72] M. Tsai,et al. Cell-specific and ubiquitous factors are responsible for the enhancer activity of the rat insulin II gene. , 1991, The Journal of biological chemistry.
[73] S. Efrat,et al. Glucose induces insulin gene transcription in a murine pancreatic beta-cell line. , 1991, The Journal of biological chemistry.
[74] R. Unger,et al. Diabetic hyperglycemia: link to impaired glucose transport in pancreatic beta cells. , 1991, Science.
[75] W. Rutter,et al. Two related helix-loop-helix proteins participate in separate cell-specific complexes that bind the insulin enhancer. , 1991, Molecular endocrinology.
[76] R. Umek,et al. CCAAT-enhancer binding protein: a component of a differentiation switch. , 1991, Science.
[77] M. J. MacDonald,et al. Elusive Proximal Signals of β-Cells for Insulin Secretion , 1990, Diabetes.
[78] J. H. Johnson,et al. Underexpression of beta cell high Km glucose transporters in noninsulin-dependent diabetes , 1990, Science.
[79] J. H. Johnson,et al. Regulation of beta-cell glucose transporter gene expression. , 1990, Proceedings of the National Academy of Sciences of the United States of America.
[80] M. Tsai,et al. Cooperativity of sequence elements mediates tissue specificity of the rat insulin II gene , 1990, Molecular and cellular biology.
[81] R. Vigneri,et al. Chronic Exposure to High Glucose and Impairment of K+-Channel Function in Perifused Rat Pancreatic Islets , 1990, Diabetes.
[82] R. Vigneri,et al. Chronic exposure to high glucose and impairment of K(+)-channel function in perifused rat pancreatic islets. , 1990, Diabetes.
[83] W. Malaisse,et al. Perturbation of pancreatic islet function in glucose-infused rats. , 1990, Metabolism: clinical and experimental.
[84] R. Robertson,et al. Insulin Secretion and cAMP Metabolism in HIT Cells: Reciprocal and Serial Passage-Dependent Relationships , 1989, Diabetes.
[85] D. Pipeleers,et al. Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells. , 1988, Proceedings of the National Academy of Sciences of the United States of America.
[86] S. O’Rahilly,et al. Impaired pulsatile secretion of insulin in relatives of patients with non-insulin-dependent diabetes. , 1988, The New England journal of medicine.
[87] W. Rutter,et al. A mutational analysis of the insulin gene transcription control region: expression in beta cells is dependent on two related sequences within the enhancer. , 1987, Proceedings of the National Academy of Sciences of the United States of America.
[88] S. Bonner-Weir,et al. Partial pancreatectomy in the rat and subsequent defect in glucose-induced insulin release. , 1983, The Journal of clinical investigation.
[89] G. Weir. Non-insulin-dependent diabetes mellitus: interplay between B-cell inadequacy and insulin resistance. , 1982, The American journal of medicine.
[90] M. MacDonald,et al. High content of mitochondrial glycerol-3-phosphate dehydrogenase in pancreatic islets and its inhibition by diazoxide. , 1981, The Journal of biological chemistry.
[91] D. Porte,et al. Relationships between fasting plasma glucose levels and insulin secretion during intravenous glucose tolerance tests. , 1976, The Journal of clinical endocrinology and metabolism.
[92] H. Lodish,et al. HRAS downregulates GLUT 2 in I 6 cells of transgenic mice without affecting glucose homeostasis , 2022 .