Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
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[1] T. McKinsey. Faculty Opinions recommendation of A compendium of chromatin contact maps reveals spatially active regions in the human genome. , 2018, Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature.
[2] P. Elliott,et al. Genetic Predisposition to High Blood Pressure and Lifestyle Factors: Associations With Midlife Blood Pressure Levels and Cardiovascular Events , 2017, Circulation.
[3] K. Rawlik,et al. An atlas of genetic associations in UK Biobank , 2017, Nature Genetics.
[4] Y. Fukumoto,et al. Elevated Plasma Transforming Growth Factor &bgr;1 Levels Predict the Development of Hypertension in Normotensives: The 14-Year Follow-Up Study , 2017, American journal of hypertension.
[5] Andrew D. Johnson,et al. Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney , 2017, Hypertension.
[6] P. Donnelly,et al. Genome-wide genetic data on ~500,000 UK Biobank participants , 2017, bioRxiv.
[7] Yang I Li,et al. An Expanded View of Complex Traits: From Polygenic to Omnigenic , 2017, Cell.
[8] David M. Evans,et al. Collider scope: when selection bias can substantially influence observed associations , 2016, bioRxiv.
[9] Katsuya Tanaka,et al. Phosphatidylinositol 3‐kinase inhibition induces vasodilator effect of sevoflurane via reduction of Rho kinase activity , 2017, Life sciences.
[10] Jing Wang,et al. WebGestalt 2017: a more comprehensive, powerful, flexible and interactive gene set enrichment analysis toolkit , 2017, Nucleic Acids Res..
[11] L. Dell’Italia,et al. Novel Paradigms of Salt and Hypertension. , 2017, Journal of the American Society of Nephrology : JASN.
[12] R. Mägi,et al. Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel , 2017, European Journal of Human Genetics.
[13] P. D. Bakker,et al. Resetting the bar: Statistical significance in whole‐genome sequencing‐based association studies of global populations , 2017, Genetic epidemiology.
[14] K. Caron,et al. Cardiovascular effects of exogenous adrenomedullin and CGRP in Ramp and Calcrl deficient mice , 2017, Peptides.
[15] Ivy Shiue,et al. Global Burden of Hypertension and Systolic Blood Pressure of at Least 110 to 115 mm Hg, 1990-2015 , 2017, JAMA.
[16] He Gao,et al. Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk , 2017, Nature Genetics.
[17] Marcelo P. Segura-Lepe,et al. Rare and low-frequency coding variants alter human adult height , 2016, Nature.
[18] Helen E. Parkinson,et al. The new NHGRI-EBI Catalog of published genome-wide association studies (GWAS Catalog) , 2016, Nucleic Acids Res..
[19] N. Risch,et al. Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation , 2016, Nature Genetics.
[20] Núria Queralt-Rosinach,et al. DisGeNET: a comprehensive platform integrating information on human disease-associated genes and variants , 2016, Nucleic Acids Res..
[21] Anthony D. Schmitt,et al. A Compendium of Chromatin Contact Maps Reveals Spatially Active Regions in the Human Genome. , 2016, Cell reports.
[22] Jacqueline P Mitchell,et al. Circulating Apolipoprotein E Concentration and Cardiovascular Disease Risk: Meta-analysis of Results from Three Studies , 2016, PLoS medicine.
[23] Claude Bouchard,et al. Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci , 2016, Nature Genetics.
[24] He Zhang,et al. Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension , 2016, Nature Genetics.
[25] Xiaofeng Zhu,et al. The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals , 2016, Nature Genetics.
[26] Ricardo Pong-Wong,et al. Evaluating the contribution of genetic and familial shared environment to common disease using the UK Biobank , 2016, Nature Genetics.
[27] Stephen Burgess,et al. PhenoScanner: a database of human genotype–phenotype associations , 2016, Bioinform..
[28] P. Elliott,et al. Worldwide Exposures to Cardiovascular Risk Factors and Associated Health Effects: Current Knowledge and Data Gaps , 2016, Circulation.
[29] Hai-Jian Sun,et al. Relaxin in paraventricular nucleus contributes to sympathetic overdrive and hypertension via PI3K-Akt pathway , 2016, Neuropharmacology.
[30] Mary Brophy,et al. Million Veteran Program: A mega-biobank to study genetic influences on health and disease. , 2016, Journal of clinical epidemiology.
[31] Ashutosh Kumar Singh,et al. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015 , 2016, Lancet.
[32] Morris J. Brown,et al. Pregnancy, Primary Aldosteronism, and Adrenal CTNNB1 Mutations. , 2015, The New England journal of medicine.
[33] O. Troyanskaya,et al. Predicting effects of noncoding variants with deep learning–based sequence model , 2015, Nature Methods.
[34] Beth Wilmot,et al. Edinburgh Explorer Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture , 2022 .
[35] L. Wain,et al. Novel insights into the genetics of smoking behaviour, lung function, and chronic obstructive pulmonary disease (UK BiLEVE): a genetic association study in UK Biobank , 2015, The Lancet. Respiratory medicine.
[36] Gabor T. Marth,et al. A global reference for human genetic variation , 2015, Nature.
[37] R. Mägi,et al. Cohort Profile Cohort Profile : Estonian Biobank of the Estonian Genome Center , University of Tartu , 2015 .
[38] P. Val,et al. Adrenal cortex tissue homeostasis and zonation: A WNT perspective , 2015, Molecular and Cellular Endocrinology.
[39] J. Tanus-Santos,et al. Polymorphisms in VEGFA gene affect the antihypertensive responses to enalapril , 2015, European Journal of Clinical Pharmacology.
