The purpose of this study was to evaluate the clinical performance of two to five-unit implant-supported all-ceramic reconstructions and to compare the results of two different all-ceramic systems, Denzir (DZ) and In-Ceram Zirconia (InZ). Eighteen patients were treated with a total of 25 two- to five-unit implant-supported reconstructions. Nine patients were given reconstructions of the DZ system and the other nine reconstructions of the InZ system. The reconstructions were cemented with zinc phosphate cement onto preparable titanium abutments and were evaluated after 6 and 12 months. At the 12-month follow-up, all reconstructions were in function; none had fractured. Superficial cohesive (chip-off) fractures were, however, observed in 6 of the 18 patients (8 of 25 reconstructions). Nine units in the DZ group (in 7 of 13 reconstructions) and one in the InZ group (1 of 12 reconstructions) had chip-off fractures. The difference between the two groups regarding frequency of chip-off fractures was statistically significant (P < 0.01). Marginal integrity was rated excellent at 34 abutments (56%) and acceptable at 27 (44%). Results from this 12-month trial suggest that all-ceramic implant-supported fixed partial dentures of two- to five-units may be considered a treatment alternative. When comparing the two ceramic systems under study, however, this study concludes that the DZ system exhibits an unacceptable amount of veneering porcelain fractures and thus cannot be recommended for the type of treatment evaluated in this trial. Further studies and long-term follow-ups must be performed before the materials and technique can be recommended for general use.