Inhaled endotoxin and organic dust particulates have synergistic proinflammatory effects in equine heaves (organic dust‐induced asthma)

Background Equine heaves is a naturally occurring organic dust‐induced asthma characterized by airway neutrophilia, mucus hypersecretion and obstructive lung dysfunction. However, the relative role of different dust components in disease severity remains unclear.

[1]  P. Gustin,et al.  Acute Effects of Endotoxin Inhalation on the Respiratory Tract in Pigs: Interaction with Ammonia , 1996 .

[2]  G. Mclachlan,et al.  Evaluation of nebulised hay dust suspensions (HDS) for the diagnosis and investigation of heaves. 1: Preparation and composition of HDS. , 2010, Equine veterinary journal.

[3]  M. Olszewski,et al.  The pathogenesis of chronic obstructive pulmonary disease of horses. , 1996, The British veterinary journal.

[4]  R. Sergysels,et al.  Dose-response relationship to inhaled endotoxin in normal subjects. , 1997, American journal of respiratory and critical care medicine.

[5]  B. McGorum,et al.  Evaluation of nebulised hay dust suspensions (HDS) for the diagnosis and investigation of heaves. 3: Effect of fractionation of HDS. , 2010, Equine veterinary journal.

[6]  A. Imrich,et al.  Lipopolysaccharide priming amplifies lung macrophage tumor necrosis factor production in response to air particles. , 1999, Toxicology and applied pharmacology.

[7]  D. Collie,et al.  Pulmonary and systemic effects of inhaled endotoxin in control and heaves horses. , 2010, Equine veterinary journal.

[8]  V. Castranova,et al.  Effects of diesel exhaust particles (DEP), carbon black, and silica on macrophage responses to lipopolysaccharide: evidence of DEP suppression of macrophage activity. , 1999, Journal of toxicology and environmental health. Part A.

[9]  E. Bleecker,et al.  Asthma and endotoxin: lipopolysaccharide-binding protein and soluble CD14 in bronchoalveolar compartment. , 1996, The American journal of physiology.

[10]  Z. Prażmo,et al.  Airborne microorganisms and endotoxin in animal houses , 1994 .

[11]  D. Schwartz,et al.  Role of endotoxin in grain dust-induced lung inflammation in mice. , 1996, The American journal of physiology.

[12]  Güunter Oberdürster Toxicology of ultrafine particles: in vivo studies , 2000, Philosophical Transactions of the Royal Society of London. Series A: Mathematical, Physical and Engineering Sciences.

[13]  A. Imrich,et al.  Alveolar macrophage cytokine production in response to air particles in vitro: role of endotoxin. , 2000, Journal of toxicology and environmental health. Part A.

[14]  F. Derksen Chronic obstructive pulmonary disease (heaves) as an inflammatory condition. , 1993, Equine Veterinary Journal.

[15]  J. Murphy,et al.  Chronic obstructive pulmonary disease (COPD) in horses: aetiological studies: responses to intradermal and inhalation antigenic challenge. , 1979, Equine veterinary journal.

[16]  J. Murphy,et al.  The presence of precipitating antibodies in the sera of horses with chronic obstructive pulmonary disease (COPD). , 1979, Equine veterinary journal.

[17]  J. Beech,et al.  The role of allergy in chronic pulmonary disease of horses. , 1979, Journal of the American Veterinary Medical Association.

[18]  R. Rylander Plant constituents of cotton dust and lung effects after inhalation. , 1988, The European respiratory journal.

[19]  D. Altman,et al.  STATISTICAL METHODS FOR ASSESSING AGREEMENT BETWEEN TWO METHODS OF CLINICAL MEASUREMENT , 1986, The Lancet.

[20]  M. Olszewski,et al.  The pathogenesis of chronic obstructivepulmonary disease of horses , 1996 .

[21]  B. McGorum,et al.  Total and respirable airborne dust endotoxin concentrations in three equine management systems. , 1998, Equine veterinary journal.

[22]  R. Rylander,et al.  Pulmonary function and symptoms after inhalation of endotoxin. , 1989, The American review of respiratory disease.

[23]  W. Popendorf Report on agents , 1986 .

[24]  M. Beard,et al.  Effect of phone book paper versus sawdust and straw bedding on the presence of airborne gram-negative bacteria, fungi and endotoxin in horse stalls , 1998 .

[25]  R. Ulevitch,et al.  Lipopolysaccharide binding protein enhances the responsiveness of alveolar macrophages to bacterial lipopolysaccharide. Implications for cytokine production in normal and injured lungs. , 1992, The Journal of clinical investigation.

[26]  B. McGorum,et al.  Responses of horses affected with chronic obstructive pulmonary disease to inhalation challenges with mould antigens. , 1993, Equine veterinary journal.

[27]  D. Collie,et al.  Evaluation of nebulised hay dust suspensions (HDS) for the diagnosis and investigation of heaves. 2: Effects of inhaled HDS on control and heaves horses. , 2010, Equine veterinary journal.

[28]  Günter Oberdörster,et al.  Toxicology of ultrafine particles: in vivo studies , 2000 .

[29]  A. Beckett,et al.  AKUFO AND IBARAPA. , 1965, Lancet.

[30]  J. Milanowski EXPERIMENTAL STUDIES ON THE EFFECTS OF ORGANIC DUST-DERIVED AGENTS ON RESPIRATORY SYSTEM : COMPARISON BETWEEN ENDOTOXINS AND GLUCANS , 1997 .

[31]  N. E. Robinson,et al.  Aerosolized Micropolyspora faeni antigen as a cause of pulmonary dysfunction in ponies with recurrent airway obstruction (heaves). , 1988, American journal of veterinary research.

[32]  J M Bland,et al.  Statistical methods for assessing agreement between two methods of clinical measurement , 1986 .