Effect of Bisphenol A Administration on Reproductive Characteristic and Blood Metabolite in Mice

The objective of this study was to investigate the effects of BPA on reproductive characteristic and blood hematological and chemical values in mice. The male mice were intraperitoneally injected BPA in native control(no treatment), positive control(corn oil, 3 m /kg B.W), 0.05, 0.5 and 5.0 mg BPA/kg B.W and female mice were injected BPA in control(corn oil, 3 m /kg B.W), 0.05, 0.5 and 5.0 mg BPA/kg B.W with 5 times at 3 days interval for 14 days. The administration of BPA in male mice didn't affect the body and re- productive organ weight such as testis, epididymis, vesicular gland and coagulating gland. We found that the 5.0 mg BPA group was significantly reduced the sperm concentration and increased the sperm abnormality compared to native, positive control and 0.05 mg BPA groups(P 0.05). However, the value of WBC was slightly lower in BPA treatment groups than that of control groups and PLT was slightly higher in BPA groups than that of control groups, but not sig- nificantly defference among the experimental groups(P > 0.05). In female mice, the effects of BPA on body weight didn't affect in all experimental groups, but ovary weights in 0.5 and 5.0 mg BPA groups were sig- nificantly increased compared to those in control and 0.05 mg BPA group(P 0.05). The RBC, Hb, HT, MCV, MCH, MCHC, albumin and total protein of blood hematological and chemical values in female were not different in all experimental groups(P > 0.05). The values of WBC and PLT in BPA groups were slightly higher than that of control, but not significantly different among the experimental groups. The concentration of BUN was the higher in BPA groups than that of control group. The histological evaluation of testis, ovary and uterus were not different in all experimental groups.