[40] Núria Queralt-Rosinach,et al. DisGeNET: a discovery platform for the dynamical exploration of human diseases and their genes , 2015, Database J. Biol. Databases Curation.
[41] P. Munroe,et al. Exploring hypertension genome‐wide association studies findings and impact on pathophysiology, pathways, and pharmacogenetics , 2015, Wiley interdisciplinary reviews. Systems biology and medicine.
[42] P. Elliott,et al. UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age , 2015, PLoS medicine.
[43] J. Hirschhorn,et al. Biological interpretation of genome-wide association studies using predicted gene functions , 2015, Nature Communications.
[44] B. Berger,et al. Efficient Bayesian mixed model analysis increases association power in large cohorts , 2014, Nature Genetics.
[45] M. Daly,et al. LD Score regression distinguishes confounding from polygenicity in genome-wide association studies , 2014, Nature Genetics.
[46] M. Caulfield,et al. Hypertension , 1931, The Lancet.
[47] Ewan Birney,et al. FORGE: A tool to discover cell specific enrichments of GWAS associated SNPs in regulatory regions , 2014, bioRxiv.
[48] Neva C. Durand,et al. A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping , 2014, Cell.
[49] Jeanette Spear,et al. The Airwave Health Monitoring Study of police officers and staff in Great Britain: rationale, design and methods. , 2014, Environmental research.
[50] M. Woodward,et al. Blood pressure-lowering treatment based on cardiovascular risk: a meta-analysis of individual patient data , 2014, The Lancet.
[51] Zoltán Kutalik,et al. Quality control and conduct of genome-wide association meta-analyses , 2014, Nature Protocols.
[52] J. Ioannidis,et al. Meta-analysis methods for genome-wide association studies and beyond , 2013, Nature Reviews Genetics.
[53] M. Caulfield,et al. Genes for blood pressure: an opportunity to understand hypertension. , 2013, European heart journal.
[54] Hollis G. Potter,et al. Author Manuscript , 2013 .
[55] Eurie L. Hong,et al. Annotation of functional variation in personal genomes using RegulomeDB , 2012, Genome research.
[56] Christian Gieger,et al. Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure , 2011, Nature Genetics.
[57] Christian Gieger,et al. Genetic Variants in Novel Pathways Influence Blood Pressure and Cardiovascular Disease Risk , 2011, Nature.
[58] E. Lalli,et al. The Wnt/beta-catenin pathway in adrenocortical development and cancer , 2011, Molecular and Cellular Endocrinology.
[59] P. Visscher,et al. GCTA: a tool for genome-wide complex trait analysis. , 2011, American journal of human genetics.
[60] Yun Li,et al. METAL: fast and efficient meta-analysis of genomewide association scans , 2010, Bioinform..
[61] K. Conrad. Unveiling the vasodilatory actions and mechanisms of relaxin. , 2010, Hypertension.
[62] Ayellet V. Segrè,et al. Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis , 2010, Nature Genetics.
[63] P. O’Reilly,et al. Genome-wide association study identifies eight loci associated with blood pressure , 2009, Nature Genetics.
[64] D. Levy,et al. Association of common variants in NPPA and NPPB with circulating natriuretic peptides and blood pressure , 2009, Nature Genetics.
[65] W. Elliott,et al. Prevalence of primary hyperaldosteronism in resistant hypertension: a retrospective observational study , 2009 .
[66] A. Triantafyllou,et al. Prevalence of primary hyperaldosteronism in resistant hypertension: a retrospective observational study , 2008, The Lancet.
[67] Evangelos Evangelou,et al. Heterogeneity in Meta-Analyses of Genome-Wide Association Investigations , 2007, PloS one.
[68] Manuel A. R. Ferreira,et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. , 2007, American journal of human genetics.
[69] E. Porteri,et al. A prospective study of the prevalence of primary aldosteronism in 1,125 hypertensive patients. , 2006, Journal of the American College of Cardiology.
[70] Nuala A Sheehan,et al. Adjusting for treatment effects in studies of quantitative traits: antihypertensive therapy and systolic blood pressure , 2005, Statistics in medicine.
[71] J. Bertherat,et al. Mutations of beta-catenin in adrenocortical tumors: activation of the Wnt signaling pathway is a frequent event in both benign and malignant adrenocortical tumors. , 2005, Cancer research.
[72] J. Rothstein,et al. Signal-Crosstalk Between Rho/ROCK and c-Jun NH2-Terminal Kinase Mediates Migration of Vascular Smooth Muscle Cells Stimulated by Angiotensin II , 2005, Arteriosclerosis, thrombosis, and vascular biology.
[73] D. Calhoun,et al. Hyperaldosteronism Among Black and White Subjects With Resistant Hypertension , 2002, Hypertension.
[74] Y. Benjamini,et al. THE CONTROL OF THE FALSE DISCOVERY RATE IN MULTIPLE TESTING UNDER DEPENDENCY , 2001 .
[75] R. Trembath,et al. Heterozygous germline mutations in BMPR2, encoding a TGF-β receptor, cause familial primary pulmonary hypertension , 2000, Nature Genetics.
[76] L. Powell-Braxton,et al. Hypertension and endothelial dysfunction in apolipoprotein E knockout mice. , 1999, Arteriosclerosis, thrombosis, and vascular biology.
[77] Y. Benjamini,et al. Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .
[78] J C Christian,et al. The NHLBI twin study of cardiovascular disease risk factors: methodology and summary of results. , 1977, American journal of epidemiology.